检索结果-南通市图书馆

Transactions of Nonferrous Metals Society of China 2020年第2期30卷 463-471页

作者： kuan-hong zeng Qing-song MA Xing-yu GU Science and Technology on Advanced Ceramic Fibers&Composites Laboratory National University of Defense TechnologyChangsha 410073China

3D carbon fiber needled felt and polycarbosilane-derived SiC coating were selected as reinforcement and interfacial coating,respectively,and the sol-impregnation-drying-heating(SIDH)route was used to fabricate C/Al2O3 *** effects of Si C interfacial coating on the mechanical properties,oxidation resistance and thermal shock resistance of C/Al2O3 composites were *** is found that the fracture toughness of C/Al2O3 composites was remarkably superior to that of monolithic Al2O3 *** introduction of SiC interfacial coating obviously improved the strengths of C/Al2O3 composites although the fracture work diminished to some *** to the tight bonding between SiC coating and carbon fiber,the C/SiC/Al2O3 composites showed much better oxidation and thermal shock resistance over C/Al2O3 composites under static air.

关键词： alumina carbon fiber reinforcement interfacial coating mechanical properties oxidation resistance thermal shock resistance

Influence of Electrolyte Composition on the Calcium-Phosphorus compound Coating on Titanium Substrate by Micro-arc Oxidation

在线全文

学校读者我要写书评

暂无评论

材料热处理学报 2004年第05B期25卷 1064-1067页

作者： ZHUXiu-hong WANGCong-zeng KOUBin-da SUXue-kuan ZHANGWen-quan CollegeofMaterialsScienceandEngineering BeijingUniversityofTechnologyBeijingChina

The compound bioceramic coating containing calcium (Ca) and phosphorus (P) on titanium alloy substrate was prepared by means of micro-arc oxidation (MAO) treatment. The results show that under the different electrolyte the coating with the color of gray or black and surface morphology of cauliflower or honeycomb, where Ca content and P contain can attain 30% and 20% respectively, can be obtained. Meanwhile, the influences of electrolyte temperature, current density and discharge time on morphology and thickness of coating are also discussed here.

关键词：微电弧氧化钛合金磷涂层钙涂层陶瓷涂层

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang zeng Jun-hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Analysis of Peptide Ligand Binding to FGFR1

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2003年第1期19卷 41-43页

作者： FAN hong-kuan LI Fei 等 CollegeofLifeScience SupraMolecularStrucutreandSpectroscopyofMinistryofEducation JilinUniversityChangchun130023P.R.China

Simulating annealing algorithm was used in docking computation to predict a selected peptide VYMSPF(P2) binding site on the ectodomain of FGFR1. The peptide is located on the hydrophobic surface of the receptor, which is critical for FGF binding. The synthesized peptide can effectively inhibit the mitogenic activity of aFGF, and has a potential to become a therapeutic agent as an aFGF antagonist.

关键词： Fibroblast growth factor Inhibitor Docking Simulating annealing algorithm

Quantitative Analysis on Carbon Migration in Double-Glow Discharge Plasma Surface Alloying Process

在线全文

学校读者我要写书评

暂无评论

材料热处理学报 2004年第05B期25卷 674-677页

作者： ZHANGZhen-xia WANGCong-zeng ZHANGWen-quan SUXue-kuan InstitutionofElectronics ChineseAcademyofSciencesBeijingChina CollegeofMaterialsScienceandEngineering BeijingUniversityofTechnologyBeijingChina

Carbon migration is of great significance in double-glow discharge plasma surface alloying process, but literature of quantitative analysis about carbon migration is relatively scarce. In this paper differential equations of the carbon and metal concentration distribution were established. By means of differential equations carbon migration was described and a numerical solution was acquired. The computational results fit the experiment results quite well.

关键词：双重辉光放电等离子表面铸合碳迁移碳钢

Electronic Structure and Magnetic Properties of Cr-Doped AlN

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2007年第4X期48卷 749-753页

作者： CHEN hong ZHANG Jun-Feng YUAN hong-kuan School of Physical Science and Technology Southwest University Chongqing 400715 China

To understand the electronic and magnetic properties, we have studied Cr-doped zinc-blende AlN system in detail by applying a first-principle plane wave pseudopotential method based on the density functional theory within the local spin density approximation. The analyses of the band structures, density of states, exchange interactions, and magnetic moments show that Al1-xCrxN alloys may exhibit a half-metallic ferromagnetism character, that Cr in the diluted doping limit forms near-midgap deep levels, and that the total magnetization of the cell is 3μB per Cr atom, which does not change with Cr concentration. Moreover, we have succeeded in predicting that Al1-xCrzN alloys in x = 0.0625 has a very high Curie temperature, and lind that ferromagnetic exchange interaction between magnetic dopants is short-ranged.

关键词： density functional theory electronic structure magnetism Curie temperature

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词：

同方期刊数据库

Effect of Parabolic Potential on Bipolaron

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2004年第5X期42卷 785-788页

作者： RUANYong-hong CHENQing-Hu JIAOZheng-kuan DepartmentofPhysics ZhejiangUniversityHangzhou310027China

We apply a Feynman path-integral variational approach combining with the average for the relative motion to study the stability of bipolaron in a quantum dot. The binding energy is calculated in different parameters. We find that an optimum quantum potential favors the formation of bipolaron. Compared with other methods in literature, the present pproach is better than Laudau-Pekar one in all coupling regime and full path-integral one in the strong coupling regime.

关键词：二元共聚物量子点限制势能基态能量结合能

Synthesis and Crystal Structure of N-(1′-H-Pyrrol-2′-ylcarbonyl)-5-amino-1,10-phenanthroline

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2008年第2期27卷 163-166页

作者： WANG Yue-hong LIN Hai LIN Hua-kuan Department of Chemistry Nankai University Tianjin 300071 China Key Laboratory of Functional Polymer Materials of the Ministry of Education Nankai University Tianjin 300071 China

The title compound, N-（1′-H-pyrrol-2′-ylcarbonyl）-5-amino-1,10-phenanthroline, was synthesized by the reaction of a-pyrrolyl carbonyl chloride and 5-amino-1,10-phenanthroline in pyridine. Determined by X-ray structure analysis, it crystallizes in triclinic system, space group P1 with the following crystallographic data： C20H21N5O3, Mr = 379.42, a = 7.8559（4）, b = 9.1681（6）, c = 14.6818（9） A, α= 73.254（10）,β= 88.938（15）, γ= 68.080（10）°, V= 934.66（10） A3, Z = 2, F（000） = 400, Dc = 1.348 g/cm^3 and p = 0.094 mm-1. The final R = 0.0680 and wR = 0.1419 for 2142 observed reflections with I 〉 2σ（/）, and R = 0.1084 and wR = 0.1643 for all reflections. Two aromatic ring planes （pyrrole and phenanthroline rings） are connected by the amide plane. Two different types of intermolecular hydrogen bonds, O-H…N and N-H…O, exist in the crystal. The title complex molecules are connected through hydrogen bonds and weak π-π stacking interactions to generate a 3-D supramolecule.

关键词： 1,10-phenanthroline pyrrole amide crystal structure

Distributed Algorithm for Robust Resource Allocation with Polyhedral Uncertain Allocation Parameters

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2018年第1期31卷 103-119页

作者： zeng Xianlin YI Peng hong Yiguang School of Automation Beijing Institute of Technology Beijing 100081 China Department of Electrical and Systems Engineering Washington University in St. Louis St. Louis MO 63130 USA Key Laboratory of Systems and Control Institute of Systems Science Chinese Academy of Sciences Beijing 100190 China

This paper studies a distributed robust resource allocation problem with nonsmooth objective functions under polyhedral uncertain allocation parameters. In the considered distributed robust resource allocation problem, the（nonsmooth） objective function is a sum of local convex objective functions assigned to agents in a multi-agent network. Each agent has a private feasible set and decides a local variable, and all the local variables are coupled with a global affine inequality constraint,which is subject to polyhedral uncertain parameters. With the duality theory of convex optimization,the authors derive a robust counterpart of the robust resource allocation problem. Based on the robust counterpart, the authors propose a novel distributed continuous-time algorithm, in which each agent only knows its local objective function, local uncertainty parameter, local constraint set, and its neighbors＇ information. Using the stability theory of differential inclusions, the authors show that the algorithm is able to find the optimal solution under some mild conditions. Finally, the authors give an example to illustrate the efficacy of the proposed algorithm.

关键词： Distributed optimization resource allocation robust optimization polyhedral uncertain parameters nonsmooth optimization