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Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review

World Journal of Gastroenterology 2017年第20期23卷 3589-3606页

作者： kuan-yin lin Guan-Jhou Chen Yu-lin Lee Yi-Chia Huang Aristine Cheng Hsin-Yun Sun Sui-Yuan Chang Chun-Eng Liu Chien-Ching Hung Department of Medicine National Taiwan University Hospital Jin-Shan Branch Department of Internal Medicine National Taiwan University Hospital Department of Internal Medicine Changhua Christian Hospital National Taiwan University College of Medicine Department of Clinical Laboratory Sciences and Medical Biotechnology National Taiwan University College of Medicine Department of Laboratory Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Department of Parasitology National Taiwan University College of Medicine Department of Medical Research China Medical University Hospital China Medical University

Hepatitis A virus(HAV)is one of the most common infectious etiologies of acute hepatitis *** virus is known to be transmitted fecal-orally,resulting in symptoms ranging from asymptomatic infection to fulminant *** can also be transmitted through oral-anal *** from regions of low endemicity for HAV infection often remain susceptible in their ***,clustered HAV infections or outbreaks of acute hepatitis A among men who have sex with men and injecting drug users have been reported in countries of low endemicity for HAV *** duration of HAV viremia and stool shedding of HAV may be longer in human immunodeficiency virus(HIV)-positive individuals compared to HIV-negative individuals with acute hepatitis *** guidelines recommend HAV vaccination for individuals with increased risks of exposure to HAV(such as from injecting drug use,oral-anal sex,travel to or residence in endemic areas,frequent clotting factor or blood transfusions)or with increased risks of fulminant disease(such as those with chronic hepatitis).The seroconversion rates following the recommended standard adult dosing schedule(2doses of HAVRIX 1440 U or VAQTA 50 U administered6-12 mo apart)are lower among HIV-positive individuals compared to HIV-negative *** the response rates may be augmented by adding a booster dose at week 4 sandwiched between the first dose and the 6-mo dose,the need of booster vaccination remain less clear among HIV-positive individuals who have lost anti-HAV antibodies.

关键词： Epidemiology Viral hepatitis Acute hepatitis Fecal-oral transmission Oral-anal sex Men who have sex with men Injecting drug use Immunosuppression Immunization

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Synthesis and Crystal Structure of N-(1′-H-Pyrrol-2′-ylcarbonyl)-5-amino-1,10-phenanthroline

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Chinese Journal of Structural Chemistry 2008年第2期27卷 163-166页

作者： WANG Yue-Hong lin Hai lin Hua-kuan Department of Chemistry Nankai University Tianjin 300071 China Key Laboratory of Functional Polymer Materials of the Ministry of Education Nankai University Tianjin 300071 China

The title compound, N-（1′-H-pyrrol-2′-ylcarbonyl）-5-amino-1,10-phenanthroline, was synthesized by the reaction of a-pyrrolyl carbonyl chloride and 5-amino-1,10-phenanthroline in pyridine. Determined by X-ray structure analysis, it crystallizes in triclinic system, space group P1 with the following crystallographic data： C20H21N5O3, Mr = 379.42, a = 7.8559（4）, b = 9.1681（6）, c = 14.6818（9） A, α= 73.254（10）,β= 88.938（15）, γ= 68.080（10）°, V= 934.66（10） A3, Z = 2, F（000） = 400, Dc = 1.348 g/cm^3 and p = 0.094 mm-1. The final R = 0.0680 and wR = 0.1419 for 2142 observed reflections with I 〉 2σ（/）, and R = 0.1084 and wR = 0.1643 for all reflections. Two aromatic ring planes （pyrrole and phenanthroline rings） are connected by the amide plane. Two different types of intermolecular hydrogen bonds, O-H…N and N-H…O, exist in the crystal. The title complex molecules are connected through hydrogen bonds and weak π-π stacking interactions to generate a 3-D supramolecule.

关键词： 1,10-phenanthroline pyrrole amide crystal structure

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Engineering of Fe d-band center in Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles via orbital coupling for high-efficiency oxygen reduction electrocatalysis

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Nano Research 2025年第1期18卷 129-139页

作者： Jiayi Liu Jingwen yin yingzi lin Mingxin Pang Huan Pang Songtao Zhang lin Xu Jun Yang Yawen Tang Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023Chin a 2 State Key Laboratory of Multiphase Complex Systems Center of MesoscienceInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009China Testing Center Yangzhou UniversityYangzhou 225009China

The deliberate engineering of the d-band center of metal site represents an effective strategy to boost the intrinsic electrocatalytic performance toward the oxygen reduction reaction(ORR).Herein,following a heterointerfaceinduced orbital coupling rationale,we report a judicious design of an efficient ORR electrocatalyst consisting of Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles in-situ encased into N-doped carbon nanofibers(abbreviated as Fe_(3)O_(4)/CeO_(2)@N-CNFs hereafter).The theoretic calculations uncover that the Fe_(3)O_(4)/CeO_(2)heterointerface-triggered orbital coupling can cause the down shift of the d-band center positions of Fe sites,which leads to the weakened chemisorption of oxygenated groups and lowered energy barrier for the potential-determining step,ultimately dramatically boosting the ORR intrinsic *** a consequence,the well-designed Fe_(3)O_(4)/CeO_(2)@N-CNFs display admirable ORR activity with a half-wave potential of 0.84 V and outstanding structural/electrochemical stability in an alkaline electrolyte,surpassing the commercial Pt/C benchmark and a majority of recently reported Fe_(3)O_(4)-based *** encouragingly,the Fe_(3)O_(4)/CeO_(2)@N-CNFsincorporated Zn-air battery outperforms the Pt/C-assembled counterpart with higher power density,larger energy density,and excellent cycling stability,serving as a competent candidate for ORR-involved renewable energy *** study offers an innovative approach for the rational manipulation of the d-band center and interfacial electron behavior of active sites toward the optimization of electrocatalytic performance.

关键词： hetero-nanoparticles electrospinning interfacial engineering orbital coupling oxygen reduction reaction

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Synthesis and Crystal Structure of 1-(N,N-Di-(p-toluenesulfonyl))-amino-2-(N'-p-toluenesulfonyl)-amino-3,5-dinitrobenzene

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Chinese Journal of Structural Chemistry 2007年第3期26卷 309-313页

作者： CHEN Hua-Mei lin Hai lin Hua-kuan Department of Chemistry Nankai University Tianjin 300071 China State Key Laboratory of Functional Polymer Materials for Absorption and Separation Nankai University Tianjin 300071 China

The title compound, 1-（N,N-di-（p-toluenesulfonyl））-amino-2-（N＇-p-toluenesulfonyl）- amino-3,5-dinitrobenzene, was synthesized and structurally determined by single-crystal X-ray diffraction method. It crystallizes in orthorhombic, space group Pna21 with a = 13.723（2）, b = 25.354（4）, c = 8.6565（12） A, V= 3011.9（8） A^3, Z = 4, Mr = 660.68, F（000） = 1368, Dc = 1.457 g/cm^3, μ = 0.309, the final R = 0.0609 and wR = 0.1042. The H atom of N2-H group, which is the unique recognition site to anion, is enveloped by two oxygen atoms and one benzene from two and one p-toluenesulfonyl moieties, respectively.

关键词： sulfonylamide anion recognition receptor crystal structure

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Trinuclear Metal Complexes Based on 1,10-Phenanthroline Derivates as Catalysts for Cleavage of a RNA-Model Substrate

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Chemical Research in Chinese Universities 2007年第5期23卷 493-499页

作者： XU Xin-he lin Hai lin Hua-kuan　 Department of Chemistry Key Laboratory of Functional Polymer Materials of Ministry of Education Nankai University Tianjin 300071 P. R. China

Two multidentate ligands 2,9-di[6＇-（2″-hydroxyl-3″-methoxyphenyl）-n-2＇,5＇-diazahexyl]-1,10-phenanthroline（LA）and 2,9-di（6＇-α-phenol-n-2＇,5＇-diazahexyl）-1,10-phenanthroline（LB）were synthesized and fully *** of the ligands and the stability of the complexes of the ligands with divalent metal ions were *** trinuclear metal complexes [Cu（Ⅱ）and Zn（Ⅱ）] of the ligands were studied,as catalysts,for the transphosphorylation of the RNA-model substrate 2-hydroxypropyl-p-nitrophenyl phosphate（HPNP）.The second-order rate constants of HPNP-hydrolysis catalyzed by M3L and M3LH-1 were obtained,which indicated that Zn3LBH-1 was the most efficient catalyst among *** proposed mechanisms included the activation of the substrate via binding to the metal ions and intramolecular nucleophilic attack by the deprotonated C2-hydroxyl of HPNP.

关键词： (:eywords Trinuclear metal complex 1, 10-Phenanthroine derivate Catalyst Cleavage of RNA-model substrate

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Design,Synthesis and Recognition Properties of a New Acetate Ion Receptor Based on Shiff-base Derivative

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Chemical Research in Chinese Universities 2011年第4期27卷 574-577页

作者： QIAO Yan-hong lin Hai lin Hua-kuan Department of Chemistry Tianjin Normal University Tianjin 300387 P. R. China Department of Chemistry Nankai University Tianjin 300071 P. R. China Key Laboratory of Functional Polymer Materials Ministry of Education Nankai University Tianjin 300070 P. R. China

A simple colorimetric acetate ion receptor based on 3-methoxysalicylaldehyde-4＇-nitrophenyl-hydrazone was synthesized in an ethanol solution through one step,and characterized by 1H NMR and elemental *** anion-binding ability was examined by UV-Vis absorption spectroscopy in DMSO（dimethyl sulfoxide）.The result shows that the compound has a high affinity for and a high selectivity toward acetate ions,and also an advantage of ＇naked-eye＇ recognition of color changing from yellow to purple.

关键词： Anion recognition Colorimetric 'Naked-eye' recognition Schiff base

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A Modular Synthesis of Antitumor Macrolide (-)-Lasonolide A

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Chinese Journal of Chemistry 2020年第7期38卷 725-736页

作者： lin Yang Zuming lin kuan Zheng Luyao Kong Ran Hong CAS Key Laboratory of Synthetic Chemistry of Natural Substances Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai 200032China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing 100049China

Lasonolide A was identified as a potent antitumor macrolide towards various cancer cell *** two tetrahydropyrans bearing multiple stereogenic centers as well as the polyvene linkage attracted a dozen synthetic research groups to launch the total *** on the synthetic methods developed in our group,namely,the hydroboration of allene and its subsequent allylation as well as the iterative hydroboration of allene and oxidation,the polyol subunits were efficiently constructed and then integrated into the final target.A new Julia olefination reagent,double-headed sulfone,was designed to promote the rapid coupling of two aldehydes bearing multiple functional groups to secure the whole carbon *** highlight of our approach is the application of a traceless protecting group,9-BBN(9-borabicyclo[3.3.1]nonane),to hide the secondary alcohol for debenzylation,and for the first time,to mask the carboxylic acid for Julia olefination under strong basic conditions.

关键词： aldehydes linkage reagent

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A Novel Product Remaining Useful Life Prediction Approach Considering Fault Effects

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IEEE/CAA Journal of Automatica Sinica 2021年第11期8卷 1762-1773页

作者： Jingdong lin Zheng lin Guobo Liao Hongpeng yin School of Automation Chongqing UniversityChongqing 400044China

In this paper,a novel remaining useful life prediction approach considering fault effects is *** Wiener process is used to construct the degradation process of single performance characteristic with the fault *** first passage time based remaining useful life distribution is calculated by assuming fault occurrence moment is a random variable and follows a certain *** maximization algorithm is employed to estimate model parameters,where the fault occurrence moment is considered as a missing ***,a Copula function is used to describe the dependence between the multiple performance characteristics and derive joint remaining useful life(RUL)distribution of product with the fault *** effectiveness of the proposed approach is verified by the experiments of turbofan engines.

关键词： Degradation process fault effects fault occurrence moment(FOM) performance characteristic(PC) remaining useful life(RUL)

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Using hydrochemical signatures to characterize the long-period evolution of groundwater information in the Dagu River Basin,China

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Frontiers of Environmental Science & Engineering 2021年第5期15卷 311-323页

作者： Ziyue yin Qing lin Shaohui Xu School of Environmental Science and Engineering Qingdao UniversityQingdao266071China

The evolution of hydrochemical compositions influenced by long-period interactions between groundwater and the geo-environment is a fundamental issue for exploring groundwater quality and *** study systematically investigated the hydrochemical processes and anthropogenic interference occurring in the river basin by bivariate plots,Gibbs diagrams,saturation index,and the major ions *** changes in groundwater hydrochemistry have been observed in the study area,illustrating the origins of major ions are affected by various internal and external *** highlighted that TDS varied from freshwater to brackish water,ranging between 187.90 and 2294.81 mg/***^(2+)and HCO_(3)^(−)are the dominant ions in the studied *** results gained by Gibbs diagrams,bivariate plots,saturation index,and the major ions ratios demonstrated that minerals dissolution/precipitation,cation exchange,and human inputs play crucial roles in the unconfined ***,the overuse of nitrogen fertilizer,livestock manure,and industrial/domestic sewage led to nitrate and nitrite contamination and brought significant challenges to the surrounding *** present study could make an unambiguous identification of natural processes and anthropogenic interventions influencing groundwater hydrochemistry’s long-period evolution and create a preliminary strategy for groundwater resources management.

关键词： Groundwater quality Hydrochemical signatures Spatial-temporal variations Water-rock interactions Anthropogenic interventions

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