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Synthesis and Adsorption Property of Dihydroxyl Azacrown Ether-Grafted Chitosan

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Chinese Chemical Letters 2002年第1期13卷 27-28页

作者： Zhi kuan yang Li ZHUANG yang YUAN Department of Environmental Science Wuhan UniversityWuhan 430072

A novel dihydroxyl azacrown ether chitosan was synthesized by reacting dihydroxyl azacrown ether with epoxy activated chitosan. The adsorption property of the azacrown ether chitosan for Pb2+, Cr3+, and Ag+, were determined. The experimental results showed that the dihydroxyl azacrown ether grafted chitosan has high adsorption capacity and high selectivity for some metal ions.

关键词： Chitosan azacrown ether adsorption property synthesis.

Numerical simulation on ionic wind in circular channels

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Chinese Physics B 2021年第1期30卷 311-318页

作者： Gui-Wen Zhang Jue-kuan yang Xiao-Hui Lin School of Mechanical Engineering and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments Southeast UniversityNanjing 211189China

Ionic wind induced by direct-current corona discharge has attracted considerable interest because of its low energy consumption, low noise emission, flexible designs, and lack of moving parts. The purpose of this study is to investigate the configuration parameters to improve the velocity of the ionic wind. Accordingly, this study develops a three-dimensional(3 D) model of circular tube with multi-needle-to-mesh electrode configurations, in this model, the influences of various parameters were explored,such as the mesh gap, the distribution of needle electrodes, the number of needle electrodes,and the radius of the circular channel. The numerical research results showed that the mesh gap, the distribution of needle electrodes, and the radius of the circular tube significantly affected the velocity of the ionic wind. When mesh gap is 12 mm,which indicates that there is an optimal mesh gap which can enhance the velocity of the ionic wind. What is more, changing the distribution of needle electrodes and increasing the number of needle electrodes can effectively improve the velocity of the ionic wind, the optimum distribution α of needle electrodes is 0.7–0.9, which greatly increase the velocity of the ionic wind. However, for multi-needle-to-mesh structure, the improvement of the radius of the circular channel is conducive to enhance the velocity and improve the velocity distribution.

关键词： corona discharge ionic wind numerical simulation wind velocity

MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer

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Research 2024年第2期2023卷 239-257页

作者： Cui Wang kuan yang Xiaoqian Liu Si Wang Moshi Song Juan Carlos Izpisua Belimonte Jing Qu Guang-Hui Liu Weiqi Zhang CAS Key Laboratory of Genomic and Precision Medicine Beijng Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Bejing 100101China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Altos Labs Inc.San DiegoCA 94022USA

Mitochondrial dysfunction is a hallmark feature of cellular senescence and organ ***,we asked whether the mitochondrial antiviral signaling protein(MAVS),which is essential for driving antiviral response,also regulates human stem cell *** answer this question,we used CRISPR/Cas9-mediated gene editing and directed differentiation techniques to generate various MAVS-knockout human stem cell *** found that human mesenchymal stem cells(hMSCs)were sensitive to MAVS deficiency,as manifested by accelerated senescence *** uncovered that the role of MAVS in maintaining mitochondrial structural integrity and functional homeostasis depends on its interaction with the guanosine triphosphatase optic atrophy type 1(OPA1).Depletion of MAVS or OPA1 led to the dysfunction of mitochondria and cellular senescence,whereas replenishment of MAVS or OPA1 in MAVS-knockout hMSCs alleviated mitochondrial defects and premature senescence *** together,our data underscore an uncanonical role of MAVS in safeguarding mitochondrial homeostasis and antagonizing human stem cell senescence.

关键词： CRISPR/Cas9 homeostasis Mitochondrial

Surface modification of Li_(3)InCl_(6)provides superior electrochemical performance for LiMn_(2)O_(4)cathode materials

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Chinese Chemical Letters 2023年第5期34卷 505-508页

作者： Yixun Gu kuan yang Hongbin Yao Weijian Li Haiqing Zhan Xianquan Ming Guanhan Huang Guiliang Li Feng Zhan School of Resources Environment and Materials Guangxi UniversityNanning 530004China South Manganese Group Limited Nanning 530000China

Li Mn_(2)O_(4)(LMO)is the substance of choice for small and medium-sized energy storage materials in daily *** this work,Li3InCl6(LIC)is prepared on the surface of LiMn_(2)O_(4)by hydrothermal method using InCl_(3)and LiCl as raw *** method stabilizes the LMO crystal structure by uniformly coating the LIC on the LMO surface and effectively maintains the morphology of LMO crystals during the cycling *** and EDS analysis confirm the morphology and homogeneity of the synthesized material LIC on the LMO *** prepared material is put into a battery,and the charge-discharge test is carried out at 0.5 C and 1 *** results show that the LIC surface-modified samples exhibit more than 6%higher cycling performance than the unmodified samples after long cycling.

关键词： Li-ion batteries Cathode material LiMn_(2)O_(4) Li_(3)InCl_(6) Surface modification

Acute cytomegalovirus hepatitis in an immunocompetent patient:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12605-12609页

作者： Jack P Wang Bou-Zenn Lin Chih-Lin Lin kuan-yang Chen Tsung-Jung Lin Department of Gastroenterology Taipei City HospitalTaipei City 10629Taiwan University of Taipei Taipei City 10066Taiwan

BACKGROUND Cytomegalovirus(CMV)infection is usually subclinical and asymptomatic in the healthy population,whereas severe complications occur in immunocompromised *** SUMMARY In this case report,we described a rare case of acute CMV hepatitis in a 35-yearold male immunocompetent patient who presented with a history of week-long intermittent fever with nonspecific constitutional *** hepatitis was suspected according to the initial serological *** ruling out other etiologies,including viral hepatitis A,B,C,drug,alcohol,autoimmune,and Wilson disease,acute CMV hepatitis was diagnosed based on positive CMV IgM and DNA quantitative *** there was no any local acute hepatitis E reported in Taiwan,so hepatitis E was not *** patient recovered both clinically and serologically with symptomatic management and without antiviral therapy within 12 days from the onset of *** In conclusion,a diagnosis of CMV infection should be considered when nonspecific prodromal symptoms occur in acute hepatitis with an uncertain *** therapy should not be used in immunocompetent patient who had no decompensation of the liver,such as this *** available noninvasive tests for CMV can facilitate early diagnosis if used ***–benefit analysis is essential before using antiviral therapy in immunocompetent patients.

关键词： Cytomegalovirus Acute hepatitis Immunocompetent Case report

Hybrid vs sequential therapy for eradication of Helicobacter pylori in Taiwan: a prospective randomized trial

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World Journal of Gastroenterology 2015年第36期21卷 10435-10442页

作者： kuan-yang Chen Tsung-Jung Lin Chin-Lin Lin Hsi-Chang Lee Chung-Kwe Wang Deng-Chyang Wu Institute of Clinical Medicine National YangMing University Institute of Neuroscience National Chengchi University Liver Center Department of GastroenterologyRen-Ai BranchTaipei City Hospital Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital Division of Internal Medicine Kaohsiung Municipal Hsiao-Kang HospitalKaohsiung Medical University Center for Stem Cell Research Kaohsiung Medical University Hospital Department of Medicine Faculty of MedicineCollege of MedicineKaohsiung Medical University Center for Infectious Disease and Cancer Research Kaohsiung Medical University

AIM: To evaluate the efficacy of sequential vs hybrid therapy in patients with Helicobacter pylori(H. pylori) ***: From March 2013 to May 2014,one hundred and seventy-five H. pylori infected patients who had not been treated for H. pylori before wererandomized to receive either sequential therapy(rabeprazole 20 mg and amoxicillin 1 g twice daily for 5 d,followed by rabeprazole 20 mg,clarithromycin 500 mg and metronidazole 500 mg twice daily for 5 d) or hybrid therapy(rabeprazole 20 mg and amoxicillin 1 g for 7 d,followed by rabeprazole 20 mg,amoxicillin 1 g,clarithromycin 500 mg and metronidazole 500 mg twice daily for 7 d). H. pylori status was confirmed by positive results of both rapid urease test and histology examination or a positive result of culture. Eradication efficacy was assessed by follow-up endoscopy with rapid urease test and histological examination 8 wk after the end of anti-H. pylori therapy,or 13C-urea breath test at least 4 wk after completion of treatment. The primary outcome was H. pylori eradication by intension-to-treat(ITT) and per-protocol(PP) ***: One hundred and sixty-seven patients(83 patients in the sequential group and 84 patients in the hybrid group) completed the study. The compliance rates were 97.6% and 97.7% for the two groups,respectively. The eradication rate was 78.2% for the sequential group and 92% for the hybrid group by ITT analysis(P = 0.01). The eradication rate was 81.9% for the sequential group and 96.4% for the hybrid group by PP analysis(P = 0.01). Univariate analysis for the clinical and bacterial factors did not identify any risk factors associated with treatment failure. Severe adverse events were observed in 2.3% of patients in the sequential group and 2.4% of those in the hybrid ***: Due to a grade A(> 95%) success rate for H. pylori eradication by PP analysis,similar compliance and adverse events,hybrid therapy seems to be an appropriate eradication regimen in Taiwan.

关键词： Helicobacter pylori Sequential therapy Hybrid ther

CRISPR-based screening identifies XPO7 as a positive regulatorof senescence

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Protein & Cell 2023年第8期14卷 623-628页

作者： Lan-Zhu Li kuan yang Yaobin Jing Yanling Fan Xiaoyu Jiang Si Wang Guang-Hui Liu Jing Qu Shuai Ma Weiqi Zhang State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China School of Future Technology University of Chinese Academy of SciencesBeijing 100190China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China

Dear Editor,Cells enter senescence,or irreversible growth arrest,when exposed to stressors such as DNA damage,epigenetic alterations and chronic inflammation(Zhao and Chen,2022).In aging and aging-related diseases,sen... 详细信息

关键词： alterations organs

CYP2C19 polymorphism has no influence on rabeprazole-based hybrid therapy for Helicobacter pylori eradication

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World Journal of Clinical Cases 2018年第12期6卷 514-520页

作者： Tsung-Jung Lin Hsi-Chang Lee Chih-Lin Lin Chung-Kwe Wang kuan-yang Chen Deng-Chyang Wu Department of Health care and Social Work Taipei University of Marine Technology Department of Gastroenterology Taipei City Hospital Institute of Clinical Medicine National YangMing University Institute of Neuroscience National Chengchi University Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital Division of Internal Medicine Kaohsiung Municipal Ta-Tung HospitalKaohsiung Medical University Center for Infectious Disease and Cancer Research Kaohsiung Medical University

AIM To evaluate the impact of cytochrome P450 2C19(CYP2C19) and interleukin-1β(IL-1β) polymorphisms on the efficacy of Helicobacter pylori(H. pylori) eradication by using rabeprazole-based hybrid *** A total of 88 H. pylori-infected patients were recruited to receive 14-d of hybrid therapy from March 2013 to May 2014. Three patients were excluded from analysis because of incomplete compliance. Either a follow-up endoscopy or 13 C-urea test was performed to determine the results of H. pylori eradication therapy. The genotypes of CYP2C19 and IL-1β were analyzed to investigate the impact on treatment effect. RESULTS The total eradication rate of H. pylori was 92.94%(79/85). According to the CYP2C19 genotypes, the rates of H. pylori eradication were 89.19% in extensive metabolizers(EM) and 95.83% in non-EM. The *** eradication rates regarding the IL-1β genotypes were 92.59% in the normal acid secretion group and 93.10% in the low acid secretion group. After multivariable logistic regression analysis, both the genotypes of CYP2C19 and IL-1β had no significant influences on the eradication rates of H. *** The CYP2C19 and IL-1β polymorphisms are not significantly independent factors of *** eradication using rabeprazole-based hybrid therapy.

关键词： Helicobacter pylori Cytochrome P450 2C19 Interleukin-1β Hybrid therapy Rabeprazole

条约单方退出的国际法律规制的完善——从美国退出《巴黎协定》谈起

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北京理工大学学报(社会科学版) 2019年第1期21卷 154-161页

作者：杨宽北京理工大学法学院

国家单方退出条约行为近年来屡屡发生且具有任意性,这在很大程度上影响了国际法律秩序的稳定性。现行有关条约退出的国际法律规制存在缺陷,不能对条约单方退出行为进行合理有效的限制。条约单方退出不仅要符合条约中的退出条款,同时也... 详细信息

国家单方退出条约行为近年来屡屡发生且具有任意性,这在很大程度上影响了国际法律秩序的稳定性。现行有关条约退出的国际法律规制存在缺陷,不能对条约单方退出行为进行合理有效的限制。条约单方退出不仅要符合条约中的退出条款,同时也要受条约必须信守、诚信原则、国际合作等国际法基本原则的限制。为完善对于条约单方退出行为的国际法律规制,应明确条约退出权的权利基础及其限制,严格条约单方退出的要求,理清单方退出的法律责任,并加强应对不正当单方退出行为的国际合作。

关键词：条约单方退出条约必须信守法律责任诚信原则国际合作