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The effect of rehabilitation exercise on the expression of glutaminase and cardiopulmonary remodeling in pulmonary hypertension

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Medicine in Novel Technology and Devices 2022年第3期15卷 134-143页

作者： Shang Wang Ping Yuan Yuan-Yuan Sun Yi Yan Yu-Xia Huang Xiao-Yi Hu Lan Wang kuan cheng Rong Jiang Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai200433China Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease Shanghai Children's Medical CenterNational Children's Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina Institute for Cardiovascular Prevention(IPEK) Ludwig Maximilian University MunichMunichGermany Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai200032China

Pulmonary hypertension(PH)is featured by pulmonary vascular and cardiac *** exercise can improve patients’quality of *** previously pinpointed a potential glutamine metabolism dysfunction in ***,we aim to investigate whether rehabilitation exercise could mitigate right ventricular and pulmonary vascular remodeling and its effect on glutaminase(GLS).We collected clinical indicators of PH patients and analyzed their correlation with *** exercise(moderate intensity swimming exercise)was performed in monocrotaline-induced PH(MCT-PH)*** found that plasma GLS1 level in patients was lower than healthy subjects,and it was negatively correlated with end-systolic stage eccentricity index,right atrial transverse dimension and right atrial longitudinal ***-PH rats displayed pulmonary vascular remodeling and right ventricular *** to control rats,higher levels of GLS1 and GLS2 mRNA in lung and lower levels of these two isoforms of GLS in right ventricle(RV)were displayed in MCT-PH *** swimming exercise,GLS mRNA levels in the lung and RV were significantly upregulated,and the cross-sectional area of right ventricular cardiomyocytes was significantly decreased although the percentage of pulmonary arteriolar medial wall thickness was not significantly ***,we hold the opinion that plasma GLS1 level was decreased in *** transcriptional levels of GLS1 and GLS2 were increased in the lung tissues in PH,but were decreased in the RV ***,the changes of GLS levels indicated the pulmonary vascular and right ventricular *** moderate intensity swimming exercise might improve the right ventricular remodeling by regulating the levels of GLS.

关键词： Pulmonary hypertension Pulmonary vascular remodeling Cardiac remodeling Glutaminase

Giant left atrium mimics massive pleural effusion in rheumatic heart disease

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Chinese Medical Journal 2012年第24期125卷 4533-4534页

作者： CHEN Yeh-Peng HSIEH Li-Chuan LO Ping-Han CHANG kuan-cheng Division of Cardiology Department of Medicine China Medical University Hospital China Medical University Taichung Taiwan China

49-year-old woman with a history of rheumatic heart disease was admitted to the hospital because ofwo Fou rep pro reg rsening dyspnea and orthopnea with cyanosis of the r extremities. She underwent prosthetic mitral valve lacement 15 years ago for mitral stenosis. Due to sthetic valve dysfunction and severe aortic urgitation, she received both mechanical aortic and ral valve replacements 2 years later.

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Precise mapping of hilar cholangiocarcinoma with a skip lesion by SpyGlass cholangioscopy:A case report

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 965-971页

作者： cheng-Han Chiang kuan-Chih Chen Benedict Devereaux Chen-Shuan Chung Kuei-Chang Kuo Chien Chu Lin cheng-kuan Lin Hsiu-Po Wang Kuo-Hsin Chen Division of Gastroenterology and Hepatology Department of Internal MedicineXin-Tai General HospitalNew Taipei 242063Taiwan Department of Internal Medicine Far Eastern Memorial HospitalNew Taipei 22060Taiwan Department of Gastroenterology Royal Brisbane and Women's HospitalHerston 4029QueenslandAustralia Department of Internal Medicine College of MedicineNational Taiwan UniversityTaipei 10002Taiwan Department of Surgery Far Eastern Memorial HospitalNew Taipei 22060Taiwan

BACKGROUND Cholangiocarcinoma(CC)is a very aggressive cancer with a poor *** surgery is the only curative therapy,preoperative evaluation of the tumor extent is essential for surgical *** high-quality image modalities such as computed tomography and magnetic resonance imaging have been used extensively in preoperative evaluation,the accuracy is *** obtain precise localization of tumor spread arising from the hilar region preoperatively,the development of an acceptable imaging modality is still an unmet *** SUMMARY A 52-year-old female presented to our emergency department with jaundice,abdominal pain,and ***,she was treated for *** retrograde cholangiopancreatography with the cholangiogram showed long segment filling defect in the common hepatic duct with dilatation of bilateral intrahepatic *** biopsy was performed,and the pathology suggested intraductal papillary neoplasm with high-grade *** treatment of cholangitis,contrasted-enhanced computed tomography revealed a hilar lesion with undetermined Bismuth-Corlette *** cholan gioscopy showed that the lesion involved the confluence of the common hepatic duct with one skip lesion in the posterior branch of the right intrahepatic duct,which was not detected by previous image *** surgical plan was modified from extended left hepatectomy to extended right *** final diagnosis was hilar CC,*** patient has remained disease-free for more than 3 *** SpyGlass cholangioscopy may have a role in precision localization of hilar CC to provide surgeons with more information before the operation.

关键词： Hilar cholangiocarcinoma Jaundice SpyGlass cholangioscopy Bismuth-Corlette classification Hepatectomy Case report

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行为AANA阵列的完全收敛性

数学的实践与认识 2018年第12期48卷 308-313页

作者：王宽程闽南理工学院信息管理学院

利用截尾方法和矩不等式方法,在h-可积和一致可积条件下分别研究行为AANA阵列的完全收敛性,建立并证明了关于AANA阵列的两个定理,所得结果推广了前人的相应结果.

关键词： AANA阵列完全收敛性一致可积 h-可积

咪唑类离子液体表面活性剂的合成及其形成微乳液的增溶能力研究

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化学试剂 2011年第11期33卷 1029-1032页

作者：秦承宽滨州学院物理与电子科学系山东滨州256603

合成并提纯了3种离子液体表面活性剂——溴代-1-十二烷基(十四烷基、十六烷基)-3-甲基咪唑(C12 mimBr、C14mimBr、C16mimBr),利用平衡表面张力法测定了临界胶束浓度,检验了其纯度。利用δ-γ"鱼形"相图研究了C12 mimBr(C14mimBr、C16mim... 详细信息

合成并提纯了3种离子液体表面活性剂——溴代-1-十二烷基(十四烷基、十六烷基)-3-甲基咪唑(C12 mimBr、C14mimBr、C16mimBr),利用平衡表面张力法测定了临界胶束浓度,检验了其纯度。利用δ-γ"鱼形"相图研究了C12 mimBr(C14mimBr、C16mimBr)/醇/烷烃/盐水(5%NaCl)微乳液体系的增溶能力,利用HLB平面方程计算了亲水-亲油平衡界面膜的组成及微乳液体系的相关物理化学参数,研究发现,表面活性剂分子碳链越长、醇碳链越长以及烷烃碳链越短,微乳液的增溶能力越强。

关键词：离子液体表面活性剂微乳液增溶能力

The Clinical Outcomes of Mosaic Embryo Transfer in Preimplantation Genetic Testing Cycles

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Advances in Sexual Medicine 2023年第2期13卷 11-20页

作者： Shujing He Linan Xu Huiling Pan kuan cheng Zhiqiang Zhang Cong Fang Zi Ren Reproductive Medicine Research Center The Sixth Affiliated Hospital Sun Yat-sen University Guangzhou China Biomedical Innovation Center The Sixth Affiliated Hospital Sun Yat-sen University Guangzhou China Guangdong Engineering Technology Research Center of Fertility Preservation Guangzhou China

Purpose: We aimed to analyze the pregnancy outcomes and perinatal follow-up of mosaic embryo transfer in the preimplantation genetic testing (PGT) cycles. Method: We retrospectively selected 27 mosaic embryo transfer cycles as the study group and 97 euploid embryo transfer cycles as the control group after propensity score matching, which were performed in the reproductive medicine center of the Sixth Affiliated Hospital, Sun Yat-sen University, from March 2019 to September 2023. The biopsy cells from blastocyst were undertaken next generation sequencing (NGS). Results: No significant difference in pregnancy outcomes compared between the two groups. According to the size of aneuploid, fragment the level of mosaicism or blastocyst morphological gradings, there were no significant difference in mosaic embryo transfers. Conclusion: Mosaic embryo detected in the PGT cycle can lead to clinical pregnancy and live birth of healthy offspring, which can be considerate suitable for transfer.

关键词： Mosaic Embryo PGT Pregnancy Outcomes Perinatal Follow-Up

GEDO CE轨道检测系统在无砟轨道施工测量中的应用

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铁道工程学报 2009年第3期26卷 57-61页

作者：杨成宽中铁十五局集团有限公司河南洛阳471013

研究目的:无砟轨道施工中测量的主要任务是采用必备的测量仪器,依据轨道设计参数和CPⅢ控制点,通过精调测量的方法,实现轨道几何尺寸准确及确保轨道几何尺寸的质量。研究结论:通过介绍GEDO CE轨道检测系统的特点、功能,阐述了温福铁路... 详细信息

研究目的:无砟轨道施工中测量的主要任务是采用必备的测量仪器,依据轨道设计参数和CPⅢ控制点,通过精调测量的方法,实现轨道几何尺寸准确及确保轨道几何尺寸的质量。研究结论:通过介绍GEDO CE轨道检测系统的特点、功能,阐述了温福铁路分水关隧道双块式无砟轨道轨排架法施工精调测量控制技术,并总结得出GEDO CE轨道检测系统在无砟轨道施工测量控制中的有效方法,保证了无砟轨道施工的高平顺性和强稳定性等要求。

关键词：无砟轨道 GEDOCE轨检小车精调测量

Assessment of left ventricular systolic synchronicity by real-time three-dimensional echocardiography in patients with dilated cardiomyopathy

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Chinese Medical Journal 2006年第11期119卷 919-924页

作者： ZENG Xin SHU Xian-hong PAN Cui-zhen CHEN Rui-zhen cheng kuan LIU Shi-zhen CHEN Hao-zhu Department of Echocardiography Zhongshan Hospital of FudanUniversity Shanghai Institute of Cardiovascular Disease Shanghai200032 China Department of Cardiology Zhongshan Hospital of FudanUniversity Shanghai Institute of Cardiovascular Disease Shanghai200032 China

Background Recent advances in real-time three-dimensional echocardiography （RT3DE） offer the potential to assess the left ventricular （LV） dyssynchrony simultaneously by analyzing the 17 segments time-volume curves. The purpose of this study was to test the feasibility and accuracy of RT3DE for quantitative evaluation of left ventricular systolic synchronicity. Methods Twenty-four patients with dilated cardiomyopathy （DCM） and twenty-ftve healthy volunteers were enrolled in this study. Full volume RT3DE was performed by using Philips IE33 with X3-1 probe. The global and 17-segmental time-volume curves were obtained by the on-line Qlab software （version 4.2）. The time to minimal systolic volume in each segment （Tmsv） was taken to derive the following indexes of systolic asynchrony： Tmsv 16-SD, Tmsv 16-Dif, Tmsv 12-SD, Tmsv 12-Dif, Tmsv 6-SD and Tmsv 6-Dif, which meant the standard deviation or the maximal difference of Tmsv among the 16, 12 and 6 segments of the left ventricle respectively. The software also provided with each of the above parameters as a percentage of the cardiac cycle. Results Tmsv 16-SD, Tmsv 12-SD and Tmsv 6-SD were all significantly larger in the DCM group than those of the control group [Tmsv 16-SD：（52.9±40.6） ms vs （8.8±6.2） ms; Tmsv 12-SD：（29.5＋30.8） ms vs （6.9±4.0） ms; Tmsv 6-SD：（28.9±34.6） ms vs （7.0±4.7）ms, all P≤0.001]. Tmsv 16-Dif, Tmsv 12-Dif and Tmsv 6-Dif were also significantly larger in the DCM group. There were close negative relations between the LVEF determined by RT3DE and each of the indexes of systolic asynchrony, among which the indexes of Tmsv-16-SD% and Tmsv-16-Dif% correlated most closely （r=-0.703 and r=-0.701, respectively）. The DCM patients had significantly larger EDV and ESV, with significantly reduced LVEF compared with the healthy subjects. Conclusion RT3DE provides a simple, useful and unique approach to assess the systolic synchronicity of all the left ventricular segments simultaneously.

关键词： echocardiography, real-time three-dimensional left ventricular function myocardial contraction cardiac resynchronization therapy

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芯片级布图规划中的缓冲器规划算法

中国科学（E辑） 2004年第8期34卷 869-881页

作者：陈松洪先龙董社勤马昱春蔡懿慈 Chung-kuan cheng 顾钧清华大学计算机科学与技术系北京100084 University of California San DiegoUSA 香港科技大学计算机科学与技术系

文中对纳米技术下, 互连驱动的芯片级布图规划问题中的缓冲器规划问题进行了研究, 提出了基于空白区重分布(redistribution)的缓冲器规划算法; 布局中的空白区是指在布局中不被任何电路模块占用的闲置区域; 该算法充分利用布局中的空白... 详细信息

文中对纳米技术下, 互连驱动的芯片级布图规划问题中的缓冲器规划问题进行了研究, 提出了基于空白区重分布(redistribution)的缓冲器规划算法; 布局中的空白区是指在布局中不被任何电路模块占用的闲置区域; 该算法充分利用布局中的空白区插入缓冲器. 在基于拓扑的布图规划表示中, 可以把电路模块和空白区相关联, 在相应区域内移动一些电路模块就可以达到重分布空白区的目的. 在进行空白区重分布的过程中, 给定布局的总面积和拓扑结构将维持不变. 通过重分布布局中的空白区, 可以增加满足时延约束的线网数目; 实验证实, 满足时延约束的线网数的增长率平均达到9%.

关键词：缓冲器规划空白区重分布布图规划 VLSI 角模块序列独立可行区域超大规模集成电路