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hsa_circ_0007099 and PIP4K2A coexpressed in diffuse large B-cell lymphoma with clinical significance

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Genes & Diseases 2024年第4期11卷 98-101页

作者： Jinghan Wang Xin ku.Qiuling Ma haiku. Li Sujuan huang Liping Mao Fang Yu Jie Jin wei Yan Department of hematology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Key Laboratory of hematologic Malignancies Diagnosis and TreatmentHangzhouZhejiang 310003China Zhejiang Provincial Clinical Research Center for hematologic Diseases HangzhouZhejiang 310003China Cancer Center Zhejiang UniversityHangzhouZhejiang 310003China Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai JiaoTong UniversityShanghai 200240China The Second School of Clinical Medicine Henan University of Chinese MedicineZhengzhouHenan 450046China Department of Pathology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China

Diffuse large B-cell lymphoma(DLBCL)is the most common subtype of B-cell lymphoma in adult *** to the clinical and molecular heterogeneity of DLBCL patients,robust biomarkers in clinical practice are still ***,the int... 详细信息

关键词： clinical lymphoma patients

Nanocavity enriched CuPd alloy with high selectivity for CO_(2) electroreduction toward C_(2)h_(4)

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Rare Metals 2024年第4期43卷 1513-1523页

作者： Ze-Yu Zhang hai-Bin Wang Fei-Fei Zhang Jing-wei Li Xin-Zhuo hu Si-wei Yan Yi-Ming Bai Xun Zhang Gu-Rong Shen Peng-Fei Yin Jing Yang Cun-ku.Dong Jing Mao hui Liu Xi-Wen Du Institute of New-Energy Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350China

Electrocatalysis of CO_(2)reduction reaction is an effective way to convert CO_(2)into high value-added products,but the selectivity of Cu-based catalysts for C2+products needs to be improved due to the high energy barrier of C-C ***,a viable catalyst design strategy to decrease energy barrier of C-C coupling should be put ***,a nanocavity-enriched CuPd single atom alloy(CuPd SAA)catalyst is designed to promote CC coupling *** faradaic efficiency of CuPd SAA for ethylene and C_(2+)reaches 75.6%and 85.7%at-0.7 V versus reversible hydrogen electrode(RhE),*** on the results given by in situ characterization,the porous hollow structure dramatically increases the ratio of the linear-bond*CO,thus enhancing the faradaic efficiency for *** functional theory(DFT)calculation reveals that the Pd doping can regulate the electronic structure of neighboring Cu atoms to decrease the energy barrier of C-C coupling,further improving the faradaic *** work provides a new idea for designing catalyst with high selectivity for ethylene.

关键词： Adsorption configuration C-C coupling CO_(2) electrocatalysis Ethylene Single atom alloy

Nanoindentation responses of NiCoFe medium-entropy alloys from cryogenic to elevated temperatures

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Journal of Iron and Steel Research International 2024年第8期31卷 2068-2077页

作者： Qin-qin Xu Kamran Karimi Amirhossein h.Naghdi Wen-yi huo Chong wei Stefanos Papanikolaou NOMATEN Centre of Excellence National Centre for Nuclear ResearchOtwock 05-400MazowszePoland College of Mechanical and Electrical Engineering Nanjing Forestry UniversityNanjing 210037JiangsuChina Science and Technology on Thermo Structural Composite Materials Laboratory Northwestern Polytechnical UniversityXi'an 710072ShaanxiChina School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072ShaanxiChina

NiCoFe alloy,a medium-entropy alloy,shows potential for applications in extreme ***,there is a theoretical barrier concerning the unclear understanding of its high-temperature dislocation motion *** load response exhibits distinct signatures relevant to thermal activation,most notably a decrease in critical force(i.e,softening)from cryogenic to elevated temperatures,e.g.,from 200 to 1000 *** onset of plasticity is characterized by the nucleation of stacking faults and prismatic loops at low temperatures,whereas the surface nucleation of Shockley partial dislocations dominates plasticity at elevated *** show that thermal effects lead to non-uniform atom pile-ups and control the rate of phase transformation with increasing indentation *** findings in this work extend the understanding of the mechanical response of NiCoFe alloys under indentation at different temperatures,shedding light on the underlying dislocation motion mechanisms and surface deformation *** observed transformation-induced plasticity mechanism has implications for the properties of medium-entropy alloys and their potential applications in extreme environments.

关键词： Orientation Dislocations Mechanical behaviors Phase transition

humic acid-mediated transport of a typical soil passivation remediation product(chloropyromorphite)in saturated porous media

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Journal of Environmental Sciences 2024年第7期141卷 51-62页

作者： Xinying Li Mengjia Zhang Siyuan Li wei wei School of Environment Jiangsu Engineering Lab of Water and Soil Eco-remediationJiangsu Province Engineering Research Center of Environmental Risk Prevention and Emergency Response TechnologyNanjing Normal UniversityNanjing 210023China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China

Conversion of labile Pb species into chloropyromorphite(CPY)using phosphorus-bearing amendments was considered to be an ideal strategy in soil passivation ***,the fate and transport of CPY in the soil are poorly *** study aims to fill the knowledge gap by evaluating the fate and transport of CPY under environmentally relevant conditions of humic acid(hA),ph,electrolyte concentration,and species through the saturated sandy *** showed that bare CPY colloids are basically immobile in sandy porous media while the co-existence of hA made the transport of CPY improved by30%-93.5%.Facilitated transport of CPY was attributed to the increased stability of CPY and the repulsive interaction between CPY particles and sands due to hA *** mobility of CPY was also increased with increasing ph from 5.0 to *** the ph was 9 with a10 mmol/L NaCl background solution,the stronger energy barrier between CPY and sand led to enhanced transport *** divalent Ca^(2+)had a more dramatic effect than monovalent Na^(+)on the aggregation and sedimentation of CPY colloids due to its effectivescreening of the surface charge of CPY and bridging interaction with CPY ***-LandauVerwey-Overbeek theory and attachment efficiency calculation indicated that high energy barriers were responsible for the high mobility of CPY colloids,while the retention of CPY in sands was mainly caused by secondary energy minimum and physically *** findings of this work can help to evaluate the fate of soil passivation remediation products in natural water and soil.

关键词： Chloropyromorphite DLVO theory Stability Saturated porous medium Transport

high-sensitivity formaldehyde gas sensor based on Ce-doped urchin-like SnO_(2) nanowires derived from calcination of Sn-MOFs

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Frontiers of Materials Science 2024年第1期18卷 29-43页

作者： wei Xiao wei Yang Shantang Liu hubei Key Lab of Novel Reactor&Green Chemical Technology School of Chemistry and Environmental EngineeringWuhan Institute of TechnologyWuhan 430073China hubei Key Laboratory of Wudang Local Chinese Medicine Research Department of ChemistrySchool of Pharmaceutical SciencesHubei University of MedicineShiyan 442000China

Metal-organic frameworks(MOFs)have attracted widespread attention due to their regular structures,multiple material centers,and various *** are always considered as one kind of ideal templates for developing highly sensitive and selective gas *** this study,the advantages of MOFs with the high specific surface area(71.9891 m^(2)·g^(-1))and uniform morphology were fully utilized,and urchin-like SnO_(2) nanowires were obtained by the hydrothermal method followed by the calcination using Sn-MOFs consisting of the ligand of C_(9)h_(6)O_(6)(h_(3)BTC)and Sn/Ce center ions as sacrificial *** unique urchin-like nanowire structure facilitated gas diffusion and adsorption,resulting in superior gas sensitivity.A series of Ce-doped SnO_(2) nanowires with different doping ratios were synthesized,and their gas sensing properties towards formaldehyde were *** resulted Ce-SnO_(2) was revealed to have high sensitivity(201.2 at 250℃),rapid response(4 s),long-term stability,and good repeatability for formaldehyde sensing,and the gas sensing mechanism of Ce-SnO_(2) exposed to formaldehyde was also systematically discussed.

关键词： Ce-SnO_(2) SnO_(2) gas sensor formaldehyde Sn-MOF

Dynamic Crosslinked Phosphorescent Poly(vinyl alcohol)-Terpyridine Films with Enhanced Mechanical Properties and Tunable Shape Memory

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Chinese Journal of Polymer Science 2024年第10期42卷 1595-1601,I0015页

作者： Meng wei wei-hao Feng Chen Yu Zhen-Yi Jiang Guang-Qiang Yin wei Lu Tao Chen Key Laboratory of Advanced Marine Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China School of Chemical Sciences University of Chinese Academy of SciencesBeijing100049China School of Materials Science and Chemical Engineering Ningbo UniversityNingbo315211China

Achieving versatile room temperature phosphorescence(RTP)materials,especially with tunable mechanical properties and shape memory is attractive and essential but rarely ***,a strategy was reported to realize multi-functional RTP films with multicolor fluorescence,ultralong afterglow,adjustable mechanical properties,and shape memory through the synergistic dynamic interaction of lanthanide(Ln~Ⅲ)-terpyridine coordination,borate ester bonds,and hydrogen bondings in a poly(vinyl alcohol)(PVA)*** varying the amount of borax,the mechanical properties of the films could be finely controlled due to the change of crosslinking degree of dynamic borate ester bonds in *** assembly and disassembly of borate ester bonds upon the trigger of borax and acid were applied as reversible linkage to achieve programmable shape memory *** addition,the films displayed both fascinating multicolor fluorescence and ultralong afterglow characteristics due to the presence of Ln III doping and confinement of terpyridine in *** study provides a new avenue to impart modulable mechanical strength and shape memory to RTP materials.

关键词： Room temperature phosphorescence materials Dynamic bonds Multicolor fluorescent Tunable mechanical properties Shape memory

Tet methylcytosine dioxygenase 2(TET2)deficiency elicits EGFR-TKI(tyrosine kinase inhibitors)resistance in non-small cell lung cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1706-1720页

作者： Jian Zhang Kejia Zhao Wenjing Zhou Ran Kang Shiyou wei Yueli Shu Cheng Yu Yin ku.Yonghong Mao hao Luo Juqin Yang Jiandong Mei Qiang Pu Senyi Deng Zhengyu Zha Gang Yuan Shensi Shen Yaohui Chen Lunxu Liu Department of Thoracic Surgery and Institute of Thoracic Oncology West China Hospital of Sichuan UniversityChengdu 610097China Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer Sichuan UniversityChengdu 610097China Biobank of West China hospital Sichuan UniversityChengdu 610041China

Despite epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKl)have shown remarkable efficacy in patients with EGFR-mutant non-small cell lung cancer(NSCLC),acquired resistance inevitably develops,limiting clinical *** found that TET2 was poly-ubiquitinated by E3 ligase CUL7^(FBXW11) and degraded in EGFR-TKI resistant NSCLC *** perturbationof TET2 rendered parental cells more tolerant to TKI ***2 was stabilized by MEK1 phosphorylation at Ser 1107,while MEK1 inactivation promoted its proteasome degradation by enhancing the recruitment of CUL7^(FBXW11),Loss of TET2 resulted in the upregulation of TNF/NF-kB signaling that confers the EGFR-TKI *** or pharmacological inhibition of NF-kB attenuate the TKI resistance both in vitro and in *** findings exemplified how a cell growth controlling kinase MEK1 leveraged the epigenetic homeostasis by regulating TET2,and demonstrated an alternative path of non-mutational acquired EGFR-TKI resistance modulated by TET2 ***,combined strategy exploiting EGFR-TKI and inhibitors of TET2/NF-κB axis holds therapeutic potential for treating NSCLC patients who suffered from this resistance.

关键词： TET2 TKI resistance

A novel cascaded h-bridge photovoltaic inverter with flexible arc suppression function

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Global Energy Interconnection 2024年第4期7卷 513-527页

作者： Junyi Tang wei Gao College of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108P.R.China

This paper presents a novel approach that simultaneously enables photovoltaic(PV)inversion and flexible arc suppression during single-phase grounding *** compensate for ground currents through an arc-elimination function,while outputting a PV direct current(DC)power *** method effectively reduces the residual grounding *** reduce the dependence of the arc-suppression performance on accurate compensation current-injection models,an adaptive fuzzy neural network imitating a sliding mode controller was *** online adaptive adjustment law for network parameters was developed,based on the Lyapunov stability theorem,to improve the robustness of the inverter to fault and connection ***,a new arc-suppression control exit strategy is proposed to allow a zerosequence voltage amplitude to quickly and smoothly track a target value by controlling the nonlinear decrease in current and reducing the regulation *** results showed that the proposed method can effectively achieve fast arc suppression and reduce the fault impact current in single-phase grounding *** to other methods,the proposed method can generate a lower residual grounding current and maintain good arc-suppression performance under different transition resistances and fault locations.

关键词： Photovoltaic inverter Flexible arc suppression Adaptive control Fuzzy neural network Sliding mode control Exit strategy

Distinct effect of preparation methods on reaction efficiency of Mn-Ce/Al2O3 catalysts in low-temperature Nh3-SCR

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Journal of Rare Earths 2024年第10期42卷 1865-1872页

作者： Shijie hao Yandi Cai wei wei Yanan Lv Jiawei Ji wei Tan Jingfang Sun Liwei Jia Changjin Tang Lin Dong State Key Laboratory of Pollution Control and Resource Reuse School of EnvironmentJiangsu Key Laboratory of Vehicle Emissions ControlCenter of Modern AnalysisKey Laboratory of Mesoscopic Chemistry of MOESchool of Chemistry and Chemical EngineeringNanjing University Wuxi weifu Environmental Catalysts Co. Ltd. School of Environment Nanjing Normal University

In this study,a series of Mn-Ce/Al2O3catalysts was prepared by different methods of depositionprecipitation（MnCeAl-DP）,impregnation（MnCeAl-IM） and citric acid（MnCeAl-CA）,and the distinct effect of preparation methods on NOxremoval performance at low temperature was *** show that MnCeAl-DP exhibits not only the best activity but also the highest resistance against SO2/*** the assistance of comprehensive characterizations from scanning electron microscopy（SEM）,Brunauer-Emmett-Teller（BET）,X-ray diffraction（XRD）,h2-temperature programmed reduction（h2-TPR）,Nh3-te mperature programmed deso rption（Nh3-TPD）,and X-ray photoelectron spectroscopy（XPS）,it is revealed that the MnCeAl-DP sample owns admired features of large surface area and pore volume,enriched Mn4+and chemisorbed oxygen species originating from enhanced interaction between MnOxand CeO2,as well as improved adsorption capacity to Nh3and *** these factors contribute to activity *** in-situ DRIFTS studies reveal that the improvement of Nh3-SCR performance over MnCeAI-DP is related to the formation of abundant nitrate species,which is beneficial to the "Nh4NO3" reaction pathway and thus enhances low-temperature activity.

关键词： Fast SCR Low temperature Mn-Ce/Al2O3 catalysts Nh3-SCR Nh4NO3 Rare earths