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Comparison of diode laser continuous wave and in soft tissue surgery using pulsed modes in vitro

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Frontiers of Optoelectronics 2015年第2期8卷 212-219页

作者： Andrey v. BELIKOv Alexei v. SKRYPNIK ksenia v. shatilova Saint-Petersburg National Research University of Information Technologies Mechanics and Optics (ITMO University) Saint-Petersburg 197101 Russia

In this study, the interaction between diode laser radiation and chicken soft tissue was studied in vitro by a high-speed digital video camera. We used a diode laser with a wavelength of （980 ±10）nm and average power of 10 W. The diode laser was operated in continuous wave （CW） and pulsed modes. In CW mode, the average laser radiation power was 10 W; in pulsed mode, the average laser radiation power was I0 W and the peak power was 20 W. Diode laser radiation was delivered to soft tissue （chicken meat） using a quartz optical fiber with either a clear distal end （clear tip） or a distal end containing an optothermal converter （hot tip）. Application of the diode laser in pulsed mode resulted in crater depths and areas of collateral damage in soft tissue about 1.6 times greater than those observed in CW mode at treatment with the clear tip. Significant differences in the crater depth and collateral damage width of chicken meat were not found after hot-tip treatment with the diode laser in CW and pulsed modes. Soft tissue treated with the hot tip showed crater depths about 3.4 times greater than those observed after treatment with the clear tip. Hot tip treatment further resulted in collateral damage widths about 2.7 times lower than those obtained after treatment with the clear tip.

关键词： diode laser thermo-optically powered sur-gery hot tip surgery laser surgery soft tissue

Spontaneous Twist and Intrinsic Instabilities of Pristine Graphene Nanoribbons

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Nano Research 2009年第2期2卷 161-166页

作者： ksenia v.Bets Boris I.Yakobson Department of Mechanical Engineering&Materials Science Department of Chemistryand The Richard E.Smalley Institute for Nanoscale Science and TechnologyRice UniversityHoustonTexas 77005USA

In pristine graphene ribbons,disruption of the aromatic bond network results in depopulation of covalent orbitals and tends to elongate the edge,with an effective force of fe~2 ev/Å(larger for armchair edges than for zigzag edges,according to calculations).This force can have quite striking macroscopic manifestations in the case of narrow ribbons,as it favors their spontaneous twisting,resulting in the parallel edges forming a double helix,resembling DNA,with a pitchλt of about 1520 lattice *** atomistic simulations,we investigate how the torsionτ~1/λt decreases with the width of the ribbon,and observe its bifurcation:the twist of wider ribbons abruptly vanishes and instead the corrugation localizes near the *** length-scale(λe)of the emerging sinusoidal“frill”at the edge is fully determined by the intrinsic parameters of graphene,namely its bending stiffness D=1.5 ev and the edge force fe withλe~D/*** reveals other warping configurations and suggests their sensitivity to the chemical passivation of the edges,leading to possible applications in sensors.

关键词： Graphene nanoribbons mechanics twist

Will Russia become a blueprint for emerging nations’hightech reforms?evidence from a 26-countries dataset

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International Journal of Innovation Studies 2023年第4期7卷 312-324页

作者： Elena G.Popkova Aleksei v.Bogoviz ksenia v.Ekimova Bruno S.Sergi RUDN University MoscowRussia Independent Researcher MoscowRussia Department of Financial Management Plekhanov Russian University of EconomicsMoscowRussian Federation University of Messina Italy

The central question of this study concerns the emergence of the Russian development model over the past *** highlights that this development model could be a blueprint for other emerging *** is one of the leaders of the Fourth Industrial Revolution,having improved its standing in international ratings for quality of life,human development,sustainable development,innovation,and high ***'s experience can be helpful to developing *** study and evaluate innovation in a digital business society amid technological turmoil competing with artificial *** focus on the digital competitiveness index,the density of robots in industry,and unemployment,thereby building a novel comprehensive dataset of the economy's systemic socioeconomic and technological development under the conditions of the Fourth Industrial *** draw attention to Russia's new business environment that exhibits valuable specifics(e.g.,emerging institutions and imperfect competition as clouds in the business landscape)shaped by its current transitional *** estimate that technological progress will ensure digitalization,the prevention of extended unemployment,and the achievement of full-scale ***'s innovation policy has substantial advantages for emerging market *** study also shows that institutionalizing the new approach provides enduring digital economy advantages for emerging markets,including effectiveness,progressiveness,and sustainability.

关键词： New business paradigms Innovation Digital modernization Industry 4.0 Smart technologies Russia Emerging markets Sustainability Unfolding new social innovations New digital era

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俄罗斯极地乌拉尔硬玉岩成因矿物学研究

地学前缘 2020年第5期27卷 88-98页

作者：孟繁聪白盛锦 Alexander B.MAKEYEv ksenia v.KULIKOvA 中国地质科学院地质研究所北京100037 中国地质大学(北京)地球科学与资源学院北京100083 俄罗斯科学院矿床地质、岩石学、矿物学和地球化学研究所莫斯科119017 俄罗斯科学院乌拉尔分院科米科学中心地质研究所塞克提夫卡尔167982

俯冲带是壳-幔物质循环的重要场所,硬玉岩可以记录这一循环过程。文中总结了俄罗斯极地乌拉尔硬玉岩的研究进展。硬玉岩呈脉状或透镜状产在蛇纹石化的方辉橄榄岩中,主要由硬玉和绿辉石组成。根据结构和颜色,硬玉可识别出两个世代。硬玉... 详细信息

俯冲带是壳-幔物质循环的重要场所,硬玉岩可以记录这一循环过程。文中总结了俄罗斯极地乌拉尔硬玉岩的研究进展。硬玉岩呈脉状或透镜状产在蛇纹石化的方辉橄榄岩中,主要由硬玉和绿辉石组成。根据结构和颜色,硬玉可识别出两个世代。硬玉韵律环带发育,含有H2O和CH4流体包裹体,显示从流体中结晶的特征。硬玉岩中的锆石为热液锆石,锆石稀土元素中LaN/YbN=0.001~0.01,LuN/GdN=10~83,Ce/Ce*=2.8~72,显示正异常,δ^Eu=0.53~1.02,类似于岩浆锆石。锆石的^176Hf/^177Hf=0.282708~0.283017,εHf(t)=+6^+17,类似于N-MORB的Hf同位素组成,锆石δ^18O组成为5.03‰~6.04‰,平均δ^18 O为(5.45±0.11)‰,类似于岩浆热液和地幔的氧同位素组成。这可能反映了锆石是被俯冲带流体从途经火成岩中捕获的或者形成锆石的流体与寄主岩(方辉橄榄岩)达到了平衡。硬玉岩稀土元素配分模式近平坦或轻稀土元素略显富集,LaN/YbN比值为0.82~2.42,δEu为1.2~1.6,显示正异常,这与寄主岩稀土元素配分模式相似。富集Sr、Ba、Zr、Hf,Nb为负异常,与岛弧岩浆特征类似。(^87Sr/^86Sr)t为0.703400~0.703519(t=368 Ma),变化较小,与古海水差别明显;εNd(t)值为+0.77^+5.61,变化较大,与寄主岩(方辉橄榄岩)的Nd同位素组成类似,但不同于海水及沉积物的Nd同位素组成,表明硬玉岩的物质来源与寄主岩有明显继承关系,海水与沉积物的贡献不是主要的。矿物学和岩石学证据支持极地乌拉尔的硬玉岩主要是俯冲带流体与橄榄岩相互作用后并在其中结晶的产物。

关键词：硬玉岩硬玉锆石全岩地球化学俯冲带流体极地乌拉尔俄罗斯

IR-transparent MgO-Gd_(2)O_(3) composite ceramics produced by self-propagating high-temperature synthesis and spark plasma sintering

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Journal of Advanced Ceramics 2021年第2期10卷 237-246页

作者： Dmitry A.Permin Maksim S.Boldin Alexander v.Belyaev Stanislav S.Balabanov vitaly A.Koshkin Atrem A.Murashov Igor v.Ladenkov Evgeny A.Lantsev ksenia E.Smetanina Nadia M.Khamaletdinova G.G.Devyatykh institute of chemistry of high-purity substances of the ras nizhny novgorod603137russia Lobachevsky state university of nizhny novgorod nizhny novgorod603950russia “Joint-stock company”research and production enterprise“salut” nizhny novgorod603950russia G.A.Razuvaev institute of organometallic chemistry of the ras nizhny novgorod603137russia

A glycine–nitrate self-propagating high-temperature synthesis(SHS)was developed to produce composite MgO-Gd_(2)O_(3) *** X-ray powder diffraction(XRD)analysis confirmed the SHS-product consists of cubic MgO and Gd_(2)O_(3) phases with nanometer crystallite size and retains this structure after annealing at temperatures up to 1200℃.Near full dense high IR-transparent composite ceramics were fabricated by spark plasma sintering(SPS)at 1140℃and 60 *** in-line transmittance of 1 mm thick MgO-Gd_(2)O_(3) ceramics exceeded 70%in the range of 4–5 mm and reached a maximum of 77%at a wavelength of 5.3 *** measured microhardness Hv0.5 of the MgO-Gd2O3 ceramics is 9.5±0.4 GPa,while the fracture toughness(KIC)amounted to 2.0±0.5МPa·m1/*** characteristics demonstrate that obtained composite MgO-Gd_(2)O_(3) ceramic is a promising material for protective infra-red(IR)windows.

关键词： MgO-Gd_(2)O_(3) self-propagating high-temperature synthesis(SHS) spark plasma sintering(SPS) optical properties infra-red(IR)ceramics

Features of structure of external layer of murine hair at different stages of malignant tumor development

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Journal of Innovative Optical Health Sciences 2015年第3期8卷 3-8页

作者： valeriya S.Maryakhina Larisa S.Scheglova ksenia A.Anenkova Institute of Micro-and Nanotechnologies Orenburg State University 13 Pobedy st. Orenburg 460018Russia Molecular Physics Department M.v.Lomonosov Moscow State University 1 Leninskiye Gory Moscow 119991Russia

In the paper,the results of experimental investigations on the diferences of wool structure ofhealthy mice and mice with malignant tumor(s)are *** is shown that destruction ofwool structure happens during pathology *** of cells of external wool layerand their thickness decrease when the tumor capsule *** is seen even when thetumor is *** obtained results can be used to improve optical techniques of biomedicaldiagnostics of cancer diseases.

关键词： Breast cancer hair optical biomedical diagnost ics atomic force microscopy dynamiclight scattering

Resistance of LEDs Based on AIGalnP Heterostructures to Irradiation by Fast Neutrons

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Journal of Chemistry and Chemical Engineering 2013年第5期7卷 409-413页

作者： Gradoboev Alexander v Orlova ksenia N. Asanov Ivan A Yurga Technology Institute (Branch) Tomsk Polytechnic University Leningradskaya 652050 Yurga

The change of light output power of LEDs based on A1GalnP heterostructures with multiple quantum wells （590 nm and 630 nm） under irradiation by fast neutrons depends on the operating current density. It can be distinguished the regions of high, average and low electron injection. Operating current, this corresponds to the position of the boundary between the selected levels of the electron injection, increases with increasing neutron fluence. The final stage of the reducing process of the light output power under irradiation is the regime of low electron injection. The relative change in light output power depends on the operating current （operating current density） and can be described by a fairly simple equation. Established relations predict radiation resistance of LEDs, and it makes the most rational justification of operating modes of light-emitting diodes in terms of radiation resistance.

关键词： LEDs heterostructures AIGalnP quantum wells fast neutrons.

Quantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor,aging,and Parkinson’s disease

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Nano Research 2023年第5期16卷 7119-7133页

作者： Alexander v.Romashchenko Dmitrii v.Petrovskii Sergey Yu.Trotsky ksenia N.Morozova Nina B.Illarionova Maria v.Zhukova Elena v.Kiseleva Marina B.Sharapova Daniil S.Zuev Konstantin E.Kuper Sergey Yu.Taskaev Anna I.Kasatova Dmitrii A.Kasatov Olga I.Solovieva Ivan A.Razumov Ludmila A.Gerlinskaya Mikhail P.Moshkin Yuri M.Moshkin The Federal Research Center Institute of Cytology and Genetics SB RASAcademician Lavrentiev Avenue10Novosibirsk 630090Russia International tomography center Institutskaya st.3ANovosibirsk 630090Russia G.K.Boreskov Institute of Catalysis SB RASAcademician Lavrentiev Avenue5Novosibirsk 630090Russia The Federal Research Center Budker Institute of Nuclear Physics SB RASAcademician Lavrentiev Avenue11Novosibirsk 630090Russia Institute of Computational Technologies Academician M.A.Lavrentiev avenue6Novosibirsk 630090Russia Institute of Gene Biology Russian Academy of SciencesMoscow 117334Russia Institute of Molecular and Cellular Biology SB RASAcad.Lavrentiev Ave8/2Novosibirsk 630090Russia Federal Research Centre of Biological Systems and Agrotechnologies RASst.January 929Orenburg 460000Russia

Nanoparticles(NPs)can be transported via the nose-to-brain(N_(2)B)***,quantitative data on their spatiotemporal dynamics and regulation of the N_(2)B transport are largely *** surveyed metal oxide/hydroxide NPs as magnetic resonance imaging(MRI)contrasts for quantitative N_(2)B *** containing divalent transition metals were the only ones capable of N_(2)B *** T1-weighted(T1W)MRI,we showed that Mn_(3)O_(4)-NPs were readily engulfed by olfactory receptor neurons(ORNs)without disrupting olfactory sensing,we mapped their N_(2)B *** neurons,the Mn_(3)O_(4)-NPs were localized to the cytosol,mitochondria,vesicles,moved at mixed fast and slow axonal transport velocities intraand extra-vesicularly through *** NPs’axonal transport is dependent on neuronal activity and microtubule *** Mn_(3)O_(4)-NPs were trans-synaptically transmitted through at least four synapses across the olfactory ***-synaptic transmission of the NPs was dependent on N-type Ca^(2+)channels and NMDA receptors but blocked by GABAB receptor activation.A five-parameter Weibull signal increase/decrease model fitted to the T1W MRI data allowed for estimating kinetic parameters of Mn_(3)O_(4)-NP accumulation/*** and relative accumulation rates,but not elimination,correlated negatively with the number of synapses from ORNs,indicating a coupling of the NPs’N_(2)B transport with spontaneous neuronal ***,olfactory stimuli(2,5-dimethylpyrazine and acetophenone)significantly modulated and rerouted the Mn_(3)O_(4)-NP N_(2)B transport odor ***,the NPs’trans-synaptic transmission was impaired by aging and the onset of Parkinson’s *** data suggest new approaches to diagnostics,functional neuroimaging,controlling N_(2)B drug delivery.

关键词： Mn_(3)O_(4)nanoparticles magnetic resonance imaging(MRI) nose-to-brain transport trans-synaptic transmission olfactory stimulation

Efficacy and safety of COvID-19 vaccination in patients with cirrhosis

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World Journal of Hepatology 2022年第7期14卷 1470-1479页

作者： vladimir Ivashkin Albina Ismailova ksenia Dmitrieva Roman Maslennikov Maria Zharkova Salekh Aliev vyacheslav Bakhitov vadim Marcinkevich Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia Department of Internal Diseases Consultative and Diagnostic Center№2 of Department of HealthMoscow 107764Russia Administration Consultative and Diagnostic Center№2 of Department of HealthMoscow 107764Russia The First Hospital Surgery Department Pirogov Russian National Research Medical UniversityMoscow 117997Russia

BACKGROUND The clinical efficacy and safety of vaccination against novel coronavirus disease 2019(COvID-19)in patients with cirrhosis have not been evaluated *** To evaluate the clinical efficacy and safety of vaccination against COvID-19 in patients with *** This was a retrospective cohort study of patients with *** first cohort included patients vaccinated with Gam-COvID-vac(Sputnik v);the second one consisted of unvaccinated *** The study included 89 vaccinated patients and 148 unvaccinated *** were 4 cases of COvID-19 in the vaccinated group and 24 cases in the unvaccinated group(P=0.035).No severe cases of COvID-19 were revealed in the vaccinated group,while there were 12 ones in the unvaccinated group(P=0.012)with 10 deaths detected(P=0.012).The vaccine efficacy was 69.5%(95%confidence interval[CI]:18.5%-94.4%)against symptomatic cases of COvID-19,100%(95%CI:25.1%-100.0%)against severe cases,and 100%(95%CI:1.6%-100.0%)against death associated with *** efficacy of full vaccination with revaccination against symptomatic cases of COvID-19 was 88.3%(95%CI:48.0%-99.6%).The overall mortality rate was higher in the unvaccinated group than in the vaccinated group(17.1%vs 3.0%;P=0.001).Higher Child-Turcotte-Pugh class cirrhosis(hazard ratio[HR]=4.13,95%CI:1.82-9.35)and higher age(HR=1.08,95%CI:1.04-1.15)were independent predictors of overall mortality,while vaccination had a protective effect(HR=0.09,95%CI:0.01-0.76).There was no significant difference in liver-related mortality(P=0.135)or the incidence of liver decompensation(P=0.077),bleeding esophageal varices(P=0.397),and vascular events(P=0.651)between the two groups of *** vaccination against COvID-19 in patients with cirrhosis is effective and safe.

关键词： Coronavirus vaccination Revaccination Booster SARS-Cov-2 Sputnik v