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Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

Metals content in sediments of ephemeral streams with small reservoirs(the Negev Desert)

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International journal of Sediment Research 2020年第3期35卷 269-277页

作者： Ma?gorzata Kijowska-Struga?a ?ukasz Wiejaczka Rafa? Koz?owski judith Lekach Polish Academy of Sciences Institute of Geography and Spatial OrganizationResearch Station in Szymbark Polish Academy of Sciences Institute of Geography and Spatial OrganizationDepartment Polish Academy of SciencesInstitute of Geography and Spatial OrganizationDepartment of Geoenvironmental Research The jan Kochanowski University Institute of Geography and Environmental Sciences Bar-Ilan University Department of Geography and Environment

The content of 19 metals(chromium,cobalt,nickel,strontium,arsenic,magnesium,barium,cesium,gallium,rubidium,uranium,vanadium,zinc,lead,copper,cadmium,iron,manganese,and aluminum) in sediment in three ephemeral streams(Nahal Sansana,Nahal Revivim and Nahal Pura) with reservoirs in the Negev Desert is studied *** study was done in September *** samples were collected from the surface layer of sediment(up to 10 cm) in the reservoirs and in the channels upstream and downstream of the ***,which on average,accounted for 72% dominated in the *** the spatial distribution of the particle size,sand and gravel fractions were deposited in the ***,iron,and magnesium accounted for 99% of all analyzed *** Principal Component Analysis(PCA) and Hierarchical Cluster Analysis(HCA) showed that sediment in the Negev Desert channel upstream of the reservoirs had similar concentrations of *** were also found between the analyzed *** bottom sediment in reservoirs had higher concentrations of metals than sediment upstream and downstream of the *** comparison of concentrations in upstream and downstream locations did not show any unambiguous trends because metal concentrations downstream from the reservoirs were not always lower than upstream of the *** analysis of the sediment enrichment factor(EF) showed the highest value in the reservoirs and the lowest downstream of the *** concentrations of most analyzed metals did not indicate the possibility of potential ecological risk(SQG).

关键词： Metal content Sediment Reservoir Arid zone Israel

Analysis of the State of the Fine-Dispersive Precipitations in the Structure of High Strength Steel Weldox 1300 by Means of Electron Diffraction

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journal of Iron and Steel Research International 2011年第S1期18卷 135-142页

作者： Ozgowicz Wojciech Labisz krzysztof Division of Constructional and special Materials Division of Materials Processing Technology Management and Computer Techniques in Materials ScienceInstitute of Engineering Materials and BiomaterialsSilesian University of TechnologyKonarskiego St.18A44-100 GliwicePoland

The paper deals with investigations concerning the structure and state of dispersive precipitations of the phases consolidating in the high-strength steel Weldox 1300 after its high temperature thermomechanical *** use of transmission technique of electron microscopy (TEM) mainly the microstructure and morphology of martensite was analysed,as well as the state of dispersive precipitations of carbides and nitrides resulting from microadditives of such alloys as Nb,V,Ti or B,introduced into the *** revealed both a fine lathed and twin structure of the matrix of martensite in the investigated *** means of the method of electron diffraction particles of secondary strengthening phases of the M(C,N) type of a nanocrystalline size could be identified,and also non-metallic oxide inclusions,affecting the mechanism of strengthening of the investigated steel.

关键词： weldox 1300 HSLA steel thermomechanical treatment martensitic steel structural steel

Microstructure evolution of Solid Oxide Fuel Cell anodes characterized by persistent homology

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Energy and AI 2023年第4期14卷 73-85页

作者： Piotr Pawłowski Szymon Buchaniec Tomasz Prokop Hiroshi Iwai Grzegorz Brus AGH University of Science and Technology Mickiewicz Ave 3030-059KrakowPoland Kyoto University Nishikyo-ku615-8540KyotoJapan

Uncovering microstructure evolution mechanisms that accompany the long-term operation of solid oxide fuel cells is a fundamental challenge in designing a more durable energy system for the *** date,the study of fuel cell stack degradation has focused mainly on electrochemical performance and,more rarely,on averaged microstructural *** we show an alternative approach in which an evolution of three-dimensional microstructural features is studied using electron tomography coupled with topological data *** latter produces persistent diagrams of microstructure before and after long-term operation of *** diagrams unveil a new insight into the degradation process of three involved phases:Nickel,pores,and yttrium-stabilized zirconium.

关键词： Fuel cell Hydrogen Microstructure Persistent homology Persistent diagrams Machine learning

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Modifying current thin-film microextraction(TFME)solutions for analyzing prohibited substances:Evaluating new coatings using liquid chromatography

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journal of Pharmaceutical Analysis 2022年第3期12卷 470-480页

作者： Łukasz Sobczak Dominika Kołodziej krzysztof Gorynski Bioanalysis Scientific Group Faculty of PharmacyCollegium Medicum in Bydgoszcz at Nicolaus Copernicus University in Torun85-089BydgoszczPoland

For identifying and quantifying prohibited substances,solid-phase microextraction(SPME)continues to arouse interest as a sample preparation ***,the practical implementation of this method in routine laboratory testing is currently hindered by the limited number of coatings compatible with the ubiquitous high-performance liquid chromatography(HPLC)*** octadecyl(C18)and polydimethylsiloxane/divinylbenzene ligands are currently marketed for this *** address this situation,the present study evaluated 12 HPLC-compatible coatings,including several chemistries not currently used in this *** stationary phases of SPME devices in the geometry of thin filmcoated blades were prepared by applying silica particles bonded with various functional ligands(C18,octyl,phenyl-hexyl,3-cyanopropyl,benzenesulfonic acid,and selected combinations of these),as well as unbonded silica,to a metal *** of these chemistries have not been previously used as microextraction *** 48 most commonly misused substances were selected to assess the extraction efficacy of each coating,and eight desorption solvent compositions were used to optimize the desorption *** samples were analyzed using an HPLC system coupled with triple quadrupole tandem mass *** evaluation enables selection of the best-performing coatings for quantifying prohibited substances and investigates the relationship between extraction efficacy and the physicochemical characteristics of the ***,using the most suitable coatings is essential for trace-level analysis of chemically diverse prohibited substances.

关键词： Sample preparation Solid-phase microextraction Thin-film microextraction Prohibited substances Drugs of abuse High-performance liquid chromatography

Geomorphic indices and relative tectonic uplift in the Guerrero sector of the Mexican forearc

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Geoscience Frontiers 2017年第4期8卷 885-902页

作者： krzysztof Gaidzik María Teresa Ramírez-Herrera Laboratorio Universitario de Geofísica Ambiental & Instituto de Geografía Universidad Nacional Autónoma de MéxicoCiudad Universitaria Berkeley Seismological Laboratory Department of Earth and Planetary ScienceUniversity of California Berkeley

Tectonically active areas,such as forearc regions,commonly show contrasting relief,differential tectonic uplift,variations in erosion rates,in river incision,and in channel gradient produced by ongoing tectonic ***,information on the tectonic activity of a defined area could be derived via landscape *** study uses topography and geomorphic indices to extract signals of ongoing tectonic deformation along the Mexican subduction forearc within the Guerrero *** this purpose,we use field data,topographical data,knickpoints,the ratio of volume to area（Rva）.the stream-length gradient index（St）,and the normalized channel steepness index（k_（sn））.The results of the applied landscape analysis reveal considerable variations in relief,topography and geomorphic indices values along the Guerrero sector of the Mexican subduction *** argue that the reported differences are indicative of tectonic deformation and of variations in relative tectonic uplift along the studied forearc.A significant drop from central and eastern parts of the study area towards the west in values of R_（VA）（from ~500 to^300）,St（from ~500 to ca.400）,maximum St（from ~1500-2500 to ~ 1000） and k_（sn）（from ~150 to ~100） denotes a decrease in relative tectonic uplift in the same *** suggest that applied geomorphic indices values and forearc topography are independent of climate and *** mechanisms responsible for the observed variations and inferred changes in relative forearc tectonic uplift call for further studies that explain the physical processes that control the forearc along strike uplift variations and that determine the rates of *** proposed methodology and results obtained through this study could prove useful to scientists who study the geomorphology of forearc regions and active subduction zones.

关键词： Relative tectonic uplift Forearc Active tectonics Geomorphic index Drainage network Mexican subduction zone

Development of open-porosity magnesium foam produced by investment casting

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journal of Magnesium and Alloys 2022年第7期10卷 1941-1956页

作者： Honorata Kapłon Carsten Blawert jacek Ch˛ecmanowski krzysztof Naplocha Faculty of Mechanical Engineering Wrocław University of Science and TechnologyUl.Smoluchowskiego 25Wrocław 50-370Poland Institute of Surface Science Helmholtz-Zentrum GeesthachtMax-Planck-Straβe 1Geesthacht21502Germany Faculty of Chemistry Wrocław University of Science and TechnologyWybrze˙ze Stanisława Wyspia´nskiego 27Wrocław50-370Poland

High-porosity,open-cell AZ91 magnesium alloy foams of two pore sizes were fabricated by means of investment casting technology,using PUR foam *** casting variables such as pressure,mould temperature and metal pouring temperature were thoroughly investigated to define the most optimal casting *** mechanical properties of the fabricated foams were measured in compression tests.A potential application for the foams considered is temporary bioresorbable bone implants,therefore the mechanical properties of the foams were compared with those of cancellous bone *** with smaller pore size and lower porosity(20 PPI and 80%±87%)exhibited mechanical properties in the lower regions of the cancellous bone property range(Young’s modulus 36.5±77.5 MPa),while foams with higher pore size and porosity(10 PPI and~90%)were found to have insufficient compression strength(Young’s modulus 11.65±23.8),but thickening their walls and lowering their porosity below 90%yielded foams with Young’s modulus between 36.5 and 77.5 *** fractures were also investigated to determine their collapse mechanism.A series of corrosion tests in stimulated body fluid was carried out to determine their applicability as a *** Plasma Electrolytic Oxidation(PEO)process was used in a feasibility study to examine the microstructure and chemical composition of foams with protective coating.

关键词： Magnesium foams AZ91 investment casting Bone implants Plasma electrolytic oxidation

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times