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Cognitive function and adherence to anticoagulation treatment in patients with atrial fibrillation

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Journal of Geriatric Cardiology 2016年第7期13卷 559-565页

作者： Beata Jankowska-Polanska Lomper Katarzyna Alberska Lidia Jaroch Joanna krzysztof Dudek Uchmanowicz Izabella Department of Clinical Nursing Wroctaw Medical University Bartla Wroclaw Poland Emergency Medicine Centre Anesthesiology Unit Marciniak Lower-Silesian Specialist Hospital Fieldorfa Wroctaw Poland Emergency Medicine Centre Cardiology Unit Marciniak Lower-Silesian Specialist Hospital Fieldorfa Wroelaw Poland Department of Logistic and Transport Systems University of Technology Wybrzeze Stanistawa Wyspianskiego Wroctaw Poland

Background Medication adherence is an integral part of the comprehensive care of patients with atrial fibrillation （AF） receiving oral anticoagulations （OACs） therapy. Many patients with AF are elderly and may suffer from some form of cognitive impairment. This study was conducted to investigate whether cognitive impairment affects the level of adherence to anticoagulation treatment in AF patients. Me- thods The study involved 111 AF patients （mean age, 73.5±8.3 years） treated with OACs. Cognitive function was assessed using the Mini Mental State Examination （MMSE）. The level of adherence was assessed by the 8-item Mot^sky Medication Adherence Scale （MMAS-8）. Scores on the MMAS-8 range from 0 to 8, with scores 〈 6 reflecting low adherence, 6 to 〈 8 medium adherence, and 8 high adherence. Re- sults 46.9% of AF patients had low adherence, 18.8% had moderate adherence, and 33.3% had high adherence to OACs. Patients with lower adherence were older than those with moderate or high adherence （76.6 ±8.7 vs. 71.3 ~ 6.4 vs. 71.1 ± 6.7 years） and obtained low MMSE scores, indicating cognitive disorders or dementia （MMSE = 22.3 ± 4.2）. Patients with moderate or high adherence obtained high MMSE test results （27.5 ±1.7 and 27,5 ± 3.6）. According to Spearman＇s rank correlation, worse adherence to treatment with OACs was determined by older age （rs = -0.372） and lower MMSE scores （rs = 0.717）. According to multivariate regression analysis, the level of cognitive function was a significant independent predictor of adherence （b = 1.139）. Conclusions Cognitive impairment is an independent determinant of compliance with pharmacological therapy in elderly patients with AF. Lower adherence, beyond the assessment of cognitive function, is related to the age of patients.

关键词： Anticoagulation treatment Atrial fibrillation Cognitive impairment Medication adherence

Use of the finite elements method for modelling the dynamic load impact on hydraulic leg equipped with gas accumulator

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Journal of Coal Science & Engineering(China) 2008年第2期14卷 171-175页

作者： GONDEK Horst MAZUREK krzysztof SZWEDA Stanislaw VB-Technical University of Ostrava Ostrava 70833Czech Republic KOMAG Mining Mechanization Centre GliwicePoland Mining and Geology Department Silesian University of TechnologyGliwicePoland

Procedures of preparation of numerical analysis,consisting in a simulation of cooperation of three different media: steel,liquid and gas undergoes dynamic load were *** of the initial static load of the mechanical system was *** using the *** products the following exemplary computer simulations were made: dynamic load impact on the hydraulic leg as well as effectiveness of the hydraulic leg protection against overload with help of gas accumulator.

关键词： finite elements dynamic load hydraulic leg equipped gas accumulator

Exceptionally rare cause of a total stomach resection

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World Journal of Gastroenterology 2012年第20期18卷 2582-2585页

作者： Jadwiga Snarska krzysztof Jacyna Jacek Janiszewski Danuta Shafie Katarzyna Iwanowicz Anna Zurada Department of General Surgery Faculty of Medical Sciences University of Warmia and Mazury in Olsztyn10561 Olsztyn Poland Department of Internal Diseases Medical Care Centre of the Ministry of the Interior and Administration with the Warmia and Mazury Centre of Oncology in Olsztyn 10561 OlsztynPoland Department of Pathology Faculty of Medical SciencesUniversity of Warmia and Mazury in Olsztyn10561 OlsztynPoland Department of Anatomy Faculty of Medical SciencesUniversity of Warmia and Mazury in Olsztyn10561 OlsztynPoland

The first-ever case of a 54-year-old woman who overdosed on non-steroidal anti-inflammatory drugs in an attempt at *** that incident,she had not been treated for coexisting diseases such as rheumatoid arthritis or *** the time of admission to the General Surgery Department,the patient reported pains in the epigastric region with accompanying nausea and vomiting with mucous content as well as the inability to ingest food *** parenteral and enteral feeding,the patient exhibited a drop in body *** histopathologic examination of a sample taken from the stomach during gastroscopy showed some non-specific necrotic and inflammatory masses with ***,a very small,infiltrated stomach with an initial section of duodenum was identified.A total stomach resection together with the reconstruction of digestive tract continuity was performed using the Roux-Y *** examination of the stomach revealed a deep,chronic and exacerbated inflammatory condition with an extensive ulceration over the entire length of the stomach,reaching up to the ***,numerous lymphatic glands with inflammatory reaction changes were observed.

关键词： Non-steroidal anti-inflammatory drugs poisoning Total stomach resection Roux-Y anastomosis

Liver steatosis correlates with iron overload but not with HFE gene mutations in chronic hepatitis C

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Hepatobiliary & Pancreatic Diseases International 2013年第4期12卷 377-384页

作者： Katarzyna Sikorska Piotr Stalke Tomasz Romanowski Robert Rzepko krzysztof Piotr Bielawski Department of Infectious Diseases Medical University of GdanskSmoluchowskiego 18 80-214 Gdansk Poland Department of Biotechnology Intercollegiate Faculty of Biotechnology University of Gdansk and Medical University of GdanskKladki 24 80-822 Gdansk Poland Department of Pathology Medical University of GdanskDebinki 7 80-952 Gdansk Poland

BACKGROUND: Liver steatosis and iron overload, which are frequently observed in chronic hepatitis C (CHC), may contribute to the progression of liver injury. This study aimed to evaluate the correlation between liver steatosis and iron overload in Polish patients with CHC compared to non- alcoholic fatty liver disease (NAFLD) and HFE-hereditary hemochromatosis (HH) patients. METHODS: A total of 191 CHC patients were compared with 67 NAFLD and 21 HH patients. Liver function tests, serum markers of iron metabolism, cholesterol and triglycerides were assayed. The inflammatory activity, fibrosis, iron deposits and steatosis stages were assessed in liver specimens. HFE gene polymorphisms were investigated by PCR-RFLP. RESULTS: Liver steatosis was associated with obesity and diabetes mellitus. This disease was confirmed in 76/174 (44%) CHC patients, most of whom were infected with genotype 1. The average grade of steatosis was higher in NAFLD patients. CHC patients had significantly higher iron concentrations and transferrin saturations than NAFLD patients. Compared with CHC patients, HH patients had higher values of serum iron parameters and more intensive hepatocyte iron deposits without differences in the prevalence and intensity of liver steatosis. In the CHC group, lipids accumulation in hepatocytes was significantly associated with the presence of serummarkers of iron overload. No correlation between the HFE gene polymorphism and liver steatosis in CHC patients was found. CONCLUSIONS: Liver steatosis was diagnosed in nearly half of CHC patients, most of whom were infected with genotype 1. The intensity of steatosis was lower in CHC patients than that in NAFLD patients because of a less frequent diagnosis of metabolic syndrome. Only in CHC patients were biochemical markers of iron accumulation positively correlated with liver steatosis; these findings were independent of HFE gene mutations.

关键词： hepatitis C virus iron overload fatty liver hemochromatosis metabolic syndrome X

Short- and medium-term reproducibility of gastric emptying of a solid meal determined by a low dose of ^(13)C-octanoic acid and nondispersive isotope-selective infrared spectrometry

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World Journal of Gastroenterology 2006年第8期12卷 1243-1248页

作者： Anna Kasicka-Jonderko Magdalena Kami■ska krzysztof Jonderko Olga Setera Barbara Blo■ska-Fajfrowska Department of Basic Biomedical Science.School of Pharmacy Medical University of SilesiaSosnowiecPoland Department of Basic Biomedical Science.School of Pharmacy Medical University of SilesiaSosnowiecPoland Department of PhysiologyInstitute of Occupational Medicine and Environmental HealthSosnowiecPoland

AIM： To evaluate the reproducibility of a modified 13^C breath test-based measurement of solid phase gastric emptying （GE） within the frames of a simple-repeated measure study protocol. METHODS： Twelve healthy subjects （6 females and 6 males, mean age 24.9＋0.7 years） were recruited to undergo three identical GE examinations. In six subjects the first two examinations were performed 2 d apart, and the third session was carried out at a median interval of 19.5 d （range 18 - 20 d） from the second one. In another six subjects the first two measurements were taken 20 d apart （median, range： 17-23 d）, whereas the third session took place 2 d after the second one. Probes of expiratory air collected before and during six hours after intake of a solid meal （378 kcal） labelled with 75 μL （68 mg） 13^C-octanoic acid, were measured for 13^CO2 enrichment with the nondispersive isotopeselective infrared spectrometry NDIRS apparatus. RESULTS： Taking coefficients of variation for paired examinations into account, the short-term reproducibility of the GE measurement was slightly but not significantly better than the medium-term one： 7.7% and 11.2% for the lag phase （T-Lag）, 7.3% and 10.9% for the gastric half emptying time （T1/2）. The least differences in GE parameters detectable at P= 0.05 level in the 12 paired examinations were 9.6 and 15.6 min for T-Lag, 11.6 and 19.7 min for T1/2 by a two-day or two to three-week time gap, respectively CONCLUSION： The low-cost modification of the breath test involving a lower dose of 13^C-octanoic acid and NDIRS, renders good short- and medium-term reproducibility, as well as sensitivity of the measurement of gastric emptying of solids.

关键词： 13^C breath test Gastric emptying Nondispersive isotope-selective infrared spectrometry 13^C-octanoic acid Reproducibility

Robust and highly efficient electrocatalyst based on ZIF-67 and Ni^(2+) dimers for oxygen evolution reaction:In situ mechanistic insight

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Journal of Energy Chemistry 2023年第11期86卷 263-276,I0006页

作者： Anna Dymerska Bartosz Środa krzysztof Sielicki Grzegorz Leniec Beata Zielińska Rustem Zairov Renat Nazmutdinov Ewa Mijowska Department of Nanomaterials Physicochemistry Faculty of Chemical Technology and EngineeringWest Pomeranian University of TechnologySzczecinPiastów Ave.1771-065 SzczecinPoland Department of Technical Physics Faculty of Mechanical Engineering and MechatronicsWest Pomeranian University of Technology in Szczecinal.Piastów 4870-311 SzczecinPoland A.M.Butlerov Institute of Chemistry Kazan Federal UniversityKazan4200081/29 Lobachevskogo str.Russian Federation Arbuzov Institute of Organic and Physical Chemistry FRC Kazan Scientific CenterRussian Academy of Sciences420088Arbuzov str.8KazanRussian Federation Kazan National Research Technological University 420015 KazanK.Marx Str.68Russian Federation

Electrochemical water splitting is a straightforward process that involves two distinct reactions:the oxygen evolution reaction(OER)which produces oxygen(O_(2))and the hydrogen evolution reaction(HER)which generates hydrogen(H_(2)).However,in the whole process,the OER is a bottleneck as it requires more energy than a four-electron reaction involving critical raw materials(such as RuO_(2)or IrO_(2))as ***,here,we address the challenge of erratic kinetics/limited durability of OER in water electrolysis,In this paper,we demonstrate that the deposition of ultrasmall amounts of nickel(Ⅱ)nitrate in zeolitic imidazolate framework-67(ZIF-67)can be used as a general approach to enhance the electrocatalytic performance of the *** investigated the influence of Ni(NO_(3))·x6H_(2)O loading on ZIF-67(from 0.1 to 0.0001 M)and found that ZIF-67 enriched with only 0.001 M of Ni(NO_(3))2·x6H_(2)O(ZIF-670.001 Ni)exhibited massive promotion in *** ZIF-670.001 Ni showed a large specific surface area of 2577 m^(2)g^(-1),a low overpotential of 299 mV,a lower Tafel slope of 94.1 mA dec^(-1),and an outstanding overpotential retention of 99.8%(at 50 mA cm^(-2)).By conducting electron paramagnetic resonance(EPR)measurements,we also discovered that the 0.001 M of Ni(NO_(3))_(2)·x6H_(2)O loading in ZIF-67 introduces Ni^(^(2+))dimers,which contribute to the enhanced electroactivity of the modified *** phenomenon was further revealed during density-functional theory(DFT)calculations,which allowed us to identify different possible forms of Ni^(^(2+))dimers and modeling of active *** with in situ experiments,we provide mechanistic insight into the OER mechanism under alkaline conditions and found that it follows the lattice oxygen mechanism(LOM).Our study proposes a facile and efficient room-temperature route to boost the electrochemical performance of ZIF-67 in *** the first time,we demonstrate that modifying ZIF-67 with an ultrasmall amoun

关键词： ZIF-67 Oxygen evolution reaction Nickel(Il)nitrate Electrocatalysis

Iron overload and HFE gene mutations in Polish patients with liver cirrhosis

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Hepatobiliary & Pancreatic Diseases International 2011年第3期10卷 270-275页

作者： Katarzyna Sikorska Piotr Stalke Tomasz Romanowski Ewa Izycka-Swieszewska krzysztof Piotr Bielawski Department of Infectious Diseases Medical University of Gdanskul.Smoluchowskiego 1880-218 GdanskPoland Department of Biotechnology Intercollegiate Faculty of BiotechnologyUniversity of Gdansk and Medical University of Gdanskul.Kladki 2480-822 GdańskPoland Department of Pathology Medical University of Gdanskul.Debinki 780-952 GdanskPoland

BACKGROUND:Increased liver iron stores may contribute to the progression of liver injury and fibrosis,and are associated with a higher risk of hepatocellular carcinoma ***-transplant symptoms of iron overload in patients with liver cirrhosis are associated with higher risk of infectious and malignant complications in liver transplant *** gene mutations may be involved in the pathogenesis of liver iron overload and influence the progression of chronic liver diseases of different *** study was designed to determine the prevalence of iron overload in relation to HFE gene mutations among Polish patients with liver ***:Sixty-one patients with liver cirrhosis included in the study were compared with a control group of 42 consecutive patients subjected to liver biopsy because of chronic liver *** function tests and serum iron markers were assessed in both *** patients were screened for HFE mutations (C282Y,H63D,S65C).Thirty-six of 61 patients from the study group and all controls had liver biopsy performed with semiquantitative assessment of iron deposits in ***:The biochemical markers of iron overload and iron deposits in the liver were detected with a higher frequency (70% and 47% respectively) in patients with liver *** were no differences in the prevalence of all HFE mutations in both *** patients with a diagnosis of hepatocellular carcinoma,no significant associations with iron disorders and HFE gene mutations were ***:Iron disorders were detected in patients with liver cirrhosis frequently but without significant association with HFE gene *** the homozygous C282Y mutation seems to occur more frequently in the selected population of patients with liver *** elevated biochemical iron indices accompanied liver iron deposits more frequently in liver cirrhosis compared to controls with chronic liver disease,there is a need for more extensive s

关键词： liver cirrhosis iron overload gene mutations iron deposits hepatocytes

Hydrogen Evolution on Binary and Ternary Cobalt Alloys Deposited With Superimposed Magnetic Field

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Journal of Iron and Steel Research International 2012年第S2期19卷 1152-1157页

作者： ZABINSKI Piotr MECH krzysztof KOWALIK Remigiusz Faculty of Non-Ferrous Metals AGH University of Science and Technology

The article presents results of electrodeposition of Co-Mo Co-Mo-C alloys in a magnetic field characterized by low overvoltage of hydrogen *** of molybdenum and carbon was to lower the values of overvoltage of hydrogen evolution on *** influence of bath pH,bath composite,current density and magnetic field with different orientation on the deposits composition,structure and overpotential for hydrogen evolution reaction(HER) was *** properties of the obtained alloy coatings within the range of hydrogen evolution were tested in a concentrated NaOH *** comparison of electrocatalytic properties of Co-Mo alloys with properties of Co-Mo-C ones enabled determining the influence of carbon presence in cathodic deposits on the overpotential values for hydrogen evolution.

关键词： Co-Mo alloys Co-Mo-C alloys hydrogen evolution magneto-electrochemistry

Tailoring thermoelectric properties of Zr(0.43)Hf(0.57)NiSn half-Heusler compound by defect engineering

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Rare Metals 2020年第6期39卷 659-670页

作者： krzysztof Galazka Wenjie Xie Sascha Populoh Myriam H.Aguirre Songhak Yoon Gesine Büttner Anke Weidenkaff Institute of Plasma Physics and Laser Microfusion Warsaw 01-497Poland Department of Materials Science Technische Universitat DarmstadtDarmstadt 64287Germany Laboratory for Solid State Chemistry and Catalysis EmpaDlibendorf 8600Switzerland Instituto de Nanociencia de Aragon Universidad de ZaragozaSaragossa 50018Spain Departamento de Fisica de la Materia Condensada Universidad de ZaragozaSaragossa 50009Spain Laboratorio de Microscopias Avanzadas Universidad de ZaragozaSaragossa 50018Spain Fraunhofer Research Institution for Materials Recycling and Resource Strategies IWKS Hanau 63457Germany

The thermoelectric transport properties of Zr0.43Hf0.57 NiSn half-Heusler compounds were investigated for samples sintered with different spark plasma sintering(SPS)periods:8,32 and 72 *** means of scanning transmission electron microscopy with a highangular annular dark-field detector(STEM-HAADF),it was found that sintering time affected the defect concentration,namely the amount of Ni interstitial atoms,and created locally ordered inclusions of full-Heusler *** structural information,phase composition and electrical transport properties could be consistently explained by the assumption that Ni interstitials give rise to an impurity band situated about 100 meV below the bottom of the conduction band via a self-doping *** impurity band was found to merge with the conduction band for the sample with intermediate SPS *** effect was ascribed to the gradual dissolution of full-Heusler phase inclusions and production of interstitial Ni defects,which eventually vanished for the sample with the longest sintering *** was demonstrated that the modification of the density of states near the edge of the conduction band and enhanced overall charge carrier concentration provided by defect engineering led to overall 26%increase in the thermoelectric figure of merit(ZT)with respect to the other samples.

关键词： Thermoelectric Half-Heusler Interstitial Defect engineering