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There is more to the knee joint than just the quadriceps:A systematic review with meta-analysis and evidence gap map of hamstring strength,flexibility,and morphology in individuals with gradual-onset knee disorders

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Journal of Sport and Health Science 2024年第4期13卷 521-536页

作者： Helder S.Lopes marina C.Waiteman Liliam B.Priore Neal R.Glaviano David m.Bazett-jones Ronaldo V.Briani Fabio m.Azevedo School of Science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA School of Exercise and Rehabilitation Sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

Background:Impairments in hamstring strength,flexibility,and morphology have been associated with altered knee biomechanics,pain,and *** the presence of these impairments in individuals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic review aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in individuals with gradual-onset knee ***:Five databases(mEDLINE,Embase,CINAHL,SPORTDiscus,and Web of Science)were searched from inception to September *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between individuals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the Grading of Recommendations Assessment,Development,and Evaluation,and evidence gap maps were ***:Seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(PFP),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(SmD)=-0.76,95%confidence interval(95%CI):-1.32 to-0.21)and concentric contractions(SmD=-0.97,95%CI:-1.49 to-0.45).Individuals with PFP presented with reduced hamstring strength compared to painfree controls during isometric(SmD=-0.48,95%CI:-0.82 to-0.14),concentric(SmD=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions(SmD=-0.59,95%CI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with PFP presented with reduced hamstring flexibility when compared to pain-free controls(SmD=-0.76,95%CI:-1.15 to-0.36).Evidence gap maps identified insufficient evidence for chondromalacia patel

关键词： Chondromalacia patellae Knee flexors Knee osteoarthritis Patellar tendinopathy Patellofemoral pain

Dim artificial light at night reduces the cellular immune response of the black field cricket, Teleogryllus commodus

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Insect Science 2020年第3期27卷 571-582页

作者： Joanna Durrant mark P.Green Theresa m.jones The School of BioSciences Faculty of ScienceUniversity of MelbourneVictoria3010Australia

A functioning immune system is crucial for protection against disease and illness,yet increasing evidence suggests that species living in urban areas could be suffering from immune suppression,due to the presence of artificial light at night(ALAN).This study examined the effects of ecologically relevant levels of ALAN on three key measures of immune function(haemocyte concentration,lytic activity,and phenoloxidase activity)using a model invertebrate species,the Australian black field cricket,Teleogryllus *** reared crickets under an ecologically relevant daily light‐cycle consisting of 12 hr bright daylight(2600 lx)followed by either 12 h darkness(0 lx)or dim environmentally relevant ALAN(1,10,100 lx),and then assessed immune function at multiple time points throughout adult life using haemolymph *** found that the presence of ALAN had a clear negative effect on haemocytes,while the effects on lytic activity and phenoloxidase activity were more complex or largely unaffected by ***,the effects of lifelong exposure to ALAN of 1 lx were comparable to those of 10 and 100 *** data suggest that the effects of ALAN could be large and widespread,and such reductions in the core immune response of individuals will likely have greater consequences for fitness and survival under more malign conditions,such as those of the natural environment.

关键词： circadian rhythm ecophysiology immune function immunomodulation invertebrate light pollution melatonin urbanization

Recent advances and future directions in preclinical research of argininevasopressin(AVP) receptor blocker conivaptan in the context of stroke

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Neural Regeneration Research 2016年第3期11卷 392-393页

作者： Emil Zeynalov Susan m.jones Swedish medical Center Neurotrauma Research Department Englewood

Stroke is a major cause of mortality and permanent *** onset of stroke is followed by life-threatening pathophysiological responses including brain edema,elevation of intracranial pressure,disruption of blood-brain barrier（BBB）,brain infarct and permanent tissue *** edema develops due to accumulation of water in intracellular and extracellular compartments of the brain,

关键词： edema permanent disability intracranial elevation blocker infarct disruption advances mortality

Developing an identities-based approach to support more robust resilience and recovery in heritage planning and management

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Built Heritage 2023年第2期7卷 3-14页

作者： Zachary m.jones Théodora Pappas DASTU Politecnico di MilanoMilanItaly

Resilience has become an increasingly important concept in the cultural heritage feld,particularly in the aftermath of the unprecedented challenges the COVID-19 global pandemic ***,on a conceptual and practical level,resilience remains closely linked to the technical conservation of built heritage,and there remains a need to develop broader approaches inclusive of cultural and socioeconomic *** article investigates the potential applicability of theoretical concepts linked to identity and identities in heritage planning to help fll these gaps and develop approaches that consider resilience and are better able to address a range of unanticipated *** frst review the literature and policy documents to defne and identify the potential for identities-based *** then examine the case of matera,an extremely fragile world heritage site in southern Italy that has been continuously inhabited for more than 8000 years and provides a relevant example of *** explore the trends and efects of globalised tourism development before the pandemic and the post pandemic emergence of more local/regional and slow tourism patterns,largely based on cultural solutions to local development challenges and knowledge *** this comparison,we analyse the potential and limitations of introducing identities-based concepts into heritage planning as a more robust way to enhance resilience and prepare cities for unexpected future crises.

关键词： identity heritage management plans matera resilience locally based development mode

Ligand-mediated contaminant degradation by bare and carboxymethyl cellulose-coated bimetallic palladium-zero valent iron nanoparticles in high salinity environments

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Journal of Environmental Sciences 2019年第3期31卷 303-311页

作者： Xiaoming ma Di He Adele m.jones T.David Waite Taicheng An Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control School of Environmental Science and Engineering Guangzhou University of Technology School of Civil and Environmental Engineering University of New South Wales

The application of nanoscale zero-valent iron(nZVI) for the degradation of contaminants has been extensively investigated, however, few studies have focused on degradation in high salinity environments. In this study, the ability of bare and carboxymethyl cellulose(CmC)-coated bimetallic Pd-nZVI particles to degrade 33′44′-tetrachlorobiphenyl in high saline water(SW) is examined with particular attention given to the effects of ethylenediaminetetraacetic acid(EDTA) on the rate of degradation. EDTA enhances the reactivity of Pd-nZVI in SW, with evidence provided to link this to the removal of the passivating layer. Additionally, a conceptual model is proposed which provides a quantitative description of the removal of these iron oxide layers in the presence of EDTA. An optimum EDTA to bare Pd-nZVI molar ratio of 0.1 exists, with insufficient EDTA unable to remove the passivating layer whilst excess EDTA results in Fe loss and enhanced agglomeration due to magnetic attraction of the bare Fe(0) particles. In contrast, CmCcoating of Pd-nZVI assemblages actually impedes degradation, despite the coated particles displaying a smaller average size compared to uncoated particles, with even the presence of EDTA in this case not significantly improving degradation. The reduced reactivity in the presence of CmC is primarily attributed to the effect of CmC on the association of Pd with nZVI particles. In particular, the presence of CmC reduced the total amount of Pd incorporated with the stabilized particles compared to the non-stabilized ***, the presence of CmC results in less Pd present in its reactive zero-valent oxidation state.

关键词： Bimetallic zero valent iron ligand-mediated depassivation polychlorinated biphenyls high salinity water

The Influence of Variable (monsoon) Rainfall on Sedimentation in the Roaches Grit and Other Upper Carboniferous Delta Sequences in the UK Pennine Basin

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International Journal of Geosciences 2024年第8期15卷 632-666页

作者： Colin michael jones Retired Cambridge UK

The Roaches Grit in the UK Pennine Basin was a complex deep water deltaic sequence deposited during the Late Carboniferous glacial period. The channels of the upper part of the Roaches Grit, deposited towards the end of the cyclothem after the eustatic minimum, contain evidence for very high seasonal discharges related to strong monsoon rainfall in the catchment areas. In some channels, intense turbulence near the delta front, led to knick point recession and deep incision. These channels were filled with sediments during reduced discharge, including very large sets of cross-bedding up to 16 m thick. Channels were short-lived with frequent avulsions. Over time slightly lower discharges formed laterally migrating channels dominated by bar forms. Different discharge-controlled processes operated on the reactivated delta slope. Incised channels generated turbidity currents during floods which transported sediments directly into the basin far from the delta. migrating channels built mouth bars;resedimentation during floods formed density currents which then deposited sediment on the lower parts of the slope.

关键词： Carboniferous Delta Climate monsoon Rainfall ITCZ Precession

mobilization of Lead by Several Chelating Agents in mice Injected with Lead

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中国医科大学学报 1989年第S2期18卷 36-42页

作者：徐兆发 mark m.jones Department of Public Health China Medical University Department of Chemistry and Center in molecular Toxicology Vanderbilt University USA

The relative abilities of several chelating agents to act as antagonists for acute and chronic lead poisoning have been examined in the *** acute LD50 for lead acetate trihydrate was determined and found to be 135.3 mg Pb/kg for i. p. injection with a 95% confidence interval of 87.1 to 210.3 mg Pb/kg. The relative efficacy of chelating agents to reduce liver,kidney, spleen, bone and brain levels of lead was determined. The spleen levels were found to undergo little differences between the control and treated groups, but the liver, kidney, bone and brain levels showed significant differences in some cases. Of the compounds examind, meso-2, 3-dimercaptosuccinic acid （DmSA）and sodium 2,3-dimercaptopropane-1-sulfonate（DmPS） were as effective as disodium calcium ethylenediaminetetraacetate （Na2CaEDT A）. The resuits indicated that DmSA was a promising chelating agent and may be worthy of further investigation in the clinic.

关键词： chelating sulfonate acetate poisoning disodium spleen worthy confidence solubility allowed

LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis

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Genes & Diseases 2024年第3期11卷 417-426页

作者： Zijian Xu Elizabeth R.Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben G.marshall David Hancock Tim Wallis Julian Downward Rob m.Ewing Donna E.Davies mark G.jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and Experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK University Hospital Southampton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factors that determine fibrosis progression or normal tissue repair are largely *** previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition(EmT)in human alveolar epithelial type Il(ATIl)cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine ***,we report that liver kinase B1(LKB1)inactivation in ATIl cells inhibits autophagy and induces EmT as a *** IPF lungs,this is caused by the down-regulation of CAB39L,a key subunit within the LKB1 complex.3D co-cultures of ATIl cells and mRC5 lung fibroblasts coupled with RNA sequencing(RNA-seq)confirmed that paracrine signaling between LKB1-depleted ATIl cells and fibroblasts augmented myofibroblast ***,these data suggest that reduced autophagy caused by LKB1 inhibition can induce EmT in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk.

关键词： CAB39L Crosstalk EmT LKB1 Pulmonary fibrosis

Arterial Stiffness as a Cardiovascular Risk Factor in Prostate Cancer Survivors:A Case-Control Study

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Journal of Science in Sport and Exercise 2021年第2期3卷 171-178页

作者： Lynnette m.jones Rebekah Wilson Lee Stoner J.Chris Baldi School of Physical Education Sportand Exercise SciencesUniversity of OtagoPO Box 56DunedinNew Zealand Department of Sport and Exercise Science University of North CarolinaChapel HillNC 27599-8700USA Department of medicine University of OtagoPO Box 56DunedinNew Zealand

Purpose In New Zealand,prostate cancer (PCa) is the most commonly diagnosed cancer in men and the third most common cause of male cancer *** these patients,the most common non-cancer related cause of death is cardiovascular disease (CVD).Aortic arterial stiffness may be clinically viable solution for detecting and tracking CVD risk factor in PCa *** aim of the study was to determine whether aortic arterial stiffness is increased in PCa survivors compared to age-matched *** Participants recruited for this prospective comparative study were PCa survivors who had completed treatment(other than endocrine therapy) or were on active surveillance compared,or were age-matched non-cancer *** a single 1-h appointment,all participants had measures of aortic arterial stiffness,arterial wave reflection,central blood pressure and body composition *** Ninety-eight men were recruited,51 PCa survivors and 47 *** was no significant between group dif-ference for aortic arterial stiffness[12.0 m/s (SD:1.7) vs.12.0 m/s (SD:1.9),P=0.953,d=0.0].Fat free mass[60.7 kg(SD:4.9) vs.65.1 kg (SD:8.3),P=0.007,d=0.6]and skeletal muscle index[8.6 kg/m2 (SD:0.6) vs.9.0 kg/m2 (SD:0.9),P=0.050,d=0.5]were lower in the PCa *** Aortic arterial stiffness is not increased (worse) in men with PCa who receive various treatments,compared to age-matched *** findings may indicate that factors other than increased aortic arterial stiffness contribute to heightened risk of cardiovascular events in this population.

关键词： Prostate cancer Cardiovascular disease Risk Arterial stiffness