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Decreased serum platelet derived growth factor BB levels in acute and increased in chronic pancreatitis

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World Journal of Gastroenterology 2014年第36期20卷 13127-13132页

作者： Magdalena Stojek krystian Adrych Lukasz Rojek Marian Smoczynski Tomasz Sledzinski Sylwia Szrok Julian Swierczynski Department of Gastroenterology and Hepatology Medical University of Gdansk 80-952 Gdansk Poland Department of Pharmaceutical Biochemistry Medical University of Gdansk 80-211 Gdansk Poland Department of Biochemistry Medical University of Gdansk 80-211 Gdansk Poland

AIM: To examine circulating growth factor concentrations in patients with acute pancreatitis(AP) and chronic pancreatitis(CP), and walled-off pancreatic necrosis(WOPN). METHODS: Forty patients with mild AP, 40 patients with alcoholic CP, 33 patients with WOPN and 40 healthy subjects were examined. Serum concentrations of platelet derived growth factor BB(PDGF-BB), transforming growth factor β-1(TGFβ-1), chemerin and high-mobility group box chromosomal protein 1(HMBG1) were assayed by enzyme linked immunosorbent ***: Patients with mild AP and those with WOPN had significantly lower serum levels of PDGF-BB compared to healthy subjects(4.0 ± 0.61 ng/mL vs 6.2 ± 0.76 ng/mL, P = 0.027, and 1.60 ± 0.31 ng/mL vs 6.2 ± 0.76 ng/mL, P < 0.001, respectively), while CP was associated with higher serum levels of PDGF-BB(12 ± 1.3 ng/mL vs 6.2 ± 0.76 ng/mL, P < 0.001). Circulating TGFβ-1 and chemerin levels were elevated in CP patients(57 ± 3.6 ng/mL vs 39 ± 3.6 ng/mL, P < 0.001 and 73 ± 7.2 ng/mL vs 48 ± 2.3 ng/mL, P < 0.001, respectively), but not in patients with AP and WOPN. No significant changes in serum HMBG1 levels were found either in patients with AP, WOPN or CP. CONCLUSION: The serum levels of some growth factors and cytokines differ significantly in AP, WOPN and CP. These data suggest that selected growth factors and cytokines may be considered as potential diagnostic biomarkers in patients with pancreatic diseases.

关键词： Acute pancreatitis Chronic pancreatitis Walled-off

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波兰研究钢液过滤器对过滤的影响 008

Noise Detection in the Photogrammetric Images Using Wavelets

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作者： krystian Janiszewski 陈小丽

本报讯近日，波兰西里西亚工业大学冶金系的学者对用于钢液过滤的多孔陶瓷过滤器的长径比在钢液过滤过程中的影响进行了研究，并将过滤器的长径比作为新的研究参数。该研究通过一系列实验室规模的实验得出：长径比通过改变钢中非金属...

本报讯近日，波兰西里西亚工业大学冶金系的学者对用于钢液过滤的多孔陶瓷过滤器的长径比在钢液过滤过程中的影响进行了研究，并将过滤器的长径比作为新的研究参数。该研究通过一系列实验室规模的实验得出：长径比通过改变钢中非金属夹杂物的数量和份额来影响钢液的过滤

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地球科学与工程：英文版 2012年第2期2卷 105-111页

作者： krystian Pyka Jacek Siedlik AGH University of Science and Technology Faculty of Mining Surveying and Environmental Engineering Department ofGeoinformation Photogrammetry and Remote Sensing of Environment Krakow 30-059 Poland MGGP AERO Company Tarnow 33-100 Poland

The paper presents the method of the valuation of random noise in the photogrammetric images, based on wavelets. The proposed method involves the analysis of the dynamics of the components of wavelet decomposition on several resolution levels. The hypothesis was made that the noise-free images are characterized by systematically growing variances of the single components with growing decomposition. This hypothesis was studied on several dozen fragments of airborne images recorded both with a photogrammetric analogue camera and digital camera. For all the studied photos taken with a digital camera, the hypothesis of growing variances of details was confirmed. The images from an analogue camera had different dynamics of variance, and the cause was recognized as random noise, caused by the grains from of the photographs. Referring to earlier applications of wavelets to noise evaluation, the proposed method is characterized by smaller dependence upon the structure and texture of the image.

关键词：摄影图像小波变换噪声检测模拟摄像机随机噪声小波分解数码相机噪声图像

Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation

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World Journal of Gastroenterology 2013年第27期19卷 4363-4373页

作者： Piotr M Wierzbicki krystian Adrych Dorota Kartanowicz Marcin Stanislawowski Anna Kowalczyk Janusz Godlewski Iwona Skwierz-Bogdanska Krzysztof Celinski Tomasz Gach Jan Kulig Bartlomiej Korybalski Zbigniew Kmiec Department of Histology Faculty of MedicineMedical University of Gdansk Department of Hepatology and Gastroenterology Faculty of MedicineMedical University of Gdansk Department of Human Histology and Embryology Faculty of Medical SciencesUniversity of Varmia and Masuria Department of General Surgery Hospital Ministry Internal Affairs Department of Gastroenterology Medical University of Lublin 1st Department of General Surgery Jagiellonian University Endoscopy Unit St. Adalbert Hospital

AIM:To investigate large tumor suppressor 1 (LATS1 ) expression, promoter hypermethylation, and microsatellite instability in colorectal cancer (CRC).METHODS:RNA was isolated from tumor tissue of 142 CRC patients and 40 colon mucosal biopsies of healthy controls. After reverse transcription, quantitative polymerase chain reaction (PCR) was performed, and LATS1 expression was normalized to expression of the ACTB and RPL32 housekeeping genes. To analyze hypermethylation, genomic DNA was isolated from 44 tumor CRC biopsies, and methylation-specific PCR was performed. Microsatellite instability (MSI) status was checked with PCR using BAT26, BAT25, and BAT40 markers in the genomic DNA of 84 CRC patients, followed by denaturing gel electrophoresis. RESULTS:Decreased LATS1 expression was found in 127/142 (89.4%) CRC cases with the average ratio of the LATS1 level 10.33 ± 32.64 in CRC patients vs 32.85 ± 33.56 in healthy controls. The lowest expression was found in Dukes' B stage tumors and G1 (welldifferentiated) cells. Hypermethylation of the LATS1 promoter was present in 25/44 (57%) CRC cases analyzed. LATS1 promoter hypermethylation was strongly associated with decreased gene expression; methylated cases showed 162× lower expression of LATS1 than unmethylated cases. Although high-grade MSI (mutation in all three markers) was found in 14/84 (17%) cases and low-grade MSI (mutation in 1-2 markers) was found in 30/84 (36%) cases, we found no association with LATS1 expression. CONCLUSION:Decreased expression of LATS1 in CRC was associated with promoter hypermethylation, but not MSI status. Such reduced expression may promote progression of CRC.

关键词： Large tumor suppressor 1 Colorectal cancer Quantitative polymerase chain reaction Reduced expression Promoter hypermethylation Microsatellite instability Salvador-Warts-Hippo pathway

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波兰华沙国家体育场

城市环境设计 2013年第7期 174-177页

作者：福尔克温·玛格胡贝特·尼恩霍夫马库斯费斯德 krystian Trela Marcus Bredt

2012年,乌克兰和波兰共同承办了欧洲杯足球锦标赛。新建华沙波兰国家体育场的国际建筑设计竞赛于2007年举行。gmp国际建筑设计有限公司作为方案设计者与J.S.K.建筑设计事务所和施莱希伯格曼(schlaichbergermannundpartner)工程师事务所... 详细信息

2012年,乌克兰和波兰共同承办了欧洲杯足球锦标赛。新建华沙波兰国家体育场的国际建筑设计竞赛于2007年举行。gmp国际建筑设计有限公司作为方案设计者与J.S.K.建筑设计事务所和施莱希伯格曼(schlaichbergermannundpartner)工程师事务所共同组成的设计团队赢得了项目的设计委托。

关键词：波兰

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泥炭泥浆在治疗中的放射性

腐植酸 2018年第3期 81-81页

作者： Maria Karpińska krystian Mnich Jacek Kapa?a 矫威中国腐植酸工业协会

为确定泥炭泥浆中天然和人工同位素的含量,并估算标准泥炭泥浆处理过程中患者皮肤吸收的辐射剂量,分析了从波兰8个矿泉采集的37个样本,用γ能谱法测量同位素浓度活性。标准泥炭泥浆浴治疗中的皮肤剂量约为300 nSv,泥炭泥浆这种治疗的有... 详细信息

为确定泥炭泥浆中天然和人工同位素的含量,并估算标准泥炭泥浆处理过程中患者皮肤吸收的辐射剂量,分析了从波兰8个矿泉采集的37个样本,用γ能谱法测量同位素浓度活性。标准泥炭泥浆浴治疗中的皮肤剂量约为300 nSv,泥炭泥浆这种治疗的有效剂量被认为是22 nSv。

关键词：泥浆处理泥炭治疗放射性辐射剂量皮肤吸收 γ能谱法有效剂量