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电力与电工 1989年第4期9卷 49-52页

作者： krup.,JT 郭忠尧

Harnessing the potential of gene editing technology using CRISPR in inflammatory bowel disease

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World Journal of Gastroenterology 2019年第18期25卷 2177-2187页

作者： Viktor Limanskiy Arpita vyas Lakshmi Shankar Chaturvedi Dinesh vyas Department of Surgery San Joaquin General Hospital College of Medicine CNSU College of Medicine and College of Pharmacy California Northstate University

The molecular scalpel of clustered regularly interspersed short palindromic repeats/CRISPR associated protein 9(CRISPR/Cas9) technology may be sharp enough to begin cutting the genes implicated in inflammatory bowel disease(IBD) and consequently decrease the 6.3 billion dollar annual financial healthcare burden in the treatment of IBD. For the past few years CRISPR technology has drastically revolutionized DNA engineering and biomedical research field. We are beginning to see its application in gene manipulation of sickle cell disease,human immunodeficiency virus resistant embryologic twin gene modification and IBD genes such as Gatm(Glycine amidinotransferase, mitochondrial),nucleotide-binding oligomerization domain-containing protein 2, KRT12 and other genes implicated in adaptive immune convergence pathways have been subjected to gene editing, however there are very few publications. Furthermore,since Crohn's disease and ulcerative colitis have shared disease susceptibility and share genetic gene profile, it is paramount and is more advantageous to use CRISPR technology to maximize impact. Although, currently CRISPR does have its limitations due to limited number of specific Cas enzymes, off-target activity,protospacer adjacent motifs and crossfire between different target sites. However,these limitations have given researchers further insight on how to augment and manipulate enzymes to enable precise gene excision and limit crossfire between target sites.

关键词： Clustered regularly interspersed short palindromic repeats Inflammatory bowel disease Crohn’s disease Ulcerative colitis Gene excision Gene editing Gene therapy Financial impact of inflammatory bowel disease on healthcare Clustered regularly interspersed short palindromic repeats crossfire

pH-metric and thermodynamic studies of rare earth metal chelates

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Journal of Rare Earths 2009年第3期27卷 457-460页

作者： Alok vyas R. P. Mathur The Werner Lab Department of ChemistryDungar College

Proton ligand stability constants of hydroxybenzoic acid containing nitro group （2-Hydroxy-4-nitrobenzoic acid and 3-Hydroxy-4- nitrobenzoic acid） were determined through lrving-Rossoti pH titration technique. The stability constants of rare earth metal chelates containing 2-Hydroxy-4-nitrobenzoic acid and 3-Hydroxy-4-nitrobenzoic acid as ligands were studied in aqueous medium at different ionic strength （p=0.01, 0.05 and 0.1 mol/L） and temperatures （298, 308 and 318± 0.1 K）. The values of stability constant were evaluated through different computational methods like successive approximation, least square treatment, correction term method, and convergence method. The observed value of thermodynamic parameters （△G°, △H° and △S°） favors the complex formation between metal and ligands. The order of stabifity constant was found to be Pr（III）〈Nd（III）〈Sm（III）〈Tb（III）〈Ho（III）〈Er（III） as reported by Stagg and Powell.

关键词： hydroxy nitrobenzoic acid rare earth metal chelates Irving-Rossoti method

Effect of contrasting climates on antioxidant and bioactive constituents in five medicinal herbs in Western Himalayas

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Journal of Mountain Science 2016年第3期13卷 484-492页

作者： Tarandeep KAUR Rohini BHAT Dhiraj vyas Biodiversity and Applied Botany Division Indian Institute of Integrative Medicine(CSIR) Academy of Scientific and Innovative Research Indian Institute of Integrative Medicine (CSIR)

To understand the effect of climate change on constitutive antioxidant and biochemical metabolites in Western Himalayas, five medicinal herbs were selected and grown at two altitudes in Jammu(305 m) and Srinagar(1730 m) with subtropical and temperate climates, *** variations were observed in phenols and flavonoids in Hypericum perforatum L., Matricaria chamomilla L., Thymus vulgaris L., Cynara cardunculus L. and Echinacea purpurea L. growing at two locations. High altitude temperate site show variable(up to 13 fold) increase in their ***(1.3- 1.8 times), sugars(2.8- 4.1 times) and free amino acid(1.04- 1.22 times) were also higher at Srinagar(1730 m). Within these plants, *** and M. chamomilla have shown higher accumulation of phenols, xanthophylls and proline even at subtropical environment in Jammu(305 m)suggesting potential for increasing their geographical area. The results demonstrate that changing environmental conditions significantly affect the bioactive constituents, which accumulate as a defence strategy by these temperate plants. Their medicinal significance during climate change scenario has also been discussed.

关键词： Medicinal herbs Flavonoids Phenols Glutathione Western Himalayas Climate change

A Novel Application of Multi-Resonant Dissipative Elastic Metahousing for Bearings

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Acta Mechanica Solida Sinica 2021年第4期34卷 449-465页

作者： Muhammad C.W.Lim N.S.vyas Department of Architecture and Civil Engineering City University of Hong KongKowloonHong Kong SARChina Department of Mechanical Engineering Indian Institute of Technology KanpurKanpur208016India

Bearing as an important machine element is widely used for industrial and automotive *** certain operational speed,bearings induce disturbing vibrations and noises that affect machine service life,productivity and passenger comfort in case of vehicle *** elastic metamaterials have caught considerable attention of scientific community due to their effective medium properties and peculiar dynamic characteristics including frequency bandgaps that can be effectively applied to attenuate and control undesirable vibration and *** a substantial amount of theoretical work for effective medium characteristics and dynamic properties of acoustic/elastic metamaterials has been reported,the practical design and application of these composite structures for real-life engineering problems still remain *** present study intends to investigate a potential application of dissipative elastic metamaterials in controlling the bearing-generated vibration and noises over an ultrawide frequency *** study is based on a simple analytical model together with rigorous finite element numerical *** has been established that the dissipative characteristic of resonant system caused by larger material mismatch broadens the local resonance bandgaps beyond the bounding resonance frequency at the cost of wave *** order to achieve broadband vibration and noise control,multi-resonant composite structures are embedded inside the bearing housing in five different *** reported results revealed the presence of broadband wave attenuation zone distributed from 3 to 52 kHz with consideration of material *** bearing-generated vibration and noises lying inside the wave attenuation zone will be *** feasibility study provides a new concept for the design and application of acoustic/elastic metamaterials in the bearing industry to improve machine service life and to enhance productivity and passenger comfo

关键词： Bearing metahousing Dissipative elastic metamaterials Frequency Local resonance bandgap Vibration attenuation zone

The role of postsynaptic density proteins in neural degeneration and regeneration

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Neural Regeneration Research 2016年第6期11卷 906-907页

作者： Yukti vyas Johanna M.Montgomery Department of Physiology and Centre for Brain Research University of Auckland

The structure,function and plasticity of excitatory glutamatergic synapses in the brain are significantly altered by neurodevelopmental and neurodegenerative disorders（Grabrucker et al.,2011;Fourie et al.,2014;Musard... 详细信息

关键词： degeneration regeneration synaptic sensory altered glutamate excitatory plasticity neurological NMDA

Screening colonoscopy:The present and the future

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World Journal of Gastroenterology 2021年第3期27卷 233-239页

作者： Chelsea V Hayman Dinesh vyas College of Medicine California Northstate UniversityElk GroveCA 95757United States Department of Surgery San Joaquin General HospitalFrench CampCA 95231United States

In the United States,colorectal cancer(CRC)is the second leading cause of mortality in men and *** are now seeing an increasing number of patients with advanced-stage diagnosis and mortality from colorectal cancer before 50 years of age,which requires earlier *** the increasing need for CRC screening through colonoscopy,and thus endoscopists,easier and simpler techniques are needed to train proficient *** most widely used approach by endoscopists is air insufflation colonoscopy,where air distends the colon to allow visualization of the colonic *** technique is uncomfortable for patients and requires an anesthetist to administer *** addition,patients commonly complain about discomfort post-op as air escapes into the small bowel and cannot be adequately *** research into the use of water insufflation colonoscopies has proved promising in reducing the need for sedation,decreasing discomfort,and increasing the visibility of the colonic *** direction into water insufflation colonoscopies which have shown to be simpler and easier to teach may increase the number of proficient endoscopists in training to serve our aging population.

关键词： Colorectal cancer Water-insufflation colonoscopy Air-insufflation colonoscopy Adenomatous polyps Adenoma detection rate

The influence of AAR coupler features on estimation of in-train forces

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Railway Engineering Science 2023年第3期31卷 233-251页

作者： Om Prakash Yadav Nalinaksh S.vyas Department of Mechanical Engineering Indian Institute of Technology KanpurKanpurUttar Pradesh 208016India

Inadequate management of large in-train forces transferred through coupler systems of a railway train leads to running and structural failures of *** these phenomena and their mitigation requires accurate estimation of relative motions and in-train forces between vehicle *** numerical studies have ignored inertia of coupling elements and the impacts between ***,existing models underestimate the additional dynamic variations in in-train *** multi-body dynamic models of two AAR(Association of American Railroads)coupler systems used in passenger and freight trains are developed,incorporating coupler inertia and various *** to the modeling and simulation com-plexities involved in a full train model,with such details of coupler system,actual longitudinal train dynamics is not studied.A system comprising only two coupling units,inter-connecting two consecutive vehicles,is *** system has been fixed at one end and an excitation force is applied at the other end,to mimic a relative force transmission through combined coupler *** results obtained from this representative system show that,noticeable influence in in-train forces are expected due to the combined effect of inertia of couplers and intermittent impacts between couplers in the slack *** amplitude of longitudinal reaction force,transferred from draft gear housing to vehicle body,is expected to be significantly higher than that predicted using existing models of coupler *** is also observed that the couplers and knuckles are subjected to significant longitudinal and lateral contact forces,due to the intermittent impacts between ***,accurate estimation of draft gear reaction force and impact forces between couplers are essential to design vehicle and coupler components,respectively.

关键词： Automatic railway coupler Draft gear Longitudinal train dynamics In-train forces Coupler slack Intermittent impacts

Anisotropy Properties of Tissues: A Basis for Fabrication of Biomimetic Anisotropic Scaffolds for Tissue Engineering

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Journal of Bionic Engineering 2019年第5期16卷 842-868页

作者： Pallab Datta Veena vyas Santanu Dhara Amit Roy Chowdhury Ananya Barui Centre for Healthcare Science and Technology Indian Institute Engineering Science and Technology ShibpurHowrahWest Bengal 711103India School of Medical Science and Technology Indian Institute of Technology KharagpurWest Bengal 721302India Department of Aerospace Engineering and Applied Mechanics Indian Institute Engineering Science and Technology ShibpurHowrahWest Bengal 711103India

Tissue engineering has been a subject of extensive scientific exploration in the last two decades making gradual inroads into clinical studies as *** with regenerative cells and growth factors,biomaterial scaffolds are integral to the development of a tissue engi neered *** is now appreciated that scaffolds should mimic the target tissue properties intimately in order to provide a micro-environment milieu that allows the seeded cells to differentiate into the desired *** from a structural viewpoint,mismatch between scaffold and native matrix properties can cause cell necrosis through mechanisms such as stress *** of the key prop erties of most body tissues is that they exhib社***,most fabrication methods generate isotropic scaffolds and require specific modifications to produce anisotropic *** the last decade,the advent of additive manufacturing and bioprinting has provided facile tools to fabricate scaffolds with desired *** the other hand,a biomimetic scaffold can be designed only when target tissue anisotropy is well known to the tissue *** review presents an overview of the anisotropic properties of different tissues,which will be critical for developing biomimetic engineered *** traditional anatomical records do not adequately present these properties from the perspective of designing tissue engineering ***,present state-of-the art in devel opment of anisotropic scaffolds as well as tissue constructs using different conventional and emerging fabrication techniques is *** is expected that the readers will obtain a comprehensive reference on the research area by examining these two aspects juxtaposed to each other and gain key trends for fabrication of anisotropic scaffolds,plausibly with improved regenerative outcomes.

关键词： biomimetics scaffolds tissue engineering anisotropy electrospinning bioprinting

Advances in endoscopic balloon therapy for weight loss and its limitations

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World Journal of Gastroenterology 2017年第44期23卷 7813-7817页

作者： Dinesh vyas Kaivalya Deshpande Yagnik Pandya Department of Surgery Texas Tech University Department Of Surgery Michigan State University Department of Surgery Metro West Medical Center

The field of medical and surgical weight loss is undergoing an explosion of new techniques and devices. A lot of these are geared towards endoscopic approaches rather than the conventional and more invasive laparoscopic or open approach. One such recent advance is the introduction of intrgastric balloons. In this article, we discuss the recently Food and Drug Administration approved following balloons for weight loss: the Orbera? Intragastric Balloon System(Apollo Endosurgery Inc, Austin, TX, United States), the Re Shape? Integrated Dual Balloon System(Re Shape Medical, Inc., San Clemente, CA, United States), and the Obalon(Obalon? Therapeutics, Inc.). The individual features of each of these balloons, the method of introduction and removal, and the expected weight loss and possible complications are discussed. This review of the various balloons highlights the innovation in the field of weight loss.

关键词： Weight loss Gastric balloons Endoscopic balloons Orbera Obalon Reshape