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Burden of atrial fibrillation in patients with rheumatic diseases

World Journal of Clinical Cases 2021年第14期9卷 3252-3264页

作者： Muhammad Zubair Khan Kirtenkumar patel krunalkumar a patel Rajkumar Doshi Vraj Shah Devina Adalja Zainulabedin Waqar Sona Franklin Neelesh Gupta Muhammad Hamdan Gul Shruti Jesani Steven Kutalek Vincent Figueredo Department of Internal Medicine St.Mary Medical CenterLanghornePA 19047United States Division of Cardiology North Shore University HospitalManhassetNY 11030United States Department of Internal Medicine University of Nevada Reno School of MedicineRenoNV 89502United States Division of Cardiology Medical College of BarodaBaroda 390001India Department of Internal Medicine GMERS Gotri Medical CollegeVadodara 390021India Department of Internal Medicine Mercy St.Vincent Medical CenterToledoOH 43608United States Department of Internal Medicine Nazareth HospitalPhiladelphiaPA 19115United States Department of Internal Medicine Saint Joseph HospitalChicagoIL 60657United States Department of Internal Medicine Trinitas Regional Medical CenterElizabethNJ 07202United States Department of Cardiology St.Mary Medical CenterLanghornePA 19047United States

BACKGROUND Studies have suggested that atrial fibrillation(AF)in patients with rheumatic diseases(RD)may be due to *** morbidity and mortality associated with AF in hospitalized patients with *** The National inpatient sample database from October 2015 to December 2017 was analyzed to identify hospitalized patients with RD with and without AF.A subgroup analysis was performed comparing outcomes of AF among different *** The prevalence of AF was 23.9%among all patients with RD(n=3949203).Among the RD subgroup,the prevalence of AF was highest in polymyalgia rheumatica(33.2%),gout(30.2%),and pseudogout(27.1%).After adjusting for comorbidities,the odds of having AF were increased with gout(1.25),vasculitis(1.19),polymyalgia rheumatica(1.15),dermatopolymyositis(1.14),psoriatic arthropathy(1.12),lupus(1.09),rheumatoid arthritis(1.05)and pseudogout(1.04).In contrast,enteropathic arthropathy(0.44),scleroderma(0.96),ankylosing spondylitis(0.96),and Sjorgen’s syndrome(0.94)had a decreased association of *** mortality,length of stay,and hospitalization costs were higher in patients with RD having AF vs without *** the RD subgroup,the highest mortality was found with scleroderma(4.8%),followed by vasculitis(4%)and dermatopolymyositis(3.5%).CONCLUSION A highest association of AF was found with gout followed by vasculitis,and polymyalgia rheumatica when compared to other *** was two-fold higher in patients with RD with AF.

关键词： Atrial fibrillation Rheumatic diseases Lupus Gout Scleroderma Vasculitis

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Optimization of gas lift system for well performance improvement in Asmari formation:A techno-economic perspective

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Petroleum Research 2024年第1期9卷 115-124页

作者： Hari Sreenivasan Jash patel Dev Jain Setu patel Isaac Wilson Shanker Krishna Drilling Cementing&Stimulation(DCS)Research CentreDepartment of Petroleum EngineeringSchool of Energy Technology(SoET)Pandit Deendayal Energy University(PDEU)Knowledge CorridorRaysanGandhinagarGujarat382426India

Well productivity in the Asmari carbonate formation of southwest Iran has decreased in recent years as a result of production *** production rate must be maintained below 1500 STB/day to prevent water *** this study,a gas lift well is modeled using data from one of the producing wells of this *** analysis is performed using lift-gas injection rates and wellhead pressures at different reservoir pressures and water cut conditions to optimize *** aspects are considered to optimize the artificial gas injection rates at different tubing head pressures and water cut *** the lift-gas injection rate from 0.4 MMscf/day to 1 MMscf/day enhances the oil production rate by 37.71%and 43.89%for 10%and 30%water cut conditions,*** injection rates of 5.2 MMscf/day and 5.4 MMscf/day are determined to be economically optimal for 30%water cut with tubing head pressures of 260 psig and 270 psig,respectively.

关键词： Production enhancement Artificial lift Gas lift Asmari carbonate formation Techno-economic analysis Well productivity

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Predictive active control of building structures using LQR and artificial intelligence

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 489-502页

作者： Nirmal S.Mehta Vishisht Bhaiya K.A.patel Ehsan Noroozinejad Farsangi Department of Civil Engineering SVNIT SuratGujarat 395007India Urban Transformations Research Centre Western Sydney UniversityNSWAustralia

This study presents a neural network-based model for predicting linear quadratic regulator(LQR)weighting matrices for achieving a target response *** on the expected weighting matrices,the LQR algorithm is used to determine the various responses of the *** responses are determined by numerically analyzing the governing equation of motion using the state-space *** training a neural network,four input parameters are considered:the time history of the ground motion,the percentage reduction in lateral displacement,lateral velocity,and lateral acceleration,Output parameters are LQR weighting *** study the effectiveness of an LQR-based neural network(LQRNN),the actual percentage reduction in the responses obtained from using LQRNN is compared with the target percentage ***,to investigate the efficacy of an active control system using LQRNN,the controlled responses of a system are compared to the corresponding uncontrolled *** trained neural network effectively predicts weighting parameters that can provide a percentage reduction in displacement,velocity,and acceleration close to the target percentage *** on the simulation study,it can be concluded that significant response reductions are observed in the active-controlled system using ***,the LQRNN algorithm can replace conventional LQR control with the use of an active control system.

关键词： active control system linear quadratic regulator artificial neural networks state-space approach response effectiveness factor resilience

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Colorimetric Sensor for Detection of Tabun Mimic Diethyl Cyanophosphonate

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Journal of Analysis and Testing 2024年第03期8卷 374-384页

作者： Madhu Bala Dheeraj Pandey Nikita patel Sheetal Yadav Abha Sharma Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research RaebareliTransit Campus

Herein,a colorimetric chemosensor （probe 7） was designed and synthesized for sensing diethyl cyanophosphonate （DCNP）,a Tabun nerve agent *** sensitive,selective,fast response and photostable probe 7 in dimethylsulfoxide （DMSO）responded to DCNP at low concentrations with visual naked eye color change from pink to pale yellow and displayed unresponsive behaviour against various interferences except for copper ions,which can be di?erentiated by adding ethylene diamine where the yellow color persisted in the case of DCNP but turned to pink in the case of copper ***,the yellow aqueous solution of probe 7 at pH 10 and 12 turned colorless against the response of *** limit of detection（LOD） of probe 7 was found to be 50 nmol/L in an aqueous basic solution at pH 10 for the detection of *** formation of the cyclized product was elucidated by1H and31P NMR nuclear magnetic resonance (1H NMR,31P NMR),Fourier transform infrared spectroscopy （FTIR）,and high-resolution mass spectrometry （HRMS） ***?lter paper and silica plate loaded with probe 7 were fabricated for real-time and on-site detection of DCNP.

关键词： Chemosensor Colorimetric Fluorescence Tabun mimic

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Hepatocellular carcinoma presenting as an extrahepatic mass:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2241-2252页

作者： Wei Kelly Wu Krutika patel Chandrasekhar Padmanabhan Kamran Idrees Department of Surgery Vanderbilt University Medical CenterNashvilleTN 37232United States Department of Pathology Microbiology and ImmunologyVanderbilt University Medical CenterNashvilleTN 37232United States Division of Surgical Oncology and Endocrine Surgery Department of SurgeryVanderbilt University Medical CenterNashvilleTN 37232United States

BACKGROUND Hepatocellular carcinoma(HCC)is a primary liver tumor generally diagnosed based on radiographic *** disease is typically associated with increased tumor diameter,multifocality,and vascular *** report a case of a patient who presented with extrahepatic HCC metastasis to a portocaval lymph node with occult hepatic primary on computed tomography(CT).We review the literature for cases of extrahepatic HCC presentation without known hepatic lesions and discuss strategies to differentiate between metastatic and ectopic *** SUMMARY A 67-year-old male with remotely treated hepatis C was referred for evaluation of an enlarging portocaval,mixed cystic-solid *** CT evaluations demonstrated steatosis,but no cirrhosis or liver *** ultrasound demonstrated a normal-appearing pancreas,biliary tree,and *** needle aspiration yielded atypical *** differential diagnosis included duodenal or pancreatic cyst,lymphoproliferative cyst,stromal or mesenchymal lesions,nodal involvement from gastrointestinal or hematologic malignancy,or duodenal gastrointestinal stromal *** review by a multidisciplinary tumor board,the patient underwent open surgical resection of a 5.2 cm×5.5 cm retroperitoneal mass with pathology consistent with moderately-differentiated *** resonance imaging(MRI)subsequently demonstrated a 1.2 cm segment VIII hepatic lesion with late arterial enhancement,fatty sparing,and intrinsic T1 *** fetoprotein was 23.3 ng/*** patient was diagnosed with HCC with portocaval nodal ***:We surveyed the literature for HCC presenting as extrahepatic masses without history of concurrent or prior intrahepatic *** identified 18 cases of extrahepatic HCC ultimately found to represent metastatic lesions,and 30 cases of extrahepatic HCC found to be primary,ectopic *** Hepatocellular carcinoma can seldomly present with extrahepatic metastasis in the setting of

关键词： Extrahepatic Metastasis Portocaval Lymph node Case report

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Design,optimization,and characterization of an in-situ pore-forming system for controlled delivery of paliperidone

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Medicine in Novel Technology and Devices 2024年第1期21卷 71-79页

作者： Priya Pate Bhumi Ladani Gayatri patel Ramanbhai patel College of Pharmacy Charotar University of Science and TechnologyCHARUSAT–CampusChanga388421AnandGujaratIndia

The purpose of the current investigation was to develop a pharmaceutical equivalent osmotic drug delivery formulation of Paliperidone(PLD)in the form of controlled porosity osmotic pump tablets(CPOT)in order to keep the drug's steady state concentration in the *** helps to achieve the greatest therapeutic benefit with the fewest side *** the purpose of identifying various formulation attributes,preliminary trials were *** design was used to study the influence of seven input factors namely drug to polymer ratio,polymer 1(HPMC K100 M)to polymer 2(HPMC K15M),drug to total osmogens,coating level,amount of pore former,concentration of ethyl cellulose and amount of plasticizer on dependent variable similarity factor(f2).Utilizing the Minitab 17,data analysis was *** similarity factor(f2)was computed using the osmotic tablet reference product INVEGA®.The findings demonstrate that each of the seven independent variables significantly affects the similarity *** optimized batch,both core and coated tablets showed acceptable pharmaco-technical *** release profile of the optimized batch tablets was found to be similar to that of reference product with good zero-order release *** release was observed through the channels formed by in-situ pores on tablet surface performed using *** the results it can be concluded that prepared CPOT of PLD was found pharmaceutical equivalent with commercial product which is cost effective and fully compliance with cGMP.

关键词： Controlled release pH-independent release Similarity factor Pharmaceutical equivalent Reference product

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Therapeutic nucleic acids in regenerative medicine and tissue repair

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Nano Research 2024年第10期17卷 8942-8976页

作者： Qimanguli Saiding Duotian Qin Soohwan An Dylan Neal patel Muhammad Muzamil Khan Na Kong Wei Tao Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMassachusetts 02115USA

In the vanguard of biomedical innovation,regenerative medicine emerges as a transformative paradigm,concentrating its efforts on rectifying tissue deficits and functional aberrations in patients through the strategic augmentation of endogenous cellular *** to this approach is nucleic acid therapy,which offers a novel pathway for tissue regeneration by modulating key signaling *** one of the most effective ways to regulate cell function,nucleic acids are crucial for various tissue regeneration;however,their in vivo therapeutic applications face substantial challenges,including nuclease degradation,cell membrane impermeability,and targeted intracellular ***-based gene delivery systems offer a solution for stable and localized drug delivery by enabling the controlled overexpression of therapeutic nucleic acids,producing functional regulatory *** review presents examples of nucleic acid applications in regenerative medicine,highlighting the synergy between nucleic acids and biomaterial *** underlines the importance of nucleic acid delivery techniques,the choice of therapeutic nucleic acids,and biomaterials for advancing tissue *** latest developments in designing nucleic acid biomaterial-based delivery vehicles are explored,the mechanism of nucleic acids in tissue regeneration is elucidated,and their limitations are discussed while considering future directions for the clinical translation of nucleic acid-based therapeutics.

关键词： tissue repair nucleic acids biomaterials delivery systems regenerative medicine

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Microstructure,Corrosion and Mechanical Properties of Medium-Thick 6061-T6 Alloy/T2 Pure Cu Dissimilar Joints Produced by Double Side Friction Stir Z Shape Lap-Butt Welding

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 385-400页

作者： Jiuxing Tang Guoxin Dai Lei Shi Chuansong Wu Sergey Mironov Surendra Kumar patel Song Gao Mingxiao Wu MOE Key Lab for Liquid-Solid Structure Evolution and Materials Processing Shandong UniversityJinan 250061China Laboratory of Mechanical Properties of Nanoscale Materials and Superalloys Belgorod State UniversityBelgorod 308015Russia School of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China State Grid Henan Electric Power Research Institute Zhengzhou 450052China

A novel double side friction stir Z shape lap-butt welding(DS-FSZW)process was proposed to achieve excellent mechanical properties of Al/Cu medium-thick dissimilar *** influence of welding parameters on weld microstructure and properties of DS-FSZW joint were systematically *** indicated that defect-free medium-thick Al/Cu DS-FSZW joint could be achieved under an optimal welding ***-FSZW joint was prone to form void defects in the bottom of the second-pass *** recrystallization mechanisms at the top and middle of the weld nugget zone(WNZ)were continuous dynamic recrystallization(CDRX)and geometric dynamic recrystallization(GDRX).While the major recrystallization mechanism at the bottom of the WNZ was ***-FSZW joint of the optimal welding condition with 850 r/min-400 mm/min was produced with a continuous thin and crack-free IMCs layer at the Al/Cu interface,and the maximum tensile strength of this joint is 160.57 MPa,which is equivalent to 65.54%of pure Cu base ***,the corrosion resistance of Al/Cu DS-FSZW joints also achieved its maximum value at the optimal welding parameter of 850 r/min-400 mm/*** demonstrates that the DS-FSZW process can simultaneously produce medium-thick Al/Cu joints with excellent mechanical performance and corrosion resistance.

关键词： DS-FSZW Al/Cu dissimilar joint Corrosion behaviour Intermetallic compounds Microstructure Mechanical properties

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Post-endoscopic retrograde cholangiopancreatography pancreatitis:a review

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Journal of Pancreatology 2024年第1期7卷 28-34页

作者： Parth S.patel Venkata S.Akshintala Department of Gastroenterology Johns Hopkins Medical InstitutionsBaltimoreMD

Endoscopic retrograde cholangiopancreatography(ERCP)has continued to develop over recent decades with regard to both indications for its use and improvements in *** most common complication is post-ERCP pancreatitis(PEP)with incidence rates being reported at~10%.The exact mechanism of PEP is unknown but is likely multifactorial with papillary edema contributing to the activation of the inflammatory cascade playing an important *** risk factors include patient-related factors(female sex,younger age,sphincter of Oddi dysfunction,and history of PEP)and procedure-related factors(difficult cannulation,multiple pancreatic duct guidewire passes,pancreatic acinarization,multiple pancreatic duct contrast injections,and precut sphincterotomy).Several preventative prophylactic strategies have been posited;however,current guidelines recommend the use of rectal non-steroidal anti-inflammatory drugs(NSAIDs),aggressive intravenous(IV)fluid hydration,and pancreatic duct *** patient selection and the use of noninvasive imaging modalities for diagnosis of pancreaticobiliary abnormalities is a key aspect in *** studies continue to explore various pharmacologic,procedure-related,and combination strategies for prevention and will be important as the use of ERCP continues to grow.

关键词： ERCP Pancreatitis PEP risk factors Prevention

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3D electromagnetic modelling for high-temperature superconducting dynamo flux pumps using T-A formulation

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High Voltage 2024年第2期9卷 367-379页

作者： Luning Hao Fangliang Dong Jintao Hu Qi Wang Haigening Wei Ismail patel Adil Shah Yuyang Wu Tim Coombs Department of Engineering University of CambridgeCambridgeUK Plasma Science and Fusion Center Massachusetts Institute of TechnologyCambridgeMassachusettsUSA

A high-temperature superconducting(HTS)dynamo flux pump can inject DC currents into closed-loop HTS magnets without *** enables the realisation of current-lead-free or even through-wall charging systems for high-field applications such as nuclear magnetic resonance/magnetic resonance imaging(MRI)magnets,fusion reactors and *** have proposed many simulation models to understand the working principle of HTS dynamos,few of which are in 3D because of converging ***,the influences of many key 3D parameters in the HTS dynamo are scarcely *** authors propose an efficient 3D modelling method of the HTS dynamo based on the T-A *** rotating magnets are modelled by a ring-shaped permanent magnet with space-time-variant remanent flux density to avoid moving ***,together with the T-A formulation,makes the 3D model efficient and *** accuracy of the model is verified by the experimental instantaneous and time-integrated dynamic *** this model,the authors present systematic case studies to thoroughly explore the influences of the key parameters of a dynamo flux pump on the dynamic voltage and *** proposed modelling method and results could significantly benefit the design and optimisation of HTS dynamos for high-field magnets.

关键词： formulation magnets pump

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