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世界核心医学期刊文摘（胃肠病学分册） 2005年第5期1卷 38-39页

作者： kronenberger b. Herrmann E. Micol F. et al. S. Zeuzem 翟惠虹 Klinik für Innere Medizin II Universitatsklinikum des Saarlandes Kirrberger Strasse D-66421 Homburg/Saar Germany Dr.

The aim of the present study was to compare viral kinetics b.tween patients with chronic hepatitis C and persistently normal alanine aminotransferase (ALT) levels and those with elevated ALT levels. Kinetic parameters were derived from nonlinear, least square fitting of serum hepatitis C virus RNA quantifications collected from patients with chronic hepatitis C and persistently normal (n = 20) and elevated (n = 19) ALT levels b.fore and during treatment with 180 μg pegylated interferon α-2a once weekly plus daily rib.virin. Patients with chronic hepatitis C and persistently normal ALT levels showed a trend to lower pre-treatment infected cell loss (δ) (P = .13) b.t no differences in efficacy of b.ocking virus production (ε)and infected cell loss during treatment (mδ) compared with patients with elevated ALT levels. Differences were significant for ε(P = .02) and δ(P = .04) when applying updated “healthy”levels for ALT (0.75 times and 0.63 times upper limit of normal for male and female patients, respectively). A significant reduction of the kinetic parameters , δ,and mδwas ob.erved in patients with elevated γ-glutamyltranspeptidase (GGT) levels compared with patients with normal GGT levels (P = .02, P = .005, and P = .02, respectively). In conclusion, viral kinetics are similar in patients with chronic hepatitis C and persistently normal ALT levels and those with elevated ALT levels. However, in patients with elevated GGT levels, a major association with reduced efficacy of b.ocking virus production and lower infected cell loss was ob.erved. These data show that virological response in patients with chronic hepatitis C is less associated with b.seline ALT than with GGT levels.

关键词：慢性丙型肝炎 ALT水平抗病毒干扰素α 丙型肝炎患者丙氨酸转氨酶拟合值感染细胞定量的转肽酶

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维普期刊数据库

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Three challenges for future research on cochlear implants

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2017年第4期3卷 240-254页

作者： David b.Pisoni William G.kronenberger Michael S.Harris Aaron C.Mob.rly Department of Otolaryngology-Head and Neck Surgery DeVault Otologic Research LaboratoryIndiana University School of Medicine Indianapolis IN 46205 USA Department of Otolaryngology and Communication Sciences Medical College of WisconsinMilwaukee WI 53211 USA Department of Otolaryngology-Head and Neck Surgery The Ohio State University Wexner Medical Center Columbus OH 43212 USA

Cochlear implants (CIs) often work very well for many children and adults with profound sensorineural (SNHL) hearing ***,while many CI patients display sub.tantial b.nefits in recognizing speech and understanding spoken language forlowing cochlear implantation,a large numb.r of patients achieve poor *** and explaining the reasons for poor outcomes forlowing implantation is a very challenging research prob.em that has received little attention despite the pressing clinical *** this paper,we discuss three challenges for future research on ***,we consider the issue of individual differences and variab.lity in outcomes following *** the present time,we still do not have a complete and satisfactory account of the causal underlying factors that are responsib.e for the enormous individual differences and variab.lity in ***,we discuss issues related to the lack of preimplant predictors of *** little prospective research has b.en carried out on the development of preimplant predictors that can b. used to reliab.y identify CI candidates who may b. at high risk for a poor outcome forlowing *** than conventional demographics and hearing history,there are no prognostic tools availab.e to predict speech recognition outcomes after ***,we discuss the third challenge-what to do with a CI-user who has a poor *** suggest that new research efforts need to b. devoted to studying this neglected clinical population in greater depth to find out why they are doing poorly with their Cl and what novel interventions and treatments can b. developed to improve their speech recognition *** these three challenges as ob.ectives for future research on Cls,we suggest that the field needs to adopt a new narrative grounded in theory and methods from Cognitive Hearing Science and information processing *** knowing which specific b.ological and neurocognitive

关键词： Hearing loss Cochlear implants Outcomes following implantation

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维普期刊数据库

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Interferon-mediated reprogramming of memb.ane cholesterol to evade b.cterial toxins

Interferon-mediated reprogramming of membrane cholesterol to...

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第四届中国生物物理学会代谢生物学分会学术研讨会

作者： Quan D.Zhou Xun Chi Min Sub.Lee Wei Yuan Hsieh Jonathan J.Mkrtchyan An-Chieh Feng Cuiwen He Autumn G York Viet L.b.i Eliza b.kronenberger Alessandra Ferrari Xu Xiao Allison E.Daly Elizab.th J.Tarling Rob.rt Damoiseaux Philip O.Scumpia Stephen T.Smale Kevin J.Williams Peter Tontonoz Steven J.b.nsinger Zhejiang University School of Medicine

＜正＞Cholesterol is an important determinant of the b.ochemical and b.ophysical properties of animal cell memb.anes. Given the requirement for cholesterol in memb.anes, it is not surprising that microorganisms and viruses have evolved strategies that take advantage of cholesterol availab.lity in memb.anes to facilitate pathogenesis. Cholesterol-dependent cytolysins （CDCs） are a group of secreted toxins produced mainly b. Gram-positive b.cteria that depend on memb.ane cholesterol for their function.

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