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An image segmentation framework for extracting tumors from breast magnetic resonance images

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Journal of Innovative Optical Health Sciences 2018年第4期11卷 1-15页

作者： Le Sun Jinyuan He Xiaoxia Yin Yanchun Zhang Jeon-Hor Chen Tomas kron Min-Ying Su School of Computer and Software Nanjing University of Information Science and Technology P.R.China Center for Applied Informatics Victoria University Australia Center for Functional Onco-Imaging of the Department of Radiological Sciences University of California Irvine USA Department of Radiology E-Da Hospital and I-Shou University KaohsiungTaiwan Peter MacCallum Cancer Centre Australia

Magnetic resonance imaging(MRI)has been a prevalence technique for breast cancer ***-aided detection and segmentation of lesions from MRIs plays a vital role for the MRI-based disease *** are two main issues of the existing breast lesion segmentation techniques:requir ing manual delineation of Regions of Interests(ROIs)as a step of initialization;and requiring a large amount of labeled images for model construction or parameter lear ning,while in real clinical or experimental settings,it is highly challenging to get suficient labeled *** resolve these issues,this work proposes a semi-supervised method for breast tumor segmentation based on super voxel *** image segmentation with advanced cluster techniques,we take a supervised learning step to classify the tumor and nontumor patches in order to automatically locate the tumor regions in an MRI To obtain the opt imal performance of tumor extraction,we take extensive experiments to learn par ameters for tumor segmentation and dassification,and design 225 classifiers corresponding to diferent parameter *** call the proposed method as Semi supervised Tumor Segmentation(SSTS),and apply it to both mass and nonmass *** results show better performance of SsTS compared with five state of-the art methods.

关键词： Breast lesion image segmentation MRI

Global Aspects of Flood Risk Management

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Journal of Hydraulic Engineering 2015年第1期1卷 35-46页

作者： Wolfgang kron Geo Risks Research Munich Reinsurance Company 80802 Munich Germany

Various flood disasters in the last decade have confirmed that the risk from flooding has been increasing significantly worldwide. The driving factors for the risk are the unabated increase in global population, the concentration of people in high-risk areas such as coasts and flood plains, the rise in vulnerability of assets, infrastructure and social systems, and the consequences of climate change. Risk reduction is based on comprehensive risk management from identification of the hazard and assessing the risk to building defenses. To achieve this, general awareness at all levels in a society is key. It is not sufficient merely to be aware of the situation-findings must be acted upon with no significant delay. Flood-related computations have progressed considerably in recent years, but model results can only be as good as their input data. Modeling floods and flood losses is very complex, as model parameters are subject to change during an event and conditions sometimes greatly depend on small-scale factors.

关键词： Flood disasters, flood risk, risk reduction, risk management, insurance.

STOCIIASTIC DESIGN IN ALLUVIAL RIVERS

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International Journal of Sediment Research 1994年第3期 65-74页

作者： Woifgng kron ( , GeoForschungsZentrum 14473 Potsdam, Germany)

ＳＴＯＣＩＩＡＳＴＩＣＤＥＳＩＧＮＩＮＡＬＬＵＶＩＡＬＲＩＶＥＲＳ￥ＷｏｉｆｇｎｇＫｒｏｎ（ＲｅｓｅａｒｃｈＡｓｓｏｃｉａｔｅ，ＧｅｏＦｏｒｓｃｈｕｎｇｓＺｅｎｔｒｕｍ（ｔｈｅＲｅｓｅａｒｃｈＣｅｄｅｒ），１４４７３...

ＳＴＯＣＩＩＡＳＴＩＣＤＥＳＩＧＮＩＮＡＬＬＵＶＩＡＬＲＩＶＥＲＳ￥ＷｏｉｆｇｎｇＫｒｏｎ（ＲｅｓｅａｒｃｈＡｓｓｏｃｉａｔｅ，ＧｅｏＦｏｒｓｃｈｕｎｇｓＺｅｎｔｒｕｍ（ｔｈｅＲｅｓｅａｒｃｈＣｅｄｅｒ），１４４７３Ｐｏｔｓｄａｍ，Ｇｅｒｍａｎｙ）Ａ...

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Additive manufacturing in radiation oncology:a review of clinical practice,emerging trends and research opportunities

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International Journal of Extreme Manufacturing 2020年第1期2卷 47-66页

作者： Rance Tino Martin Leary Adam Yeo Elizabeth Kyriakou Tomas kron Milan Brandt RMIT Centre for Additive Manufacture School of EngineeringRMIT UniversityMelbourneAustralia Physical Sciences Department Peter MacCallum Cancer CentreMelbourneAustralia ARC Industrial Transformation Training Centre in Additive Biomanufacturing Queensland University of TechnologyBrisbaneAustralia Centre for Medical Radiation Physics University of WollongongWollongong Australia

The additive manufacturing(AM)process plays an important role in enabling cross-disciplinary research in engineering and personalised *** available clinical tools currently utilised in radiotherapy are typically based on traditional manufacturing processes,often leading to non-conformal geometries,time-consuming manufacturing process and high *** emerging application explores the design and development of patient-specific clinical tools using AM to optimise treatment outcomes among cancer patients receiving radiation *** this review,we:•highlight the key advantages of AM in radiotherapy where rapid prototyping allows for patient-specific manufacture•explore common clinical workflows involving radiotherapy tools such as bolus,compensators,anthropomorphic phantoms,immobilisers,and brachytherapy moulds;and•investigate how current AM processes are exploited by researchers to achieve patient tissuelike imaging and dose ***,significant AM research opportunities in this space are highlighted for their future advancements in radiotherapy for diagnostic and clinical research applications.

关键词： additive manufacturing radiotherapy tools dosimetry EBRT patient-specific cancer treatment quality assurance

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(E)-2-Benzylidenecycloalkanones XII.*Kinetic Measurement of Bovine and Human Serum Albumine Interaction with Selected Chalcones and Their Cyclic Chalcone Analogues by UV Spectrophotometry

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Spectral Analysis Review 2015年第1期3卷 1-8页

作者： Beáta Veliká Vladimíra Tomecková Krisztina Fodor Ivan kron Pál Perjési Department of Medical Chemistry Biochemistry and Clinical BiochemistryFaculty of Medicine UPJSTrieda SNP 1KosiceSlovakia Institute of Pharmaceutical Chemistry University of PécsPécsHungary

UV-VIS spectroscopic investigations of interaction of bovine and human serum albumin with selected chalcones (1) and their cyclic chalcone analogues: (E)-2-(4’-X-benzylidene-1-tetralones (3), benzosuberones (4) with dimethylamino and methoxy substituents and (E)-2-(2’,4’-dimethox- ybenzylidene)-1-indanone (2) were performed in polar respiration medium. Absorption maxima of the tested compounds were investigated in the presence of bovine and human serum albumin at the 0, 10, 30 and 60 minute timepoints of the interaction. The absorbance of all studied compounds in the presence of proteins decreased after one hour of the reaction. Molecule 4a showed the strongest and fastest kinet initial interaction with both albumins.

关键词： Chalcones Cyclic Chalcone Analogues UV Spectra Kinetic Measurements Binding Constant Bovine Serum Albumin Human Serum Albumin

MASS MOVEMENTS AND SEDIMENT TRANSPORT AS A NATURAL HAZARD

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International Journal of Sediment Research 1997年第3期 333-341页

作者： Wolfgang kron Senior Hydraulic Engineer, Geosciences Research Group, Munich Reinsurance Company, 80791 Munich, Germany

Compared to other natural disasters such as earthquakes, cyclones, floods and volcanic eruptions, events related to the movement of sediment cause fewer deaths and less damage. However, considerable costs abase and numerous people lose their lives every year due to sliding slopes, debris flows, lahars, erosion of embankments, and collapses of bridges. Sediment transport related disasters are not only often caused, triggered or induced by human activities, they also can be reduced or even prevented if they are anticipated through scientific and other investigations, observation of nature, and adequate treatment of artificial deposits and design of structures in rivers.

关键词： landslides sediment transport human influence economic consequences disaster prevention and mitigation

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根治性前列腺切除术后的生存率

美国医学会杂志（中文版） 1998年第2期17卷 105-108页

作者： kron.,A Lai,H

背景-现有根治性前列腺切除术后生存率估计的普遍性均有理论上的局限性。研究目的-对根治性前列腺切除术后生存率进行总体估计。研究设计-以人群为基础的回顾性队列研究。参加者-美国九个地区。病例-1983-1987年接受根治性前列腺切除和... 详细信息

背景-现有根治性前列腺切除术后生存率估计的普遍性均有理论上的局限性。研究目的-对根治性前列腺切除术后生存率进行总体估计。研究设计-以人群为基础的回顾性队列研究。参加者-美国九个地区。病例-1983-1987年接受根治性前列腺切除和淋巴结清扫的前列腺癌患者。统计方法-采用比例风险模型拟合不同地区、年龄、种族、病理分期、淋巴结转移状况及肿瘤分级情况,揭示影响疾病特异及总生存率的独立因素;应用寿命表法估计10年生存率的分布情况。结果-共有3626例患者参与本研究,平均年龄65岁,其中92.6%为白人,54.2%为中分化癌,60.4%无前列腺外扩散,91.2%无淋巴结转移。以加州旧金山-奥克兰为参照,其他地区疾病特异死亡率及总死亡率无显著差异。高龄及黑人总生存率较差,但疾病特异死亡率并无差别。肿瘤分化差、前列腺外转移以及淋巴结转移都是疾病特异及总生存率较差的独立相关因素。肿瘤分化中等或较好者10年疾病特异生存率为75%-97%,而肿瘤分化较差者则为60%-86%。结论-疾病特异及总生存率无地区差异,提示各地区选择根治性前列腺切除术的标准一致。在所有地区,总生存率因患者和肿瘤情况的不同而异,疾病特异生存率则仅依肿瘤的情况而变化。本研究为根治性前列腺切除术后生存率的估计提供了最具普遍意义的资料。

关键词：前列腺切除根治性生存率