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A comperative clinical study of mucotomy and KTP laser treatment of the inferior turbinate in allergic and non-allergic subjects

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Health 2010年第11期2卷 1287-1293页

作者： ágnes Patzkó Eszter Tóth krisztina somogyvári Imre Gerlinger 不详

Mucotomy is one of the most frequently applied surgical techniques for the management of inferior turbinate hyperplasia. Mucotomy guarantees patent airway, however, it might lead to the emergence of sicca syndrome. In contrast, KTP (potassium titanyl phosphate) laser treatment spares the medial part of the inferior turbinate mucosa, contributing to maintenance of physiological nasal function. A retrospective comparative clinical study was performed to reveal the advantages and side-effects of both surgical methods in medium- and long-term in allergic rhinitis and non-allergic patients. Furthermore, we wished to determine the exact indications of the up-to-date laser treatment. Ninety-one of the 117 patients who underwent bilateral turbinate surgery during an 8-year period (2000-2007) responded to our questionnaire focusing on subjective postoperative changes. Patients were separated into 6 groups, based on the type of operation they underwent, the length of the follow-up and whether they suffered from allergies. The major complaint, nasal obstruction, improved in all 6 groups, which reached significance (p ? 0.05) in 4 groups. The most pronounced improvement was observed in the group of non-allergic patients with medium-term follow-up who underwent mucotomy. Nevertheless, a serious side- effect: crusting also increased significantly (p ? 0.05) in the latter group, while it was absent in allergic patients with medium-term follow-up, who underwent mucotomy. These results lead us to propose the following protocol for the treatment of inferior turbinate hyperplasia: 1) after unsuccessful conservative treatment, laser treatment is suggested for non-allergic patients;2) following unsuccessful conservative and even repeated laser treatment in the allergic group, mucotomy or turbinoplasty should be attempted.

关键词： Crusting Inferior Turbinate KTP Laser Mucotomy Turbinoplasty

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A comperative clinical study of mucotomy and KTP laser treatment of the inferior turbinate in allergic and non-allergic subjects

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Health（健康） 2010年第11期

作者： ágnes Patzkó Eszter Tóth krisztina somogyvári Imre Gerlinger

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Non-pancreatic hyperlipasemia:A puzzling clinical entity

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World Journal of Gastroenterology 2024年第19期30卷 2538-2552页

作者： krisztina Eszter Feher David Tornai Zsuzsanna Vitalis Laszlo Davida Nora Sipeki Maria Papp Division of Gastroenterology Department of Internal MedicineFaculty of MedicineUniversity of DebrecenDebrecen H-4032Hajdu-BiharHungary Kalman Laki Doctoral School of Biomedical and Clinical Sciences Faculty of MedicineUniversity of DebrecenDebrecen H-4032Hungary

BACKGROUND Increased lipase level is a serological hallmark of the diagnosis of acute pancreatitis(AP)but can be detected in various other diseases associated with lipase leakage due to inflammation of organs surrounding the pancreas or reduced renal clearance and/or hepatic *** non-pancreatic hyperlipasemia(NPHL)is puzzling for attending physicians during the diagnostic procedure for *** would be clinically beneficial to identify the clinical and laboratory variables that hinder the accuracy of lipase diagnosis with the aim of improve it.A more precise description of the NPHL condition could potentially provide prognostic factors for adverse outcomes which is currently *** To perform a detailed clinical and laboratory characterization of NPHL in a large prospective patient cohort with an assessment of parameters determining disease *** A Hungarian patient cohort with serum lipase levels at least three times higher than the upper limit of normal(ULN)was prospectively evaluated over 31 *** were identified using daily electronic laboratory reports developed to support an ongoing observational,multicenter,prospective cohort study called the EASY trial(ISRCTN10525246)to establish a simple,easy,and accurate clinical scoring system for early prognostication of *** of NPHL was established based on≥3×ULN serum lipase level in the absence of abdominal pain or abdominal imaging results characteristic of *** A total of 808 patients[male,n=420(52%);median age(IQR):65(51-75)years]were diagnosed with≥3×ULN serum lipase levels.A total of 392 patients had AP,whereas 401 had NPHL with more than 20 different *** and acute kidney injury(AKI)were the most prevalent etiologies of NPHL(27.7%and 33.2%,respectively).The best discriminative cut-off value for lipase was≥666 U/L(sensitivity,71.4%;specificity,88.8%).The presence of AKI or sepsis negatively affected the diagnostic performance of *** w

关键词： Non-pancreatic hyperlipasemia Acute pancreatitis Glycoprotein 2 Acute kidney injury Sepsis Mortality

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Effect of irrigation water containing arsenic on elemental composition of bean and lettuce plants cultivated in calcareous sandy soil

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食物生产加工与营养(英文) 2019年第1期1卷 1-10页

作者： Sirat Sandil Péter Dobosy krisztina Kröpfl Anna Füzy MihályÓvári Gyula Záray MTA Centre for Ecological Research Danube Research InstituteKarolinaút 29-31Budapest H-1113Hungary Cooperative Research Centre of Environmental Sciences Eötvös Loránd UniversityPázmány Péter sétány 1/ABudapest H-1117Hungary MTA Centre for Agricultural Research Institute for Soil Sciences and Agricultural ChemistrHerman Ottóút 15Budapest H-1022Hungary

Background:The uptake of arsenic by vegetables from soil irrigated with arsenic enriched groundwater poses a major health *** edible portion of these vegetables transfer arsenic to the human *** uptake of arsenic was studied in bean(Phaseolus vulgaris L.)and lettuce(Lactuca sativa L.)in a controlled greenhouse pot culture with calcareous sandy soil as *** plants were irrigated with water containing sodium arsenate at concentrations 0.1,0.25 and 0.5 mg L^(-1).The total arsenic concentration of the different plants parts was determined by ICP-MS,following microwave-assisted acid *** change in plant biomass production and essential macroelements(Mg,P,K)and microelements concentration(Fe,Mn,Cu,Zn)was also ***:The As concentration in the bean was in the order:root>stem>leaf>bean fruit and in lettuce:root>*** the highest dose(0.5 mg L^(-1))the As concentration in the bean fruit and lettuce leaves was 22.1μg kg^(-1)and 1207.5μg kg^(-1)DW,*** As concentration in the irrigation water resulted in decreased edible biomass production in bean,while in lettuce the edible biomass production *** plant exhibited any visible toxicity *** significant change was observed in the macro and microelements *** total and the water-soluble arsenic in soil amounted to 3.5 mg kg^(−1)and 0.023 mg kg^(−1),*** transfer factor was found to increase with increase in the As treatment *** transfer factor range for bean from root to fruit was 0.003–0.005,and for lettuce from root to leaves was 0.14–***:Considering the FAO-WHO recommended maximum tolerable daily intake(MTDI)limit of 2.1μg kg^(-1)body weight,and the biomass production,both plants should not be cultivated at As treatment level higher than 0.1 mg L^(-1).

关键词： Arsenic irrigation water uptake transfer factor calcareous sandy soil vegetables

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Helicobacter pylori infection: New pathogenetic and clinical aspects

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World Journal of Gastroenterology 2014年第21期20卷 6386-6399页

作者： krisztina Hagymási Zsolt Tulassay 2~(nd) Department of Internal Medicine Semmelweis UniversityH-1088 BudapestHungary

Helicobacter pylori (H. pylori) infects more than half of the world’s human population, but only 1% to 3% of infected people consequently develop gastric adenocarcinomas. The clinical outcome of the infection is determined by host genetic predisposition, bacterial virulence factors, and environmental factors. The association between H. pylori infection and chronic active gastritis, peptic ulcer disease, gastric cell carcinoma, and B cell mucosa-associated lymphoid tissue lymphoma has been well established. With the exception of unexplained iron deficiency anemia and idiopathic thrombocytopenic purpura, H. pylori infection has no proven role in extraintestinal diseases. On the other hand, there is data showing that H. pylori infection could be beneficial for some human diseases. The unpredictability of the long-term consequences of H. pylori infection and the economic challenge in eradicating it is why identification of high-risk individuals is crucial.

关键词： Helicobacter pylori Virulence factor Host factors Gastroduodenal diseases Extraintestinal disorders

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Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer

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World Journal of Clinical Cases 2019年第23期7卷 3990-4003页

作者： Zsolt Kovacs Ioan Jung krisztina Szalman Laura Banias Tivadar Jr Bara Simona Gurzu Department of Pathology University of MedicinePharmacySciences and Technology“George Emil Palade”Targu Mures 530149Romania Department of Internal Medicine University of MedicinePharmacySciences and Technology“George Emil Palade”Targu Mures 530149Romania Department of Surgery University of MedicinePharmacyScience and Technology“George Emil Palade”Tirgu Mures 530149Romania Research Center(CCAMF) University of MedicinePharmacySciences and TechnologyTargu Mures 540139Romania

BACKGROUND Although it has been shown that arylsulfatases are lost in colorectal cancer(CRC)cell lines,their exact role in the carcinogenesis and behavior of this cancer was not *** data about the correlation between serum and immunohistochemical(IHC)level of arylsulfatases(ARSA,ARSB)in patients with CRC were published *** To evaluate the possible prognostic value of ARSA and/or ARSB in CRC,at circulating and protein *** The present study included 45 consecutive patients who were prospectively diagnosed with *** IHC stains(protein expression)ARSA,ARSB and maspin expression were *** these markers,cytoplasmic expression was taken into *** gene expression study,circulating mRNA was isolated from all patients,before surgery.A group of 45 healthy patients without inflammatory or tumor pathologies was used as control *** transcription and Taqman Gene Expression Array were used for ARSB gene *** The preoperative circulating RNA level of the ARSB gene was significantly decreased in patients with CRC(RQ1).A more significant decrease(RQrisk for lymph node metastasis,while triple positivity for maspin/ARSA/ARSB and ARSB gene expression levelriple positivity for maspin,ARSA and ARSB,and low ARSB gene expression.

关键词： Arylsulfatase Maspin Colorectal cancer ARSB gene Blood Tissue

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Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 927-934页

作者： ANDrea krisztina Sükosd krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám Department of Ophthalmology University of Pecs Medical School and Clinical CentrePecs 7623Hungary Department of Experimental Zoology and Neurobiology University of PecsPecs 7624Hungary Department of Biophysics University of Pecs Medical School and Clinical CentrePecs 7624Hungary Janos Szentagothai Research Centre University of PecsPecs 7624Hungary Optimum Laser Centre Budapest 1124Hungary Gemini Eye Clinics Zlin 76001Czech Republic Department of Medical Biology and Central Electron Microscopic Laboratory University of Pecs Medical SchoolPecs 7624Hungary

AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by *** of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were *** order to map the actin network of cells,fluorescently labeled phalloidin was *** samples were examined using confocal laser scanning ***:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to *** CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological *** the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were *** FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were ***:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells.

关键词： lens epithelial cell cytoskeleton capsulotomy glial fibrillary acidic protein actin

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Dental evaluation is helpful in the differentiation of functional heartburn and gastroesophageal reflux disease

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世界胃肠病学杂志:英文版 2023年第31期29卷 4774-4782页

作者： krisztina Helle Anna ZsófiaÁrok Georgina Ollé Márk Antal András Rosztóczy Department of Internal Medicine Division of GastroenterologyUniversity of SzegedSzeged 6725Hungary Department of Operative and Esthetic Dentistry University of SzegedSzeged 6725Hungary

BACKGROUND Heartburn is identically the key symptom of both,gastroesophageal reflux disease(GERD)and functional heartburn(FHB),making the differential diagnosis *** manifestations of GERD can be easily examined;therefore,their exploration might be a cheap,widely available,and useful tool in the differentiation of GERD and *** To evaluate the prevalence of dental erosions(DE)and periodontal diseases(PD)in patients with heartburn and their association with GERD and *** A total of 116[M/F:51/65,mean age:54(17-80)years]consecutive patients with heartburn were enrolled for detailed esophageal function and orodental *** Dental disorders were detected in 89%(103/116).Patients with PD+DE had significantly more often pathologic reflux(90.0%vs 27.8%;P<0.05),higher esophagitis scores(1.8 vs 0.9;P<0.05),and a significantly different mean impedance curve(P=0.04)than those without any dental *** opposite approach established that patients with GERD had significantly higher prevalence of DE and PD,especially if both were present(28.9%vs 2.0%;P<0.01),more severe PD(1.5 vs 1.0;P<0.01),and longer history of heartburn(15 years vs 9 years;P<0.01)than those with *** The dental evaluation of patients with heartburn seems to be useful in the differential diagnosis of GERD and *** the studied parameters,the co-appearance of DE and PD seems to be the best predictor of GERD,whereas the absence of dental disorders was mostly observed in FHB.

关键词： Gastroesophageal reflux disease Gastric acid Heartburn Differential diagnosis Epidemiology Oral manifestations Prevalence risk factors Dental erosion Periodontal diseases

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Double-brooding and annual breeding success of great tits in urban and forest habitats

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Current Zoology 2022年第5期68卷 517-525页

作者： Boglárka Bukor Gábor Seress Ivett Pipoly krisztina Sándor Csenge Sinkovics ErnőVincze András Liker Behavioral Ecology Research Group Center for Natural SciencesUniversity of PannoniaVeszprém H-8200Hungary MTA-PE Evolutionary Ecology Research Group University of PannoniaVeszprém H-8200Hungary MTA-ELTE Comparative Ethology Research Group BudapestHungary Department of Biology Theoretical Population Ecology and Evolution GroupLund UniversityLundSweden

Urban areas differ from natural habitats in several environmental features that influence the characteristics of animals living *** example,birds often start breeding seasonally earlier and fledge fewer offspring per brood in cities than in natural ***,longer breeding seasons in cities may increase the frequency of double-brooding in urban compared with nonurban populations,thus potentially increasing urban birds’annual reproductive output and resulting in lower habitat difference in reproductive success than estimated by studies focusing on first clutches *** this study,we investigated 2 urban and 2 forests great tit Parus major populations from 2013 to *** compared the probability of double-brooding and the total number of annually fledged chicks per female between urban and forest habitats,while controlling for the effects of potentially confounding *** was a trend for a higher probability of double-brooding in urban(44%of females)than in forest populations(36%),although this was not consistent between the 2 urban *** produced significantly fewer fledglings annually in the cities than in the forest sites,and this difference was present both within single-and double-brooded ***,double-brooded urban females produced a similar number of fledglings per season as single-brooded forest *** results indicate that double-brooding increases the reproductive success of female great tits in both habitats,but urban females cannot effectively compensate in this way for their lower reproductive output per ***,other mechanisms like increased post-fledging survival can mitigate habitat differences in reproductive success.

关键词： annual reproductive success habitat differences population self-sustainability second brood urban conservation

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Hierarchical porous induced competent removal of low concentration azo dye molecules by generating a leachy crystalline structure H-MIL-53(Fe)

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Chinese Chemical Letters 2020年第10期31卷 2717-2720页

作者： Tao Feng Jean Pierre Bavumiragira Mumbi Anne Wambui Daniel Manaye Kabtamu krisztina László Ying Wang Fengting Li State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Department of Physical Chemistry and Materials Science Budapest University of Technology and EconomicsH-1521 BudapestHungary

The development in technology of synthetic azo dyes,has led to excessive water resources *** n at lower concentration they can impart the quality of water and human ***,we have developed a novel synthesis strategy via introducing salicylic acid(SA)for the synthesis of a leachy crystalline material H-MIL-53(Fe)with hierarchical pores(HP)and exposed coordination unsaturated sites(CUS),which had higher surface area and larger pore volume than the as synthesized MIL-53(Fe).Due to these characteristics,H-MIL-53(Fe)was competent removal of orange G(OG,one of the frequently used azo dyes)with equilibrium in 300 min and the maximum adsorption capacity of 163.9 mg/*** adsorption mechanism of OG onto H-MIL-53(Fe)was mostly based on electrostatic attraction between CUS of HMIL-53(Fe)along with HP as active species to OG diffusion and *** comparing H-MIL-53(Fe)with other adsorbents for OG adsorption,it is undoubtedly that H-MIL-53(Fe)can be used as a promising adsorbent for OG removal from aqueous solutions.

关键词： H-MIL-53(Fe) Salicylic acid Leachy crystalline Adsorption Orange G removal

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