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Local translation of cell adhesion molecules in axons

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Neural Regeneration Research 2016年第4期11卷 543-544页

作者： Shruti Jain kristy welshhans Department of Biological Sciences Kent State University School of Biomedical Sciences Kent State University

During development and regeneration,axonal growth depends on a rapid response to extracellular growth and guidance *** mechanism underlying this rapid response is local protein synthesis（Jung et al.,2012）.Local prot... 详细信息

关键词： ALCAM Local translation of cell adhesion molecules in axons cell

Applying Earth Observation Technologies to Economic Consequence Modeling:A Case Study of COVID‑19 in Los Angeles County,California

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International Journal of Disaster Risk Science 2024年第1期15卷 18-31页

作者： Fynnwin Prager Marina T.Mendoza Charles K.Huyck Adam Rose Paul Amyx Gregory Yetman kristy F.Tiampo California State University Dominguez HillsCarsonCA 90747USA ImageCat Inc.Long BeachCA 90802USA University of Southern California Los AngelesCA 90015USA CIESIN–Center for International Earth Science Information Network Columbia UniversityPalisadesNY 10964USA Cooperative Institute for Research in Environmental Sciences(CIRES) University of Colorado BoulderBoulderCO 80309USA

Earth observation(EO) technologies,such as very high-resolution optical satellite data available from Maxar,can enhance economic consequence modeling of disasters by capturing the fine-grained and real-time behavioral responses of businesses and the *** investigated this unique approach to economic consequence modeling to determine whether crowd-sourced interpretations of EO data can be used to illuminate key economic behavioral responses that could be used for computable general equilibrium modeling of supply chain repercussions and resilience *** applied our methodology to the COVID-19 pandemic experience in Los Angeles County,California as a case *** also proposed a dynamic adjustment approach to account for the changing character of EO through longer-term disasters in the economic modeling *** found that despite limitations,EO data can increase sectoral and temporal resolution,which leads to significant differences from other data sources in terms of direct and total impact *** findings from this analytical approach have important implications for economic consequence modeling of disasters,as well as providing useful information to policymakers and emergency managers,whose goal is to reduce disaster costs and to improve economic resilience.

关键词： Computable general equilibrium models COVID-19 Disaster economic impacts Earth observation Economic consequence analysis Los Angeles County

Patent foramen ovale and cryptogenic stroke:diagnosis and updates in secondary stroke prevention

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Stroke & Vascular Neurology 2018年第2期3卷 84-91页

作者： kristy Yuan Scott Eric Kasner Department of Neurology University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

The patent foramen ovale(PFO),given its high prevalence in the general population and especially in patients with cryptogenic stroke,has long generated investigation and debate on its propensity for stroke by paradoxical embolism and its management for stroke *** pendulum has swung for percutaneous PFO closure for secondary stroke prevention in cryptogenic *** on a review of current evidence,the benefit from PFO closure relies on careful patient selection:those under the age of 60 years with few to no vascular risk factors and embolic-appearing stroke deemed cryptogenic after thorough *** these data look towards influencing guideline statements and device approvals in the future,patient selection remains the crucial ingredient for clinical decision making and future trials.

关键词： prevention diagnosis closure

Dietary nano chromium picolinate can ameliorate some of the impacts of heat stress in cross-bred sheep

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Animal Nutrition 2021年第1期7卷 198-205页

作者： Alex T.Hung Brian J.Leury Matthew A.Sabin Fahri Fahri kristy DiGiacomo Tu-Fa Lien Frank R.Dunshea Faculty of Veterinary and Agricultural Sciences The University of MelbourneParkvilleVIC3010Australia Murdoch Children's Research Institute The University of MelbourneParkvilleVIC3010Australia Department of Animal Science National Chiayi UniversityChina Faculty of Biological Sciences The University of LeedsLeeds LS29JTUnited Kingdom

Two studies were conducted to evaluate the effect of nano chromium picolinate(nCrPic)during heat stress(HS)in *** the initial study,36 Merino×Poll cross-bred sheep were individually penned and allocated to 3 dietary treatments(0,400 and 800μg/kg nCrPic)for 8 *** composition was determined at the beginning and end of the experiment using dual energy X-ray *** sheep remained in their dietary groups but were then placed in metabolic cages and randomly allocated within the dietary group to differing ambient temperature regimes,i.e.,thermo-neutral(TN)(n=18)and HS(n=18),for 3 *** nCrPic had no effect on growth performance and body composition during the initial study conducted under TN *** stress decreased average daily feed intake(ADFI)(P=0.002)whereas sheep under HS had reduced average daily gain(ADG)and indeed lost weight(P<0.001).Dietary nCrPic increased both ADFI(P=0.041)and ADG(P=0.049)under both TH and HS conditions such that the performance of sheep receiving supplemental nCrPic and exposed to HS was similar to that of control sheep maintained under TN *** stress increased rectal temperature(P<0.001)and respiration rate(P<0.001),particularly during the hottest parts of the day as indicated by interactions(P<0.001)between time of day and thermal *** temperature was lower in sheep fed nCrPic(P=0.050),particularly under peak HS conditions during the afternoon as indicated by the interactions between dietary nCrPic and time of day(P<0.001)and dietary nCrPic,thermal treat-ment and time of day(P=0.010).Similarly,respiration rate was lower in sheep fed nCrPic under peak HS conditions during the afternoon as indicated by the interactions between dietary nCrPic and thermal treatment(P<0.001)and dietary nCrPic and time of day(P=0.030).In conclusion,dietary nCrPic can partially ameliorate the negative effects of HS as indicated by the maintenance of ADFI and decreased physiological responses,such as elevatio

关键词： Chromium picolinate Sheep Heat stress Nanotechnology Physiology

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Nano-chromium picolinate and heat stress enhance insulin sensitivity in cross-bred sheep

作者：谢孟吟 (Ho kristy Wen)亨

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Animal Nutrition 2023年第2期13卷 173-184页

作者： Alex T.Hung Brian J.Leury Matthew A.Sabin Fahri Fahri kristy DiGiacomo Tu-Fa Lien Frank R.Dunshea Faculty of Veterinary and Agricultural Sciences The University of MelbourneParkvilleVIC 3010Australia Murdoch Children's Research Institute The University of MelbourneParkvilleVIC 3010Australia Department of Animal Science National Chiayi UniversityChiayiChina Faculty of Biological Sciences The University of LeedsLeeds LS29JTUnited Kingdom

This study evaluated the effects of heat stress(HS)and dietary nano chromium picolinate(nCrPic)on metabolic responses of sheep to an intravenous glucose tolerance test(IVGTT),an intravenous insulin tolerance test(ITT)and an intramuscular adrenocorticotropin hormone(ACTH)challenge in ***-six sheep housed in metabolic cages were randomly allocated within 3 dietary groups(0,400 and 800 mg/kg supplemental nCrPic)to either thermoneutral(22℃)or cyclic HS(22 to 40℃)conditions for 3 *** plasma glucose tended to be increased during HS(P=0.052)and decreased by dietary nCrPic(P=0.013)while plasma non-esterified fatty acid concentrations were decreased(P=0.010)by ***-etary nCrPic reduced the plasma glucose area under the curve(P=0.012)while there were no significant effects of HS on plasma glucose area under the curve in response to the *** plasma insulin response over the first 60 min after the IVGTT was decreased by HS(P=0.013)and dietary nCrPic(P=0.022)with the effects being *** response to the ITT plasma glucose reached a nadir sooner(P=0.005)in sheep exposed to HS,although there was no effect on the depth of the *** nCrPic decreased(P=0.007)the plasma glucose nadir after *** the duration of the ITT plasma insulin concentrations were lower in sheep exposed to HS(P=0.013)whereas there was no significant effect of supplemental *** was no effect of either HS or nCrPic on cortisol response to *** nCrPic supple-mentation decreased(P=0.013)mitogen-activated protein kinase-8(JNK)and increased(P=0.050)carnitine palmitoyltransferase 1B(CPT1B)mRNA expression in skeletal *** of this experiment demonstrated that animals under HS and supplemented with nCrPic had greater insulin sensitivity.

关键词： Chromium picolinate Sheep Heat stress Insulin sensitivity

A Neighborhood Analysis of Underage Tobacco Sales within the Serving Area of a Canadian Public Health Unit

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Open Journal of Statistics 2017年第6期7卷 920-935页

作者： Saber Fallahpour Tanya Navaneelan kristy McBeth Prithwish De Surveillance and Cancer Registry Cancer Care Ontario Toronto Canada Knowledge Management Windsor-Essex County Health Unit Windsor Canada

Despite the fact that the sale of tobacco to minors is illegal in Ontario, youth are still able to purchase tobacco. This study aims to determine the geographic variations of underage tobacco sales at the neighborhood level within the Windsor-Essex County Health Unit. Data were collected on all inspections of tobacco retail stores from 2007 to 2011 in the Windsor-Essex County Health Unit. Data were split into season 1 (September-February) and season 2 (March-August) to assess a possible seasonal effect. Relative risks were calculated for each dissemination area (DA) by modeling the risks in a hierarchical Bayesian fashion, incorporating appropriate random effects terms for both spatially correlated and uncorrelated random errors with adjustments for neighborhood income. The association between violation rate and proximity to a school was assessed through a buffer analysis. Elliptical analysis detected a significant cluster of high risk DAs in season 1 in Windsor (p-value = 0.022) but no significant cluster in season 2. Some DAs exhibited higher relative risks of tobacco sales to minors, however after adjusting the model for neighborhood income no excess risk was observed. The results of the buffer analysis showed that in season 1 there was a significantly higher probability (p-value = 0.045) of tobacco vendors located closer to schools to sell tobacco to minors. This analysis demonstrates the utility of a systematic approach to identifying neighborhoods with higher risks of tobacco sales to minors. The insights provided by this exploratory, ecologic study are valuable for program planning and directing tobacco enforcement efforts to high risk areas.

关键词： Tobacco Dissemination Area Bayesian Disease Mapping Cluster Buffer Analysis

Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection

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Cellular & Molecular Immunology 2014年第5期11卷 410-427页

作者： Philip V Nguyen Jessica K Kafka Victor H Ferreira kristy Roth Charu Kaushic McMaster Immunology Research Centre (MIRC) and Michael G.DeGroote Institute ot Intectious Dtseas Research (IIDR) Department of Pathology and Molecular Medicine McMaster University Hamilton Ontario Canada

The male and female reproductive tracts are complex microenvironments that have diverse functional demands. The immune system in the reproductive tract has the demanding task of providing a protective environment for a fetal allograft while simultaneously conferring protection against potential pathogens. As such, it has evolved a unique set of adaptations, primarily under the influence of sex hormones, which make it distinct from other mucosal sites. Here, we discuss the various components of the immune system that are present in both the male and female reproductive tracts, including innate soluble factors and cells and humoral and cell-mediated adaptive immunity under homeostatic conditions. We review the evidence showing unique phenotypic and functional characteristics of immune cells and responses in the male and female reproductive tracts that exhibit compartmentalization from systemic immunity and discuss how these features are influenced by sex hormones. We also examine the interactions among the reproductive tract, sex hormones and immune responses following HIV-1 infection. An improved understanding of the unique characteristics of the male and female reproductive tracts will provide insights into improving clinical treatments of the immunological causes of infertility and the design of prophylactic interventions for the prevention of sexually transmitted infections.

关键词： female reproductive tract genital immunity HIV-1 male reproductive tract mucosal immune responses sexhormones sexually transmitted infections

Scrutiny of Microorganisms in Fermented Milk Beverage and Water from Dairy under State Inspection

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Food and Nutrition Sciences 2021年第11期12卷 1008-1019页

作者： kristy Ellen Oliveira Santos Ludmilla Santana Soares e Barros Federal University of Recôncavo of Bahia Cruz das Almas Brazil

The aim of the study was to examine microorganisms in samples of fermented milk beverage and water from dairy under state inspection. In a dairy located in the Recôncavo of Bahia, fifteen samples of fermented milk beverage were collected, corresponding to three different batches, and six water samples, two from each point of use in the industry: Point 1—Sanitary barrier;Point 2—Internal faucet for cleaning surfaces and utensils;Point 3—Drinking fountain for employees. All samples were submitted to microbiological research of total coliforms, Escherichia coli and Aeromonas spp. In the water samples, there was also quantification of heterotrophic bacteria and analysis of free residual chlorine. The fermented milk beverage samples did not show growth of total coliforms, E. coli and Aeromonas spp. With regard to water, no sample showed measurable levels of free residual chlorine, while in the microbiological analysis the count of heterotrophic bacteria in the drinking water exceeded the limit established by legislation (5.6 × 102 CFU.mL-1). In addition, the water from the sanitary barrier revealed total coliforms above the allowed value (1.3 × 101 CFU됔 mL-1) and showed contamination by Aeromonas spp. (7.0 × 101 CFU