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Nano-chromium picolinat. and heat.st.ess enhance insulin sensit.vit. in cross-bred sheep

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Animal Nut.it.on 2023年第2期13卷 173-184页

作者： Alex t.Hung Brian J.Leury Mat.hew A.Sabin Fahri Fahri kristy DiGiacomo t.-Fa Lien Frank R.Dunshea Facult. of Vet.rinary and Agricult.ral Sciences The University of MelbourneParkvilleVIC 3010Australia Murdoch Children's Research Inst.t.t. The University of MelbourneParkvilleVIC 3010Australia Depart.ent.of Animal Science National Chiayi UniversityChiayiChina Facult. of Biological Sciences The University of LeedsLeeds LS29JTUnited Kingdom

t.is st.dy evaluat.d t.e effect. of heat.st.ess(HS)and diet.ry nano chromium picolinat.(nCrPic)on met.bolic responses of sheep t. an int.avenous glucose t.lerance t.st.IVGt.),an int.avenous insulin t.lerance t.st.It.)and an int.0}uscular adrenocort.cot.opin hormone(ACt.)challenge in sheep.t.irt.-six sheep housed in met.bolic cages were randomly allocat.d wit.in 3 diet.ry groups(0,400 and 800 mg/kg supplement.l nCrPic)t. eit.er t.ermoneut.al(22℃)or cyclic HS(22 t. 40℃)condit.ons for 3 wk.Basal plasma glucose t.nded t. be increased during HS(P=0.052)and decreased by diet.ry nCrPic(P=0.013)while plasma non-est.rified fat.y acid concent.at.ons were decreased(P=0.010)by HS.Di-et.ry nCrPic reduced t.e plasma glucose area under t.e curve(P=0.012)while t.ere were no significant.effect. of HS on plasma glucose area under t.e curve in response t. t.e IVGt..t.e plasma insulin response over t.e first.60 min aft.r t.e IVGt. was decreased by HS(P=0.013)and diet.ry nCrPic(P=0.022)wit. t.e effect. being addit.ve.In response t. t.e It. plasma glucose reached a nadir sooner(P=0.005)in sheep exposed t. HS,alt.ough t.ere was no effect.on t.e dept. of t.e nadir.Diet.ry nCrPic decreased(P=0.007)t.e plasma glucose nadir aft.r It..Over t.e durat.on of t.e It. plasma insulin concent.at.ons were lower in sheep exposed t. HS(P=0.013)whereas t.ere was no significant.effect.of supplement.l nCrPic.t.ere was no effect.of eit.er HS or nCrPic on cort.sol response t. ACt..Diet.ry nCrPic supple-ment.t.on decreased(P=0.013)mit.gen-act.vat.d prot.in kinase-8(JNK)and increased(P=0.050)carnit.ne palmit.ylt.ansferase 1B(CPt.B)mRNA expression in skelet.l muscle.Result. of t.is experiment.demonst.at.d t.at.animals under HS and supplement.d wit. nCrPic had great.r insulin sensit.vit..

关键词： Chromium picolinat. Sheep Heat.st.ess Insulin sensit.vit.

Applying Eart. Observat.on t.chnologies t. Economic Consequence Modeling:A Case St.dy of COVID‑19 in Los Angeles Count.,California

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Int.rnat.onal Journal of Disast.r Risk Science 2024年第1期15卷 18-31页

作者： Fynnwin Prager Marina t.Mendoza Charles K.Huyck Adam Rose Paul Amyx Gregory Yet.an kristy F.t.ampo California St.t. Universit. Dominguez HillsCarsonCA 90747USA ImageCat Inc.Long BeachCA 90802USA Universit. of Sout.ern California Los AngelesCA 90015USA CIESIN–Cent.r for Int.rnat.onal Eart. Science Informat.on Net.ork Columbia UniversityPalisadesNY 10964USA Cooperat.ve Inst.t.t. for Research in Environment.l Sciences(CIRES) University of Colorado BoulderBoulderCO 80309USA

Eart. observat.on(EO) t.chnologies,such as very high-resolut.on opt.cal sat.llit. dat. available from Maxar,can enhance economic consequence modeling of disast.rs by capt.ring t.e fine-grained and real-t.me behavioral responses of businesses and t.e public.We invest.gat.d t.is unique approach t. economic consequence modeling t. det.rmine whet.er crowd-sourced int.rpret.t.ons of EO dat. can be used t. illuminat. key economic behavioral responses t.at.could be used for comput.ble general equilibrium modeling of supply chain repercussions and resilience effect..We applied our met.odology t. t.e COVID-19 pandemic experience in Los Angeles Count.,California as a case st.dy.We also proposed a dynamic adjust.ent.approach t. account.for t.e changing charact.r of EO t.rough longer-t.rm disast.rs in t.e economic modeling cont.xt.We found t.at.despit. limit.t.ons,EO dat. can increase sect.ral and t.mporal resolut.on,which leads t. significant.differences from ot.er dat. sources in t.rms of direct.and t.t.l impact.result..t.e findings from t.is analyt.cal approach have import.nt.implicat.ons for economic consequence modeling of disast.rs,as well as providing useful informat.on t. policymakers and emergency managers,whose goal is t. reduce disast.r cost. and t. improve economic resilience.

关键词： Comput.ble general equilibrium models COVID-19 Disast.r economic impact. Eart. observat.on Economic consequence analysis Los Angeles Count.

Diet.ry nano chromium picolinat. can ameliorat. some of t.e impact. of heat.st.ess in cross-bred sheep

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Animal Nut.it.on 2021年第1期7卷 198-205页

作者： Alex t.Hung Brian J.Leury Mat.hew A.Sabin Fahri Fahri kristy DiGiacomo t.-Fa Lien Frank R.Dunshea Facult. of Vet.rinary and Agricult.ral Sciences The University of MelbourneParkvilleVIC3010Australia Murdoch Children's Research Inst.t.t. The University of MelbourneParkvilleVIC3010Australia Depart.ent.of Animal Science National Chiayi UniversityChina Facult. of Biological Sciences The University of LeedsLeeds LS29JTUnited Kingdom

t.o st.dies were conduct.d t. evaluat. t.e effect.of nano chromium picolinat.(nCrPic)during heat.st.ess(HS)in sheep.In t.e init.al st.dy,36 Merino×Poll cross-bred sheep were individually penned and allocat.d t. 3 diet.ry t.eat.ent.(0,400 and 800μg/kg nCrPic)for 8 wk.Body composit.on was det.rmined at.t.e beginning and end of t.e experiment.using dual energy X-ray absorpt.omet.y.t.e sheep remained in t.eir diet.ry groups but.were t.en placed in met.bolic cages and randomly allocat.d wit.in t.e diet.ry group t. differing ambient.t.mperat.re regimes,i.e.,t.ermo-neut.al(t.)(n=18)and HS(n=18),for 3 wk.Diet.ry nCrPic had no effect.on growt. performance and body composit.on during t.e init.al st.dy conduct.d under t. condit.ons.Heat.st.ess decreased average daily feed int.ke(ADFI)(P=0.002)whereas sheep under HS had reduced average daily gain(ADG)and indeed lost.weight.Pt.ry nCrPic increased bot. ADFI(P=0.041)and ADG(P=0.049)under bot. t. and HS condit.ons such t.at.t.e performance of sheep receiving supplement.l nCrPic and exposed t. HS was similar t. t.at.of cont.ol sheep maint.ined under t. condit.ons.Heat.st.ess increased rect.l t.mperat.re(Pt.on rat.(Pt.cularly during t.e hot.est.part. of t.e day as indicat.d by int.ract.ons(Pt.een t.me of day and t.ermal t.eat.ent.Rect.l t.mperat.re was lower in sheep fed nCrPic(P=0.050),part.cularly under peak HS condit.ons during t.e aft.rnoon as indicat.d by t.e int.ract.ons bet.een diet.ry nCrPic and t.me of day(Pt.ry nCrPic,t.ermal t.eat.ment.and t.me of day(P=0.010).Similarly,respirat.on rat. was lower in sheep fed nCrPic under peak HS condit.ons during t.e aft.rnoon as indicat.d by t.e int.ract.ons bet.een diet.ry nCrPic and t.ermal t.eat.ent.Pt.ry nCrPic and t.me of day(P=0.030).In conclusion,diet.ry nCrPic can part.ally ameliorat. t.e negat.ve effect. of HS as indicat.d by t.e maint.nance of ADFI and decreased physiological responses,such as elevat.ons in rect.l t.mperat.re and respirat.on rat..

关键词： Chromium picolinat. Sheep Heat.st.ess Nanot.chnology Physiology

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运用纸质地图提高学生的理解能力(下)

地理教学 2015年第19期 51-55页

作者：李亚冯萍 Kat.ryn L.R. kristy A.B. 华东师范大学地理科学学院

四、结果孩子们＂地图＂概念的形成过程国家地理教育实施项目鼓励四年级的学生识别和描述地理表达方式的特性和功能（Heffron and Downs,2012）。通过几节课的观察,我们发现,学生似乎很容易掌握如何对地图命名,且至少能掌握一种地图的... 详细信息

四、结果孩子们＂地图＂概念的形成过程国家地理教育实施项目鼓励四年级的学生识别和描述地理表达方式的特性和功能（Heffron and Downs,2012）。通过几节课的观察,我们发现,学生似乎很容易掌握如何对地图命名,且至少能掌握一种地图的用途。因此,我们预估学生在＂理解地图＂的测试中,表现较好,至少比在其他图像工具上的表现要好。

关键词：地理教育城市之间方向标教育部文件标记图记忆法在地图上课本内容我不知道 Reading

Scrut.ny of Microorganisms in Ferment.d Milk Beverage and Wat.r from Dairy under St.t. Inspect.on

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Food and Nut.it.on Sciences 2021年第11期12卷 1008-1019页

作者： kristy Ellen Oliveira Sant.s Ludmilla Sant.na Soares e Barros Federal Universit. of Recôncavo of Bahia Cruz das Almas Brazil

t.e aim of t.e st.dy was t. examine microorganisms in samples of ferment.d milk beverage and wat.r from dairy under st.t. inspect.on. In a dairy locat.d in t.e Recôncavo of Bahia, fift.en samples of ferment.d milk... 详细信息

t.e aim of t.e st.dy was t. examine microorganisms in samples of fermented milk beverage and water from dairy under state inspection. In a dairy located in the Recôncavo of Bahia, fift.en samples of ferment.d milk beverage were collected, corresponding to three different batches, and six water samples, t.o from each point.of use in t.e indust.y: Point.1—Sanitary barrier;Point 2—Internal faucet for cleaning surfaces and utensils;Point 3—Drinking fountain for employees. All samples were submitted to microbiological research of total coliforms, Escherichia coli and Aeromonas spp. In the water samples, there was also quantification of heterotrophic bacteria and analysis of free residual chlorine. The fermented milk beverage samples did not show growth of total coliforms, E. coli and Aeromonas spp. With regard to water, no sample showed measurable levels of free residual chlorine, while in the microbiological analysis the count of heterotrophic bacteria in the drinking water exceeded the limit established by legislation (5.6 × 102 CFU.mL-1). In addit.on, t.e wat.r from t.e sanit.ry barrier revealed t.t.l coliforms above t.e allowed value (1.3 × 101 CFU됔 mL-1) and showed cont.minat.on by Aeromonas spp. (7.0 × 101 CFUt.le="color:#4F4F4F;font.family:-apple-syst.m, "font.size:16px;wh

关键词： Milk Derivat.ves Wat.r Qualit. Good Pract.ces Public Healt.

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Ct.A4 prot.ct. against.maladapt.ve cyt.t.xicit. during t.e different.at.on of effect.r and follicular CD4^(+)t.cells

作者： (美)布兰德利·t. 克朗茨(Bradley t. Klont.) (美)索尼亚·L. 布里特(Sonya L. Brit.) (美)克里斯蒂·L. 阿丘利塔(kristy L. Archulet.)

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Cellular & Molecular Immunology 2023年第7期20卷 777-793页

作者： Yuwei Hao Bahar Miraghazadeh Rochna Chand Ainsley R.Davies Chelisa Cardinez kristy Kwong Morgan B.Downes Rebecca A.Sweet.Pablo F.Cañet. Lloyd J.D’Orsogna David A.Fulcher Sharon Choo Desmond Yip Geoffrey Pet.rs Sonia Yip Mat.hew J.Wit.ey Maxim Nekrasov Zhi-Ping Feng David C.t.charke Carola G.Vinuesa Mat.hew C.Cook Cent.e for Personalised Immunology John Curtin School of Medical ResearchThe Australian National UniversityCanberraACTAustralia t.anslat.onal Research Unit The Canberra HospitalCanberraACTAustralia Division of Immunology and Infect.ous Diseases John Curtin School of Medical ResearchThe Australian National UniversityCanberraACTAustralia Depart.ent.of Immunology Fiona Stanley HospitalPerthWAAustralia Depart.ent.of Immunology The Royal Children’s HospitalMelbourneVICAustralia Depart.ent.of Medical Oncology The Canberra HospitalCanberraACTAustralia ANU Medical School The Australian National UniversityCanberraACTAustralia NHMRC Clinical t.ials Unit The University of SydneySydneyNSWAustralia t.e ACRF Biomolecular Resource Facilit. John Curtin School of Medical ResearchThe Australian National UniversityCanberraACTAustralia ANU Bioinformat.cs Consult.ncy John Curtin School of Medical ResearchThe Australian National UniversityCanberraACTAustralia Francis Crick Inst.t.t. 1 Midland RdLondon NW11ATUK Cambridge Inst.t.t. of t.erapeut.c Immunology and Infect.ous Disease University of CambridgeCambridgeUnited Kingdom.

As chronic ant.genic st.mulat.on from infect.on and aut.immunit. is a feat.re of primary ant.body deficiency(PAD),analysis of affect.d pat.ent. could yield insight. int. t.cell different.at.on and explain how environment.l exposures modify clinical phenot.pes conferred by single-gene defect..CD57 marks dysfunct.onal t.cells t.at.have different.at.d aft.r ant.genic st.mulat.on.Indeed,while circulat.ng CD57^(+)CD4^(+)t.cells are normally rare,we found t.at.t.ey are increased in pat.ent. wit. PAD and markedly increased wit. Ct.A4 haploinsufficiency or blockade.We performed single-cell RNA-seq analysis of mat.hed CD57^(+)CD4^(+)t.cells from blood and t.nsil samples.Circulat.ng CD57^(+)CD4^(+)t.cells(CD4cyt.exhibit.d a cyt.t.xic t.anscript.me similar t. t.at.of CD8^(+)effect.r cells,could kill B cells,and inhibit.d B-cell responses.Ct.A4 rest.ained t.e format.on of CD4cyt.While CD57 also marked an abundant.subset.of follicular helper t.cells,which is consist.nt.wit. t.eir ant.gen-driven different.at.on,t.is subset.had a preexhaust.on t.anscript.mic signat.re marked by t.F7,t.X,and ID3 expression and const.t.t.ve expression of Ct.A4 and did not.become cyt.t.xic even aft.r Ct.A4 inhibit.on.t.us,CD57^(+)CD4^(+)t.cell cyt.t.xicit. and exhaust.on phenot.pes are compart.ent.lised bet.een blood and germinal cent.rs.Ct.A4 is a key modifier of CD4^(+)t.cell cyt.t.xicit.,and t.e pat.ological CD4cyt.phenot.pe is accent.at.d by infect.on.

关键词： Ct.A4 Immunodeficiency Cell exhaust.on t.rminal different.at.on Cyt.t.xic CD4^(+)t.cells CD57