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Metabolite profile comparisons between ascending and descending colon tissue in healthy adults

World Journal of Gastroenterology 2020年第3期26卷 335-352页

作者： Bridget A Baxter kristopher d parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsFort CollinsCO 80523United States University of Colorado Health Gastroenterology Clinic Fort CollinsCO 80524United States department of Clinical Sciences Colorado State UniversityFort CollinsCO 80523United States Harmony Surgery Center Fort CollinsCO 80528United States director of Clinical Operations Harmony Surgery CenterFort CollinsCO 80523United States

BACKGROUNd Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely *** study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese *** To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer *** Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite *** colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal *** Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass *** acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite *** weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(Pdults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending *** and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese *** There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy *** lipids and other metabolites in

关键词： Colon Ascending descending Metabolomics Obesity Stool

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There is no real evidence for a diminishing trend of the Atlantic meridional overturning circulation

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Journal of Ocean Engineering and Science 2016年第1期1卷 30-35页

作者： A.parker C.d.Ollier School of Engineering and Physical Science James Cook UniversityTownsvilleQLDAustralia School of Earth and Environment University of Western AustraliaCrawley WAAustralia

The Atlantic Meridional Overturning Circulation(AMOC)is part of the great ocean“conveyor belt”that circulates heat around the *** the early 2000s,ocean sensors have started to monitor the AMOC,but the measurements are still far from accurate and the time window does not permit the separation of short term variability from a longer term *** works have claimed that global warming is slowing down the AMOC,based on models and proxies of *** other observations demonstrate a stable circulation of the *** using tide gauge data complementing recent satellite and ocean sensor observations,the stability of the AMOC is shown to go back to *** is concluded that no available information has the due accuracy and time coverage to show a clear trend outside the inter-annual and multi-decadal variability in the direction of increasing or decreasing strength over the last decades.

关键词： Ocean circulation Conveyor belt Global warming Climate change.

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A Constantly Evolving Journal:Reflecting on 2023

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Psycho-Oncologie 2024年第1期18卷 1-3页

作者： kristopher Lamore University.Lille CNRSUMR 9193—SCALab—Sciences Cognitives et AffectivesLilleF-59000France

Introduction La revue Psycho-Oncologie est une revue scientifique publiée depuis ***ès 21 ans de publications,la revue continue d’é*** 2023,la revue a connu un changement majeur:précédemment publiée par l’éditeur Lavoisier,elle est depuis juin 2023éditée par Tech Science *** nouvelle collaboration avec le comitééditorial de la revue et la SociétéFrançaise et Francophone de Psycho-Oncologie offre ainsi de nouvelles perspectivesàla revue.

关键词： continue les ais

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Promoting Health democracy

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Psycho-Oncologie 2024年第1期18卷 5-7页

作者： Sabine dutheil Marie-Frédérique Bacqué kristopher Lamore Clinique Tivoli LISAL’Institut du Sein d’AquitaineBordeaux33300France UR3071 Universitéde StrasbourgStrasbourg67000France University.Lille CNRSUMR 9193—SCALab—Sciences Cognitives et AffectivesLilleF-59000France

Introduction,L’histoire de la démocratie sanitaire-devenue par un glissement sémantique la démocratie en santé-est un long processus encore et toujours en marche de la relation entre les citoyens et leur système de santé[1,2].Cette relation aétéet continue d’être influencée par des changements sociétaux majeurs au cours des dernières décennies.

关键词： des continue relation

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Subspace Methods in Multi-Parameter Seismic Full Waveform Inversion

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Communications in Computational Physics 2020年第6期28卷 228-248页

作者： Yu Geng kristopher A.Innanen Wenyong Pan department of Geosciences CREWES ProjectUniversity of CalgaryAlberta T2N 1N4Canada department of Geoscience CREWES ProjectUniversity of CalgaryAB T2N 1N4Canada Los Alamos National Laboratory Geophysics GroupMS D452Los AlamosNM 87545USA

In full waveform inversion(FWI)high-resolution subsurface model param-eters are *** is normally treated as a nonlinear least-squares inverse problem,in which the minimum of the corresponding misfit function is found by updating the model *** multiple elastic or acoustic properties are solved for,simple gradient methods tend to confuse parameter *** is referred to as parameter cross-talk;it leads to incorrect model solutions,poor convergence and strong dependence on the scaling of the different parameter *** step lengths in a subspace domain,rather than directly in terms of gradients of different parameters,is a potentially valuable approach to address this *** particular subspace used can be defined over a span of different sets of data or different parameter classes,provided it involves a small number of vectors compared to those contained in the whole model *** a subspace method,the basis vectors are defined first,and a local min-imum is found in the space spanned by *** examine the application of the sub-space method within acoustic FWI in determining simultaneously updates for velocity and *** first discuss the choice of basis vectors to construct the spanned space,from linear updates by distinguishing only the contributions of different parameter classes towards nonlinear updates by adding the contributions of higher-order pertur-bations of each parameter *** numerical character of FWI solutions generated via subspace methods involving different basis vectors is then analyzed and compared with traditional FWI *** subspace methods can provide better reconstructions of the model,especially for the velocity,as well as improved convergence rates,while the computational costs are still comparable with the traditional FWI methods.

关键词： Waveform inversion inverse problem subspace method

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Atmospheric and kinetic studies of OH and HO_2 by the FAGE technique

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Journal of Environmental Sciences 2012年第1期24卷 78-86页

作者： d.Amedro K.Miyazaki A.parker C.Schoemaecker C.Fittschen Laboratoire PC2A Universit de Lille 1- Ba timent C1159655 Villeneuve d'AscqFrance department of Applied Chemistry Tokyo Metropolitan UniversityJapan

A new FAGE setup has recently been built at the University of Lille,*** permits the quantification of OH and HO 2 in the atmosphere with a detection limit of 3×10 5 molecules/（cm 3 ·min） for OH and 1×10 6 molecules/（cm 3 ·min） for HO *** coupling to a photolysis cell enables the measurement of the total reactivity of the hydroxyl radical in ambient air and kinetic studies in *** configurations have been considered：one with the photolysis cell at 90° to the FAGE nozzle,the other on line with the FAGE *** two configurations have been tested and validated by measuring the well known rate constants of OH with CH 4,C 3 H 8 and *** advantages and drawbacks of each configuration have been *** ＂on line＂ configuration limits losses and permits measurements over a larger reactivity range but is affected by OH formation from the laser beam striking the FAGE nozzle,thus limiting the ability to carry out energy dependence studies which can,in contrast,be successfully performed in the 90° configuration.

关键词： OH kinetic reactivity laser induced fluorescence

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Assessment of the uncertainties in temperature change in China during the last century

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Chinese Science Bulletin 2010年第19期55卷 1974-1982页

作者： LI QingXiang dONG WenJie LI Wei GAO XiaoRong JONES P KENNEdY J parker d National Meteorological Information Center Beijing 100081 China Beijing Normal University Laboratory of Surface Process and Resources Economies Beijing 100875 China National Meteorological Center Beijing 100081 China Climatic Research Unit School of Environmental Sciences University of East Anglia Norwich NR4 7TJ UK Met Office Hadley Centre Exeter EX1 3PB UK

We have used the China Homogenized Historic Temperature dataset and some long-term station series of the neighbor countries from CRUTEM3,a 5°×5° gridded dataset of monthly mean temperature since 1900,to provide a 107-year record of surface temperature trends and *** derived a comprehensive set of uncertainty estimates to accompany the data:measurement and sampling errors,uncertainties in temperature bias estimates,and uncertainties arising from limited observational coverage on large-scale averages have all been *** reanalysed the temperature changes during the period of *** best estimates of trends for 1900-2006 with uncertainties at 95% confidence range are about 0.09±0.017°C/decade for the year as a whole,and 0.14±0.021°C/decade,0.11±0.021°C/decade,0.04±0.017°C/decade,and 0.07±0.017°C/decade for winter,spring,summer and autumn *** 1954-2006,the trends for annual,winter,spring,summer and autumn are:0.26±0.032°C/decade,0.35±0.046°C/decade,0.25±0.051°C/decade,0.16±0.037°C/decade and 0.22±0.055°C/*** saw the most significant warming trend in both 1900-2006 and 1954-2006,while during the most recent period(the satellite era,1979-2006),all the seasons show similar warming trends:0.45±0.13°C/decade,0.51±0.11°C/decade,0.52±0.16°C/decade,0.37±0.10°C/decade and 0.50±0.16°C/decade for annual,winter,spring,summer and *** arising from urbanization have been evaluated as less than 5% of the total warming trend for 1951-2001,so this bias was not removed.

关键词：不确定性温度变化中国历史评估变暖趋势偏差估计月平均温度抽样误差

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Oxygen isotopic variations in modern cetacean teeth and bones： implications for ecological, paleoecological, and paleoclimatic studies

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Science Bulletin 2016年第1期61卷 92-104页

作者： Burcu Ciner Yang Wang William parker department of Earth Ocean and Atmospheric Scienceand National High Magnetic Field LaboratoryFlorida State UniversityTallahasseeFLUSA department of Geological Engineering Balikesir UniversityBalikesirTurkey department of earth ocean and atmospheric scienceflorida state universityTallahasseeFLUSA

The oxygen isotope ratios （δ18O） preserved in marine sediments have been widely used to reconstruct past ocean temperatures. However, there remain significant uncertainties associated with this method, owing to assumptions about the δ18O of ancient seawater which affects the temperature inferred from sediment δ18O records. In this study, oxygen isotope compositions of phosphate in teeth and bones from five different modem cetacean species, including sperm whale, pygmy sperm whale, short-finned pilot whale, killer whale, and Cuvier＇s beaked whale, and three fossil whales were determined. The data were used to assess whether the oxygen isotope ratios of biogenic phosphate （δ18Op） from cetaceans are a reliable proxy for the oxygen isotopic composition of ocean water （δ18Ow）. The δ18Op values of modem cetaceans range from 15.5 ‰ to 21.3 ‰, averaging （19.6 ‰ ±0.8 ‰）（n = 136）.Using a greatly expanded global cetacean δ18Op dataset, the following regression equation is derived for cetaceans： δ18Ow = 0.95317 （4-0.03293） δ18Op- 17.971 （＋0.605）, r = 0.97253. The new equation, when applied to fossil teeth and bones, yielded reasonable estimates of ancient seawater δ18Ow values. Intra-tooth isotopic variations were observed within individual teeth. Among the selected species, the killer whale （O. orca） has largest intra-tooth δ18Op preference and migratory the lowest δ18Op values and the variation, reflecting its habitat behavior. The results show that oxygen isotope analysis of phosphate in cetacean teeth and dense ear bones provides a useful tool for reconstructing the oxygen isotopic composition of seawater and for examining environmental preferences （including migratory behavior） of both modem and ancient whales.

关键词： Oxygen isotopes Phosphate Cetacean Whales Teeth Bones

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New Astrophysical Reaction Rates for ^18F（P,α）^15O and ^18F（P,γ）^19Ne

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Chinese Physics Letters 2003年第9期20卷 1470-1473页

作者：舒能川 d.W.Bardayan J.C.Blackmon 陈永寿 R.L.Kozub P.d.parker M.S.Smith ChinaInstituteofAtomicEnergy Beijing102413 Physicsdivision OakRidgeNationalLaboratoryOakRidgeTennessee37831USA Physicsdepartment TennesseeTechnologicalUniversityCookevilleTennessee38505USA A.W.WrightNuclearStructureLaboratory YaleUniversityNewHavenConnecticut06520USA

The rates of the thermonuclear 18F(p, α)15O and 18F(p,γ)19Ne reactions in hot astrophysical environments are needed to understand gamma-ray emission from nova explosions. The rates for these reactions have been uncertain due to discrepancies in recent measurements, as well as to a lack of a comprehensive examination of the available structure information in the compound nucleus 19Ne. We have examined the latest experimental measurements with radioactive and stable beams, and made estimates of the unmeasured 19Ne nuclear level parameters, to generate new rates with uncertainties for these reactions. The rates are expressed as numerical values over the temperature range relevant for stellar explosions, as well as analytical expressions as functions of temperature in a format suitable for use in astrophysical simulations. Comparisons with the previous rate calculations are carried out, and the astrophysical implications are briefly discussed.

关键词： Gamma rays

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Antagonism of Transcription Factor MYC2 by EdS1/PAd4 Complexes Bolsters Salicylic Acid defense in Arabidopsis Effector-Triggered Immunity

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Molecular Plant 2018年第8期11卷 1053-1066页

作者： Haitao Cui Jingde Qiu Yue Zhou deepak d. Bhandari Chunhui Zhao Jaqueline Bautor Jane E. parker department of Plant-Microbe Interactions Max-Planck Institute for Plant Breeding Research Carl-von-Linne Weg 10 50829 Cologne Germany department of Plant developmental Biology Max-Planck Institute for Plant Breeding Research 50829 Cologne Germany Key Laboratory of Ministry of Education for Genetics Breeding and Multiple Utilization of Crops Plant Immunity Center Fujian Agriculture University Fuzhou 350002 China These authors contributed equaily to this article.

In plant immunity, pathogen-activated intracellular nucleotide binding/leucine rich repeat （NLR） receptors mobilize disease resistance pathways, but the downstream signaling mechanisms remain obscure. Enhanced disease susceptibility 1 （EdS1） controls transcriptional reprogramming in resistance triggered by Toll-lnterleukinl-Receptor domain （TIR）-family NLRs （TNLs）. Transcriptional induction of the salicylic acid （SA） hormone defense sector provides one crucial barrier against biotrophic pathogens. Here, we present genetic and molecular evidence that in Arabidopsis an EdS1 complex with its partner PAd4 inhibits MYC2, a master regulator of SA-antagonizing jasmonic acid （JA） hormone pathways. In the TNL immune response, EdSl/PAd4 interference with MYC2 boosts the SA defense sector independently of EdS1-induced SA synthesis, thereby effectively blocking actions of a potent bacterial JA mimic, coronatine （COR）. We show that antagonism of MYC2 occurs after COR has been sensed inside the nucleus but before or coincident with MYC2 binding to a target promoter, pANAC019. The stable interaction of PAd4 with MYC2 in planta is competed by EdS1-PAd4 complexes. However, suppression of MYC2-promoted genes requires EdS1 together with PAd4, pointing to an essential EdS1-PAd4 heterodimer activity in MYC2 inhibition. Taken together, these results uncover an immune receptor signaling circuit that intersects with hormone pathway crosstalk to reduce bacterial pathogen growth.

关键词： NLR receptor stress hormone network Pseudomonas syringae AvrRps4 RRS1/RPS4 coi1

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