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Comorbidities between tuberculosis and common mental disorders:a scoping review of epidemiological patterns and person-centred care interventions from low-to-middle income and BRICs countries

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Infectious Diseases of Poverty 2020年第1期9卷 95-95页

作者： AndréJanse Van Rensburg Audry Dube Robyn Curran Fentie Ambaw Jamie Murdoch Max Bachmann Inge petersen Lara Fairall Centre for Rural Health School of Nursing and Public HealthUniversity of KwaZulu-Natal Howard CollegeBereaDurbanSouth Africa 不详

Background:There is increasing evidence that the substantial global burden of disease for tuberculosis unfolds in concert with dimensions of common mental ***-centred care holds much promise to ameliorate these comorbidities in low-to-middle income countries(LMICs)and emerging *** this end,this paper aims to review 1)the nature and extent of tuberculosis and common mental disorder comorbidity and 2)person-centred tuberculosis care in low-to-middle income countries and emerging *** text:A scoping review of 100 articles was conducted of English-language studies published from 2000 to 2019 in peer-reviewed and grey literature,using established guidelines,for each of the study *** broad tuberculosis/mental disorder comorbidities were described in the literature,namely alcohol use and tuberculosis,depression and tuberculosis,anxiety and tuberculosis,and general mental health and *** of comorbidity varied widely across countries for depression,anxiety,alcohol use and general mental *** use and tuberculosis were significantly related,especially in the context of *** initial tuberculosis diagnostic episode had substantial sociopsychological effects on service *** men tended to report higher rates of alcohol use and treatment default,women in general had worse mental health *** age and a history of mental illness were also associated with pronounced tuberculosis and mental disorder ***-centred tuberculosis care interventions were almost absent,with only one study from Nepal ***:There is an emerging body of evidence describing the nature and extent of tuberculosis and mental disorders comorbidity in low-to-middle income *** the potential of person-centred interventions,evidence is *** review highlights a pronounced need to address psychosocial comorbidities with tuberculosis in LMICs,where models of person-centred tube

关键词： Tuberculosis Mental disorder Comorbidity Person-centred care Low-to-middle income countries BRICs

左室致密化不全:来自心血管磁共振成像的启示

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世界核心医学期刊文摘（心脏病学分册） 2005年第11期1卷 50-51页

作者： petersen s. E. selvanayagam J. B. Wiesmann F. s. Neubauer 李天霞 University of Oxford Centre for Clinical Magnetic Resonance Research University Department of Cardiovascular Medicine John Radcliffe Hospital Oxford OX3 9DU United Kingdom Dr.

OBJECTIVEs: We aimed to test the diagnostic accuracy of cardiovascular magnetic resonance(CMR) imaging in distinguishing pathological left ventricular non-compaction(LVNC) from lesser degrees of trabecular layering seen in healthy volunteers and, in those with cardiomyopathies and concentric left ventricular hypertrophy, potential differential diagnoses. We hypothesized that pathological trabeculation could be distinguished by determining the ratio of non-compacted to compacted myocardium(NC/C ratio). BACKGROUND: Left ventricular non-compaction is characterized by a non-compacted myocardial layer in the left ventricle. Cardiovascular magnetic resonance images this layer with unprecedented quality, particularly in the ventricular apex, where echocardiography has inherent difficulties. METHODs: We analyzed magnetic resonance cine images, using the 17-segment model in 45 healthy volunteers, 25 athletes, 39 patients with hypertrophic cardiomyopathy and 14 with dilated cardiomyopathy, 17 with hypertensive heart disease, and 30 with aortic stenosis, as well as images from 7 patients previously diagnosed with LVNC whose diagnoses were supported by additional features. REsULTs: Areas of non-compaction were common and occurred more frequently in all groups studied in apical and lateral, rather than in basal or septal, segments. A NC/C ratio of >2.3 in diastole distinguished pathological non-compaction, with values for sensitivity, specificity, and positive and negative predictions of 86%, 99%, 75%, and 99%, respectively. CONCLUsIONs: Left ventricular non-compaction is diagnosed accurately with CMR using the NC/C ratio in diastole.

关键词：磁共振成像心肌病患者超声心动图肥厚性心肌病鉴别诊断主动脉狭窄心尖部心脏舒张期左心室心肌层

sortilins in the blood-brain barrier:impact on barrier integrity

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Neural Regeneration Research 2023年第3期18卷 549-550页

作者： Andrea E.Toth Morten s.Nielsen Department of Biomedicine Faculty of HealthAarhus UniversityAarhusDenmark

sortilin was discovered in 1997 by petersen and his *** single transmembrane receptor was isolated as a 95 kDa membrane glycoprotein by receptor-associated protein affinity chromatography and therefore initially named *** cDNA library screening revealed sequence homology between the luminal segment of gp95/sortilin and the yeast vacuolar sorting protein 10 protein(Vps10p)domain(petersen et al.,1997).The Vps10p domain was first identified in the saccharomyces cerevisiae protein Vps10p that directs lysosomal enzymes from the Golgi to the vacuole(Marcusson et al.,1994).

关键词： al. petersen sortilin

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用离子色谱技术分析污泥中的硫酸盐

国外农业环境保护 1992年第2期 40-41页

作者： soren P. petersen 赵晨曦

前言硫酸盐经常存在于城市废水和工业废水中。由于各种原因,在废水的厌氧处理中,高浓度硫酸盐的存在是令人讨厌的。这是因为硫酸盐还原细菌会把硫酸盐转化为硫化物产生大量的H_2s。H_2s是一种潜在的有毒化合物,它会给厌氧过程带来麻烦... 详细信息

前言硫酸盐经常存在于城市废水和工业废水中。由于各种原因,在废水的厌氧处理中,高浓度硫酸盐的存在是令人讨厌的。这是因为硫酸盐还原细菌会把硫酸盐转化为硫化物产生大量的H_2s。H_2s是一种潜在的有毒化合物,它会给厌氧过程带来麻烦。在厌氧处理体系中,硫酸盐浓度和微生物硫酸盐还原率的测定对于控制令人讨厌的微生物活动产物H_2s,具有重要意义。

关键词：污泥硫酸盐离子色谱色谱法

1,2,3,4-四苯基丁二烯二环戊二烯铌的合成和顺磁共振研究

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高等学校化学学报 1984年第4期5卷 451-456页

作者：刘举正郭用猷 petersen J.L. 吉林大学理论化学研究所吉林大学化学系美国West Virginia大学化学系

合成1,2,3,4-四苯基丁二烯二环戊二烯妮(Ⅳ)金属环化合物.测定它的甲苯溶液和玻璃态固体多晶EPR波谱.由计算机模拟分析得到各向异性EPR参数:g_(x)=1.9915,g_(y)=2.0017,g_(z)=2.0005;T_(x)=-69.5G,T_(y)=-103.2G,T_(2)=-18.0G和最高占... 详细信息

关键词：二环戊二烯玻璃态丁二烯计算机模拟分析顺磁共振混合系数甲苯溶液分子轨道

网状Meta分析结论形成的方法:部分背景化框架

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中国循证医学杂志 2021年第9期21卷 1110-1116页

作者：朱鸿飞栗梦婷后亮瑛王琪田金徽陈耀龙杨克虎邓宏勇曾力楠张伶俐 Romina Brignardello-petersen 葛龙兰州大学公共卫生学院社会医学与卫生事业管理研究所兰州730000 兰州大学公共卫生学院循证社会科学研究中心兰州730000 兰州大学基础医学院循证医学中心兰州730000 甘肃省循证医学与临床转化重点实验室兰州730000 兰州大学健康数据科学研究院兰州730000 世界卫生组织指南实施与知识转化合作中心兰州730000 GRADE中国中心兰州730000 上海中医药大学中医健康协同创新中心上海201203 四川大学华西第二医院药学部成都610041 四川大学华西第二医院循证药学中心成都610041 出生缺陷与相关妇儿疾病教育部重点实验室成都610041 麦克马斯特大学卫生研究方法、证据和影响力系加拿大汉密尔顿L8S4L8

目前网状Meta分析已得到飞速发展和广泛应用,具有可量化比较相同主题的2种以上不同处理措施的相对优势的特点。但由于存在多个干预措施的比较,增加了其结果解读的复杂性,解读时对证据可信度的忽略也导致了结论存在误导性。近期,GRADE工... 详细信息

目前网状Meta分析已得到飞速发展和广泛应用,具有可量化比较相同主题的2种以上不同处理措施的相对优势的特点。但由于存在多个干预措施的比较,增加了其结果解读的复杂性,解读时对证据可信度的忽略也导致了结论存在误导性。近期,GRADE工作组提出了2种网状Meta分析结论形成的方法,即部分背景化框架与最小背景化框架。本文聚焦于部分背景化框架,当使用该框架时,作者必须确定效应阈值,以区分无效、较小效应、中等效应和较大效应。部分背景化框架的指导原则包括根据效应大小与利弊对干预措施进行分类,及分类时考虑效应的点估计值和干预措施排序,综合考虑证据可信度(证据质量)以得出结论。本文结合实例,对部分背景化框架的原理步骤进行描述和阐释,以期为该方法在网状Meta分析结果解读与结论形成环节的应用提供指导。

关键词：网状Meta分析 GRADE方法结论形成方法证据可信度部分背景化框架

网状Meta分析结论形成的方法:最小背景化框架

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中国循证医学杂志 2021年第9期21卷 1102-1109页

作者：栗梦婷朱鸿飞后亮瑛王琪田金徽陈耀龙杨克虎邓宏勇曾力楠张伶俐 Romina Brignardello-petersen 葛龙兰州大学公共卫生学院社会医学与卫生事业管理研究所兰州730000 兰州大学公共卫生学院循证社会科学研究中心兰州730000 兰州大学基础医学院循证医学中心兰州730000 甘肃省循证医学与临床转化重点实验室兰州730000 兰州大学健康数据科学研究院兰州730000 世界卫生组织指南实施与知识转化合作中心兰州730000 GRADE中国中心兰州730000 上海中医药大学中医健康协同创新中心上海201203 四川大学华西第二医院药学部成都610041 四川大学华西第二医院循证药学中心成都610041 出生缺陷与相关妇儿疾病教育部重点实验室成都610041 麦克马斯特大学卫生研究方法、证据和影响力系加拿大汉密尔顿L8S4L8

网状Meta分析的最大优势在于可量化比较针对同一疾病的不同干预措施,并按某一指标对其优劣进行排序。多种干预措施的纳入增加了网状Meta分析结果解读的复杂性,仅基于排序结果进行解读可能会存在误导性。目前,对网状Meta分析结果的解读... 详细信息

网状Meta分析的最大优势在于可量化比较针对同一疾病的不同干预措施,并按某一指标对其优劣进行排序。多种干预措施的纳入增加了网状Meta分析结果解读的复杂性,仅基于排序结果进行解读可能会存在误导性。目前,对网状Meta分析结果的解读尚无公认的标准。2020年11月,GRADE工作组基于网状Meta分析的GRADE分级结果,提出了2种网状Meta分析结论形成的方法:部分背景化框架(partially contextualised framework)和最小背景化框架(minimally contextualised framework)。本文结合具体实例,旨在对最小背景化框架的方法、原理和步骤进行介绍,以期为网状Meta分析制作者采用该方法呈现和解读结果提供指导。

关键词：网状Meta分析 GRADE方法结果呈现最小背景化框架

Occurrence of Nanobacteria-Like Particles in Renal stones of a southern Brazilian Population

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Open Journal of Urology 2012年第1期2卷 1-5页

作者： Amauri Braga simonetti Carlos Teodósio Da Ros Cintia de David Karen Campos Paulo Renato petersen Behar Eduardo Ribeiro Gelsa Edith Navarro Hidalgo Center of Andrology and Urology Porto Alegre Brazil

Purpose: Identifying the source of stone formation in recurrent stone formers has always been a big problem. Material and Methods: In this study kidney stones from 52 patients were submitted to direct examination by scanning electronic microscopy (sEM) after manual fracture and 27 calculi were cultured in Eagle’s Minimum Essential Medium (E-MEM) and Brain-Heart Infusion (BHI) for eight weeks at 37°C in 5% CO2 atmosphere. Twenty-seven powdered and demineralized stones were suspended in sterile PBs, filtered through 0.22 m-pore-size sterile filters Millex (Millipore, Massachusetts, UsA) and submitted to DNA extraction (Quiagen-Brazil). Platinum PCR superMIX (GIBCO-BRL), primers (Invitrogen), and Ultra Pure Water (Advanced Biotechnologies, Columbia, MD) were used for PCR (Polymerase Chain Reaction), which was generally conducted for 30 or 35 cycles with annealing of primers for 40 sec at 55°C and extension for 1 min at 72°C. Results: In 36 out 52 (69%) kidney stones it was detected the presence of biofilm coating the mineral surface of the stone when examined by sEM, consisting of coccoid particles, isolated or clustered, with diameter of 500 nm or less. Eleven out 27 (41%) kidney stone cultures produced white-colored sediment on the bottom of the tubes after eight-week incubation, revealing tiny structures similar to those observed directly by sEM. These structures were similar in size and morphology to spherical apatite particles previously observed in human kidney stones and named as nanobacteria (NB). No PCR products were observed in the samples. Conclusion: We found a strong correlation between renal stones and calcifying nanoparticles (CNP) in this study and these results open a new insight on this area to explore the etiology of stone formation. Whether NB/CNP are truly microorganisms or self-propagating mineral compounds is still controversial and its contribution, if any, in apatite nucleation and crystal growth remains uncertain.

关键词： Nanobacteria Calcifying Nanoparticles Renal stone

原发良性心脏肿块与肿瘤样病变的对比剂增强首过MR灌注成像的初步研究

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国际医学放射学杂志 2008年第5期31卷 418-419页

作者： O.K.Mohrs T.Voigtlaender s.E.petersen M.Zander T.schulze A.Pottmeyer 唐光健 Department of Cardiovascular Imaging at A lice -Hospital Darmstadt Radiology Dieburger Strasse 29-31 64287 Darmstadt Germany.

本研究的目的是评价怀疑心脏肿块与肿瘤样病变的对比剂增强首过MR灌注成像的诊断价值。20例病人在临床MRI检查后接受了对比剂增强首过饱和一恢复稳态一自由一动脉MR灌注成像扫描。3位阅片人以盲法在意见一致的条件下分析11个诊断数据：... 详细信息

本研究的目的是评价怀疑心脏肿块与肿瘤样病变的对比剂增强首过MR灌注成像的诊断价值。20例病人在临床MRI检查后接受了对比剂增强首过饱和一恢复稳态一自由一动脉MR灌注成像扫描。3位阅片人以盲法在意见一致的条件下分析11个诊断数据：部位（心包／心壁／心腔内），良恶性（良性／恶性）与首过强化形式（均匀／不均匀以及无灌注，低灌注／等灌注／高灌注）。结果与综合参考相对照，包括组织学、

关键词： MRI 心脏肿块肿瘤样病变灌注