检索结果-南通市图书馆

Incretin based therapies:A novel treatment approach for non-alcoholic fatty liver disease

World Journal of Gastroenterology 2014年第23期20卷 7356-7365页

作者： kristina blaslov Tomislav Bulum Karin Zibar Lea Duvnjak Vuk Vrhovac Clinic for Diabetes Endocrinology and Metabolic DiseasesUniversity Hospital MerkurSchool of MedicineUniversity of Zagreb10000 ZagrebCroatia

Non-alcoholic fatty liver disease is considered a hepatic manifestation of metabolic syndrome(MS).The current treatment of non-alcoholic fatty liver disease(NAFLD)principally includes amelioration of MS components by lifestyle modifications but the lack of success in their implementation and sustainment arises the need for effective pharmacological agent in fatty liver *** are gut derived hormones secreted into the circulation in response to nutrient ingestion that enhances glucose-stimulated insulin ***-like peptide-1(GLP-1)is the most important *** receptor agonist and inhibitors of dipeptidyl peptidase-4(DPP-4)are used in treatment of type2 diabetes ***-4 serum activity and hepatic expression are shown to be elevated in several hepatic *** are several experimental and clinical trials exploring the efficacy of incretin based therapies in NAFLD *** suggest that GLP-1 analogues might have beneficial effect on hepatic steatosis acting as insulin sensitizers and directly by stimulating GLP-1 receptors expressed on *** use of DPP-4 inhibitors also results in hepatic fat reduction but the mechanism of action remains *** is growing evidence that incretin based therapies have beneficial effects on hepatocytes,however further study analysis are needed to assess the long term effect of incretin based therapies on NAFLD.

关键词： Non-alcoholic fatty liver disease Insulin resistance Glucagon-like peptide-1 Dipeptidyl peptidase-4 Metabolic syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Treatment approach to type 2 diabetes:Past,present and future

引用

World Journal of Diabetes 2018年第12期9卷 209-219页

作者： kristina blaslov Fran Stjepan Naranda Ivan Kruljac Ivana Pavlic Renar Department of Endocrinology Diabetes and Metabolic Diseases Mladen SeksoUniversity Hospital Center Sestre MilosrdniceZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia

Type 2 diabetes mellitus(DM) is a lifelong metabolic disease, characterized by hyperglycaemia which gradually leads to the development and progression of vascular complications. It is recognized as a global burden disease, with substantial consequences on human health(fatality) as well as on health-care system costs. This review focuses on the topic of historical discovery and understanding the complexity of the disease in the field of pathophysiology, as well as development of the pharmacotherapy beyond insulin. The complex interplay of insulin secretion and insulin resistance developed from previously known "ominous triumvirate" to "ominous octet" indicate the implication of multiple organs in glucose metabolism. The pharmacological approach has progressed from biguanides to a wide spectrum of medications that seem to provide a beneficial effect on the cardiovascular system. Despite this, we are still not achieving the target treatment goals. Thus, the future should bring novel antidiabetic drug classes capable of acting on several levels simultaneously. In conclusion, given the raising burden of type 2 DM, the best present strategy that could contribute the most to the reduction of morbidity and mortality should be focused on primary prevention.

关键词： Type 2 diabetes mellitus Physical activity Hyperglycaemia Insulin resistance Hypoglycaemic agents

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of creatinine methodology on glomerular filtration rate estimation in diabetes

引用

World Journal of Diabetes 2017年第5期8卷 222-229页

作者： Marijana Vucic Lovrencic Vanja Radisic Biljak kristina blaslov Sandra Bozicevic Lea Smircic Duvnjak Department of Laboratory Medicine Merkur University Hospital Vuk Vrhovac University Clinic Merkur University Hospital

AIM To evaluate the influence of creatinine methodology on the performance of chronic kidney disease(CKD)-Epidemiology Collaboration Group-calculated estimated glomerular filtration rate(CKD-EPI-eGFR) for CKD diagnosis/staging in a large cohort of diabetic patients. METHODS Fasting blood samples were taken from diabetic patients attending our clinic for their regular annual examination, including laboratory measurement of serum creatinine and *** Our results indicated an overall excellent agreement in CKD staging(kappa = 0.918) between the Jaffé serum creatinine-and enzymatic serum creatinine-based CKDEPI-eGFR, with 9% of discordant cases. As compared to the enzymatic creatinine, the majority of discordances(8%) were positive, i.e., associated with the more advanced CKD stage re-classification, whereas only 1% of cases were negatively discordant if Jaffé creatinine was used for eGFR calculation. A minor proportion of the discordant cases(3.5%) were re-classified into clinically relevant CKD stage indicating mildly to moderately decreased kidney function(< 60 m L/min per 1.73 m^2). Significant acute and chronic hyperglycaemia, assessedas plasma glucose and Hb A1 c levels far above the recommended glycaemic goals, was associated with positively discordant cases. Due to a very low frequency, positive discordance is not likely to present a great burden for the health-care providers, while intensified medical care may actually be beneficial for the small number of discordant patients. On the other hand, a very low proportion of negatively discordant cases(1%) at the 60 m L/min per 1.73 m^2 eGFR level indicate a negligible possibility to miss the CKD diagnosis, which could be the most prominent clinical problem affecting patient care, considering high risk of CKD for adverse patient outcomes. CONCLUSION This study indicate that compensated Jaffé creatinine procedure, in spite of the glucose-dependent bias, is not inferior to enzymatic creatinine in CKD diagnosis/

关键词： Diabetes Estimated glomerular filtration rate Chronic kidney disease-Epidemiology Collaboration Group Creatinine Enzymatic method Chronic kidney disease Impact Compensated Jaffé method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：