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A clinically relevant combination treatment with doxorubicin and cyclophosphamide does not induce hepatotoxicity in C57BL/6J mice

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Liver Research 2021年第4期5卷 239-242页

作者： Satyanarayana R Pondugula Julia M Salamat Kodye L Abbott Patrick C Flannery Mohammed Majrashi Mohammed Almaghrabi Manoj Govindarajulu Sindhu Ramesh Maninder Sandey Suneel K Onterue Chen-Che J Huang Yoshimi Iwaki kristina gill Natasha Narayanan Edwin McElroy Darshini Desai Rishi Nadar Timothy Moore Muralikrishnan Dhanasekaran Department of Anatomy Physiology and PharmacologyCollege of Veterinary MedicineAuburn UniversityAuburnALUSA Department of Pharmacology Faculty of MedicineUniversity of JeddahJeddahSaudi Arabia Department of Drug Discovery and Development Harrison School of PharmacyAuburn UniversityAuburnALUSA Department of Pathobiology College of Veterinary MedicineAuburn UniversityAuburnALUSA Animal Biochemistry Division National Dairy Research InstituteICAR-National Dairy Research InstituteKarnalHaryanaIndia Department of Clinical Science College of Veterinary MedicineAuburn UniversityAuburnALUSA

Background and aims:Chronic exposure to chemotherapeutics can lead to severe adverse events including hepatotoxicity.A combination chemotherapy regimen of doxorubicin(DOX)and cyclophos-phamide(CPS)is employed in treatment of several cancers such as leukemia,lymphoma,and breast *** is not well understood whether a combination therapy with DOX and CPS can induce *** therefore sought to determine whether co-administration of DOX and CPS at their clini-cally relevant doses and frequency results in ***:Male C57BL/6J mice received one intraperitoneal injection of saline or DOX-2 mg/kg and CPS-50 mg/kg once a week for 4 *** the treatment period,liver histology and various serum bio-markers of hepatotoxicity were ***:Co-treatment with DOX and CPS did not alter the serum levels of alanine aminotransferase(ALT),alkaline phosphatase(ALP),bilirubin,albumin,globulin,or total ***,co-administration of DOX and CPS did not result in a noticeable change in liver ***,it was notable that the concomitant treatment with DOX and CPS resulted in a significant increase in serum levels of aspartate aminotransferase(AST).Elevated serum AST levels were also associated with increased serum creatinine kinase(CK)levels,suggesting that the elevated serum AST levels are likely due to muscle injury following the co-administration of DOX and ***:Taken together,our results,for the first time,suggest that co-administration of DOX and CPS,at their clinically relevant doses and frequency does not induce a significant hepatotoxicity in the mice.

关键词： Cyclophosphamide(CPS) Doxorubicin(DOX) Hepatotoxicity Liver injury Muscle injury

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Rethinking Enterprise Architecture for Sustainable Energy System Development

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Journal of Electronic Science and Technology 2015年第3期13卷 212-220页

作者： Jovita Vasauskaite Asif Qumer gill Kaunas University of Technology University of Technology Sydney

The development of a sustainable energy system throughout an enterprise is a complex task, which requires an agile holistic approach. Such an approach needs to include a variety of objectives including energy strategy formation and strategic decision-making, which are directly related to the analysis and management of the main areas of sustainable development： The economic, technological, environmental, and social. These multidimensional requirements of sustainability are often difficult to achieve within the enterprise, because these aspects are interrelated and influenced by various internal and external environment factors. This paper first reviews the main challenges for an energy system, and then demonstrates how a strategic agile enterprise architecture driven approach could effectively guide the sustainable energy system development. The study presented in this paper provides a holistic approach that contributes to the advancement and usage of literature dealing with issues of sustainable energy system development and agile enterprise architecture, which has not been discussed before to any great extent.

关键词： Development energy system,enterprise architecture industry sustainability.

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Study of obliquely propagating electron acoustic shock waves with non-extensive electron population

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Plasma Science and Technology 2019年第1期21卷 29-35页

作者： Sona BANSAL Munish AGGARWAL Tarsem S gill Sikh National College Research Scholar I K Gujral Punjab Technical University Department of Applied Science Lyallpur Khalsa College of Engineering Department of Physics Guru Nanak Dev University

Obliquely propagating electron acoustic shock waves in magnetized plasma composed of stationary ions, cold and non-extensive hot electrons are investigated by deriving Korteweg–de Vries Burgers(KdVB) equation. The tangent hyperbolic method is used to solve the KdVB equation in dissipative medium. The dissipation effect is introduced in the model by means of kinematic viscosity term. The analytical calculations of the KdVB equation shows that the structures(amplitude, velocity and width) of the shock waves are modified significantly with kinematic viscosity(η_0), obliqueness(k_z) and magnetic field(ω_c). Since plasmas are ubiquitously permeated with magnetic field, it is pertinent to explore the characteristics of KdVB equation in a magnetized plasmas.

关键词： dissipative medium non-extensive electrons tangent hyperbolic method

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Enabling silicon photoanodes for efficient solar water splitting by electroless-deposited nickel

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Nano Research 2018年第6期11卷 3499-3508页

作者： Jiheng Zhao Thomas Mark gill Xiaolin Zheng Department of Mechanical Engineering Stanford University Stanford 9430S USA

Enabling Si photoanodes for efficient solar water oxidation would facilitate the development of solar fuel conversion, but it is challenging owing to Si surface passivation via photo-induced corrosion in aqueous electrolytes. To overcome this challenge, most approaches have focused on improving the stability of Si by coating dense and thin protective layers using high vacuum-based techniques such as atomic layer deposition. However, these procedures are costly, making scalability for practical applications difficult. Herein, we report a modified electroless deposition （ELD） method to uniformly deposit protective and catalytic Ni films on Si wafers, resulting in efficient and stable Si photoanodes for solar water oxidation. The optimized Ni/n-Si photoanode achieves an onset potential of -1.09 V vs. a reversible hydrogen electrode and a saturation current density of -27.5 mA/cm^2 under AM 1.5 G illumination at pH 14. The ELD method is additionally capable of Ni deposition on a 4-inch n-Si wafer, demonstrating the first 4-inch Si photoanode. The solar water oxidation of the ELD-Ni/n-Si photoanode can be further improved by surface texturing, built-in n-p junctions, or coupling with more efficient catalysts.

关键词： Ni deposition electroless plating Si photoanode oxygen evolution reaction (OER) photoelectrochemical water splitting

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Photophysical,optical,and photocatalytic hydrogen production properties of layered-type BaNb_(2-x)Ta_(x)P_(2)O_(11)(x=0,0.5,1.0,1.5,and 2.0)compounds

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Journal of Materials Science & Technology 2022年第3期98卷 26-32页

作者： Min Je Kang gill Sang Han In Sun Cho Department of Materials Science and Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Energy Systems Research Ajou UniversitySuwon 16499Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea

Layered-type metal phosphates of BaNb_(2-x)Ta_(x)P_(2)O_(11)(x=0,0.5,1.0,1.5,and 2.0)were synthesized using a solid-state reaction *** photophysical,optical,and photocatalytic hydrogen production properties of the resulting powders were investigated for the first ***-pure and homogeneous powders with irregular morphologies were obtained at a calcination temperature of 1200℃.As the Ta content increased,the interlayer distance along the c-axis increased by up to 0.14%.Additionally,the optical bandgap values increased from 3.32 to 3.59 *** energy band positions were estimated from the Mott–Schottky ***_(2)P_(2)O_(11)(x=0)exhibited the lowest conduction band edge position(-0.14 V *** normal hydrogen electrode,NHE),which is located above the water reduction potential(0.0 V ***).In comparison,BaTa_(2)P_(2)O_(11)(x=2.0)exhibited the highest conduction band edge position(-0.29 V ***),comparable to that of TiO_(2).The photocatalytic activity for hydrogen produced from splitting water was measured under ultraviolet light ***,BaTa_(2)P_(2)O_(11)exhibited the highest activity(7.3μmol/h),which was 15 and 10 times larger than BaNb_(2)P_(2)O_(11)(0.5μmol/h)and nano-TiO_(2)(0.7μmol/h),*** activity of BaTa_(2)P_(2)O_(11)increased to 24.4μmol/h after deposition of the NiO_(x)co-catalyst(1 wt.%),which remained stable during continuous operation(~35 h).

关键词： BaNb_(2)P_(2)O_(11) BaTa_(2)P_(2)O_(11) Layered crystal structure Bandgap Band edge positions Photocatalytic hydrogen production

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Campylobacterjejuni in Musca domestica： An examination of survival and transmission potential in light of the innate immune responses of the house flies

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Insect Science 2017年第4期24卷 584-598页

作者： Carson gill Simon Bahrndorff Carl Lowenberger Department of Biological Sciences Simon Fraser University 8888 University Drive Burnaby BC Canada National Food Institute Technical University of Denmark 2800 Kongens Lyngby Denmark

The house fly, Musca domestica, has been implicated as a vector of Campy- lobacter spp., a major cause of human disease. Little is known whether house flies serve as biological amplifying hosts or mechanical vectors for Campylobacterjejuni. We in- vestigated the period after C. jejuni had been ingested by house flies in which viable C. jejuni colonies could be isolated from whole bodies, the vomitus and the excreta of adult M. domestica and evaluated the activation of innate immune responses of house flies to ingested C. jejuni over time. C. jejuni could be cultured from infected houseflies soon after ingestion but no countable C. jejuni colonies were observed 〉 24 h postingestion. We detected viable C. jejuni in house fly vomitus and excreta up to 4 h after ingestion, but no viable bacteria were detected 〉 8 h. Suppression subtractive hybridization identi- fied pathogen-induced gene expression in the intestinal tracts of adult house flies 4-24 h after ingesting C. jejuni. We measured the expression of immune regulatory （thor, JNK, and spheroide） and effector （cecropin, diptericin, attacin, defensing, and lysozyme） genes in C. jejuni-infected and -uninfected house flies using quantitative real time PCR. Some house fly factor, or combination of factors, eliminates C. jejuni within 24 h postingestion. Because C. jejuni is not amplified within the body of the housefly, this insect likely serves as a mechanical vector rather than as a true biological, amplifying vector for C. jejuni, and adds to our understanding of insect pathogen interactions.

关键词： antimicrobial peptides Campylobacter spp. Campylobacteriosis house fly innate immunity Musca domestica suppression subtractive hybridization (SSH) vector

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The development of spatial decision support system tool for marine spatial planning

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International Journal of Digital Earth 2018年第9期11卷 863-879页

作者： Dewayany Sutrisno Suzan Novtalia gill Suseno Suseno Center for Research Promotion and CooperationGeospatial Information Agency(BIG)CibinongIndonesia Center for Institutional Standardization of Geospastial Information Geospatial Information Agency(BIG)CibinongIndonesia Center for Management and Dissemination of Geospatial Information Geospatial Information Agency(BIG)CibinongIndonesia

A major problem associated with marine spatial planning(MSP)involves the difficult and time-consuming practice of creating a scenario that encompasses complex datasets in near real time via the use of a simple spatial analysis ***,decision-makers require a reliable,user-friendly system to quickly and accessibly acquire accurate spatial planning *** development of national spatial data infrastructure(NSDI),which links the spatial data of a nation’s many diverse institutions,may pave the way for the development of a tool that can better utilize spatial datasets,such as a spatial decision support system(SDSS).Thus,this project aimed to develop an SDSS for MSP and to evaluate the feasibility of its integration within the NSDI *** seaweed culture was selected as an example due to its economic and technological acceptance by traditional ***,a multicriteria analysis was used to develop the ***,a feasibility evaluation of its implementation within the NSDI framework was conducted based on the Delphi *** results of the assessment indicated that the SDSS can be incorporated into the NSDI framework by addressing the policy issue–one map policy,updating custodians’decree and data,and improve the standard and protocol.

关键词： Spatial data infrastructure spatial decision support system marine spatial planning seaweed culture

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Fragility assessment of wood sheathing panels and roof-to-wall connections subjected to wind loading

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Frontiers of Structural and Civil Engineering 2021年第4期15卷 867-876页

作者： Amira gill Aikaterini S.GENIKOMSOU Georgios P.BALOMENOS Department of Civil Engineering Queen’s UniversityKingstonK7L 3N9Canada Department of Civil Engineering McMaster UniversityHamiltonL8S 4L7Canada

The performance of the wood-frame buildings after tornadoes has shown that the majority of the wind damage resulted from building envelope failure most typically due to the loss of the *** assess the performance and the reliability of low-rise wood-frame residential buildings with a focus on the roofs,fragility analysis can be used to estimate the probability of failure of a roof when constructed with specified nails and sheathing ***,this paper examines the fragility of specific types of nails,roof-to-wall(RW)connection details,and sheathing sizes based on the damaged roofs that were previously assessed in the Dunrobin area in Ottawa(Ontario)that was hit with an Enhanced Fujita(EF3)tornado on September 21,*** presented fragility analysis considers four scenarios,including different sheathing and nail *** loads,wind loads,and resistance on the sheathing panels were compiled and analyzed to determine the failure of the examined *** eight fragility models suggest that the safest roof sheathing(RS)is the 1.22 m×1.22 m sheathing panel with 8 d nails,and the safest RW connections is achieved by using H2.5 hurricane clips.

关键词： tornadoes wind loads low-rise buildings fragility analysis risk assessment structural failures

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Computational-Analysis of the Non-Isothermal Dynamics of the Gravity-Driven Flow of Viscoelastic-Fluid-Based Nanofluids Down an Inclined Plane

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Fluid Dynamics & Materials Processing 2023年第3期19卷 767-781页

作者： Idrees Khan Tiri Chinyoka Andrew gill Centre for Research in Computational&Applied Mechanics University of Cape TownRondebosch7701South Africa Department of Mathematics and Applied Mathematics University of Cape TownRondebosch7701South Africa Centre for High Performance and Computing Council for Scientific and Industrial ResearchRosebankCape Town7700South Africa

The paper explores the gravity-driven flow of the thin film of a viscoelastic-fluid-based nanofluids(VFBN)along an inclined plane under non-isothermal conditions and subjected to convective cooling at the *** Newton’s law of cooling is used to model the convective heat-exchange with the ambient at the *** Giesekus viscoelastic constitutive model,with appropriate modifications to account for non-isothermal effects,is employed to describe the polymeric *** unsteady and coupled non-linear partial differential equations(PDEs)describing the model problem are obtained and solved via efficient semi-implicit numerical schemes based on finite difference methods(FDM)implemented in *** response of the VFBN velocity,temperature,thermal-conductivity and polymeric-stresses to variations in the volume-fraction of embedded nanoparticles is *** is shown that these quantities all increase as the nanoparticle volume-fraction becomes higher.

关键词： Semi-implicit numerical scheme finite difference methods viscoelastic-fluid-based nanofluid(VFBN) nonisothermal viscoelastic flow giesekus constitutive model nanofluid thermal-conductivity gravity-driven flow

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Seasonal Prediction Skill and Biases in GloSea5 Relating to the East Asia Winter Monsoon

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Advances in Atmospheric Sciences 2023年第11期40卷 2013-2028页

作者： Daquan ZHANG Lijuan CHEN gill MMARTIN Zongjian KE China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science&TechnologyNanjing 210044China Met Office Hadley Centre Met OfficeExeter EX13PBUK

The simulation and prediction of the climatology and interannual variability of the East Asia winter monsoon(EAWM),as well as the associated atmospheric circulation,was investigated using the hindcast data from Global Seasonal Forecast System version 5(GloSea5),with a focus on the evolution of model bias among different forecast lead *** GloSea5 reproduces the climatological means of large-scale circulation systems related to the EAWM well,systematic biases exist,including a cold bias for most of China’s mainland,especially for North and Northeast ***5 shows robust skill in predicting the EAWM intensity index two months ahead,which can be attributed to the performance in representing the leading modes of surface air temperature and associated background ***5 realistically reproduces the synergistic effect of El Niño–Southern Oscillation(ENSO)and the Arctic Oscillation(AO)on the EAWM,especially for the western North Pacific anticyclone(WNPAC).Compared with the North Pacific and North America,the representation of circulation anomalies over Eurasia is poor,especially for sea level pressure(SLP),which limits the prediction skill for surface air temperature over East *** representation of SLP anomalies might be associated with the model performance in simulating the interaction between atmospheric circulations and underlying surface conditions.

关键词： East Asia winter monsoon(EAWM) Global Seasonal Forecast System version 5(GloSea5) El Niño–Southern Oscillation(ENSO) prediction skill model bias

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