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In vitro performance and in vivo fertility of antibiotic-free preserved boar semen stored at 5℃

Journal of Animal Science and Biotechnology 2021年第1期12卷 250-261页

作者： Helen Jäkel Kathi Scheinpflug kristin mühldorfer Rafael Gianluppi matheus Schardong Lucca Ana Paula Gonçalves mellagi Fernando Pandolfo Bortolozzo Dagmar Waberski Unit of Reproductive medicine of the Clinics/Clinic for Pigs and Small Ruminants University of Veterinary Medicine HannoverBünteweg 1530559 HannoverGermany Department of Wildlife Diseases Leibniz Institute for Zoo and Wildlife ResearchAlfred-Kowalke-Straße 1710315 BerlinGermany Animal Science Department Swine SectorFederal University of Rio Grande do SulAvenida Bento Gonçalves9090Porto Alegre 91540-000Brazil.

Background: Hypothermic preservation of boar semen is considered a potential method for omitting antibiotics from insemination doses, thereby contributing to the global antibiotic resistance defence strategy. The main challenges are chilling injury to spermatozoa and bacterial growth during semen storage leading to reduced ***: To examine chilling injury and the number and type of bacteria in boar semen stored at 5 ℃ in the absence of antibiotics, and to assess the applicability of hypothermic semen storage under field *** and methods: Boar ejaculates were extended with AndroStar~? Premium, stored at 17 ℃ with and at 5 ℃ without antibiotics and tested for functional sperm parameters by flow cytometry. Raw semen and extended samples were investigated bacteriologically. Fertility was evaluated after once-daily inseminations of 194 sows in a field ***: Lethal sperm damage assessed by motility and membrane integrity was low throughout storage in both experimental groups. Sublethal chilling effects based on the decrease of viable spermatozoa with low membrane fluidity were higher(P m stored at 5 ℃ compared to 17 ℃ but did not differ after 144 *** 72 h, incubation in capacitating medium for 60 min induced a similar decrease in viable sperm with high mitochondria membrane potential and low cytosolic calcium in both groups. In semen stored at 5 ℃, bacteria counts were below 103 CFU/mL and the bacteria spectrum was similar to that of raw semen. In 88% of 34 boars,cooled semen fulfilled the requirements for insemination. Fertility was high and did not differ(P > 0.05) between sow groups inseminated with semen stored antibiotic-free at 5 ℃ and semen stored at 17 ℃ with ***: Despite subtle chilling effects and low bacterial numbers, antibiotic-free hypothermic storage of boar semen offers the possibility to reduce the use of antibiotics in pig insemination. However, strict sanitary gu

关键词： Antibiotics Bacteria Boar semen Chilling Fertility Semen preservation

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Ambroxol,the cough expectorant with neuroprotective effects

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Neural Regeneration Research 2024年第11期19卷 2345-2346页

作者： kristin Patzwaldt Salvador Castaneda-Vega Werner Siemens Imaging Center Department of Preclinical Imaging and RadiopharmacyEberhard Karls University TuebingenTuebingenGermany Department of Nuclear medicine and Clinical molecular Imaging University Clinic TuebingenTuebingenGermany

Ambroxol hydrochloride(2-amino-3,5-dibromo-N-methylbenzylamine hydrochloride)has been used as a mucolytic agent in the treatment of respiratory diseases since the late *** effects on mucus membranes such as mucus disruption,increased mucus production,and low toxicity profile were addressed in its original German patent in *** first described properties have kept Ambroxol available worldwide and over the counter in the pharmaceutical market to this day.

关键词： protective agent German

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Analytical evaluation of steady-state solute distribution in through- diffusion and membrane behavior test under non-perfectly flushing boundary conditions

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Journal of Rock mechanics and Geotechnical Engineering 2024年第1期16卷 258-267页

作者： Guannian Chen Yuchao Li kristin mSample-Lord Shan Tong School of Civil&Environmental Engineering and Geography Science Ningbo UniversityNingbo315211China mOE Key Laboratory of Soft Soils and Geoenvironmental Engineering College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou310058China Ningbo ZCONE High-tech Company Limited Ningbo315000China Department of Civil and Environmental Engineering Villanova UniversityVillanovaPAUSA

The through-diffusion and membrane behavior testing procedure using a closed-system apparatus has been widely used for concurrent measurement of diffusion and membrane efficiency coefficients of low-permeability clay-based barrier ***,the common assumption of perfectly flushing conditions at the specimen boundaries could induce errors in analyses of the diffusion coefficients and membrane *** this study,an innovative pseudo three-dimensional(3D)analytical method was proposed to evaluate solute distribution along the boundary surfaces of the soil-porous disks system,considering the non-perfectly flushing *** results were consistent with numerical models under two scenarios considering different inflow/outflow *** proposed model has been demonstrated to be an accurate and reliable method to estimate solute distributions along the *** calculated membrane efficiency coefficient and diffusion coefficient based on the proposed analytical method are more accurate,resulting in up to 50%less relative error than the traditional approach that adopts the arithmetic mean value of the influent and effluent *** retar-dation factor of the clay specimen also can be calculated with a revised cumulative mass ***,the simulated transient solute transport matched with experimental data from a multi-stage through-diffusion and membrane behavior test,validating the accuracy of the proposed method.

关键词： Diffusion testing membrane behavior Coupled transport Clay barrier Transport modeling

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Solvation Effects on the Dielectric Constant of 1 m LiPF6 in Ethylene Carbonate:Ethyl methyl Carbonate 3:7

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Energy & Environmental materials 2024年第1期7卷 253-256页

作者： Julian Self Nathan T.Hahn kristin A.Persson Department of Chemical Engineering Polytechnique MontrealMontrealQC H3T 1J4Canada Department of materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA material Physical and Chemical Sciences CenterSandia National LaboratoriesAlbuquerqueNM 87185USA

We report the dielectric constant of 1 m LiPF_(6)in EC:EmC 3∶7 w/w(ethylene carbonate/ethyl methyl carbonate)in addition to neat EC:EmC 3∶7 w/*** three Debye relaxations,the static permittivity value,or dielectric constant,is extrapolated to 18.5,which is compared to 18.7 for the neat solvent *** EC solvent is found to strongly coordinate with the Li^(+)cations of the salt,which results in a loss of dielectric contribution to the ***,the small amplitude and large uncertainty in relaxation frequency for EmC cloud definitive identification of the Li^(+)solvation ***,the loss of the free EC permittivity contribution due to Li^(+)solvation is almost completely balanced by the positive contribution of the associated LiPF_(6)salt,demonstrating that a significant quantity of dipolar ion pairs exists in 1 m LiPF_(6)in EC:EmC 3∶7.

关键词： batteries dielectric relaxation spectroscopy electrolytes

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High seed losses in mountain birch(Betula pubescens ***)and developmental,ecological,and environmental correlates

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Journal of Plant Ecology 2024年第4期17卷 56-69页

作者： Guorun Oskarsdottir Thora E.Thorhallsdottir kristin Svavarsdottir University of Iceland 102 ReykjavíkIceland Land and Forest Iceland ReykjavíkIceland

Plants typically experience great losses from their reproductive potential represented by ovule production to the post-dispersal crop of viable *** examined seed density and viability in a founder population of mountain birch(Betula pubescens ***),aiming to quantify losses at different stages and examine potential selection forces on the reproduction success of the founder generation of an isolated *** the time of the study(2017-2020),the population had recently reached reproductive maturity,following its colonization around 1990 through long-distance dispersal onto an early successional outwash plain in southeast *** densities were high,but 89% of apparently intact seeds did not contain an embryo,despite being visually indistinguishable from filled *** evident losses amounted to about 45% of the total seed crop and were mostly due to predation by the gall midge Semudobia *** all losses were accounted for,2.7% of the seed crop remained viable and *** limitation may partially explain the high incidence of empty *** flower production is compatible with the predator satiation hypothesis but cannot explain pre-dispersal *** adaptation to predation,masting,appears poorly developed in *** results suggest the presence of constraints on the reproduction potential of the new island population,that are more limiting than in neighbouring populations,and we discuss their developmental,ecological,and environmental correlates.

关键词： Betula pubescens ssp.tortuosa(Ledeb.)Nyman Iceland seed quality seed losses Semudobia betulae sub-arctic

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HDPairFinder:A data processing platform for hydrogen/deuterium isotopic labeling-based nontargeted analysis of trace-level amino-containing chemicals in environmental water

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Journal of Environmental Sciences 2024年第2期136卷 583-593页

作者： Tingting Zhao kristin Carroll Caley B.Craven Nicholas J.P.Wawryk Shipei Xing Jian Guo Xing-Fang Li Tao Huan Department of Chemistry Faculty of ScienceUniversity of British ColumbiaVancouver Campus2036 Main MallVancouverBritish ColumbiaV6T 1Z1Canada Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6G 2G3Canada

The combination of hydrogen/deuterium(H/D)formaldehyde-based isotopic methyl labeling with solid-phase extraction and high-performance liquid chromatography–high resolution mass spectrometry(HPLC-HRmS)is a powerful analytical solution for nontargeted analysis of trace-level amino-containing chemicals in water *** the huge amount of chemical information generated in HPLC-HRmS analysis,identifying all possible H/Dlabeled amino chemicals presents a significant challenge in data *** address this,we designed a streamlined data processing pipeline that can automatically extract H/D-labeled amino chemicals from the raw HPLC-HRmS data with high accuracy and ***,we developed a cross-correlation algorithm to correct the retention time shift resulting from deuterium isotopic effects,which enables reliable pairing of H-and D-labeled ***,we implemented several bioinformatic solutions to remove false chemical features generated by in-source fragmentation,salt adduction,and natural13C ***,we used a data mining strategy to construct the AmINES library that consists of over 38,000 structure-disjointed primary and secondary amines to facilitate putative compound ***,we integrated these modules into a freely available R program,*** rationale of each module was justified and its performance tested using experimental H/D-labeled chemical standards and authentic water *** further demonstrated the application of HDPairFinder to effectively extract N-containing contaminants,thus enabling the monitoring of changes of primary and secondary N-compounds in authentic water *** is a reliable bioinformatic tool for rapid processing of H/D isotopic methyl labeling-based nontargeted analysis of water samples,and will facilitate a better understanding of N-containing chemical compounds in water.

关键词： Isotope labeling Nontargeted analysis Reactive N-compounds HPLC-HRmS Source water

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Enjioy Nature and Reading Fund Conservation Listen to waterflls and birds on Spotify——and protect them at the same time

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空中英语教室（高级版．彭蒙惠英语） 2024年第10期 32-33,49页

作者： kristin Toussaint 不详

On April 18,a new artist debuted on Spotify and other streaming platforms,though Teaching you've definitely heard her sounds before-whether ocean waves,birdsong or the thrum of falling *** artist is nature,and streami... 详细信息

关键词： streaming hear birds

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Liquid Subcutaneous Levodopa-Carbidopa ND0612 Effects on motor Symptoms in Individuals with Parkinson’s Disease: A Systematic Review and meta-Analysis

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Advances in Parkinson's Disease 2024年第2期13卷 9-25页

作者： Paula Abola mitchell Wolden kristin Lefebvre Department of Clinical Research University of Jamestown Jamestown ND USA

Objective: In the manuscript titled “Liquid subcutaneous Levodopa-Carbidopa ND0612 effects on motor symptoms in individuals with Parkinson’s Disease: A systematic review and meta-analysis”, the objective was to conduct a systematic review with meta-analysis to investigate the effects ND0612 24-hour dosing regimen has on motor symptoms in individuals with Parkinson’s Disease (PD). Introduction: ND0612 is a novel minimally invasive continuous subcutaneous delivery system of liquid Levodopa-Carbidopa being investigated for the treatment of PD in individuals experiencing motor symptoms. methods: A systematic literature search was conducted in Pubmed, Cochrane, and EBSCO databases to identify randomized controlled trials investigating the effects of ND0612 on motor symptoms in individuals with PD. Outcomes included the Unified Parkinson’s Disease Rating Scale (UPDRS) Part II and Part III scores. methodological quality was assessed using the Cochrane Grading of Recommendations Assessment, Development, and Evaluation approach. meta-analysis was performed using a random effects model with the DerSimonian and Laird method to estimate the effects of the ND0612 24-hour dosing regimen on UPDRS Part II and Part III scores. Results: Three studies were included in our review. There were statistically significant reductions in UPDRS Part II scores (mean difference (mD) −3.299;95% confidence interval (CI) −3.438, −3.159) and in UPDRS Part III scores (mD −12.695;95% CI −24.428, −0.962) in the ND0612 24-hour dosing regimen. Results were based on very low certainty of evidence. Conclusion: Based on very low certainty evidence, the ND0612 24-hour dosing regimen is effective at improving motor symptoms in individuals with PD. Our findings suggest that ND0612 is more effective at improving UPDRS Part II and Part III scores in individuals with PD than other pharmacological and non-pharmacological treatments, warranting further study.

关键词： Parkinson’s Disease ND0612 Levodopa-Carbidopa motor Symptoms motor Complications UPDRS

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metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy

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Asian Journal of Urology 2024年第2期11卷 316-323页

作者： Ryan A.Dornbier Chirag P.Doshi Shalin C.Desai Petar Bajic michelle Van Kuiken mark Khemmani Ahmer V.Farooq Larissa Bresler Thomas m.T.Turk Alan J.Wolfe kristin G.Baldea Loyola University medical Center Department of UrologyMaywoodILUSA Loyola University Chicago Department of Microbiology and ImmunologyMaywoodILUSA

Objective:To identify possible stone-promoting microbes,we compared the profiles of microbes grown from stones of patients with and without metabolic syndrome(metS).The association between metS and urinary stone disease is well established,but the exact pathophysiologic relationship remains *** evidence suggests urinary tract dysbiosis may lead to increased nephrolithiasis ***:At the time of percutaneous nephrolithotomy,bladder urine and stone fragments were collected from patients with and without *** sample types were subjected to expanded quantitative urine culture(EQUC)and 16 S ribosomal RNA gene ***:Fifty-seven patients included 12 controls(21.1%)and 45 metS patients(78.9%).Both cohorts were similar with respect to demographics and non-metS *** controls had uric acid stone *** EQUC,bacteria were detected more frequently in metS stones(42.2%)compared to controls(8.3%)(p=0.041).Bacteria also were more abundant in stones of metS patients compared to *** validate our EQUC results,we performed 16 S ribosomal RNA gene *** 12/16(75.0%)sequence-positive stones,EQUC reliably isolated at least one species of the sequenced *** were detected in both“infectious”and“non-infectious”stone ***:Bacteria are more common and more abundant in metS stones than control *** findings support a role for bacteria in urinary stone disease for patients with metS regardless of stone composition.

关键词： Nephrolithiasis Urolithiasis metabolic syndrome Urinary microbiome Percutaneous nephrolithotomy

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Elucidating regulatory processes of intense physical activity by multi-omics analysis

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military medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu marina A.Gritsenko Young-mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie munoz Kathleen m.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa m.Bramer Fernando montes Kathleen A.Clark Grant Tietje Justin Teeguarden kristin E.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： multi-omics analysis Intense exercise Human performance Biofluids metabolism Immunity

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