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elucidating regulatory processes of intense physical activity by multi-omics analysis

Military Medical Research 2024年第4期 479-499页

作者： ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim Jennifer e.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie Munoz Kathleen M. Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L. Paurus Kent J. Bloodsworth Kelsey A. Allen Lisa M. Bramer Fernando Montes Kathleen A. Clark Grant Tietje Justin Teeguarden kristin e.burnum.johnson Biological Sciences Division Pacific Northwest National Laboratory environmental and Molecular Sciences Division Pacific Northwest National Laboratory Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Western States Division Computational Analytics Division Pacific Northwest National Laboratory National Security Directorate Pacific Northwest National Laboratory Los Angeles County Fire Department Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Respiratory Health Division environmental and Molecular Toxicology Oregon State University

Background: Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports. A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***: To study regulatory processes in intense physical activity simulating real-life conditions, we performed a multi-omics analysis of 3 biofluids(blood plasma, urine, and saliva) collected from 11 wildland firefighters before and after a 45 min, intense exercise regimen. Omics profiles post-vs. pre-exercise were compared by Student's t-test followed by pathway analysis and comparison between the different omics ***: Our multi-omics analysis identified and quantified 3835 proteins, 730 lipids and 182 metabolites combining the 3 different types of samples. The blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy demands. The urine analysis showed a strong, concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites, reabsorption of nutrients and maintenance of fluid balance. In saliva, we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides. A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***: This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility, suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

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Microbial response to designer biochar and compost treatments for mining impacted soils

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Biochar 2021年第3期3卷 299-314页

作者： Thomas F.Ducey Jeffrey M.Novak Gilbert C.Sigua James A.Ippolito Hannah C.Rushmiller Donald W.Watts kristin M.Trippe Kurt A.Spokas Kenneth C.Stone Mark G.johnson Coastal Plains Soil Waterand Plant Research CenterAgricultural Research Service-USDAFlorenceSCUSA Department of Soil and Crop Sciences Colorado State UniversityFort CollinsCOUSA National Forage Seed Production Research Center Agricultural Research Service-USDACorvallisORUSA Soil and Water Management Research Unit Agricultural Research Service-USDASt.PaulMNUSA National Health and environmental effects Research Laboratory US Environmental Protection AgencyCorvallisORUSA

The Oronogo-Duenweg mining belt is a designated United States environmental Protection Agency Superfund site due to lead-contaminated soil and groundwater by former mining and smelting *** that have undergone remediation-in which the O,A,and B horizons have been removed alongside the lead contamination-have an exposed C horizon and are incalcitrant to revegetation *** also continue to contain quantifiable Cd and Zn *** improve soil conditions and encourage successful site revegetation,our study employed three biochars,sourced from different feedstocks(poultry litter,beef cattle manure,and lodgepole pine),at two rates of application(2.5%,and 5%),coupled with compost(0%,2.5%and 5%application rates).Two plant species-switchgrass(Panicum virgatum)and buffalograss(Bouteloua dactyloides)-were grown in the amended *** of soils with poultry litter biochar applied at 5%resulted in the greatest reduction of soil bioavailable Cd and ***-ground biomass yields were greatest with beef cattle manure biochar applied at 2.5%with 5%compost,or with 5%biochar at 2.5%and 5%compost *** microbial biomass was achieved with 5%poultry litter biochar and 5%compost,and microbial communities in soils amended with poultry litter biochar distinctly clustered away from all other soil ***,poultry litter biochar amended soils had the highest enzyme activity rates forβ-glucosidase,N-acetyl-β-D-glucosaminidase,and *** results suggest that soil reclamation using biochar and compost can improve mine-impacted soil biogeophysical characteristics,and potentially improve future remediation efforts.

关键词： Biochar Compost Microbial response Mine soil reclamation Plant growth

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美国中西部地区考古遗址中动物遗存的锶同位素比值多样性基础研究

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东方考古 2017年第1期 279-299页

作者： kristin M.Hedman B.Brandon Curry Thomas M.johnson Paul D.Fullagar Thomas e.emerson 房书玉(译) 董豫(校) 伊利诺伊州交通运输部考古研究中心伊利诺伊州地质研究院伊利诺伊大学厄巴纳香槟分校地质系北卡罗来纳大学地质科学系山东大学历史文化学院

获取骨骼和牙釉质中的锶同位素比值来研究史前人群中的非本地个体,已经在全球范围内逐渐开展。在美国中西部地区开展的考古研究逐渐将人口流动视为影响文化交流变迁的一个重要因素。由于美国中西部地区在地质上的差异较小,因而相应的锶... 详细信息

获取骨骼和牙釉质中的锶同位素比值来研究史前人群中的非本地个体,已经在全球范围内逐渐开展。在美国中西部地区开展的考古研究逐渐将人口流动视为影响文化交流变迁的一个重要因素。由于美国中西部地区在地质上的差异较小,因而相应的锶的多样性可能也比较低,这对于利用锶同位素划定这一区域非本地人的灵敏度是一个问题。利用考古遗址的动物遗存,我们探索了这一区域锶同位素比值的多样性。研究结果显示锶同位素比值的多样性是可以被测量的,并且这一结果证明了利用锶同位素分析解决美国中西部地区人口来源以及迁徒问题的可能性。

关键词：锶同位素迁徙骨骼牙釉质史前伊利诺伊

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右旋美托咪啶-咪达唑仑与丙泊酚用于小儿磁共振检查中麻醉维持的比较

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麻醉与镇痛 2010年第2期6卷 49-56页

作者： Christopher Heard, MBChB, FRCA Frederick Burrows, MD kristin johnson, PharmD Prashant Joshi, MD James Houck, MD Jerrold Lerman FRCPC, FANZCA 马敏(译) 江海星(译) 饶艳(校) 王焱林(校) Department of Anesthesiology and Division of Pediatric Critical Care State University of New York at Buffalo Women and Children's Hospital of Buffalo Buffalo New York Department of Anesthesiology State University of New York at Buffalo Women and Children's Hospital of Buffalo Buffalo New York Department of Pharmacy Women and Children's Hospital of Buffalo Buffalo New York Division of Pediatric Critical Care State University of New York at Buffalo Women and Children's Hospital of Buffalo Buffalo New York Department of Anesthesiology Women and Children's Hospital of Buffalo Buffalo New York State University of New York at Buffalo and University of Rochester Rochester New York Department of Anesthesiology Women and Children's Hospital of Buffalo Buffalo and Strong Memorial Hospital Rochester New York 不详

背景右旋美托咪啶是一种仪，受体激动剂，目前正在研究其是否适合用于小儿麻醉。本研究旨在比较右旋美托咪啶一咪达唑仑与丙泊酚对于七氟烷麻醉儿童磁共振扫描（M对）中的药效学反应差异。方法40例1～10岁，ASA1或2级，拟行MRI检查的患... 详细信息

背景右旋美托咪啶是一种仪，受体激动剂，目前正在研究其是否适合用于小儿麻醉。本研究旨在比较右旋美托咪啶一咪达唑仑与丙泊酚对于七氟烷麻醉儿童磁共振扫描（M对）中的药效学反应差异。方法40例1～10岁，ASA1或2级，拟行MRI检查的患儿，随机分为2组，两组均用七氟烷诱导，一组以右旋美托咪啶．咪达唑仑维持麻醉，另一组以丙泊酚维持麻醉。右旋美托咪啶组先静注负荷量（1μg／kg）后持续泵入（0．5μg·kg^-1·h^-1）。开始泵注后静注咪达唑仑（0．1mg／kg）。丙泊酚持续泵入（250—300μg·kg^-1·min^-1）。由一名不了解麻醉方案的护士来记录复苏时间及血流动力学变化。结果右旋美托咪啶组手术后完全恢复及出院时间明显长于（约15分钟）丙泊酚组。与丙泊酚组比较，右旋美托咪啶组心率减慢，收缩压增高。两组呼吸系统指标相近。恢复过程中，两组血流动力学反应相近。在麻醉及手术后恢复过程中，心肺指标均在同年龄段儿童的正常范围内。无麻醉意外发生。结论在MRＩ检查中，右旋美托咪啶．咪达唑仑提供足够的麻醉深度，但-I丙泊酚相比麻醉复苏时间稍长。与丙泊酚组比较，使用右旋美托咪啶的患儿心率慢、收缩压高。两种方式的呼吸系统指标相近。

关键词：右旋美托咪啶咪达唑仑麻醉维持丙泊酚小儿麻醉磁共振检查血流动力学反应血流动力学变化

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