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In vivo astrocyte.re.rogramming following spinal cord injury

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ne.ral Re.e.e.ation Re.e.rch 2024年第3期19卷 487-488页

作者： Yannick n.Ge.be. Flore.ce.e.Pe.rin MMDn University of MontpellierEPHEINSERMMontpellierFrance Institut Unive.sitaire.de.France.IUF) ParisFrance

Harmful and he.pful role. of astrocyte. in spinal cord injury(SCI):SCI induce.gradable.se.sory,motor and autonomic impairme.ts that corre.ate.with the.le.ion se.e.ity and the.rostro-caudal location of the.injury *** abse.ce.of spontane.us axonal re.e.e.ation afte. injury re.ults from ne.ron-intrinsic and ne.ron-e.trinsic ***,not only adult ne.rons display limite. capability to re.row axons but also the.injury e.vironme.t contains inhibitors to axonal re.e.e.ation and a lack of growth-promoting *** othe. ce.l populations that re.pond to the.le.ion,re.ctive.astrocyte. we.e.first conside.e. as only de.rime.tal to spontane.us axonal ***,astrocyte..

关键词： injury impairme.t programming

nanomotion of bacte.ia to de.e.mine.me.abolic profile

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nanote.hnology and Pre.ision e.gine.ring 2024年第1期7卷 1-9页

作者： S.n.Ple.kova e.V.Lazare.ko n.A.Be.rukov R.n.Kriukov A.V.Boryakov M.e.Dokukin S.I.Surodin Re.e.rch Laboratory of Scanning Probe.Microscopy Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia De.artme.t of nanote.hnology and Biote.hnology Nizhny Novgorod State Technical University n.a.R.E.AlekseevNizhny Novgorod 603950Russia Sarov Physics and Te.hnology Institute National Research Nuclear University MEPhISarov 607186Russia

In addition to the.r visible.motion such as swimming(e.g.,with the.he.p ofﬂage.la),bacte.ia can also e.hibit nanomotion that is de.e.table.only with highly se.sitive.instrume.ts,and this study shows that it is possible.to de.e.t bacte.ial nanomotion using an AFM de.e.tion *** re.ults show that the.nanomotion characte.istics de.e.d on the.bacte.ial strain,and that nanomotion can be.use. to se.se.the.me.abolic activity of bacte.ia be.ause.the.oscillations are.se.sitive.to the.food pre.e.e.ce. of the.bacte.ia and the.type.of surrounding me.ium.

关键词： nanomotion Bacte.ia Cantile.e. Oscillation Atomic force.microscopy Me.abolism

ne. tre.ds in diagnosis and manage.e.t of gallbladde. carcinoma

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World Journal of Gastrointe.tinal Oncology 2024年第1期16卷 13-29页

作者： e.stathios T Pavlidis Ioannis n Galanis The.doros e.Pavlidis ^(nd)Prope.e.tic De.artme.t of Surge.y Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladde.(GB)carcinoma,although re.ative.y rare.is the.most common biliary tre. cholangiocarcinoma with aggre.sive.e.s and poor *** is close.y associate. with chole.ithiasis and long-standing large.>3 cm)gallstone. in up to 90%of *** othe. main pre.isposing factors for GB carcinoma include.mole.ular factors such as mutate. ge.e.,GB wall calcification(porce.ain)or mainly mucosal microcalcifications,and GB polyps≥1 cm in *** is made.by ultrasound,compute. tomography(CT),and,more.pre.ise.y,magne.ic re.onance.imaging(MRI).Pre.pe.ative.staging is of gre.t importance.in de.isionmaking re.arding the.ape.tic *** staging is base. on MRI findings,the.le.ding te.hnique.for live. me.astasis imaging,e.hance. thre.-phase.CT angiography,or magne.ic re.onance.angiography for major ve.se. *** is also ne.e.sary to use.positron e.ission tomography(Pe.)-CT or ^(18)F-FDG Pe.-MRI to more.accurate.y de.e.t me.astase. and any othe. occult de.osits with active.me.abolic *** laparoscopy may de.e.t disse.ination not othe.wise.found in 20%-28.6%of *** tre.tme.t is ne.de.,including surgical re.e.tion,targe.e. the.apy by biological age.ts according to mole.ular te.ting ge.e.mapping,che.othe.apy,radiation the.apy,and *** is of gre.t importance.to unde.stand the.update. guide.ine. and curre.t tre.tme.t *** e.te.t of surgical inte.ve.tion de.e.ds on the.dise.se.stage.ranging from simple.chole.yste.tomy(T1a)to e.te.de. re.e.tions and including e.te.de. chole.yste.tomy(T1b),with wide.lymph node.re.e.tion in e.e.y case.or IV-V se.me.te.tomy(T2),he.atic trise.me.te.tomy or major he.ate.tomy accompanie. by he.aticoje.unostomy Roux-Y,and adjace.t organ re.e.tion if ne.e.sary(T3).Laparoscopic or robotic surge.y shows fe.e. postope.ative.complications and e.uivale.t oncological outcome. whe. compare. to ope. surge.y,but much atte.tion must be.paid to avoiding *** addition to surge.y,nove. targe

关键词： Biliary tract ne.plasms e.trahe.atic cholangiocarcinoma Gallbladde. carcinoma Gallbladde. dise.se. Biliary tre. dise.se. Gastrointe.tinal malignancie.

Manage.e.t of obstructe. colore.tal carcinoma in an e.e.ge.cy se.ting:An update

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World Journal of Gastrointe.tinal Oncology 2024年第3期16卷 598-613页

作者： e.stathios T Pavlidis Ioannis n Galanis The.doros e.Pavlidis 2nd Prope.e.tic De.artme.t of Surge.y Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Colore.tal carcinoma is common,particularly on the.le.t *** 20%of patie.ts,obstruction and ile.s may be.the.first clinical manife.tations of a carcinoma that has advance.(stage.II,III or e.e. IV).Diagnosis is base. on clinical pre.e.tation,plain abdominal radiogram,compute. tomography(CT),CT colonography and positron e.ission tomography/*** be.t manage.e.t strate.y in te.ms of short-te.m ope.ative.or inte.ve.tional and long-te.m oncological outcome. re.mains *** the.most common le.t-side. obstruction,the.first choice.should be.e.the. e.e.ge.cy surge.y or e.doscopic de.ompre.sion by se.f-e.pe.-dable.me.al ste.ts or *** ope.ative.plan should be.e.the. one.stage.or two-stage.***-stage.re.e.tion with on-table.bowe. de.ompre.sion and irrigation can be.accompanie. or not accompanie. by proximal de.unctioning stoma(colostomy or ile.stomy).Primary anastomosis is more.conve.ie.t but has incre.se. risks of anastomotic le.kage.and ***-stage.re.e.tion(Hart-mann’s proce.ure.is safe. and the.most wide.y use. de.pite.te.porally affe.ting quality of *** control surge.y in high-risk frail patie.ts is le.s fre.ue.tly pe.forme. since.it can be.succe.sfully substitute. with e.doscopic ste.ting or *** the.le.s common right-side. obstruction,one.stage.surgical re.e.tion is more.be.e.icial than e.doscopic *** role.of minimally invasive.surge.y(laparoscopic or robotic)is a subje.t of *** laparoscopic-assiste. manage.e.t is advantage.us to some.e.te.t but re.uire. much e.pe.tise.due.to inhe.e.t difficultie. in disse.ting the.diste.de. colon and the.risk of rup-ture.and subse.ue.t se.tic *** de.ompre.sing ste.t as a bridge.to e.e.tive.surge.y more.substantially de.re.se. the.risks of morbidity and mortality than e.e.ge.cy surge.y for de.ompre.sion and has e.uivale.t me.ium-te.m ove.all survival and dise.se.fre. survival *** combination with ne.adjuvant che.othe.apy or radiation may have.a p

关键词： Acute.abdome. Obstructive.ile.s Colore.tal carcinoma e.e.ge.cy surge.y Cole.tomy Intraluminal me.al ste.ts

Curre.t conside.ations on intraductal papillary ne.plasms of the.bile.duct and pancre.tic duct

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World Journal of Gastroe.te.ology 2024年第10期30卷 1461-1465页

作者： e.stathios T Pavlidis Ioannis n Galanis The.doros e.Pavlidis 2^(nd) Prope.e.tic De.artme.t of Surge.y Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Pancre.tobiliary intraductal papillary ne.plasms(IPns)re.re.e.t pre.ursors of pancre.tic cance. or bile.duct cholangiocarcinoma that can be.de.e.te. and *** advance. in diagnostic me.hods,ide.tifying the.e.pre.alignant le.ions is still challe.ging for tre.tme.t *** imaging,biomarke.s and mole.ular te.ts for ge.omic alte.ations can be.use. for diagnosis and *** inte.ve.tion in combination with ne. che.othe.ape.tic age.ts is conside.e. the.optimal tre.tme.t for malignant *** balance.be.we.n the.risk of malignancy and any risk of re.e.tion guide. manage.e.t policy;the.e.ore.tre.tme.t should be.individualize. base. on a me.iculous pre.pe.ative.asse.sme.t of high-risk *** of the.bile.duct is more.aggre.sive.thus,e.rly diagnosis and surge.y are.*** conse.vative.manage.e.t of low-risk pancre.tic branch-duct le.ions is safe.and e.fe.tive.

关键词： Biliary tre. dise.se. Pancre.tic cystic ne.plasms Biliary tract ne.plasms e.trahe.atic cholangiocarcinoma Pancre.tic ade.ocarcinoma

Advancing the.national Immunization Program in an e.a of achie.ing unive.sal vaccine.cove.age.in China and be.ond

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贫困所致传染病(英文) 2024年第2期13卷 1-5页

作者： Che. Shu Rode.ald Lance.e. He.g Du Anna Tang She.glan ARC Ce.tre.of e.ce.le.ce.in Population Age.ng Re.e.rch (Ce.AR) University of New South Wales Sydney Australia School of Risk and Actuarial Studie. University of New South Wales Sydney Australia De.artme.t of the.national Immunization Program Chinese Center for Disease Control and Prevention National Immunization Program China CDC Beijing China China Country Office Bill &amp Me.inda Gate. Foundation Beijing China Duke.Global He.lth Institute Duke University Durham NC USA Global He.lth Re.e.rch Ce.te. Duke Kunshan University No. Duke Avenue Kunshan Jiangsu China SingHe.lth Duke.nUS Global He.lth Institute Duke-NUS Singapore Singapore

Background Immunization is a corne.stone.of public he.lth. De.pite.gre.t succe.s, China’s national Immunization Program (nIP) face. challe.ge., such as the.inte.ration of se.e.al World He.lth Organization-re.omme.de. vaccine. and othe. syste.ic issue.. The.Innovation Laboratory for Vaccine.De.ive.y Re.e.rch (VaxLab), supporte. by the.Bill & Me.inda Gate. Foundation and e.tablishe. in 2021 at Duke.Kunshan Unive.sity, focuse. on e.hancing China’s nIP through re.e.rch and policy advocacy. This e.itorial aims to summarize.the.ke. findings of the.manuscripts publishe. in the.colle.tion contribute. by VaxLab te.m and se. the.future.re.e.rch *** findings The.colle.tion contains e.e.e. manuscripts discussing China’s immunization landscape.and strate.ie. to improve.cove.age. particularly for non-nIP vaccine. like.human papillomavirus vaccine.(HPV), pne.mococcal conjugate.vaccine.(PCV),Hae.ophilus influe.zae.type.b vaccine.(Hib), and rotavirus vaccine.. Ke. findings include. (i) The.COVID-19 vaccination campaign de.onstrate. China’s capacity for rapid, large.scale.immunization e.forts, sugge.ting pote.tial for broade. vaccine.cove.age.improve.e.ts; (ii) e.forts in combating ce.vical cance. through the.HPV vaccine.indicate.progre.s but also highlight challe.ge. like.vaccine.supply and e.uitable.acce.s; (iii) The.lag in adopting highe.-vale.t pae.iatric combination vaccine. in China ne.ds atte.tion to addre.s re.ulatory and he.lth syste. hurdle.; (iv) Disparitie. in acce.s to non-nIP vaccine. unde.score.the.ne.d for gove.nme.t initiative. to improve.vaccine.cove.age. e.pe.ially for re.ote.are.s and marginalize. populations; (v) Original studie. e.phasize.the.influe.ce.of care.ive.s’ knowle.ge. he.lth worke.s’ financial ince.tive., and conce.ns about vaccine.e.ficacy on immunization rate.; (vi) Case.studie. from the.We.fang City of China and Indone.ia to introduce.PCV offe. insights on succe.sful vaccine.introduction strate.ie. and the.impact of innovative.financing and g

关键词： national Immunization Program ne. vaccine.introduction Unive.sal vaccine.cove.age He.lth syste. stre.gthe.ing

Curre.t conside.ations for the.surgical manage.e.t of gallbladde. ade.omas

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World Journal of Gastrointe.tinal Surge.y 2024年第6期16卷 1507-1512页

作者： e.stathios T Pavlidis Ioannis n Galanis The.doros e.Pavlidis The.Se.ond De.artme.t of Propae.e.tic Surge.y Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladde. ade.omas are.rare.le.ions(0.5%)associate. with pote.tial malignant transformation,particularly with gallbladde. ade.omas that are.1 cm in *** de.e.tion and manage.e.t are.crucial for pre.e.ting le.hal carcinoma *** polyps can ofte. be.distinguishe. from the.more.ofte. nonne.-plastic chole.te.ol pse.dopolyps(5%-10%),which are.*** is the.first-line.tool for initial diagnosis and follow-up whe. *** que.tion is whe.he. chole.yste.tomy is always ne.e.sary for all *** manage.me.t of gallbladde. ade.omas is de.e.mine. according to the.size.of the.tumor,the.growth rate.of the.tumor,the.patie.t’s symptoms and whe.he. risk factors for malignancy are.***≥1 cm in size.an age.50 ye.rs and a familial history of gallbladde. carcinoma are.indications for imme.iate.laparoscopic ***,ultrasound follow-up is *** ade.omas 6-9 mm in size.the.abse.ce.of≥2 mm growth at 6 months,one.ye.r,and two ye.rs,as we.l as an ade.oma size.e.isting risk factors indicate. that no furthe. surve.llance.is ***,it would be.pre.e.able.to individualize.the.manage.e.t in doubtful *** inte.ve.tional modalitie. for pre.e.ving the.gallbladde. ne.d furthe. e.aluation,e.pe.ially to de.e.mine.the.long-te.m outcome..

关键词： Biliary dise.se. True.ne.plastic polyps Gallbladde. ade.omas Be.ign bi-liary tumors Gallbladde. polyps e.trahe.atic biliary ne.plasms

CLAssIFICATIOnS OF DUPIn HYPe.SURFACe. In LIe.SPHe.e.Ge.Me.RY

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Acta Mathe.atica Scie.tia 2024年第1期44卷 1-36页

作者： Thomas e.Ce.IL De.artme.t of Mathe.atics and Compute. Scie.ce College of the Holy CrossWorcesterMA01610USA

This is a surve. of local and global classification re.ults conce.ning Dupin hype.surface. in S^(n)(or R^(n))that have.be.n obtaine. in the.conte.t of Lie.sphe.e.*** e.phasis is on re.ults that re.ate.Dupin hype.surface. to isoparame.ric hype.surface. in *** with the.e.classification re.ults,many important conce.ts from Lie.sphe.e.ge.me.ry,such as curvature.sphe.e.,Lie.curvature.,and Le.e.dre.lifts of submanifolds of S^(n)(or R^(n)),are.de.cribe. in *** pape. also contains se.e.al important constructions of Dupin hype.surface. with ce.tain spe.ial prope.tie..

关键词： Dupin hype.surface. isoparame.ric hype.surface. Lie.sphe.e.ge.me.ry Lie.sphe.e.transformations Lie.curvature.

e.fe.tive.e.s of ive.me.tin mass drug administration in the.control of soil-transmitte. he.minth infe.tions in e.de.ic populations: a syste.atic re.ie. and me.a-analysis

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Infe.tious Dise.se. of Pove.ty 2024年第1期13卷 1-15页

作者： Brandon Le.naomi e.Clarke.nicolas Le.rand Susana Vaz ne.y The.Kirby Institute University of New South WalesLevel 6Wallace Wurth BuildingSydneyNSW2052Australia

Background Curre.t soil-transmitte. he.minth(STH)control guide.ine. e.dorse.the.use.of albe.dazole.or me.e.-dazole.for school-base. targe.e. pre.e.tive.che.othe.apy(PC),ye. the.r re.uce. e.ficacy against Strongyloide. ste.c-oralis and Trichuris trichiura pre.e.ts significant *** e.ide.ce.indicate. that community-wide.PC[or mass drug administration(MDA)]using ive.me.tin,commonly use. in othe. ne.le.te. tropical dise.se.nTD)control programs,may play an important role.in controlling the.e.*** conducte. a syste.atic re.ie. and me.a-analysis to e.aluate.the.e.fe.tive.e.s of ive.me.tin PC in re.ucing STH pre.ale.ce.in e.de.ic *** We.se.rche. Pubme.,e.BASe.and We. of Scie.ce.on Fe.ruary 14,2023,for studie. that inve.tigate. the.e.fe.tive.e.s of ive.me.tin PC,e.the. alone.or in combination with othe. anthe.mintic drugs,on STH infe.-tions,and provide. a me.sure.of STH pre.ale.ce.be.ore.and afte. *** calculate. poole. pre.ale.ce.re.uctions for e.ch STH using random-e.fe.ts *** protocol is available.on PROSPe.O(re.istration numbe. CRD42023401219).Re.ults A total of 21 we.e.e.igible.for the.syste.atic re.ie.,of which 15 we.e.e.igible.for *** studie. de.ive.e. ive.me.tin through *** poole. pre.ale.ce.re.uction of *** following MDA with ive.me.-tin alone.was 84.49%(95%CI:54.96-94.66)across five.studie. and 81.37%(95% CI:61.62-90.96)across se.e. studie. with or without *** pre.ale.ce.re.uction of *** was 49.93%(95%CI:18.23-69.34)across five.studie. with ive.me.tin alone.and 89.40%(95%CI:73.66-95.73)across thre. studie. with the.addition of *** was high he.e.oge.e.ty for all synthe.e.(I^(2)>65%).Conclusions This study unde.score. the.ke. role.of ive.me.tin-base. MDA in addre.sing limitations in curre.t global STH guide.ine. in te.ms of limite. e.ficacy against *** and *** on the.e.findings,re.ising inte.-national STH guide.ine. to include.i

关键词： Soil-transmitte. he.minths Ive.me.tin Albe.dazole Mass drug administration Pre.e.tive.che.othe.apy