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Analysis of the Relationship between Helicobacter pylori Infection and Diabetic Gastroparesis

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Chinese Medical Journal 2017年第22期130卷 2680-2685页

作者： Ju huang Department of Clinical Medicine Queen Mary School of Nanchang University Nanchang Jiangxi 330031 China

Background： Whether Helicobacter pylori infection is associated with diabetic gastroparesis （DGP） is unclear. This study aimed to investigate the potential correlation between H. pylori infection and DGP. Methods： In this study, 163 patients with type 2 diabetes mellitus and 175 nondiabetic patients who were treated in our department were divided into DGP, simple diabetes, non-DGP （NDG）, and normal groups based on their conditions. The H. pyh）ri infection rate in each group was calculated. H. pylori eradication therapy was performed for patients with H. pylori infection in each group. The eradication rates were compared between the groups, and the improvements in gastroparesis-associated symptoms were compared before and after treatment in patients with DGP. Results： The tl. pylori infection rate was 74.6% in the DGP group, which was significantly higher than that in the simple diabetes （51.1%, P 〈 0.01）, NDG （57.7%, P 〈 0.05）, and normal groups （48.0%, P 〈 0.01）. With increased disease course, the incidence of DGP and the H. pylori infection rate gradually increased （P 〈 0.05）. In the DGP group, the incidences of upper abdominal pain and distention, early satiety, and anorexia were 75.5%, 66.0%, and 67.9%, respectively, before eradication treatment; and 43.4%, 35.8%, and 39.6%, respectively, after eradication treatment, and the difference was statistically significant （P 〈 0.01）. In patients with DGP with successful H. pylori eradication, the number of barium strips discharged after eradication was 5.9 ± 1.0, which was significantly larger than that before treatment （4.1 ± 0.7, P 〈 0.01）. In addition, the number of barium strips discharged was significantly larger in patients with DGP with successful H. pylori eradication than those with failed H. pylori eradication （P 〈 0.01 ）. Conclusions： DGP development might be associated with H. pylori infection. H. pylori eradication can effectively improve dyspepsia-associated symptoms and delayed gastric emptying in patien

关键词： Diabetic Gastroparesis Helicobacterpylori Infection

Trace Elements and Rare Earth Elements of Sulfide Minerals in the Tianqiao Pb-Zn Ore Deposit,Guizhou Province,China

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Acta Geologica Sinica(English Edition) 2011年第1期85卷 189-199页

作者： ZHOU Jiaxi huang Zhilong ZHOU Guofu LI Xiaobiao DING Wei BAO Guangping State Key Laboratory of Ore Deposits Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

Trace elements and rare earth elements（REE） of the sulfide minerals were determined by inductively-coupled plasma mass *** results indicate that V,Cu,Sn,Ga,Cd,In,and Se are concentrated in sphalerite,Sb,As,Ge,and tl are concentrated in galena,and almost all trace elements in pyrite are *** Ga and Cd contents in the light-yellow sphalerites are higher than that in the brown and the black *** contents of Ge,tl,In,and Se in brown sphalerites are higher than that in light-yellow sphalerites and black *** shows that REE concentrations are higher in pyrite than in sphalerite,and *** sphalerites,the REE concentration decreases from light-yellow sphalerites,brown sphalerites,to black *** ratios of Ga/In are more than 10, and Co/Ni are less than 1 in the studied sphalerites and pyrites,respectively,indicating that the genesis of the Tianqiao Pb-Zn ore deposit might belong to sedimentary-reformed genesis associated with hydrothermal *** relationship between LnGa and LnIn in sphalerite,and between LnBi and LnSb in galena,indicates that the Tianqiao Pb-Zn ore deposit might belong to sedimentary-reformed *** on the chondrite-normalized REE patterns,δEu is a negative anomaly（0.13-0.88）,andδCe does not show obvious anomaly（0.88-1.31）;all the samples have low total REE concentrations（〈3 ppm） and a wide range of light rare earth element/high rare earth element ratios（1.12-12.35）.These results indicate that the ore-forming fluids occur under a reducing *** REE compositions and parameters of sphalerites,galenas,pyrites,ores,altered dolostone rocks,strata carbonates,and the pyrite from Lower Carboniferous Datang Formation showed that the ore-forming fluids might come from polycomponent systems,that is,different chronostratigraphic units could make an important contribution to the ore-forming *** with the tectonic setting and previous isotopic geochemistry evidence,we conclude that

关键词： trace element rare earth element sphalerite galena pyrite deposit genesis Tianqiao PbZn ore deposit

Discrete element simulations and experiments of soil-winged subsoiler interaction

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International Journal of Agricultural and Biological Engineering 2021年第1期14卷 50-62,I0001页

作者： Xuezhen Wang Peng Li Jinpu He Wuquan Wei Yuxiang huang College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100ShaanxiChina Shaanxi Engineering Research center for Agricultural Equipment Yangling 712100ShaanxiChina

Understanding soil disturbance behaviors under the impact of the winged subsoiler is critical for designing or optimizing the winged subsoiler(a primary subsoiling tool).In this study,a soil-winged subsoiler interaction model was developed and the effects of winged subsoiler on soil disturbance behaviors were investigated using the discrete element method(DEM)simulations and lab soil-bin *** results showed that wings mainly affected the disturbance range and fragmentation degree of soil above *** draught forces of share section(SS),arc section in the hardpan(ASHP),arc section in the top layer(AStl)and line section(LS)were accounted for 69.53%,25.22%,4.73%and 0.52%of the total draught force of winged subsoiler;the lateral disturbance range from high to low of the soil at different depths followed the ranking:top layer(tl),hardpan disturbed by arc section(HDAS)and hardpan disturbed by share section(HDSS).Wings had the greatest influence on the draught force of *** wings to an arc-shaped subsoiler increased the disturbance areas of HDAS,tl and HDSS by 47.52%,7.74%and 4.59%,respectively,but meanwhile increased the total draught force by 36%.Compared with a non-winged subsoiler,winged subsoiler had higher soil looseness(15.83%),soil disturbance coefficient(58.59%),furrow width(448.65 mm)and soil disturbance area ratio(0.3835),but poorer soil surface flatness(19.79 mm)and lower soil loosening efficiency(39.35 mm²/N).This study provided critical information for optimizing winged subsoilers on aspects of improving soil loosening effectiveness and reducing draught force.

关键词： hardpan winged subsoiler draught force soil disturbance discrete element method(DEM) experiment

α-促黑素细胞激素和白细胞介素8在病理性瘢痕组织中的表达及意义

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中国组织工程研究与临床康复 2007年第36期11卷 7215-7218页

作者：肖调立龙剑虹黄晓元湖南省第二人民医院整形美容科湖南省长沙市410007 中南大学湘雅医院烧伤整形科湖南省长沙市410078

目的:检测α-促黑素细胞激素、白细胞介素8在增生性瘢痕、瘢痕疙瘩、正常瘢痕和正常皮肤组织中的表达,探讨其在病理性瘢痕中的作用及意义。方法:①对象:收集2005-08/10中南大学湘雅医院烧伤整形科手术切下的瘢痕标本46例(其中增生性瘢... 详细信息

目的:检测α-促黑素细胞激素、白细胞介素8在增生性瘢痕、瘢痕疙瘩、正常瘢痕和正常皮肤组织中的表达,探讨其在病理性瘢痕中的作用及意义。方法:①对象:收集2005-08/10中南大学湘雅医院烧伤整形科手术切下的瘢痕标本46例(其中增生性瘢痕18例、瘢痕疙瘩12例、正常瘢痕16例)和正常皮肤标本12例(患者和供皮者均知情同意)。②实验过程:标本用40g/L甲醛固定,行连续切片,厚4μm,应用链菌素生物素-过氧化物酶标记物免疫组织染色法染色。③实验评估:观察α-促黑素细胞激素和白细胞介素8在上述标本组织中的表达及相关性,采用着色强度和阳性细胞率二者评分相结合的方法判断结果。结果:①增生性瘢痕、瘢痕疙瘩中α-促黑素细胞激素的表达评分值和强阳性率高于正常瘢痕、正常皮肤(P0.05)。②增生性瘢痕、瘢痕疙瘩中白细胞介素8的表达评分值和强阳性率高于正常瘢痕、正常皮肤(P0.05)。③α-促黑素细胞激素、白细胞介素8在增生性瘢痕、瘢痕疙瘩和正常瘢痕中表达呈正相关(P<0.05),在正常皮肤中无相关性。结论:α-促黑素细胞激素、白细胞介素8在增生性瘢痕、瘢痕疙瘩中的表达显著高于正常瘢痕和正常皮肤,且二者在病理性瘢痕和正常瘢痕组织中表达呈正相关,提示α-促黑素细胞激素、白细胞介素8对促进病理性瘢痕的发生、发展可能起一定作用。

关键词：瘢痕瘢痕疙瘩 MSH 白细胞介素8 免疫组织化学组织构建

珠海市2020—2023年大气PM2.5的元素特征及健康风险评价

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现代预防医学 2024年第2期51卷 226-232页

作者：张瑰吴雨蔓职佳音林丽玲江倩文黄利群珠海市疾病预防控制中心威斯康星大学麦迪逊分校统计学院新乡医学院公共卫生学院

目的了解珠海市近年来大气PM2.5的元素特征及其健康风险，为珠海市污染治理提供相关依据。方法于2020年4月—2023年3月在珠海市3个行政区每月定期采集PM2.5样本，共取得756份样品，通过ICP-MS法对PM2.5中元素含量进行测量，并采用美国... 详细信息

目的了解珠海市近年来大气PM2.5的元素特征及其健康风险，为珠海市污染治理提供相关依据。方法于2020年4月—2023年3月在珠海市3个行政区每月定期采集PM2.5样本，共取得756份样品，通过ICP-MS法对PM2.5中元素含量进行测量，并采用美国EPA吸入暴露模型计算健康风险。结果每月在34种元素范围内对珠海市PM2.5样本进行分析，大部分元素质量浓度表现为夏季低，冬季高的特点，其中重金属元素3年间年均浓度由大到小依次为锌(64.1 ng/m3)>锰(14.2 ng/m3)>铅(10.9 ng/m3)>铜(6.57 ng/m3)>砷(2.41 ng/m3)>镍(1.91 ng/m3)>钒(1.83 ng/m3)>铬(1.62 ng/m3)>锑(1.21 ng/m3)>镉(0.54 ng/m3)>铊(0.13 ng/m3)>钴(0.12 ng/m3)>汞(4.88×10-3ng/m3)。与之前珠海市的相关研究比较，各元素质量浓度均有所下降，但锑、铝、砷、铬、镍、硒有再次上涨的趋势。对6种致癌元素铬、钴、镍、砷、钼和镉，10种非致癌元素铝、钒、锰、铜、锌、硒、锑、钡、汞和铅进行健康评价，结果显示非致癌元素风险均在人群可接受水平(HQ≤1),致癌元素铬和砷存在致癌风险(R>10-6)。结论珠海市大气PM2.5非致癌元素健康风险均在人群可接受水平，致癌元素铬和砷存在致癌风险，需重点关注。从元素质量浓度来看，燃料和交通污染仍是治理重点。

关键词：大气污染 PM2.5 健康风险评价

Co-delivery of mitochondrial targeted lonidamine and PIN1 inhibitor ATRA by nanoparticulate systems for synergistic metastasis suppression

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Nano Research 2022年第4期15卷 3376-3386页

作者： Cheng Chen Qiuyi Li Liyun Xing Minglu Zhou Chaohui Luo Shujie Li Lian Li Yuan huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Mitochondria are highly involved in the metastasis of cancer ***,tumor cells impede the efficiency of mitochondrial targeted drugs by protecting mitochondria through an intrinsic and adaptive antioxidant *** aim to disturb the redox homeostasis by prolyl-isomerase PIN1 inhibitor all-trans retinoic acid(ATRA)to improve the therapeutic efficacy of mitochondrial targeted lonidamine(tl).The combination of ATRA and tl with a ratio of 2:1 was found to have the best synergistic effect in inhibiting the proliferation and metastasis of metastatic 4T1 breast cancer ***-drug loaded nanoparticles(tl-ATRA NPs)were further developed by self-assembly and were observed to disturb the redox homeostasis drastically and triggered a robust mitochondrial disruption on metastatic 4T1 breast cancer *** molecular mechanism was related to the downregulation of nuclear factor E2-related factor 2(NRF2),a critical transcription factor that regulated antioxidant responses,and its downstream *** a result,tl-ATRA NPs significantly suppressed the growth of primary tumors and the formation of lung metastasis ***,our findings showed that sensitizing mitochondria to anti-cancer drugs by disturbing redox homeostasis achieved a satisfactory therapeutic effect to inhibit tumor growth and metastasis.

关键词： tumor metastasis mitochondrial dysfunction PIN1 inhibition redox homeostasis disruption combinatorial therapy

混料设计优化酶法制备中长链甘三酯复合酶配比

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粮食与油脂 2024年第6期37卷 123-127页

作者：金璐张丽霞孙强孙晓静魏松丽黄纪念河南省农业科学院农产品加工研究中心河南郑州450002

以癸酸插入率为指标,采用混料设计对酶法合成中长链甘三酯(MLCT)的3种Sn-1,3位特异性脂肪酶(Lipozyme RM IM、Lipozyme tl IM和NS40086)配比进行优化,并对MLCT产物的脂肪酸组成及复合酶的稳定性进行分析。结果表明:3种酶对MLCT产物癸酸... 详细信息

以癸酸插入率为指标,采用混料设计对酶法合成中长链甘三酯(MLCT)的3种Sn-1,3位特异性脂肪酶(Lipozyme RM IM、Lipozyme tl IM和NS40086)配比进行优化,并对MLCT产物的脂肪酸组成及复合酶的稳定性进行分析。结果表明:3种酶对MLCT产物癸酸插入率的影响依次为NS40086>Lipozyme RM IM>Lipozyme tl IM,Lipozyme RM IM、Lipozyme tl IM和NS40086的最佳质量比为0.323∶0.122∶0.555,在此条件下MLCT产物的癸酸插入率为46.87%±0.24%,Sn-2位油酸含量为73.13%,Sn-1,3位癸酸含量为62.60%,制得的复合酶具有良好的稳定性。

关键词：混料设计中长链甘三酯(MLCT) 复合酶插入率

广西佛子冲铅锌矿田闪锌矿LA-ICP-MS微量元素特征及指示意义

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矿物学报 2024年第3期44卷 335-349页

作者：常晋阳吴小雷王加昇曾南石姜海范春宝黄长帅李敏赵毅桂林理工大学地球科学学院广西隐伏金属矿产勘查重点实验室广西壮族自治区桂林541004 中国有色桂林矿产地质研究院有限公司广西壮族自治区桂林541004 昆明理工大学国土资源工程学院西南地质调查所云南昆明650093 赤峰中色白音诺尔矿业有限公司内蒙古自治区赤峰024005

广西佛子冲铅锌矿田所在的钦杭成矿带西段是广西重要的多金属矿集区,矿田范围内发现的铅锌矿有条带状、浸染状、热液脉状3种类型矿石。3种类型矿石中的闪锌矿均具有Fe元素最为富集,Cd元素富集,Co元素较富集,In元素亏损,Ge、As、Mo、tl... 详细信息

广西佛子冲铅锌矿田所在的钦杭成矿带西段是广西重要的多金属矿集区,矿田范围内发现的铅锌矿有条带状、浸染状、热液脉状3种类型矿石。3种类型矿石中的闪锌矿均具有Fe元素最为富集,Cd元素富集,Co元素较富集,In元素亏损,Ge、As、Mo、tl元素含量低且含量变化不大的特征,但三者Fe元素含量存在一定差异,条带状闪锌矿w(Fe)<浸染状闪锌矿w(Fe)<热液脉状闪锌矿w(Fe)。3种闪锌矿的Mn、Fe、Co、Cd、In元素以类质同象的形式赋存于闪锌矿的晶格中,Cu、Pb、Bi元素则以独立矿物(黄铜矿、方铅矿、辉铋矿)或显微包裹体的形式赋存于闪锌矿中,但3种闪锌矿的Ag元素的赋存形式却存在一定差异。其中,条带状与热液脉状闪锌矿的Ag元素主要以独立矿物(自然银)或显微包裹体的形式赋存于闪锌矿之中,而浸染状闪锌矿的Ag元素则可能以类质同象的形式赋存于闪锌矿的晶格中。3种闪锌矿中Fe对Cd(或Mn、Co、In)与Zn的替代所起到的作用存在一定差异,其中条带状闪锌矿中Fe对Cd(或Mn)与Zn的替代可能起一定促进作用,对Co(或In)与Zn的替代机制所起作用不明。浸染状闪锌矿中Fe对Cd(或Mn、Co、In)与Zn的替代均起促进作用。而热液脉状闪锌矿中Fe对Mn与Zn的替代起促进作用,对Cd(或In)与Zn的替代可能也起到一定促进作用,但却对Co与Zn的替代起到了抑制进作用。3种闪锌矿的形成与岩浆活动密切相关,但沉积改造作用在条带状闪锌矿的形成过程中也发挥了重要作用。条带状闪锌矿可能形成于中-低温环境,浸染状和热液脉状闪锌矿则可能形成于中-高温环境,但热液脉状闪锌矿形成温度可能高于浸染状闪锌矿。结合Ga/Ge-Zn/Cd和Zn/Cd-Mn投影及前人的研究成果综合分析认为佛子冲铅锌矿田存在喷流沉积型、矽卡岩型、岩浆热液型3种矿床成因类型。

关键词：闪锌矿微量元素佛子冲铅锌矿田 LA-ICP-MS 成因类型

装炉方式对BN1tl不锈钢边部鳞折缺陷的影响

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材料与冶金学报 2024年第3期23卷 256-263页

作者：孟新宇管国富邹宇明黄德川李中杰唐正友丁桦东北大学材料科学与工程学院沈阳110819 宝钢德盛不锈钢有限公司福州350601 东北大学辽宁省轻量化用关键金属结构材料重点实验室沈阳110819

利用ABAQUS软件对BN1tl不锈钢在步进式加热炉内的加热过程进行分析,使用JMatPro软件模拟计算了BN1tl连铸坯在平衡状态下的凝固过程并绘制出凝固相图,同时还研究了不同装炉方式下连铸坯的析出行为.结果表明:在凝固过程中,随着温度的降低... 详细信息

利用ABAQUS软件对BN1tl不锈钢在步进式加热炉内的加热过程进行分析,使用JMatPro软件模拟计算了BN1tl连铸坯在平衡状态下的凝固过程并绘制出凝固相图,同时还研究了不同装炉方式下连铸坯的析出行为.结果表明:在凝固过程中,随着温度的降低,连铸坯晶界碳化物数量逐渐增多;在加热初期,连铸坯边部区域会产生较大热应力,热冲击和晶界弱化的共同作用会降低边部质量,使冷装装炉方式下边部应力集中及晶界弱化的程度均大于热装装炉方式,这是冷装装炉方式比热装装炉方式鳞折缺陷率高的根本原因;经冷装装炉方式加工的板材卷取后,晶界碳化物数量仍较多,这可能会影响后续冷轧等工艺阶段.

关键词： BN1tl不锈钢鳞折缺陷装炉方式温度应力场析出相