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Minocycline fails to improve neurologic and histologic outcome after ventricular fibrillation cardiac arrest in rats

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World Journal of Critical Care Medicine 2019年第7期8卷 106-119页

作者： Andreas Janata Ingrid AM Magnet kristin l schreiber Caleb D Wilson Jason P Stezoski Keri Janesko-Feldman Patrick M Kochanek Tomas Drabek Safar Center for Resuscitation Research University of Pittsburgh School of MedicinePittsburghPA 15224United States Department of Critical Care Medicine University of Pittsburgh School of MedicinePittsburghPA 15213United States Emergency Department KA RudolfstiftungVienna 1030Austria Department of Emergency Medicine Vienna General HospitalMedical University of ViennaVienna 1090Austria Department of Anesthesiology and Perioperative Medicine University of Pittsburgh School of MedicinePittsburghPA 15213United States Department of Anesthesiology Perioperative and Pain MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Wyoming Otolaryngology Wyoming Medical CenterCasperWY 82604United States

BACKGROUND Prolonged cardiac arrest(CA)produces extensive neuronal death and microglial proliferation and activation resulting in neuro-cognitive *** other potential mechanisms,microglia have been implicated as triggers of neuronal death after hypoxic-ischemic *** is neuroprotective in some brain ischemia models,either by blunting the microglial response or by a direct effect on *** To improve survival,attenuate neurologic deficits,neuroinflammation,and histological damage after ventricular fibrillation(VF)CA in *** Adult male isoflurane-anesthetized rats were subjected to 6 min VF CA followed by 2 min resuscitation including chest compression,epinephrine,bicarbonate,and *** return of spontaneous circulation(ROSC),rats were randomized to two groups:(1)Minocycline 90 mg/kg intraperitoneally(i.p.)at 15 min ROSC,followed by 22.5 mg/kg *** 12 h for 72 h;and(2)Controls,receiving the same volume of vehicle(phosphate-buffered saline).The rats were kept normothermic during the postoperative *** injury was assessed daily using Overall Performance Category(OPC;1=normal,5=dead)and Neurologic Deficit Score(NDS;0%=normal,100%=dead).Rats were sacrificed at 72 *** degeneration(Fluoro-Jade C staining)and microglia proliferation(anti-Iba-1 staining)were quantified in four selectively vulnerable brain regions(hippocampus,striatum,cerebellum,cortex)by three independent reviewers masked to the group *** In the minocycline group,8 out of 14 rats survived to 72 h compared to 8 out of 19 rats in the control group(P=0.46).The degree of neurologic deficit at 72 h[median,(interquartile range)]was not different between survivors in minocycline vs controls:OPC 1.5(1-2.75)vs 2(1.25-3),P=0.442;NDS 12(2-20)vs 17(7-51),P=0.328)or between all studied *** number of degenerating neurons(minocycline vs controls,mean±SEM:Hippocampus 58±8 vs 76±8;striatum 121±43 vs 153±32;cerebellum 20±7 vs 22

关键词： Heart arrest/pathology Cardiopulmonary resuscitation Survival rate Neurons/drug effects Microglia/drug effects Minocycline/pharmacology

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Volumetric changes in the focal areas of seismic events corresponding to destress blasting

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International Journal of Mining Science and Technology 2019年第4期29卷 541-547页

作者： P.Konicek J.schreiber l.Nazarova Department of Geomechanics and Mining Research Institute of Geonics of the Czech Academy of SciencesOstrava 70800Czech Republic laboratory of Mining Informatics Chinakal Institute of Mining of the Siberian Branch of the Russian Academy of ScienceNovosibirsk 630091Russia

The typical development of total volumetric change in the focal areas of seismic events,corresponding to destress blasting,is characterized as an explosive phase followed by an implosive phase and with alternating additional phases following on from *** a few cases,a non-typical development of volumetric change was identified,where the first phase was implosive and the second phase,*** development is mainly typical for induced seismic events recorded during mining,not for destress *** events were recorded during longwall mining in the Czech part of the Upper Silesian Coal Basin,where the destress blasting technique is used as a rockburst prevention active *** source processes in the focal areas of selected seismic events were analyzed by the seismic moment tensor inversion method,as well as by studying geomechanical rock mass conditions at the localities of the seismic *** main goal of the analysis was to attempt to identify the reasons for non-typical development of volumetric changes in these *** changes were analyzed for seismic events with energy greater than 104 J,recorded in the period of time from 1993 to 2009(1109 events).80%(891)of the recorded seismic events were induced seismic events that were registered during longwall mining and 20%(218)corresponded to destress blasting *** shows that the main reason for the non-typical development of volumetric changes in the focal areas of seismic events is an association with destress blasting in the rock mass,which is very close to rock mass *** detonation of explosives in boreholes,which would dominate the first phase of volumetric changes,probably obscured stress release in the rock mass,as manifested in the first implosion phase of the volumetric changes in this case.

关键词： Destress blasting Seismic event Volumetric changes Stress release

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Effects of torpedo blasting on rockburst prevention during deep coal seam mining in the Upper Silesian Coal Basin

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第4期9卷 694-701页

作者： l. Wojtecki P. Konicek J. schreiber Polish Mining Group Powstanców 30 Katowice 40-039 Poland Department of Geomechanics and Mining Research Institute of Geonics Czech Academy of Sciences Studentska 1768 Ostrava-Poruba 708 00 Czech Republic

In the Upper Silesian Coal Basin(USCB),coal seams are exploited under progressively more difficult geological and mining conditions(greater depth,higher horizontal stress,more frequent occurrence of competent rock layers,etc.).Mining depth,dislocations and mining remnants in coal seams are the most important factors responsible for the occurrence of rockburst *** mining next to the mining edges of neighbouring coal seams is particularly *** levels of rockburst hazards are minimised via the use of rockburst prevention *** active prevention method is torpedo blasting in roof *** blastings are performed in order to decrease local stress concentrations in rock masses and to fracture the roof rocks to prevent or minimise the impact of high-energy tremors on *** estimation of the effectiveness of torpedo blasting is particularly important when mining is under difficult geological and mining *** blasting is the main form of active rockburst prevention in the assigned colliery in the Polish part of the *** effectiveness of blasting can be estimated using the seismic effect method,in which the seismic monitoring data and the mass of explosives are taken into *** seismic effect method was developed in the Czech Republic and is always being used in collieries in the Czech part of the coal ***,this method has been widely adopted for our selected colliery in the Polish part of the coal *** effectiveness of torpedo blastings in the faces and galleries of the assigned longwall in coal seam 506 has been *** results show that the effectiveness of torpedo blastings for this longwall was significant in light of the seismic effect method,which corresponds to the in situ *** seismic effect method is regularly applied to estimating the blasting effectiveness in the selected colliery.

关键词： Rockburst prevention Torpedo blasting Seismic effect Upper Silesian Coal Basin(USCB)

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Implementation of Caterpillar Inspired Rolling Gait and Nonlinear Control Strategy in a Spherical Robot

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Journal of Bionic Engineering 2018年第2期15卷 313-328页

作者： Abhra Roy Chowdhury Gim Song Soh Shaohui Foong kristin l. Wood Temasek laboratories Engineering Product Development Pillar Singapore University of Technology and Design Singapore 487372 SUTD-MIT International Design Centre Singapore University of Technology and Design Singapore 487372

This paper presents a novel Central Pattern Generator （CPG） based rolling gait generation in a small-sized spherical robot and its nonlinear control mechanism. A rhythmic rolling pattern mimicking Pleurotya caterpillar is produced for the spherical robot locomotion. A synergetically combined feedforward-feedback control strategy is proposed. The feedforward component is generated from centrally connected network of CPGs in conjunction with nonlinear robot dynamics. Two nonlinear feedback control methods namely integral （first order） Sliding Mode Control （SMC） and High （or second） Order Sliding Mode Control （HOSMC） are proposed to regulate robot stability and gait robustness in the presence of matched parameter uncertainties and bounded external disturbances. Design, implementation and experimental evaluation of both roll gait control strategies for the spherical robot are done on smooth （indoor） and irregular （outdoor） ground surfaces, The performance of robot control is quantified by measuring the roll angle stability, phase plane convergence and wheel velocities. Experimental results show that proposed novel strategy is efficient in producing a stable rolling gait and robust control of a spherical robot on two different types of surfaces. It further shows that proposed high HOSMC strategy is more efficient in robust rolling gait control of a spherical robot compared to an integral first-order SMC on two different ground conditions.

关键词： bioinspired spherical robot rolling gait CPG rolling friction integral first-order SMC control HOSMC

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The effects of temperature and resource availability on denitrification and relative N_(2)O production in boreal lake sediments

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Journal of Environmental Sciences 2016年第9期28卷 82-90页

作者： Maria Myrstener Anders Jonsson Ann-kristin Bergstrom Department of Ecology and Environmental Science Umea University90187 UmeaSweden

Anthropogenic environmental stressors（like atmospheric deposition,land use change,and climate warming） are predicted to increase inorganic nitrogen and organic carbon loading to northern boreal lakes,with potential consequences for denitrification in ***,our ability to predict effects of these changes is currently limited as northern boreal lakes have been largely neglected in denitrification *** aim of this study was therefore to assess how maximum potential denitrification and N_2O production rates,and the relationship between the two（relative N_2O production）,is controlled by availability of nitrate（NO_3^-）,carbon（C）,phosphorus（P）,and *** were performed using the acetylene inhibition technique on sediments from a small,nutrient poor boreal lake in northern Sweden in *** potential denitrification and N_2O production rates at 4°C were reached already at NO_3^-additions of 106–120 μg NO_3^-–N/l,and remained unchanged with higher NO_3 *** incubation temperatures increased maximum potential denitrification and N_2O production rates,and Q10 was somewhat higher for N_2O production（1.77） than for denitrification（1.69）.The relative N_2O production ranged between 13% and 64%,and was not related to NO_3^-concentration,but the ratio increased when incubations were amended with C and P（from a median of 16% to 27%）.Combined,our results suggests that unproductive northern boreal lakes currently have low potential for denitrification but are susceptible to small changes in NO_3 loading especially if these are accompanied by enhanced C and P availability,likely promoting higher N_2O production relative to N_2.

关键词： Acetylene NO3 Carbon DOC Nitrous oxide ratio Sediment

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Hybrid quantum-classical convolutional neural networks

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Science China(Physics,Mechanics & Astronomy) 2021年第9期64卷 1-8页

作者： Junhua liu Kwan Hui lim kristin lWood Wei Huang Chu Guo He-liang Huang Information Systems Technology and Design Singapore University of Technology and DesignSingapore 487372Singapore Forth AI Singapore 487372Singapore College of Engineering Design and ComputingUniversity of Colorado DenverColorado 80208USA Guangxi Key laboratory of Optoelectronic Information Processing Guilin University of Electronic TechnologyGuilin 541004China Key laboratory of low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China Hefei National laboratory for Physical Sciences at Microscale and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Shanghai Branch CAS Centre for Excellence and Synergetic Innovation Centre in Quantum Information and Quantum PhysicsUniversity of Science and Technology of ChinaHefei 201315China Henan Key laboratory of Quantum Information and Cryptography Zhengzhou 450000China

Deep learning has been shown to be able to recognize data patterns better than humans in specific circumstances or *** parallel,quantum computing has demonstrated to be able to output complex wave functions with a few number of gate operations,which could generate distributions that are hard for a classical computer to *** we propose a hybrid quantum-classical convolutional neural network(QCCNN),inspired by convolutional neural networks(CNNs)but adapted to quantum computing to enhance the feature mapping *** is friendly to currently noisy intermediate-scale quantum computers,in terms of both number of qubits as well as circuit’s depths,while retaining important features of classical CNN,such as nonlinearity and *** also present a framework to automatically compute the gradients of hybrid quantum-classical loss functions which could be directly applied to other hybrid quantum-classical *** demonstrate the potential of this architecture by applying it to a Tetris dataset,and show that QCCNN can accomplish classification tasks with learning accuracy surpassing that of classical CNN with the same structure.

关键词： quantum computing quantum machine learning hybrid quantum-classical algorithm convolutional neural network

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Integration of solid phase extraction with HIlIC-MS/MS for analysis of free amino acids in source water

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Journal of Environmental Sciences 2022年第7期34卷 190-196页

作者： Junlang Qiu Caley Craven Nicholas Wawryk kristin Carroll Xing-Fang li Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyUniversity of AlbertaEdmontonT6G 2G3Canada School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China

Amino acids(AAs) are prevalent in source water, particularly during spring run-off. Monitoring of amino acids in source water is desirable for water treatment plants(WTP) to indicate changes in source water quality. The objective of this study was to establish analytical procedures for reliable monitoring of amino acids in source water. Therefore, we examined two different methods, large volume inject(lVI) and solid phase extraction(SPE), for sample preparation prior to HIlIC-MS/MS. The lVI-HIlIC-MS/MS method can provide fast and sensitive detection for clean samples, but suffers from matrix effects, resulting in irreproducible separation and shortening column lifetime. We have demonstrated that SPE was necessary prior to HIlIC-MS/MS to achieve reproducible and reliable quantification of AAs in source water. A natural heterocyclic amine 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid(MTCCA) was also included in the method to indicate changes in other natural nitrogenous compounds in source water. The SPE-HIlIC-MS/MS method was able to achieve limits of detection from 2.6-3400 ng/l for the amino acids and MTCCA with RSDs( n = 3) of 1.1%-4.8%. As well, retention times(RT) of the analytes were reproducible with variation less than 0.01 min( n = 3) through the entire project. We further applied the SPE-HIlICMS/MS method to determine AAs in authentic source water samples collected from two drinking water treatment plants(WTPs) during the 2021 spring run-off season. The results support that the SPE-HIlIC-MS/MS method does not require derivatization and can provide reliable, accurate, and robust analysis of AAs and MTCCA in source water, supporting future monitoring of source water quality.

关键词： Water analysis Disinfection byproducts Amino acids HPlC MS HIlIC

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Impact loading in female runners with single and multiple bone stress injuries during fresh and exerted conditions

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Journal of Sport and Health Science 2023年第3期12卷 406-413页

作者： kristin l.Popp Jereme Outerleys Sarah Gehman Margaret Garrahan Sara Rudolph Elizabeth loranger Kathryn E.Ackerman Adam S.Tenforde Mary l.Bouxsein Irene S.Davis Military Performance Division United States Army Research Institute of Environmental MedicineNatickMA 01760USA Endocrine Unit Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Department of Physical Medicine and Rehabilitation Spaulding Rehabilitation HospitalHarvard Medical SchoolCambridgeMA 02138USA Department of Sports Medicine Boston Children's HospitalHarvard Medical SchoolBostonMA 02115USA Center for Advanced Orthopedic Studies Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215USA

Background:Bone stress injuries(BSIs)are common in female runners,and recurrent BSI rates are *** work suggests an association between higher impact loading during running and tibial ***,it is unknown whether impact loading and fatigue-related loading changes discriminate women with a history of multiple *** study compared impact variables at the beginning of a treadmill run to exertion andthe changes in those variables with exertion among female runners with no history of BSI as well as among those with a history of single or multiple ***:We enrolled 45 female runners(aged 18-40 years)for this cross-sectional study:having no history of diagnosed lower extremity BSI(N-BSI,n=14);a history of 1 lower extremity BSI(1-BSI,n=16);and diagnosed by imaging,or a history of multiple(>3)lower extremity BSIs(M-BSI,n=15).Participants completed a 5-km race speed run on an instrumented treadmill while wearing an Inertial Measurement *** vertical average loading rate(VAlR),vertical instantaneous loading rate(VIlR),vertical stiffness during impact via instrumented treadmill,and tibial shock determined as the peak po sitive tibial acceleration via Inertial Measurement Unit were measured at the beginning and the end of the ***:There were no differences between groups in VAlR,VIlR,vertical stiffness,or tibial shock in a fresh or exerted ***,compared to N-BSI,women with M-BSI had greater increase with exertion in VAlR(-1.8%vs.6.1%,p=0.01)and VIlR(1.5%vs.4.8%,p=0.03).Similarly,compared to N-BSI,vertical stiffness increased more with exertion among women with M-BSI(-0.9%vs.7.3%,p=0.006)and 1-BSI(-0.9%vs.1.8%,p=0.05).Finally,compared to N-BSI,the increase in tibial shock from fresh to exerted condition was greater among women with M-BSI(0.9%vs.5.5%,p=0.03)and 1-BSI(0.9%vs.11.2%,p=0.02).Conclusion:Women with 1-BSI or M-BSIs experience greater exertion-related increases in impact loading than women with *** observations impl

关键词： Biomechanics Bone stress injuries Fatigue Runners Stress fracture

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Animal models for the study of hepatitis C virus infection and replication

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World Journal of Gastroenterology 2012年第23期18卷 2909-2913页

作者： kristin l MacArthur Catherine H Wu George Y Wu Department of Medicine Beth Israel Deaconess Medical Center Boston MA 02215 United States Department of Medicine Division of Gastroenterology-Hepatology University of Connecticut Health Center Farmington CT 06030-1845 United States

Hepatitis C virus (HCV) hepatitis, initially termed non-A, non-B hepatitis, has become one of the leading causes of cirrhosis and hepatocellular carcinoma worldwide. With the help of animal models, our understanding of the virus has grown substantially from the time of initial discovery. There is a paucity of available animal models for the study of HCV, mainly because of the selective susceptibility limited to humans and primates. Recent work has focused modification of animals to permit HCV entry, replication and transmission. In this review, we highlight the currently available models for the study of HCV including chimpanzees, tupaia, mouse and rat models. Discussion will include methods of model design as well as the advantages and disadvantages of each model. Particular focus is dedicated to knowledge of pathophysiologic mechanisms of HCV infection that have been elucidated through animal studies. Research within animal models is critically important to establish a complete understanding of HCV infection, which will ultimately form the basis for future treatments and prevention of disease.

关键词： Hepatitis C virus Infection Replication Vac-cine Hepatitis A virus

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Preliminary evaluation of a decision support tool for biochar amendment

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Biochar 2020年第1期2卷 93-105页

作者： Claire l.Phillips Sarah E.light Adam lindsley Thomas A.Wanzek Kylie M.Meyer kristin M.Trippe USDA-ARS Forage Seed and Cereal Research Unit 3450 SW Campus WayCorvallisOR 97331USA University of California Cooperative Extension 142A Garden HighwayYuba CityCA 95991USA Department of Crop and Soil Science Oregon State UniversityCorvallisOR 97331USA

Meta-analyses have shown that only about half of biochar addition studies report improved plant *** improve yield response,here we describe a decision support tool(DST)for selecting a biochar type and amendment rate to meet soil and crop management goals,based on soil and biochar tests values and crop requirements as reported by regional extension *** data from a greenhouse wheat trial,we assessed whether this approach could predict changes in soil chemistry and whether it could identify soils in which amendment would stimulate crop *** data indicated that the DST could provide semi-quantitative predictions of biochar amendment rates needed to meet target soil pH levels,with recommended rates averaging 25%higher than were *** DST was better at predicting biochar application rates to provision P and *** six soil types,post-harvest measurements of extractable-K showed an average 104%recovery of the quantities estimated to be provisioned by conifer wood or wheat straw ***-P recovery averaged 101%in two sandy soils with low P-retention but was considerably lower in four soils with higher P-retention ***-house data also showed that wheat growth improved only when biochar alleviated pH that was substantially below critical thresholds for plant growth,and supported the principle of using crop-specific pH requirements as part of an approach for biochar *** field trials that evaluate yield responses in several nutrient-deficient or acidified soils will be needed to provide a robust evaluation of this DST.

关键词： Wheat liming Phosphorous Potassium Yield response

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