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过度通气4小时对控制式脑皮质撞击损伤大鼠的神经认知行为和病损大小的远期影响

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麻醉与镇痛 2012年第1期8卷 16-22页

作者： Eva Eberspacher, DVM, DACVA Manfred Blobner, md Christian Werner, md Stefanie Ruf, DVM Barbara Eckel, md kristin engelhard, md Wolfgang Schmahl, DW Adrian W. Gelb, MBChB, FRCP 邓希锦（译） Klinik ftir Anasthesiologie und perioperative Intensivrnedizin VeterinarmedizinischeUniversitat Wien Vienna Austria Klinik ftir Anaesthesiologie Klinikum rechts der Isar TechnischeUniversitat Munchen Munich Klinik ftir Anasthesiologie Klinikum der JohannesGutenberg-Universitat Mainz Insfitut fiirTierpathologie Tierarztliche Fakultat derLudwig-Maximilians-Universitat Miinchen Munich Germany Department of Anesthesia andPerioperative Care University of California San Francisco California

背景局部创伤性脑损伤大鼠过度通气4小时对其神经认知行为、运动功能、协调能力和病损大小的远期影响。方法对大鼠进行为期14天的神经认知行为学训练，包括孔板实验、木梁行走实验、木梁平衡实验。21只SD大鼠（369±15g），氟烷麻醉后... 详细信息

背景局部创伤性脑损伤大鼠过度通气4小时对其神经认知行为、运动功能、协调能力和病损大小的远期影响。方法对大鼠进行为期14天的神经认知行为学训练，包括孔板实验、木梁行走实验、木梁平衡实验。21只SD大鼠（369±15g），氟烷麻醉后气管插管，机械通气，行控制性皮质撞击损伤（深1．75mm，直径5mm，速度4m／s）。将大鼠随机分入正常通气组（n=10；Paco2=38-42mmHg）和过度通气组（n=11；Paco2=28-32mmHg），机械通气4小时。创伤后持续检测大鼠的行为学和运动能h20天。随后，将大鼠在深麻醉下断头取脑，冰冻脑组织，切片，评估病损大小。结果过度通气组与正常通气组相比外显记忆受损严重。两组大鼠在损伤初期的运动功能和协调能力的测试（木梁行走和木梁平衡实验）中表现均有欠缺，过度通气组更为严重。但是，在实验结束时，两组并无明显差异。创伤后第20天，过度通气组大鼠测得的病损大小（69．7±13．0mm^3）明显大于正常通气组（48．3±15．6mm^3）。结论创伤性脑损伤后过度通气4／1,时（Paco2=28-32mmHg）虽然增加了组织学损伤，但并没有对大鼠远期的神经认知功能造成不良影响。

关键词：神经认知功能过度通气 SD大鼠认知行为撞击损伤脑皮质病损创伤性脑损伤

Ambroxol,the cough expectorant with neuroprotective effects

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Neural Regeneration Research 2024年第11期19卷 2345-2346页

作者： kristin Patzwaldt Salvador Castaneda-Vega Werner Siemens Imaging Center Department of Preclinical Imaging and RadiopharmacyEberhard Karls University TuebingenTuebingenGermany Department of Nuclear Medicine and Clinical Molecular Imaging University Clinic TuebingenTuebingenGermany

Ambroxol hydrochloride(2-amino-3,5-dibromo-N-methylbenzylamine hydrochloride)has been used as a mucolytic agent in the treatment of respiratory diseases since the late *** effects on mucus membranes such as mucus disruption,increased mucus production,and low toxicity profile were addressed in its original German patent in *** first described properties have kept Ambroxol available worldwide and over the counter in the pharmaceutical market to this day.

关键词： protective agent German

The effects of temperature and resource availability on denitrification and relative N_(2)O production in boreal lake sediments

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Journal of Environmental Sciences 2016年第9期28卷 82-90页

作者： Maria Myrstener Anders Jonsson Ann-kristin Bergstrom Department of Ecology and Environmental Science Umea University90187 UmeaSweden

Anthropogenic environmental stressors（like atmospheric deposition,land use change,and climate warming） are predicted to increase inorganic nitrogen and organic carbon loading to northern boreal lakes,with potential consequences for denitrification in ***,our ability to predict effects of these changes is currently limited as northern boreal lakes have been largely neglected in denitrification *** aim of this study was therefore to assess how maximum potential denitrification and N_2O production rates,and the relationship between the two（relative N_2O production）,is controlled by availability of nitrate（NO_3^-）,carbon（C）,phosphorus（P）,and *** were performed using the acetylene inhibition technique on sediments from a small,nutrient poor boreal lake in northern Sweden in *** potential denitrification and N_2O production rates at 4°C were reached already at NO_3^-additions of 106–120 μg NO_3^-–N/L,and remained unchanged with higher NO_3 *** incubation temperatures increased maximum potential denitrification and N_2O production rates,and Q10 was somewhat higher for N_2O production（1.77） than for denitrification（1.69）.The relative N_2O production ranged between 13% and 64%,and was not related to NO_3^-concentration,but the ratio increased when incubations were amended with C and P（from a median of 16% to 27%）.Combined,our results suggests that unproductive northern boreal lakes currently have low potential for denitrification but are susceptible to small changes in NO_3 loading especially if these are accompanied by enhanced C and P availability,likely promoting higher N_2O production relative to N_2.

关键词： Acetylene NO3 Carbon DOC Nitrous oxide ratio Sediment

Test Elements, Generic Elements and Almost Primitivity in Free Products

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Algebra Colloquium 2016年第2期23卷 263-280页

作者： Ann-kristin Engel Benjamin Fine Gerhard Rosenberger Faculty of Mathematics TU-Braunschweig 38106 Braunschweig Germany Department of Mathematics Fairfield University Fairfield Connecticut 06430 USA Fachbereich Mathematik University of Hamburg Bundesstrasse 55 20146 Hamburg Germany FIM University of Passau Innstrasse 33 94032 Passau Germany

In [5, 6] the relationships between test words, generic elements, almost primitivity and tame almost primitivity were examined in free groups. In this paper we extend the concepts and connections to general free produ... 详细信息

关键词： test elements generic elements almost primitive elements free products

Solvation Effects on the Dielectric Constant of 1 M LiPF6 in Ethylene Carbonate:Ethyl Methyl Carbonate 3:7

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Energy & Environmental Materials 2024年第1期7卷 253-256页

作者： Julian Self Nathan T.Hahn kristin A.Persson Department of Chemical Engineering Polytechnique MontrealMontrealQC H3T 1J4Canada Department of Materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Material Physical and Chemical Sciences CenterSandia National LaboratoriesAlbuquerqueNM 87185USA

We report the dielectric constant of 1 M LiPF_(6)in EC:EMC 3∶7 w/w(ethylene carbonate/ethyl methyl carbonate)in addition to neat EC:EMC 3∶7 w/*** three Debye relaxations,the static permittivity value,or dielectric constant,is extrapolated to 18.5,which is compared to 18.7 for the neat solvent *** EC solvent is found to strongly coordinate with the Li^(+)cations of the salt,which results in a loss of dielectric contribution to the ***,the small amplitude and large uncertainty in relaxation frequency for EMC cloud definitive identification of the Li^(+)solvation ***,the loss of the free EC permittivity contribution due to Li^(+)solvation is almost completely balanced by the positive contribution of the associated LiPF_(6)salt,demonstrating that a significant quantity of dipolar ion pairs exists in 1 M LiPF_(6)in EC:EMC 3∶7.

关键词： batteries dielectric relaxation spectroscopy electrolytes

Color change in a marine isopod is adaptive in reducing predation

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Current Zoology 2015年第4期61卷 739-748页

作者： kristin M. HULTGREN Hannah MITTELSTAEDT Department of Biology Seattle University 901 12^th ave. Seattle WA 98122

Although background matching is a common form of camouflage across a wide diversity of animals, there has been surprisingly little experimental work testing the fitness consequences of this camouflage strategy, especially in marine ecosystems. In this study, we tested whether color camouflage enhances survival of the intertidal marine isopod Pentidotea （Idotea） wosnesenskii, quantified patterns of camouflage in different algal habitats, and examined how algal diet affected color change and growth using laboratory assays. In the field, isopods collected from two differently colored algal habitats （the brown alga Fucus distichus and the red alga Odonthaliafloccosa） matched the color of their respective algal habitats, and also differed significantly in body size： smaller red isopods were found on red algae, while larger brown isopods were found on brown algae. Predation ex- periments demonstrated these color differences had fitness benefits： brown isopods that matched their brown algae habitats sur- vived at higher rates than red unmatched isopods. Surprisingly, despite the propensity of isopods to match their algal habitats, algal diet had no effect on color change in color change experiments. Instead, isopods in all treatments turned browner, matching the color of the algal habitat that many isopods are found on as adults. In summary, our data supported our hypothesis that back- ground matching serves an adaptive function in reducing predation, with important evolutionary implications for explaining the wide variation in color change mechanisms in idoteid isopods [Current Zoology 61 （4）： 739-748, 2015].

关键词： Isopod Pentidotea wosnesenskii. Camouflage Crypsis Background matching Color change

Recruitment and functionality traits as bioindicators of ecological restoration success in the Lurg Hills district,Victoria,Australia

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Ecological Processes 2013年第1期2卷 286-296页

作者： kristin Monie Singarayer Florentine Grant Palmer Centre for Environmental Management School of ScienceInformation Technology and EngineeringUniversity of BallaratPO Box 663BallaratVictoriaAustralia

Introduction:The Regent Honeyeater Project commenced ecological restoration in the Lurg district in 1994,with an aim to restore habitats for the critically endangered Regent Honeyeater Anthochaera phrygia and a range of other threatened and declining *** this context,our study aimed to explore whether plant reproduction can be an effective measure of ecological restoration ***:Evaluation involved comparing attributes at unrestored,restored and remnant sites to establish whether sites displayed evidence of a clear restoration *** age classes(unrestored,4–6 years old,8–10 years old,12–14 years old and remnant areas)and two landforms(upper hills and lower hills)were *** diversity of woody plant species—which have easily recognisable reproductive material and which all recruit seedlings—provides easily measured parameters that have the potential to allow the determination of early establishment success and long-term ecological development of restored ***:Restoration plantings developed in a hybrid state towards a benchmark in the lower hills;seedling species composition differed significantly among age classes,increasing in similarity with time since restoration,with some divergence from the target *** of functional groups with reproductive outputs was also significantly different among age classes;however,a restoration trajectory was only evident in the upper hills where sites converged towards the target ***:Divergence or deviation from the restoration trajectory was not deemed to be a restoration failure,as the variety of functional groups with fruits and diversity of seedlings recruiting indicated a potential increase in resilience in the future due to greater variability across the *** recruitment was effective in detecting development trends towards a restoration target in this study and therefore may be a useful measure that contributes to determining ecological

关键词： Restoration Assessment Ecological development Trajectory Monitoring

A high-throughput framework for determining adsorption energies on solid surfaces

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npj Computational Materials 2017年第1期3卷 357-360页

作者： Joseph H.Montoya kristin A.Persson Lawrence Berkeley National Laboratory 1 Cyclotron RoadBerkeleyCA 94720USA Department of Materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA

In this work,we present a high-throughput workflow for calculation of adsorption energies on solid surfaces using density functional *** open-source computational tools from the Materials Project infrastructure,we automate the procedure of constructing symmetrically distinct adsorbate configurations for arbitrary *** algorithms are further used to construct and run workflows in a standard,automated way such that user intervention in the simulation procedure is *** validate our approach,we compare results from our workflow to previous experimental and theoretical benchmarks from the CE27 database of chemisorption energies on solid *** benchmarks also illustrate how the task of performing and managing over 200 individual density functional theory calculations may be reduced to a single submission procedure and subsequent *** enabling more efficient high-throughput computations of adsorption energies,these tools will accelerate theory-guided discovery of advanced materials for applications in catalysis and surface science.

关键词： theory. adsorption determining

High seed losses in mountain birch(Betula pubescens ***)and developmental,ecological,and environmental correlates

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Journal of Plant Ecology 2024年第4期17卷 56-69页

作者： Guorun Oskarsdottir Thora E.Thorhallsdottir kristin Svavarsdottir University of Iceland 102 ReykjavíkIceland Land and Forest Iceland ReykjavíkIceland

Plants typically experience great losses from their reproductive potential represented by ovule production to the post-dispersal crop of viable *** examined seed density and viability in a founder population of mountain birch(Betula pubescens ***),aiming to quantify losses at different stages and examine potential selection forces on the reproduction success of the founder generation of an isolated *** the time of the study(2017-2020),the population had recently reached reproductive maturity,following its colonization around 1990 through long-distance dispersal onto an early successional outwash plain in southeast *** densities were high,but 89% of apparently intact seeds did not contain an embryo,despite being visually indistinguishable from filled *** evident losses amounted to about 45% of the total seed crop and were mostly due to predation by the gall midge Semudobia *** all losses were accounted for,2.7% of the seed crop remained viable and *** limitation may partially explain the high incidence of empty *** flower production is compatible with the predator satiation hypothesis but cannot explain pre-dispersal *** adaptation to predation,masting,appears poorly developed in *** results suggest the presence of constraints on the reproduction potential of the new island population,that are more limiting than in neighbouring populations,and we discuss their developmental,ecological,and environmental correlates.

关键词： Betula pubescens ssp.tortuosa(Ledeb.)Nyman Iceland seed quality seed losses Semudobia betulae sub-arctic