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电子设计应用 2004年第4期 69-72页

作者： kristie valdez Olivier Meilhon 安森美半导体

本文用一种创新的方法提出了四种功率因数校正(PFC)电路设计。两种临界导通模式(CRM)升压,一种连续导通模式(CCM)升压和一种CCM单段回扫,并且推荐了基于功率要求、效率、失真程度、电路板空间和成本限制的解决方案。

关键词：稳压器设计 PFC 功率因数校正电路连续导通模式

The Rising Burden of Hepatocellular Carcinoma: Is the Gender Gap Narrowing?

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 763-764页

作者： James K.H.Ho Prem H.Thurairajah Daniel Q.Huang kristie H.Fan Division of Gastroenterology and Hepatology National University HospitalNational University Health SystemSingaporeSingapore

Dear Editors,The landscape of hepatocellular carcinoma(HCC)is continuously *** global trends indicate a significant shift in the epidemiology of HCC from viral-related to non-viral-related ***-associated fatty liver disease has emerged as the fastest-growing contributor to HCC in recent years,due to the increased prevalence of obesity and metabolic risk factors.

关键词： Carcinoma epidemiology obesity

Advancements in Lynch Syndrome Management: Applying Immunotherapy for Therapeutic Success

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Open Journal of Gastroenterology 2024年第4期14卷 139-144页

作者： Abraamyan Feruza Bobolis kristie Gauchan Dron Sutter Roseville Medical Center Roseville CA USA

Lynch syndrome is the fourth most common cancer in the United States, with an early age of onset and poor prognosis. Here, we present a unique case of a patient with progressive colon cancer due to a late diagnosis of Lynch syndrome showing excellent response to immunotherapy. A 59-year-old male with a history of rectal cancer 30 years ago came to the hospital due to a fever and further found a large necrotic colon mass. Biopsy was positive for colorectal cancer;however, due to the size of the tumor, the patient was deemed not a surgical candidate and offered hospice with palliative chemotherapy. Based on further workup, the patient was diagnosed with Lynch syndrome, with colon cancer determined to be responsive to Immunotherapy. He was started on JEMPERLI (Dosterlimab-gxly), and after three cycles of therapy, imaging and PET scan were repeated, showing decreased activity and extent of the tumor—a tremendous success.

关键词： Lynch Syndrome Colon Cancer Genetics Immunotherapy Dostarlimab

Advancements in Lynch Syndrome Management: Applying Immunotherapy for Therapeutic Success

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Pressure-dependent phase transition of 2D layered silicon telluride(Si2le3)and manganese intercalated silicon telluride

Open Journal of Gastroenterology（肠胃病学期刊） 2024年第4期 139页

作者： Abraamyan Feruza Bobolis kristie Gauchan Dron

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Nano Research 2019年第9期12卷 2373-2377页

作者： Virginia L. Johnson Auddy Anilao kristie J. Koski Department of Chemistry University of CaliforniaDavisDavisCA 95616USA

Two-dimensional(2D)layered silicon telluride(SizTes)nanocrystals were compressed to 12 GPa using diamond anvil cell *** measurements show a color change from transparent red to opaque black indicating a semiconductor-to-metal phase *** scattering was used to observe the stiffening of the crystal lattice and subsequent phase behavior.A possible phase transition was *** 9.5±0.5 GPa evidenced by the disappearance of the Atg stretching *** was intercalated with elemental manganese to^1 at.%.Intercalation lowers the pressure of the proposed phase transition to 7.5±1 *** modes show both phonon stiffening and phonon softening,suggesting negative linear *** results provide fundamental insight into the high-pressure optical phonon behavior of silicon telluride and illuminate how a specific electron-donating intercalant can chemically alter pressure-dependent optical phonon behavior.

关键词： silicon telluride Si2Te3 high pressure diamond anvil cell two-dimensional(2D)layered material

Silencing hepatitis B virus covalently closed circular DNA: The potential of an epigenetic therapy approach

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World Journal of Gastroenterology 2021年第23期27卷 3182-3207页

作者： Prashika Singh Dylan Kairuz Patrick Arbuthnot kristie Bloom Wits/SAMRC Antiviral Gene Therapy Research Unit School of PathologyUniversity of the WitwatersrandJohannesburg 2050GautengSouth Africa

Global prophylactic vaccination programmes have helped to curb new hepatitis B virus(HBV)***,it is estimated that nearly 300 million people are chronically infected and have a high risk of developing hepatocellular *** such,HBV remains a serious health priority and the development of novel curative therapeutics is urgently *** HBV infection has been attributed to the persistence of the covalently closed circular DNA(cccDNA)which establishes itself as a minichromosome in the nucleus of *** the viral transcription intermediate,the cccDNA is responsible for producing new virions and perpetuating *** is dependent on various host factors for cccDNA formation and the minichromosome is amenable to epigenetic *** HBV proteins,X(HBx)and core(HBc)promote viral replication by modulating the cccDNA epigenome and regulating host cell *** includes viral and host gene expression,chromatin remodeling,DNA methylation,the antiviral immune response,apoptosis,and *** of the cccDNA minichromosome would result in a sterilizing cure;however,this may be difficult to *** therapies could permanently silence the cccDNA minichromosome and promote a functional *** review explores the cccDNA epigenome,how host and viral factors influence transcription,and the recent epigenetic therapies and epigenome engineering approaches that have been described.

关键词： Chronic hepatitis B virus Epigenetic gene silencing Functional cure Hepatocellular carcinoma Hepatitis B surface antigen

Structural confirmation of sulconazole sulfoxide as the primary degradation product of sulconazole nitrate

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Journal of Pharmaceutical Analysis 2018年第2期8卷 96-102页

作者： Qun Xu Ashraf Khan Di Gao kristie M.Adams Fatkhulla Tadjimukhamedov Shane Tan John T.Simpson Compendial Development Laboratory United States Pharmacopeia

Sulconazole has been reported to degrade into sulconazole sulfoxide via sulfur oxidation; however,structural characterization data was lacking and the potential formation of an N-oxide or sulfone could not be excluded. To clarify the degradation pathways and incorporate the impurity profile of sulconazole into the United States Pharmacopeia–National Formulary(USP–NF) monographs, a multifaceted approach was utilized to confirm the identity of the degradant. The approach combines stress testing of sulconazole nitrate, chemical synthesis of the degradant via a hydrogen peroxide-mediated oxidation reaction,semi-preparative HPLC purification, and structural elucidation by LC–MS/MS and NMR *** determination was primarily based on the comparison of spectroscopic data of sulconazole and the oxidative degradant. The mass spectrometric data have revealed a Mc Lafferty-type rearrangement as the characteristic fragmentation pathway for alkyl sulfoxides with a β-hydrogen atom, and was used to distinguish the sulfoxide from N-oxide or sulfone derivatives. Moreover, the generated sulconazole sulfoxide was utilized as reference material for compendial procedure development and validation, which provides support for USP monograph modernization.

关键词： Sulconazole nitrate Sulconazole sulfoxide Forced degradation Structural characterization LC–MS/MS

Preliminary evidence of discourse improvement with dopaminergic medication

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Advances in Parkinson's Disease 2013年第2期2卷 37-42页

作者： Janelle Sanchez kristie A. Spencer Department of Physical Medicine & Rehabilitation MultiCare Good Samaritan Hospital Puyallup USA Department of Speech and Hearing Sciences University of Washington Seattle USA

Dopaminergic therapy can improve motor functioning in Parkinson’s disease (PD), but its effect on spoken discourse is poorly understood. This study addressed whether discourse produced during a one-minute monologue would be affected by medication withdrawal. We performed a detailed analysis of semistructured speech samples in 38 patients with PD, including measures of efficiency, syntactic complexity, cohesion (i.e., lexical and grammatical ties between sentences), and coherence (i.e., semantic relationship between the utterances and the topic, or between utterances). We found that patients produced more efficient and coherent monlogues when on versus off medication. As discourse relies heavily on cognitive processes such as working memory, these findings are consistent with research showing improved working memory and executive processes with dopaminegic medication.

关键词： Dopaminergic Therapy Discourse Language Speech Parkinson’s Disease

Climate change effects on rangelands and rangeland management:affirming the need for monitoring

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Ecosystem Health and Sustainability 2017年第3期3卷 1-14页

作者： Daniel W.McCollum John A.Tanaka Jack A.Morgan John E.Mitchell William E.Fox kristie A.Maczko Lori Hidinger Clifford S.Duke Urs P.Kreuter Rocky Mountain Research Station USDAForest Service240 W.Prospect RoadFort CollinsColorado 80526 USA James C.Hageman Sustainable Agriculture Research and Extension Center University of WyomingDept 33541000 E.University AvenueLaramieWyoming 82071 USA USDA ARS Rangelands Resources Research Unit8408 Hildreth RoadCheyenneWyoming 82009 USA Texas A&M AgriLife Research Ecosystem Science&Management720 E.Blackland RoadTempleTexas 76502 USA Consortium for Science Policyand OutcomesArizona State UniversityPO Box 875603TempeArizona 85287 USA Ecological Society of America 1990 M StreetNWSuite 700WashingtonD.C.20036 USA Ecosystem Science and Management Texas A&M University2138 TAMUCollege StationTexas 77843 USA

Uncertainty as to the extent and magnitude of changes in conditions that might occur due to climate change poses a problem for land and resource managers as they seek to adapt to changes and mitigate effects of climate *** illustrate using scenarios of projected future conditions on rangelands in the Northern Great Plains and Desert Southwest of the United *** two regions are different in the ways climate change is projected to affect the *** of a longer and warmer growing season in the Northern Great Plains could lead to increased forage production and land *** uncertain effects on summer monsoons that primarily control rangeland productivity in the Desert Southwest,combined with the possibility of more intense and/or frequent drought events,could present land managers with challenges stemming from decreased forage production and land *** projections,though uncertain,provide land managers with basic insight into future conditions they might *** need more.A focus on vulnerability and resilience,with explicit recognition of interactions between ecological and socio-economic factors,coupled with systematic monitoring and assessment of observable conditions on the land to supplement information based on climate projections,will more effectively provide critical and specific information managers need to adaptively manage rangelands under uncertain climate futures.

关键词： adaptive management climate change indicators monitoring rangelands resilience uncertainty vulnerability

Climate change and its association with the expansion of vectors and vector-borne diseases in the Hindu Kush Himalayan region:A systematic synthesis of the literature

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Advances in Climate Change Research 2021年第3期12卷 421-429页

作者： Meghnath DHIMAL Isabelle Marie KRAMER Parbati PHUYAL Shyam Sundar BUDHATHOKI Juliane HARTKE Bodo AHRENS Ulrich KUCH David AGRONEBERG Santosh NEPAL Qi-Yong LIU Cun-Rui HUANG Gueladio CISSE kristie LEBI Doris KLINGELHOFER Ruth MULLER Nepal Health Research Council(NHRC) Kathmandu44600Nepal Global Institute for Interdisciplinary Studies(GIIS) Kathmandu44600Nepal Institute of Occupational Social and Environmental MedicineGoethe UniversityFrankfurt am Main60590Germany Institute for Atmospheric and Environmental Sciences(IAU) Goethe UniversityFrankfurt am Main60438Germany Department of Biomedical Sciences Institute of Environment and Sustainable DevelopmentUniversity of AntwerpAntwerp2000Belgium Department of Primary Care and Public Health School of Public HealthImperial College LondonLondonW2 IPGUnited Kingdom Department of Biomedical Sciences Institute of Tropical MedicineAntwerp2000Belgium International Centre for Integrated Mountain Development(ICIMOD) Kathmandu44600Nepal Department of Vector Biology and Control National Institute for Communicable Disease Control and PreventionChina CDCBeijing102206China WHO Collaborating Centre for Vector Surveillance and Management Beijing102206China Department of Health Policy&Management School of Public HealthSun Yat-sen UniversityGuangzhou510275China Department of Epidemiology and Public Health(EPH) Swiss Tropical and Public Health Institute(Swiss TPH)Basel4051Switzerland University of Basel Basel4001Switzerland Department of Global Health University of WashingtonSeattleWA98104USA

Observed weather and projected climate change suggest an increase in the transmission of vector-borne diseases(VBDs)in the Hindu Kush Himalayan(HKH)*** this study,we systematically explore the literature for empiric associations between the climate variables and specific VBDs and their vectors in the HKH *** conducted a systematic synthesis of the published literature on climate variables,VBDs and vectors in the HKH region until the 8th of December *** majority of studies show significant positive associations of VBDs with climatic factors,such as temperature,precipitation,relative humidity,*** systematic review allowed us to identify the most significant variables to be considered for evidence-based trend estimates of the effects of climate change on VBDs and their vectors in the HKH *** evidence-based trend was set into the context of climate change as well as the observed expansion of VBDs and disease vectors in the HKH *** geographic range of VBDs expanded into previously considered non-endemic areas of highlands(mountains)in the HKH region.B ased on scarce,but clear evidence of a positive relationship of most climate variables and VBDs and the observed climatic changes,we strongly recommend an expansion of vector control and surveillance programmes in areas of the HKH region that were previously considered to be non-endemic.

关键词： Chikungunya Dengue Filariasis High altitude Himalayas Leishmaniasis Mountain Mosquito Malaria Sandfly