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Dissect the rice immune system using a whole-genome sequenced mutant population

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Dissect the rice immune system using a whole-genome sequence...

血球凝集素基因编码的流感抗原决定子在大肠杆菌中表达

第十九届中国作物学会学术年会

作者：沙干 Rashmi Jain Juan Zhao Xiaojing Kong Qiping Sun Lei Yang Jerry jenkins Mawsheng Chern Joel A.Martin Feng Xing Weibo Xie Qiang Li Liang Guo Rod A.Wing Jeremy Schmutz Pamela C.Ronald 李国田 College of Plant Science and Technology Huazhong Agricultural University Department of Plant Pathology University of California Joint Bioenergy Institute Lawrence Berkeley National Laboratory U.S.Department of Energy Joint Genome Institute HudsonAlpha Institute for Biotechnology National Key Laboratory of Crop Genetic Improvement National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Arizona Genomics Institute School of Plant Sciences University of Arizona BIO5 Institute School of Plant Sciences University of Arizona

Background: The availability of thousands of sequenced rice genomes from diverse varieties and accessions provides a rich genetic resource for in-depth exploration in rice function genomics. One drawback to these collections is that most of these rice varieties have long life cycles, and/or low transformation efficiencies, which limits their usefulness as model organisms for biological studies. In contrast, the rice variety Kitaake has a rapid life cycle(9 weeks seed to seed) and is easy to transform and propagate. For these reasons, Kitaake has emerged as a model for studies of diverse monocotyledonous species. Results: We report the de novo genome sequencing and analysis of an early flowering Geng/japonica variety KitaakeX. Our KitaakeX sequence assembly contains 377.6 Mb, consisting of 33 scaffolds(476 contigs) with a contig N50 of 1.4 Mb. Complementing the assembly are detailed gene annotations of 35,594 protein coding genes. To further facilitate rice research, we generated and sequenced a fast-neutron-induced mutant population. We sequenced 1,504 mutant lines at 45-fold coverage and identified 91,513 mutations affecting 32,307 genes, i.e., 58% of all rice genes. To facilitate public access to this genetic resource, we established an open access database called KitBase that provides access to sequence data and seed stocks. We have screened this mutant population for lines altered in plant immunity and identified multiple mutant candidates. One of them named rbl1 showed enhanced resistance to the rice blast fungus Magnaporthe oryzae. We cloned the target gene that is involved in phospholipid biosynthesis and plasma membrane integrity. RBL1 is mainly located in endoplasmic reticulum(ER). Lipidomics assays show that the phosphatidylinositol(PI) level is significantly reduced in the rbl1 mutant. We have used RNA-seq assays to analyze genes with altered expression levels and identified multiple downstream candidate genes, including receptor-like cytoplasmic kinases(

关键词： Rice Kitaake Lesion mimic mutant Blast resistance Lipidomics

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中国生物工程杂志 1981年第2期 35-40页

作者： J.S.Emtage W.C.A.Tacon G.H.Catlin B.jenkins A.G.Porter N.H.Carey 静国忠

鸟瘟病毒（fowl plague virus以下写为FPV）血球凝集素分子的基因序列被插入细菌质体中,其转录是在色氨酸操纵子的促进子控制之下进行的。这种质体指导合成一个蛋白质、它能同鸟瘟病毒血球凝集素的抗血清进行特异性反应。在某些情况下,... 详细信息

鸟瘟病毒（fowl plague virus以下写为FPV）血球凝集素分子的基因序列被插入细菌质体中,其转录是在色氨酸操纵子的促进子控制之下进行的。这种质体指导合成一个蛋白质、它能同鸟瘟病毒血球凝集素的抗血清进行特异性反应。在某些情况下,当将此基因在pBR322的HindⅢ位点插入时,也观察到此基因的表达。

关键词：外源基因蛋白凝集素 FPV 抗原质体色氨酸操纵子基因克隆核糖体结合位点起始密码子起译密码子大肠杆菌大肠埃希氏菌埃希氏杆菌属血球编码流感流行性感冒

An international survey of classification and treatment choices for group D retinoblastoma

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 961-967页

作者： Christina Scelfo Jasmine H Francis Vikas Khetan Thomas jenkins Brian Marr David H Abramson Carol L Shields Jacob Pe’er Francis Munier Jesse Berry J.William Harbour Andrey Yarovoy Evandro Lucena Timothy G Murray Pooja Bhagia Evelyn Paysse Samuray Tuncer Guillermo L Chantada Annette C Moll Tatiana Ushakova David A Plager Islamov Ziyovuddin Carlos A Leal Miguel A Materin Xun-Da Ji Jose W Cursino Rodrigo Polania Hayyam Kiratli Charlotta All-Ericsson Rejin Kebudi Santosh G Honavar Vicktoria Vishnevskia-Dai Sidnel Epelman Anthony B Daniels Jeanie D Ling Fousseyni Traore Marco A Ramirez-Ortiz Ophthalmic Oncology Service Department of Surgery Memorial Sloan Kettering Cancer Center New York 10065 USA Department of Ophthalmology Weill-Cornell Medical Center New York 10065 USA Department of Vitreoretinal and Ocular Oncology Sankara Nathralaya Chennai 600066 India Ocular Ontology Service Wills Eye Hospital Thomas Jefferson University Pennsylvania 19107 USA Hadassah - Hebrew University Medical Center Jerusalem 91120 Israel jules-Gonin Eye Hospital Lausanne 1004 Switzerland USC Roski Eye Institute Children＇s Hospital of Los Angeles California 90033 USA Ocular Oncology Service Bascom Palmer Eye Institute University of Miami Miller School of Medicine Florida 33136 USA Ocular Oncology Department S.N. Fyodorov Eye Microsurgery Federal State Institution Moscow 127486 Russia Department of Ocular Oncology Instituto Nacional de Cancer Rio de Janeiro 1122 Brazil Murray Ocular Oncology and Retina Miami Children＇s Hospital Florida 33143 USA St. Joseph＇s Children＇s Hospital New Jersey 07504 USA Department of Ophthalmology Baylor College of Medicine Texas 77030 USA Department of Ophthalmology Ocular Oncology Istanbul Medical Faculty Istanbul University Istanbul 34452 Turkey Oncology Department Hospital JP Garrahan Buenos Aires 1245 Argentina Department of Ophthalmology VU University Medical Center Amsterdam 1081 the Netherlands Department of Head and Neck Tumors Science Research Institute of Pediatric Oncology and Hematology N.N. Blokhin Russian Cancer Research Center Moscow 115478 Russia Pediatric Ophthalmology and Adult Strabismus Riley Hospital for Children Indiana University Medical Center Indiana 46202 USA National Oncology Center of Uzbekistan Tashkent 110508 Uzbekistan nstituto Nacional de Pediatria Coyoacan 04530 Mexico Department of Ophthalmology and Visual Science Smilow Cancer Hospital at Yale New Haven CT 06520 USA Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200092 China Department of Ophthalmology Santa Casa Mi

AIM： To determine which IIRC scheme was used by retinoblastoma centers worldwide and the percentage of D eyes treated primarily with enucleation versus globe salvaging therapies as well as to correlate trends in treatment choice to IIRC version used and geographic region. METHODS： An anonymized electronic survey was offered to 115 physicians at 39 retinoblastoma centers worldwide asking about IIRC classification schemes and treatment patterns used between 2008 and 2012. Participants were asked to record which version of the IIRC was used for classification, how many group D eyes were diagnosed, and how many eyes were treated with enucleation versus globe salvaging therapies. Averages of eyes per treatment modality were calculated and stratified by both IIRC version and geographic region. Statistical significance was determined by Chi-square, ANOVA and Kruskal-Wallis tests using Prism. RESULTS： The survey was completed by 29% of physicians invited to participate. Totally 1807 D eyes were diagnosed. Regarding IIRC system, 27% of centers used the Children＇s Hospital of Los Angeles （CHLA） version, 33% used the Children＇s Oncology Group （COG） version, 23% used the Philadelphia version, and 17% were unsure. The rate for primary enucleation varied between 0 and 100% and the mean was 29%. By IIRC version, primary enucleation rates were： Philadelphia, 8%; COG, 34%; and CHLA, 37%. By geographic region, primary enucleation rates were： Latin America, 57%; Asia, 40%; Europe, 36%; Africa, 10%, US, 8%; and Middle East, 8%. However, systemic chemoreduction was used more often than enucleation in all regions except Latin America with a mean of 57% per center （P〈0.0001）. CONCLUSION： Worldwide there is no consensus on which IIRC version is used, systemic chemoreduction was the most frequently used initial treatment during the study period followed by enucleation and primary treatment modality, especially enucleation, varied greatly with regards to IIRC version used and geographic r

关键词： retinoblastoma oncology retina enucleation chemotherapy intra-arterial chemotherapy ophthalmic arterychemosurgery cancer

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美国《国家地理》125年

2015年

作者： (美)布林克利 (美)詹金斯撰文

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灯,等灯等灯

现代装饰（家居） 2012年第4期 60-67页

作者： In-es.artdesign Artecnicainc Giorgia Zanellato CEHZ Frank LEFEBVRE et Bastien TAILLAED Ludovic ROTH MIMI'lou Thomas jenkins Ts & Ts Associ es Hctor Serrano 陈菡良事设计

俩朋友过马路,走在前边的没注意人行红灯直往前冲,后面的着急喊道:"灯!等灯等灯!"前面的朋友一扭头:"就你有英特尔i7!"这则笑话不自觉地透出了灯自身发展的历史:远古时代的夜晚,人们只能和黑夜共眠,最早的"灯"就如同这交通信号灯一样,... 详细信息

俩朋友过马路,走在前边的没注意人行红灯直往前冲,后面的着急喊道:"灯!等灯等灯!"前面的朋友一扭头:"就你有英特尔i7!"这则笑话不自觉地透出了灯自身发展的历史:远古时代的夜晚,人们只能和黑夜共眠,最早的"灯"就如同这交通信号灯一样,用通红的火苗驱散虫豸和野兽,用暖黄的光芒削减人们内心深处的恐惧和忧患。而随着火的使用,人类结束了"茹毛饮血"的时代,"灯"的用途也渐渐地改进和演变。

关键词：交通信号灯不自觉前冲人俑灯色彩心理学空间体验室内色彩要会瓷灯距离感

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来自一名美国全科医生的工作手记

中国实用乡村医生杂志 2001年第3期 45-45页

作者： Chris jenkins,MD,张岱中国医科大学!83期英文班

编者按为了实现“21世纪人人享有卫生保健”的目标 ,美国家庭医生协会的一些成员以自愿者的身份无偿向发展中国家介绍社区卫生服务方法和推广全科医学思想。美国俄克拉荷马州土耳沙市IMAGE家庭医生培训中心就是这个队伍中的一员。这个... 详细信息

编者按为了实现“21世纪人人享有卫生保健”的目标 ,美国家庭医生协会的一些成员以自愿者的身份无偿向发展中国家介绍社区卫生服务方法和推广全科医学思想。美国俄克拉荷马州土耳沙市IMAGE家庭医生培训中心就是这个队伍中的一员。这个中心是美国国家认可的机构 ,其以社区为基础 ,附属于两个较大规模的综合性医院 ,主要任务是培训家庭医生。他们与中国医科大学全科医生培训中心建立了友好联系 ,几年来连续来中国医科大学讲学 ,介绍全科医学有关方面的专业理论 ,或从全科医学的角度来讨论如何对一种疾病过程进行分析处理等等。他们的成员都是家庭医生 ,下面将要介绍的就是其中的一名家庭医生的工作手记 ,意在让各位读者充分理解全科医生的知识、技能和工作特点。重点是通过这个病例了解全科医生对病人的管理和治疗。

关键词：全科医生病人病例医疗服务全科医学美国美利坚合众国北美洲

GREENHOUSE GAS AND AMMONIA EMISSION MITIGATION PRIORITIES FOR UK POLICY TARGETS

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Frontiers of Agricultural Science and Engineering 2023年第2期10卷 268-280页

作者： Sarah BUCKINGHAM Cairistiona F.E.TOPP Pete SMITH Vera EORY David R.CHADWICK Christina K.BAXTER Joanna M.CLOY Shaun CONNOLLY Emily C.COOLEDGE Nicholas J.COWAN Julia DREWER Colm DUFFY Naomi JFOX Asma JEBARI Becky jenkins Dominika J.KROL Karina A.MARSDEN Graham A.MCAULIFFE Steven J.MORRISON Vincent O'FLAHERTY Rachael RAMSEY Karl G.RICHARDS Rainer ROEHE Jo SMITH Kate SMITH Taro TAKAHASHI Rachel E.THORMAN John WILLIAMS Jeremy WILTSHIRE Robert M.REES Scotland’s Rural College EdinburghEH93JGUK Institute of Biological&Environmental Sciences AberdeenAB243UUUK School of Natural Sciences Bangor UniversityBangorGwyneddLL572DGUK Agricultural Development and Advisory Service(ADAS) BoxworthCambridgeCB234NNUK School of Biological and Chemical Sciences University of GalwayH91 TK33Ireland Centre for Ecology and Hydrology Bush EstateMidlothianEH260QBUK The James Hutton Institute DundeeDD25DAUK Rothamsted Research North WykeOkehamptonDevonEX202SBUK Ricardo Energy&Environment HarwellOxonOX110QRUK Environment Soils and Land Use DepartmentTeagascCounty WexfordY35 TC97Ireland Agri-food and Biosciences Institute HillsboroughCounty DownBT266DRUK Bristol Veterinary School University of BristolSomersetBS405DUUK

Agriculture is essential for providing food and maintaining food security while concurrently delivering multiple other ecosystem services. However,agricultural systems are generally a net source of greenhouse gases and ammonia. They, therefore, need to substantively contribute to climate change mitigation and net zero ambitions. It is widely acknowledged that there is a need to further reduce and mitigate emissions across sectors, including agriculture to address the climate emergency and emissions gap. This discussion paper outlines a collation of opinions from a range of experts within agricultural research and advisory roles following a greenhouse gas and ammonia emission mitigation workshop held in the UK in March 2022. The meeting identified the top mitigation priorities within the UK's agricultural sector to achieve reductions in greenhouse gases and ammonia that are compatible with policy targets. In addition, experts provided an overview of what they believe are the key knowledge gaps, future opportunities and cobenefits to mitigation practices as well as indicating the potential barriers to uptake for mitigation scenarios discussed.

关键词： agriculture ammonia greenhouse gas mitigation net zero

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动态对比增强MRI生物学标志物在类风湿关节炎大型多中心试验中的可重复性及其对治疗的反应

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国际医学放射学杂志 2017年第6期 732-733页

作者： J.C.Waterton M.Ho L.H.Nordenmark M.jenkins J.Dicarlo G.Guillard 于京隔刘鹏涛 Manchester Academic Health Sciences Centre University of Manchester Stopford Building

摘要目的确定多中心实验中,动态对比增强（DCE）MRI标志物,尤其转移常数Ktrans,在类风湿性关节炎（RA）病人手及腕关节滑膜炎表达的可重复性及其对治疗的反应。方

关键词：可重复性 DCE 动态对比增强 MRI

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创伤后成人呼吸窘迫综合征的流行病学研究

骨科动态 2005年第3期1卷 132-141页

作者： TIMOTHY O. WHITE PAUL J. jenkins RICHARD D. SMITH CHRISTOPHER W.U. CARTLIDGE C. MICHAEL ROBINSON 胡孔足（译）卜海富（译） Investigation performed at the Royal lnfirmary of Edinburgh Scotland United Kingdom 安徽医科大学第一附属医院骨科 230032

背景：尽管成人呼吸窘迫综合征是钝性创伤早期重要的并发症，但是对其流行病学和发生危险因素的研究仍很欠缺。本研究的目的是通过对一组受伤后住院的病例进行前瞻性队列研究，来分析这种并发症的患病率和人口统计学特点，同时也研究了... 详细信息

背景：尽管成人呼吸窘迫综合征是钝性创伤早期重要的并发症，但是对其流行病学和发生危险因素的研究仍很欠缺。本研究的目的是通过对一组受伤后住院的病例进行前瞻性队列研究，来分析这种并发症的患病率和人口统计学特点，同时也研究了损伤的严重程度和类型对这种并发症发生的影响。我们的目标是通过确定成人呼吸窘迫综合征发病的高危因素．研究出便于早期发现该征的途径：方法：我们对8年多来收住在同一所大学医院的7192例创伤性损伤的病例进行了前瞻性研究。除髋部骨折和72小时内出院的病例外，所有创伤后需要住院，年龄在13岁以上，并且是医院属区的居民的病例都包括在本研究之内。对肌肉骨骼系统、胸部、腹部和头部创伤，包括单一或复合性创伤的病例，进行创伤后成人呼吸窘迫综合征的患病率和人口统计学的研究。根据创伤类型分析这种并发症的发病相关危险因素。应用多元logistic回归分析确定成人呼吸窘迫综合征发病的最重要的预测因素。结果：36例（0．5％）患者并发成人呼吸窘迫综合征。年轻人患病率明显较高（p=0．002），其中83％继发于高能量创伤。单一的胸部、头部、腹部或四肢创伤的成人呼吸窘迫综合征的患病率〈1％。两个解剖区域损伤者患病率较高（高达2．9％），三个解剖区域损伤者患病率更高（达10．2％）：多元logistic回归分析显示：入院时损伤严重程度评分、股骨骨折、腹部和四肢联合损伤、以及入院时观察到的生理功能受损均是后期并发成人呼吸窘迫综合征的各自独立的预测因素。结论：成人呼吸窘迫综合征的患病率随损伤的严重程度和所涉及解剖区域损伤的增加而上升。我们已经能够对这些损伤的重要性和相关危险因素进行量化：我们还对此研究结果对便于早期发现这种并发症的意义进行了讨论。

关键词：成人呼吸窘迫综合征流行病学研究创伤后多元logistic回归分析损伤严重程度评分相关危险因素创伤性损伤前瞻性队列研究人口统计学