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Phylogeography and morphometric variation in the Cinnamon Hummingbird complex:Amazilia rutila(Aves:Trochilidae)

Avian Research 2021年第4期12卷 509-525页

作者： Melisa vázquez-López Nandadevi Córtes-Rodríguez Sahid M.Robles-Bello Alfredo Bueno-Hernández Luz E.Zamudio-Beltrán kristen Ruegg Blanca E.Hernández-Baños Museo de Zoología Facultad de CienciasUniversidad Nacional Autónoma de MéxicoApartado Postal04510 Mexico CityMexico Department of Biology Ithaca CollegeIthacaNY 14850USA Museo de Zoología Facultad de Estudios Superiores ZaragozaUniversidad Nacional Autónoma de MéxicoMexico CityMexico Department of Biology Colorado State UniversityFort CollinsCO 80523USA

Background:The Mesoamerican dominion is a biogeographic area of great interest due to its complex topography and distinctive climatic *** area has a large diversity of habitats,including tropical deciduous forests,which house a large number of endemic ***,we assess phylogeographic pattern,genetic and morphometric variation in the Cinnamon Hummingbird complex Amazilia rutila,which prefers habitats in this *** resident species is distributed along the Pacific coast from Sinaloa—including the Tres Marías Islands in Mexico to Costa Rica,and from the coastal plain of the Yucatán Peninsula of Mexico south to ***:We obtained genetic data from 85 samples of ***,using 4 different molecular markers(mtDNA:ND2,COI;nDNA:ODC,MUSK)on which we performed analyses of population structure(median-joining network,STRU CTU RE,FST,AMOvA),Bayesian and Maximum Likelihood phylogenetic analyses,and divergence time *** order to evaluate the historic suitability of environmental conditions,we constructed projection models using past scenarios(Pleistocene periods),and conducted Bayesian Skyline Plots(BSP)to visualize changes in population sizes over *** analyze morphometric variation,we took measurements of 5 morphological traits from 210 study *** tested for differences between sexes,differences among geographic groups(defined based on genetic results),and used PCA to examine the variation in multivariate ***:Using mtDNA,we recovered four main geographic groups:the Pacific coast,the Tres Marías Islands,the Chiapas region,and the Yucatán Peninsula together with Central *** same groups were recovered by the phylogenetic results based on the multilocus *** based on BSP results showed constant population size over time throughout the *** complex and within each geographic *** niche model projec-tions onto past scenarios revealed no drastic changes in suitable conditions,but revealed some

关键词： Amazilia rutila Genetic structure Genetic variation Phylogeography Tres Marías Islands Trochilidae Tropical deciduous forest

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Elevated interleukin-6 levels are associated with impaired outcome in cardiac transthyretin amyloidosis

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World Journal of Cardiology 2021年第3期13卷 55-67页

作者： Selina J Hein Maximilian Knoll Fabian Aus dem Siepen Jennifer Furkel Stefan Schoenland Ute Hegenbart Hugo A Katus Arnt v kristen Mathias Konstandin Department of Cardiology Pneumology and AngiologyUniversity Hospital HeidelbergHeidelbergBW 69120Germany Department of Radiation Oncology Heidelberg Ion-Beam Therapy CenterGerman Cancer Research CenterUniversity Hospital HeidelbergHeidelbergBW 69120Germany Department of Radiation Oncology Heidelberg University HospitalHeidelbergBW 69120Germany Department of Hematology Oncology and RheumatologyAmyloidosis CenterHeidelberg University HospitalHeidelbergBW 69120Germany Department of Hematology Amyloidosis CenterHeidelberg University HospitalHeidelbergBW 69120Germany Department of Cardiology Medical University Hospital HeidelbergHeidelbergBW 69120Germany Department of Cardiology Amyloidosis CenterUniversity of HeidelbergHeidelbergBW 69120Germany

BACKGROUND Elevated interleukin(IL)-6-levels have been described in familial variant transthyretin amyloidosis(ATTRv)associated polyneuropathy and heart ***,IL-6 in cardiac ATTR amyloidosis(ATTR-CM)and its prognostic value have not been investigated *** We aim to study the correlation between IL-6 levels with clinical presentation(Gillmore-class)and outcome[heart transplantation or death(htx/death)],or the combined endpoint of cardiac decompensation or htx/death in *** IL-6 levels of 106 ATTR-CM patients[54 wild-type ATTRwt,52 ATTRv-CM],15 asymptomatic carriers of ATTR mutations(aATTRv-CM)and 27 healthy donors were quantified using Luminex *** analysis was performed using parametric survival regression *** We found that IL-6 levels from wild-type ATTR patients were significantly elevated compared to healthy controls,while aATTRv-CM carriers and ATTRv-CM patients did not show a significant ***-6 levels showed significantly higher values in increasing Gillmore *** analyses revealed association of low IL-6 levels with cardiac decompensation and htx/death[odds ratio:0.26(0.09-0.72),P=0.01]and htx/death[odds ratio:0.15(0.04-0.58),P=0.006].However,in the multivariate model,no significant improvement of risk prediction was seen for IL-6,while established prognostic factors were significantly associated with *** Raised IL-6 levels correlate with clinical presentation and are associated with worse outcome in ATTR-CM but do not improve stratification in addition to established risk factors.

关键词： Transthyretin amyloidosis Inflammation Heart failure Interleukin-6 Outcome Risk stratification

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禽流感病毒和猪流感病毒——人兽共患病危险的新认识(续完)

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国外畜牧学（猪与禽） 2008年第2期28卷 55-59页

作者：杨得胜 kristen v.R. 福建省动物疫病预防控制中心比利时根特大学兽医系病毒学实验室

4猪和禽型流感病毒引发人畜共患病的可能性 4．1人感染猪流感病毒在欧洲，亚洲和美国，偶尔可从人呼吸道分泌物或肺脏中分离到猪流感病毒。表2汇总了所记录的全部人感染猪流感病毒病例。大部分人感染猪流感病毒后所表现出的症状与在临... 详细信息

4猪和禽型流感病毒引发人畜共患病的可能性 4．1人感染猪流感病毒在欧洲，亚洲和美国，偶尔可从人呼吸道分泌物或肺脏中分离到猪流感病毒。表2汇总了所记录的全部人感染猪流感病毒病例。大部分人感染猪流感病毒后所表现出的症状与在临床上人流感症状无明显区分，但已见到人感染经典的猪H1N1亚型流感病毒后导致死亡的病例。在1976年美国发生所谓的“新泽西”事件中，

关键词：猪流感病毒人兽共患病禽流感病毒危险人畜共患病感染分泌物呼吸道

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Universal cell and tissue acquisition/analysis system: from single cell adhesion measurement and collection to archival FFPE brain tissue microdissection

Universal cell and tissue acquisition/analysis system: from ...

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中国神经科学学会第十二届全国学术会议

作者： Zhongcai MA kristen DEIGNAN Anialac ZAvALA Christopher K WILLIAMS Harry v.vINTERS Lili C.KUDO Stanislav L.KARSTEN NeuroInDx Inc. Department of Pathology David Geffen School of Medicine at UCLA

Objective: Analysis of specific cells from cultures or isolation of subanatomical regions from heterogeneous tissues is essential in today’s biomedical research. Single cell adhesion properties are a key to understanding cellular properties in health and disease. Tissue microdissection from fixed tumor biopsies and archived FFPE samples is much needed yet technically challenging. Commercially available single cell technologies do not provide concurrent single cell adhesion force measurement and acquisition, and current microdissection platforms are sample specific, complex and expensive. Methods: We applied our vacuum impulse based cell and tissue acquisition technology for single cell adhesion force measurement and fixed tissue microdissection. With our recent platform, Unipic K+?, adhesion strength for individual cells from SH-SY5 Y, CHO, and 3 T3 cultures were measured based on capillary aspiration techniques. Single cells were collected and dispensed immediately into individual wells for clonal expansion.. A novel DNA extraction method was developed to acquire region specific DNA from 5 to 20 μm thick PFA-fixed and FFPE archived human brain tissue sections using disposable capillary units preloaded with alkaline solution and a microscope stage heater set at 100°C. Results: The new system collects individual cells from adherent cultures in as small as 15 nl, compatible with various downstream single cell analyses. Manual and automatic extraction algorithms were developed for acquisition of tissue region of interest（ROI）. Dissociation and collection of ROIs down to 20 μm in diameter can be performed on fixed tissue sections within 30 s. for DNA isolation. Conclusion: A universal platform has been developed for fresh frozen and fixed tissue microdissection, single cell acquisition, adhesion force measurements and deposition into single wells for various downstream applications.

关键词： adhesion single cell analysis tissue microdissection archival tissue acquisition dispensing

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Mechanism-driven strategies for prevention of rheumatoid arthritis

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Rheumatology & Autoimmunity 2022年第3期2卷 109-119页

作者： v.Michael Holers Kristine A.Kuhn M.kristen Demoruelle Jill M.Norris Gary S.Firestein Eddie A.James William H.Robinson Jane H.Buckner Kevin D.Deane Division of Rheumatology University of Colorado School of MedicineAuroraColoradoUSA Department of Epidemiology Colorado School of Public HealthAuroraColoradoUSA Division of Rheumatology Allergy and ImmunologyUniversity of California San DiegoLa JollaCaliforniaUSA Benaroya Research Institute SeattleWashingtonUSA Division of Immunology and Rheumatology Stanford UniversityStanfordCaliforniaUSA Department of Medicine Division of RheumatologyVA Palo Alto Health Care SystemPalo AltoCaliforniaUSA

In seropositive rheumatoid arthritis(RA),the onset of clinically apparent inflammatory arthritis(IA)is typically preceded by a prolonged period of autoimmunity manifest by the presence of circulating autoantibodies that can include antibodies to citrullinated protein antigens(ACPA)and rheumatoid *** period before clinical IA can be designated preclinical RA in those individuals who have progressed to a clinical diagnosis of RA,and an“at‐risk”status in those who have not developed IA but exhibit predictive biomarkers of future clinical *** the goal of developing RA prevention strategies,studies have characterized immune phenotypes of preclinical RA/at-risk *** these studies,a model has emerged wherein mucosal inflammation and dysbiosis may lead first to local autoantibody production,which should normally be transient,but instead is followed by a systemic spread of the autoimmunity as manifested by serum autoantibody elevations,ultimately driving the development of clinically identified joint *** model can be envisioned as the progression of disease development through serial“checkpoints”that in principle should constrain or resolve autoimmunity;however,instead,the checkpoints“fail”and clinical RA *** we review the immune processes that are likely to be present at each step and the potential therapeutic strategies that could be envisioned to delay,diminish,halt,or even reverse the progression to clinical ***,these prevention strategies could utilize existing therapies approved for clinical RA,therapies approved for other diseases that target relevant pathways in the preclinical/at-risk state,or approaches that target novel pathways.

关键词： autoimmune disease inflammation mucosa prevention rheumatoid arthritis

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判断多胎妊娠羊膜性和绒毛膜性的临床实践

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中国产前诊断杂志（电子版） 2011年第1期3卷 21-25页

作者：赵胜 Jennifer J.Wan David Schrimmer v'eronique Tach'e kristen Quinn D.Yvette Lacoursiere Gina James 湖北省妇幼保健院超声科湖北武汉430070 美国加州大学圣迭戈分校医学中心生殖医学科

目的以组织病理诊断为参照,评价一所三级医院及转诊医生产前判断多胎妊娠羊膜性和绒毛膜性的准确性。方法回顾性分析289例多胎妊娠转诊医生、三级医院及组织病理学判断羊膜性和绒毛膜性的情况。结果从基层医院转诊来的289例多胎妊娠中,... 详细信息

目的以组织病理诊断为参照,评价一所三级医院及转诊医生产前判断多胎妊娠羊膜性和绒毛膜性的准确性。方法回顾性分析289例多胎妊娠转诊医生、三级医院及组织病理学判断羊膜性和绒毛膜性的情况。结果从基层医院转诊来的289例多胎妊娠中,仅43.6%(126/289)在转诊前获得准确判断。三级医院诊断羊膜性和绒毛膜性的总体准确率为94.8%(274/289),并且双胎及三胎妊娠100%在早孕期得到诊断。因为不确定羊膜性和绒毛膜性而转诊的病例中,包括46.1%(113/245)的双胎和64.1%(25/39)的三胎。结论早期发现关键性的超声特征可用以准确判断羊膜性和绒毛膜性。转诊医生准确判断羊膜性和绒毛膜性与三级医院相比明显不够准确,建议这些基层医院提高诊断技能并在诊断不确定时及时转诊。

关键词：多胎妊娠双胎羊膜性胎盘形成超声

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