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Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus

World Journal of Gastrointestinal Endoscopy 2017年第9期9卷 480-485页

作者： kristen suchniak-mussari Charles E Dye Matthew T Moyer Abraham Mathew Thomas J McGarrity Eileen M Gagliardi Jennifer L Maranki John M Levenick Department of Gastroenterology Allegheny General Hospital Section of Gastroenterology and Hepatology Penn State Hershey Medical Center

AIM To evaluate the efficacy and safety of liquid nitrogen cryotherapy as a primary or rescue treatment for BE,with and without dysplasia,or intramucosal adenocarcinoma (IMC).METHODS This was a retrospective,single-center study carried out in a tertiary care center including 45 patients with BE who was treatment-na?ve or who had persistent intestinal metaplasia(IM),dysplasia,or IMC despite prior ***'s mucosa was resected via EMR when clinically appropriate,then patients underwent cryotherapy until eradication or until deemed to have failed *** biopsies were taken at standard *** From 2010 through 2014,33 patients were studied regarding the efficacy of ***,29 patients (88%) responded to cryotherapy,with 84% having complete regression of all dysplasia and *** eradication of cancer and dysplasia was seen in 75% of subjects with IMC; the remaining two subjects did not respond to *** cryotherapy,15 patients with high-grade dysplasia (HGD) had 30% complete regression,50% IM,and 7% low-grade dysplasia (LGD); one subject had persistent *** eradication of dysplasia occurred in all 5 patients with *** 5 patients with IM,complete regression occurred in 4,and IM persisted in *** 136 cryotherapy sessions amongst 45 patients,adverse events included chest pain (1%),stricture (4%),and one gastrointestinal bleed in a patient on dual antiplatelet therapy who had previously undergone *** Cryotherapy is an efficacious and safe treatment modality for Barrett's esophagus with and without dysplasia or intramucosal adenocarcinoma.

关键词： Barrett’s esophagus Esophageal adenocarcinoma Tru Freeze Liquid nitrogen cryotherapy Radiofrequency ablation

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