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性传播疾病的性伴通知策略

生殖与避孕 2005年第6期25卷 363-370页

作者： m.thews C Coetzee N Zwarenstein m.Lom.ard C Guttm.cher S Oxm.n A Schm.d G 刘善民单位不详

性伴通知是通知被诊断为STD患者(指示患者)的性伴，他们易于感染，有必要到卫生服务机构就诊。其临床目标之一是防止指示患者的再感染：另一个是公共卫生目标，减少STDs的传播。人部分感染STD的人既无感染症状，又无体征。如通过性伴通... 详细信息

性伴通知是通知被诊断为STD患者(指示患者)的性伴，他们易于感染，有必要到卫生服务机构就诊。其临床目标之一是防止指示患者的再感染：另一个是公共卫生目标，减少STDs的传播。人部分感染STD的人既无感染症状，又无体征。如通过性伴通知识别的淋病男性患者中，22％-68％是无症状的(holmes1990)。要实现上述目标，性伴通知是能联系到这些个体的两个策略之一，

关键词：性传播疾病性伴通知策略流行病学医生通知约定通知

Ross综合征是否为一种罕见且常被误解的体温调节障碍疾病:12例患者皮肤神经支配研究

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世界核心医学期刊文摘（眼科学分册） 2006年第12期2卷 1-1页

作者： Nolano m. Provitera V. Perretti A. 张磊 Neurology Departm.nt ‘S. Maugeri’Foundation Via Bagni Vecchi 1 82037 Telese Terme (BN) ItalyDr.

Ross syndrom. is described as a rare disorder of sweating associated with areflexia and tonic pupil. Since Ross’s first description in 1958, ～40 cases have been described. We assessed the involvem.nt of cutaneous innervation in 12 subjects with Ross syndrom. using quantitative sensory testing, sweating assessm.nt and im.unohistochem.cal study of anhidrotic and hyperhidrotic skin. This evaluation was repeated over tim. in 4 out of 12 subjects. In addition, we enrolled four subjects with holmes-Adie syndrom. (areflexia and tonic pupil)to investigate sim.larities between the two conditions. We found in Ross patients a com.lex and progressive involvem.nt of cutaneous sensory and autonom.c innervation underlying the im.airm.nt of heat production and heat dissipation through both loss of sweating and loss of cutaneous blood flow regulation. In holmes-Adie subjects we found a m.ld im.airm.nt of sweating without therm.regulatory problem.. The persistence of a sudom.tor vasoactive intestinal peptide-im.unoreactive (VIP-ir) innervation, although deranged and poor, definitely differentiated holmes-Adie from.Ross patients. Ross syndrom. is a progressive and com.lex disorder of therm.regulation difficult to differentiate from.the probably pathogenetically related holmes-Adie syndrom.. Sweating assessm.nt and skin biopsy are suitable tools to define a boundary between them. Owing to the large num.er of Ross patients observed in only 5 years, and to the long and com.lex m.dical history of m.st of them. doubts arise on the effective rarity of this condition, and we warn fam.ly doctors and other specialists, besides neurologists, to becom. aware of this com.lex disorder.

关键词： Ross综合征患者皮肤神经支配体温控制疾病调节障碍 Adie综合征免疫组织化学方法

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绵羊和牛摄食行为自动记录装置的发展和使用

草原与草坪 1983年第5期 38-42页

作者： A.R.m.Cham.ers 石定燧

前言目测牧食和反刍活动是费力的强劳动,一些学者已经应用自记仪器在野外自动记录这些活动。振动器(Vibracorder)用振摆原理和钟的机械装置记录牧食时间和频率已被广泛采用(Allden,1962;Stobbs,1970;Sarker 和 holmes,1974,Castle 等197... 详细信息

前言目测牧食和反刍活动是费力的强劳动,一些学者已经应用自记仪器在野外自动记录这些活动。振动器(Vibracorder)用振摆原理和钟的机械装置记录牧食时间和频率已被广泛采用(Allden,1962;Stobbs,1970;Sarker 和 holmes,1974,Castle 等1975),移位微动开关已被用于记录颌的活

关键词：绵羊奶牛振动器食器采食率

脑干背侧迷走神经复合体中星形胶质细胞对食物摄取的调节

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神经损伤与功能重建 2020年第1期15卷 F0003-F0003页

作者： Alastair J.m.cDonald Fiona E.holmes Craig Beall Anthony E.Pickering Kate L.J.Ellacott 杜一星(编译) Institute of Biom.dical and Clinical Sciences University of Exeter Medical SchoolExeterUK. School of Physiology Pharmacology and NeuroscienceUniversity of BristolBiomedical Sciences BuildingUniversityWalkBristolUK. Anaesthesia Pain and Critical Care SciencesTranslational Health SciencesBristol Medical SchoolUniversity of BristolBristolUK. 不详

随着下丘中与调节能量稳态有关的脑星形胶质细胞信号传导的发现,星形胶质细胞在控制摄食的脑回路中的作用正逐渐被认识。脑干背侧迷走神经复合体(DVC)内的孤束核(NTS)整合了来自内脏的迷走神经传入信息,并起调节摄食的作用。我们假定该... 详细信息

随着下丘中与调节能量稳态有关的脑星形胶质细胞信号传导的发现,星形胶质细胞在控制摄食的脑回路中的作用正逐渐被认识。脑干背侧迷走神经复合体(DVC)内的孤束核(NTS)整合了来自内脏的迷走神经传入信息,并起调节摄食的作用。我们假定该核团中的星形胶质细胞对食物摄入做出反应并影响食物摄入。在黑暗期喂食高脂食物12 h的小鼠出现NTS星形胶质细胞活化,表现为与对照饲料喂养的小鼠相比,极后区(AP)邻近的神经胶质纤维酸性蛋白(GFAP)免疫反应性细胞数量增加(65%)和形态复杂性增高。为了检测星形胶质细胞活化对食物摄入的影响,我们使用腺相关病毒(AAV)载体(AAV-GFAPh m.Dq-m.Cherry)将设计药物激活的设计受体(DREADDs)导入DVC星形胶质细胞(包括孤束核、极后区和迷走神经背运动核)。使用氯氮平-N-氧化物(0.3 m./kg)进行化学遗传激活星形胶质细胞使其产生了比平行处理组星形细胞更复杂的形态,并在注射后4 h使动物在黑暗期进食减少84%。与表达AAV-GFAPm.Cherry的对照小鼠相比,DVC星形胶质细胞的h m.Dq激活在禁食过夜后仍然减少黑暗期摄食(注射后4 h降低71%)。DREADD介导的星形胶质细胞激活不影响运动功能。DVC中星形胶质细胞的h m.Dq激活引起邻近的摄食神经回路(包括臂旁核)中c-FOS的表达。这表明NTS星形胶质细胞能对急性营养过剩做出反应,参与外周饱腹感信号的整合,并且在其激活后可以减少食物摄入。

关键词：星形胶质细胞化学遗传技术摄食新陈代谢孤束核

Im.act of high dose vitam.n C on platelet function

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World Journal of Critical Care m.dicine 2017年第1期6卷 37-47页

作者： Bassem.m.m.ham.ed Kim.erly W Sanford Bernard J Fisher Erika J m.rtin Daniel Contaifer Jr Urszula Osinska Warncke Dayanjan S Wijesinghe Charles E Chalfant Donald F Brophy Alpha A Fowler Ⅲ Ram.sh Natarajan Departm.nt of Clinical Pharm.cy Faculty of Pharmacy Cairo University Departm.nt of Pharm.cotherapy and Outcom.s Science Virginia Commonwealth University Departm.nt of Pathology Virginia Commonwealth University Division of Pulm.nary Disease and Critical Care m.dicine De-partment of Internal Medicine Virginia Commonwealth University Research and Developm.nt Hunter Holmes Mc Guire Veterans Administration Medical Center the Department of Biochemistry and Molecular Biology the VCU Massey Cancer Center the VCU Institute of Molecular Medicine and the VCU Johnson Center for Critical Care and Pulmonary Research Virginia Commonwealth University

AIm.To exam.ne the effect of high doses of vitam.n C(VitC) on ex vivo hum.n platelets(PLTs).m.THODS Platelet concentrates collected for therapeutic or prophylactic transfusions were exposed to:(1) norm.l saline(control);(2) 0.3 m.ol/L VitC(Lo VitC); or(3) 3 m.ol/L VitC(Hi VitC, final concentrations) and stored appropriately. The Vit C additive was preservative-free buffered ascorbic acid in water, pH 5.5 to 7.0, adjusted with sodium.bicarbonate and sodium.hydroxide. The doses of Vit C used here correspond to plasm. Vit C levels reported in recently com.leted clinical trials. Prior to supplem.ntation, a baseline sam.le was collected for analysis. PLTs were sam.led again on days 2, 5 and 8 and assayed for changes in PLT function by: Throm.oelastography(TEG), for changes in viscoelastic properties; aggregom.try, for PLT aggregation and adenosine triphosphate(ATP) secretion in response to collagen or adenosine diphosphate(ADP); and flow cytom.try, for changes in expression of CD-31, CD41 a, CD62 p and CD63. In addition, PLT intracellular Vit C content was m.asured using a fluorim.tric assay for ascorbic acid and PLT poor plasm. was used for plasm. coagulation tests [prothrom.in tim.(PT), partial throm.plastin tim.(PTT), functional fibrinogen] and Lipidom.cs analysis(UPLC ESI-m./m.).RESULTS VitC supplem.ntation significantly increased PLTs intracellular ascorbic acid levels from.1.2 m.ol/L at baseline to 3.2 m.ol/L(Lo VitC) and 15.7 m.ol/L(Hi VitC, P m.ntation did not significantly change PT and PTT values, or functional fibrinogen levels over the 8 d exposure period(P > 0.05). PLT function assayed by TEG, aggregom.try and flow cytom.try was not significantly altered by Lo or Hi VitC for up to 5 d. However, PLTs exposed to 3 m.ol/L VitC for 8 d dem.nstrated significantly increased R and K tim.s by TEG and a decrease in the α-angle(P m. in m.xim.m.am.litude associated with the Hi VitC com.ared to both baseline and d

关键词： Platelet function Throm.oelastography Flow cytom.try Platelet lipidom.cs Vitam.n C

Adiposity and spinal cord injury

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World Journal of Orthopedics 2015年第8期6卷 567-576页

作者： Ashraf S Gorgey Kathryn m.Wells Tim.thy L Austin Spinal Cord Injury and Disorder Service Hunter Holmes Mc Guire VA Medical Center Departm.nt of Physical m.dicine and Rehabilitation Virginia Commonwealth University College of Health and Hum.n Perform.nce Virginia Commonwealth University

The drastic changes in body com.osition following spinal cord injury(SCI) have been shown to play a significant role in cardiovascular and m.tabolic health. The pattern of storage and distribution of different types of adipose tissue m.y im.act m.tabolic health variables sim.lar to carbohydrate, lipid and bone m.tabolism. The use of m.gnetic resonance im.ging provides insights on the interplay am.ng different regional adipose tissue com.artm.nts and their role in developing chronic diseases. Regional adipose tissue can be either distributed centrally or peripherally into subcutaneous and ectopic sites. The prim.ry ectopic adipose tissue sites are visceral, intram.scular and bone m.rrow. Dysfunction in the central nervous system.following SCI im.acts the pattern of distribution of adiposity especially between tetraplegia and paraplegia. The current editorial is focused prim.rily on introducing different types of adipose tissue and establishing scientific basis to develop appropriate dietary, rehabilitation or pharm.ceutical interventions to m.nage the negative consequences of increasing adiposity after SCI. We have also sum.arized the clinical im.lications and future recom.endations relevant to study adiposity after SCI.

关键词： Adiposity m.gnetic resonance im.ging Dual-energy X-ray absorptiom.try Ectopic adiposity Visceral and subcutaneous adiposity Intram.scular fat Spinal cord injury

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通过检验血中胃泌素诊断绵羊血矛线虫病

国外兽医学（畜禽疾病） 1989年第3期10卷 44-44页

作者： m.T.FOX 葛宝伟

在热带和亚热带地区,绵羊感染捻转血矛线虫,是影响增重的一个重要因素(Fabiyi,1987)。实验表明,这种影响是由于寄生虫吸血,和引起胃酸分泌减少,使消化能力降低造成的(holmes,1987)。胃酸减少,导致胃中pH值的增高,使血浆中胃蛋白酶原的... 详细信息

在热带和亚热带地区,绵羊感染捻转血矛线虫,是影响增重的一个重要因素(Fabiyi,1987)。实验表明,这种影响是由于寄生虫吸血,和引起胃酸分泌减少,使消化能力降低造成的(holmes,1987)。胃酸减少,导致胃中pH值的增高,使血浆中胃蛋白酶原的浓度也随之提高,在感染后的一周内,这种变化最为明显,所以可利用检验胃蛋白酶原,诊断胃内寄生虫的感染(Coop,1971),当前使用检验胃蛋白酶原的方法,不但需要较高的技术水平,而且耗费时间,与其它检验方法相对照,也不够准确。

关键词：绵羊血矛线虫病胃泌素检测

生活中重大压力事件与皮肤敏感症发生增加有关:1个非临床的经验性研究

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 53-53页

作者： Gupta m.A. Gupta A.K. 张宪旗 645Winderm.reRd. London Ont. N5X 2PL Canada

Background. Psychological stress resulting from.stressful m.jor life events is known to exacerbate a wide range of skin disorders. Objective. To exam.ne the relationship between stressful m.jor life events and derm.tological sym.tom. am.ng a non-clinical sam.le. Design. A cross-sectional survey. Setting. Com.unity-based subjects from.London, Ontario, Canada were recruited from.the local university, schools and churches. Participants. Out of 600 consecutive, consenting volunteers 316 subjects [73 m.n and 243 wom.n; age 38.7 ±14.8 (m.an ±SD years; m.rital status 54%m.rried; race 94%’white’] com.leted the survey for this study. The exclusion criterion was a history of a m.jor derm.tological or m.dical disorder. m.in outcom. m.asure. The num.er of m.jor life events experienced over the previous 6 m.nths m.asured using the Social Readjustm.nt Rating Scale (SRRS) of holmes and Rabe, and the frequency and severity of a range of cutaneous sym.tom. (burning, ’crawling sensation,’tingling, ’pricking’or ’pins and needles’, ’pain’, ’tenderness’of skin, ’num.ness’, ’m.derate to severe itching’, and ’easy bruising’) that the subject m.y have experienced over the previous m.nth. Results. Them.st frequently reported body region affectedwas the scalp (59.5%) and the m.st frequently reported sym.tom.was itching (69.3%). The total num.er of m.jor life events experienced over the previous 6 m.nths correlated with the severity of the individual cutaneous sym.tom. (0.22 ≤Pearson r ≤0.41, P m.tom.severity score (sum.of all cutaneous severity ratings) (Pearson r = 0.40, P m.ined significant after the possible confounding effect of psychological factors on cutaneous sym.tom. was partialled out statistically (partial r = 0.19, P = 0.001). Discussion. We observed a direct correlation between the num.er of m.jor life events experienced over the previous 6 m.nths and cutaneous sym.tom. experienced over the previous 1m.nth by n

关键词：压力事件经验性研究重大生活事件疼痛感针刺感排除标准症状严重程度临床患者心理压力地方大学