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Insulin sensitivity and complications in type 1 diabetes: New insights

World journal of Diabetes 2015年第1期6卷 8-16页

作者： Petter Bjornstad janet K Snell-Bergeon kristen j nadeau David M Maahs Department of Pediatrics University of Colorado School of Medicine Barbara Davis Center for Diabetes University of Colorado School of Medicine Department of Pediatrics Division of Pediatric Endocrinology University of Colorado School of Medicine

Despite improvements in glucose, lipids and bloodpressure control, vascular complications remain the most important cause of morbidity and mortality in patients with type 1 diabetes. For that reason, there is a need to identify additional risk factors to utilize in clinical practice or translate to novel therapies to prevent vascular complications. Reduced insulin sensitivity is an increasingly recognized component of type 1 diabetes that has been linked with the development and progression of both micro- and macrovascular complications. Adolescents and adults with type 1 diabetes have reduced insulin sensitivity, even when compared to their non-diabetic counterparts of similar adiposity, serum triglycerides, high-density lipoprotein cholesterol, level of habitual physical activity, and in adolescents, pubertal stage. Reduced insulin sensitivity is thought to contribute both to the initiation and progression of macro- and microvascular complications in type 1 diabetes. There are currently clinical trials underway examining the benefits of improving insulin sensitivity with regards to vascular complications in type 1 diabetes. Reduced insulin sensitivity is an increasingly recognized component of type 1 diabetes, is implicated in the pathogenesis of vascular complications and is potentially an important therapeutic target to prevent vascular complications. In this review, we will focus on the pathophysiologic contribution of insulin sensitivity to vascular complications and summarize related ongoing clinical trials.

关键词： Type 1 diabetes Insulin sensitivity Vascularcomplications Hyperfiltration Cystatin C Creatinine Glomerular filtration rate

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Replicating and projecting the path of COVID-19 with a model-implied reproduction number

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Infectious Disease Modelling 2020年第1期5卷 635-651页

作者： Shelby R.Buckman Reuven Glick Kevin j.Lansing Nicolas Petrosky-nadeau Lily M.Seitelman Federal Reserve Bank of San Francisco 101 Market StreetSan Francisco CA94105USA

We demonstrate a methodology for replicating and projecting the path of COVID-19 using a simple epidemiology *** fit the model to daily data on the number of infected cases in China,Italy,the United States,and *** four countries can be viewed as representing different stages,from later to earlier,of a COVID-19 epidemic *** solve for a model-implied effective reproduction number R t each day so that the model closely replicates the daily number of currently infected cases in each *** out-of-sample projections,we fit a behavioral function to the in-sample data that allows for the endogenous response of R t to movements in the lagged number of infected *** show that declines in measures of population mobility tend to precede declines in the model-implied reproduction numbers for each *** pattern suggests that mandatory and voluntary stay-at-home behavior and social distancing during the early stages of the epidemic worked to reduce the effective reproduction number and mitigate the spread of COVID-19.

关键词： Coronavirus COVID-19 SEIR Model Epidemics Reproduction number

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2004年9月28日加州帕克菲尔德M6．0级地震的初步报告

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世界地震译丛 2005年第4期36卷 14-31页

作者： j. Langbein R. Borcherdt D. Dreger j. Hetcher j. L. Hardebeck M. Hellweg C. ji M. johnston j. R. Murray R. nadeau M. j. Rymer j. A. Treiman 申彤（译）张天中（校）不详中国地震局地震预测研究所

引言 2004年9月28日17时15分14秒（协调世界时）加州中部帕克菲尔德发生了一次Mw6．0级地震。震中位于圣安德烈斯断层靠近戈尔德希尔附近的帕克菲尔德镇东南11km的地方（图1）。加州综合地震台网（CISN）报告说，震源位于北纬35．819°... 详细信息

引言 2004年9月28日17时15分14秒（协调世界时）加州中部帕克菲尔德发生了一次Mw6．0级地震。震中位于圣安德烈斯断层靠近戈尔德希尔附近的帕克菲尔德镇东南11km的地方（图1）。加州综合地震台网（CISN）报告说，震源位于北纬35．819°，西经120．364°的8．8km深的地下。

关键词：帕克菲尔德地震台网加州圣安德烈斯断层协调世界时震源

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AB035. Lactate receptor GPR81 modulates epigenetic modification in the subretina

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Annals of Eye Science 2018年第1期 441-441页

作者： Xiaojuan Yang Raphael Rouget Tang Zhu Christiane Quiniou Shasha Lv Suna jung Francois Duhamel Houda Tahiri Samy Omri Baraa Noueihed Xin Hou joséCarlos Rivera Mathieu nadeau-Vallée Pierre Lachapelle Sylvain Chemtob Department of Pharmacology McGill UniversityMontréalQCCanada Department of Pharmacology Universitéde MontréalMontréalQCCanada Research Center CHU Sainte-justine Universitéde MontréalMontréalQCCanada Department of Ophthalmology and Neurology-Neurosurgery Montréal Children’s Hospital-Research InstituteMcGill UniversityMontréalQCCanada Research Center Hôpital Maisonneuve-Rosemont Universitéde MontréalMontréalQCCanada Department of Ophthalmology Universitéde MontréalMontréalQCCanada Department of Pediatrics Universitéde MontréalMontréalQCCanada

Background:Retinal pigment epithelium(RPE)is vital for the homeostasis of the subretina including photoreceptors and ***,our previous results suggested that the recently discovered lactate receptor GPR81 is abundantly expressed in *** date,only one previous study has shown that activating GPR81 could enhance DNA repair by activating ***,we investigated whether GPR81 exhibits epigenetic modification in the subretina by using GPR81−/−***:GPR81−/−mice and wide type littermates were generated on a background of C57BL/6j *** thicknesses of their choroid were evaluated by ***,Q-PCR,western blot and choroid sprout assay were *** vitro,primary retinal pigment epithelium(pRPE)cells were isolated from mice,and cultured for ***:The thickness of choroid was reduced in GPR81−/−mice compared to GPR81+/+mice,suggesting that GPR81 is important for the integrity of *** the choroid sprout assay,lactate treated RPE/choroid complex showed a significant increase in angiogenesis compared to controls while lactate treated KO RPE/choroid complex showed no difference compared to their *** Q-PCR,most of the genes screened elevated their expression in GPR81−/−mice compared to WT mice,suggesting epigenetic modification may exist,which were confirmed by histone acetylation and HDACs activity ***:Taking together,the lactate receptor GPR81 in RPE is very important for maintaining homeostasis of the *** novel discovery sheds new light on the relationship between metabolism and epigenetic modification.

关键词： Subretina GPR81 epigenetic modification

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通过测定腹部脂肪组织能否说明心血管疾病危险因素的性别差异

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德国医学 1995年第2期12卷 119-119页

作者： S.Lemieux j.P.Després S.Moorjani A.nadeau G.Thériault D.Prud'homme A.Tremblay C.Bouchard P.j.Lupien 向世勤 Lipid Research Center Laval University Medical Research CenterLaval UniversityQuébecCanada 同济医科大学附属同济医院

研究表明,女性绝经前心血管疾病的发生率低于男性,其原因可能与男女不同的体内脂肪分布、血浆脂蛋白水平以及血糖-胰岛素平衡指数有关。体内脂肪过多是心血管疾病的易患因素,但在总体脂肪含量相同的情况下,男性较女性更易出现导致心血... 详细信息

研究表明,女性绝经前心血管疾病的发生率低于男性,其原因可能与男女不同的体内脂肪分布、血浆脂蛋白水平以及血糖-胰岛素平衡指数有关。体内脂肪过多是心血管疾病的易患因素,但在总体脂肪含量相同的情况下,男性较女性更易出现导致心血管疾病和胰岛素非依赖型糖尿病(NIDDM)的代谢异常,这可能与男女体内的脂肪分布不同有关。本文目的是证实经总体脂肪和局部脂肪即腹部脂肪因素校正后,两性的心血管疾病危险因素是否仍有差异,并探讨腹部脂肪与心血管疾病危险因素之间的关系。

关键词：脂肪组织腹部心血管疾病危险因素性别

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