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Journal of Sports Science 2015年第2期3卷 67-78页

作者： krista munroe-chandler Craig Hall Michelle Guerrero Danielle Tobin Department of Kinesiology University of Windsor Windsor Ontario N9B 3P4 Canada School of Kinesiology Western University London Ontario N6A 3K7 Canada

Telephone-delivered physical activity interventions have proven to be effective with adults, yet there is no research using this strategy with children. The purpose of the current study was to examine the feasibility of implementing a participant-initiated automated telephone imagery intervention with children. The outcomes of interest were compliance rates to and cost-analysis of the telephone system. Fifty-nine Grade 5 and 6 students (Mage = 10.24, SD = 0.80; 36 females) from two schools were randomized into either an imagery group or a short story group, and some individuals in both of these groups received an individual incentive and some received a class incentive. All participants were asked to call the automated system from home 3x/week for the duration of the study. The high compliance rate, the minimal cost of implementing such a system, and the ability to reach more children than a face-to-face intervention makes the telephone an attractive modality for behavior change researchers.

关键词：运动科学体育运动体育锻炼科学方法

Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

Serum estradiol levels decrease after oophorectomy in transmasculine individuals on testosterone therapy

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Asian Journal of Andrology 2023年第3期25卷 309-313页

作者： Sahil Kumar Elise Bertin Cormac O' Dwyer Amir Khorrami Richard Wassersug Smita Mukherjee Neeraj Mehra Marshall Dahl krista Genoway Alexander G Kavanagh Faculty of Medicine University of British ColumbiaVancouver V6T 1Z4British ColumbiaCanada Gender Surgery Program Vancouver Coastal HealthVancouver V5Z 1M9British ColumbiaCanada Department of Obstetrics and Gynecology University of British ColumbiaVancouver V6T 1Z4British ColumbiaCanada Division of Endocrinology Department of MedicineUniversity of British ColumbiaVancouver V6T 1Z2British ColumbiaCanada Division of Plastic and Reconstructive Surgery University of British ColumbiaVancouver V5Z 1M9British ColumbiaCanada Department of Urologic Sciences University of British ColumbiaVancouver V5Z 1M9British ColumbiaCanada

Transmasculine individuals,considering whether to undergo total hysterectomy with bilateral salpingectomy,have the option to have a concomitant *** studies have evaluated hormone changes following testosterone therapy initiation,most of those patients have not undergone *** are currently limited to support health outcomes regarding the decision to retain or remove the *** performed a retrospective chart review of transmasculine patients maintained on high-dose testosterone therapy at a single endocrine clinic in Vancouver,British Columbia,*** transmasculine individuals who underwent bilateral oophorectomy and had presurgical and postsurgical serum data were *** identified 12 transmasculine subjects as controls,who were on testosterone therapy and did not undergo oophorectomy,but additionally matched to the first group by age,testosterone dosing regimen,and body mass *** was a statistically significant decrease in the estradiol levels of case subjects postoophorectomy,when compared to presurgical estradiol levels(P=0.02).There was no significant difference between baseline estradiol levels between control and case subjects;however,the difference in estradiol levels at follow-up measurements was significant(P=0.03).Total testosterone levels did not differ between control and case subjects at baseline and follow-up(both P>0.05).Our results demonstrate that oophorectomy further attenuates estradiol levels below what is achieved by high-dose exogenous testosterone *** clinical outcomes,such as impacts on bone health,were not *** clinical implications of oophorectomy versus ovarian retention on endocrinological and overall health outcomes are currently limited.

关键词： estradiol gender-affirming surgery hysterectomy oophorectomy testosterone therapy transmasculine

Occupational injuries and burn out among orthopedic oncology surgeons

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World Journal of Orthopedics 2022年第12期13卷 1056-1063页

作者： Abdulrahman M Alaseem Robert E Turcotte Nathalie Ste-Marie Mohammad M Alzahrani Saad M Alqahtani krista A Goulding Department of Orthopedic Surgery College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia Department of Orthopedic Surgery McGill University Health CentreMontreal H4A3J1Canada Department of Orthopedic Surgery College of MedicineImam Abdulrahman Bin Faisal universityDammam 34212Saudi Arabia Department of Orthopaedic Surgery Mayo ClinicPhoenixArizona 85054USA

BACKGROUND Orthopedic oncology surgeons commonly engage in prolonged and complex surgical *** types of surgeries increase the risk of physical and psychological stressors,which may in turn make these physicians prone to workrelated occupational *** The aim of this study was to explore in orthopedic oncologists,the prevalence of work-related physical injuries and psychological *** A modified version of the physical discomfort survey was developed to assess occupational injuries among orthopedic oncology surgeon members of the Musculoskeletal Tumor Society,the Canadian Orthopedic Oncology Society and European Musculoskeletal Oncology *** survey was sent by email,and it explored musculoskeletal complaints,psychological disturbances,treatment required for these complaints and the requirement of time off *** A total of 67 surgeon responses were collected.A high number of orthopedic oncologists(84%)reported an occupational *** back pain(39%)was the most prevalent musculoskeletal condition,followed by lumbar disk herniation(16%),shoulder tendinitis(15%)and lateral epicondylitis(13%).Of the cohort,46%required surgery and 31%required time off work due to their ***-three respondents reported a psychological ***(27%),anxiety(20%)and insomnia(20%)were the most commonly *** required off work due to injury was associated with old age and years in *** Orthopedic oncology surgeons report a high prevalence of work-related *** back related injury and burnout were the most reported *** operative room ergonomics and prevention of stress related to the work environment should be areas to explore in upcoming research.

关键词： Orthopedic oncology Surgeons Occupational Musculoskeletal Injuries

Visualizing perceived spatial data quality of 3D objects within virtual globes

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International Journal of Digital Earth 2014年第10期7卷 771-788页

作者： krista Jones Rodolphe Devillers Yvan Bedard Olaf Schroth Department of Geography Memorial University of NewfoundlandSt.John’sCanada Departement des sciences geomatiques Universite LavalQuebecCanada Department of Landscape The University of SheffieldSheffieldUK

Virtual globes(VGs)allow Internet users to view geographic data of heterogeneous quality created by other *** article presents a new approach for collecting and visualizing information about the perceived quality of 3D data in *** aims atimproving users’awareness of the qualityof 3D *** of relying onthe existing metadata or on formal accuracy assessments that are often impossible in practice,we propose a crowd-sourced quality recommender system based on the five-star visualization method successful in other types of Web *** alternative five-star visualizations were implemented in a Google Earth-based prototype and tested through a formal user *** tests helped identifying the most effective method for a 3D *** indicate that while most websites use a visualization approach that shows a‘number of stars’,this method was the least preferred by ***,participants ranked the‘number within a star’method highest as it allowed reducing the visual clutter in urban settings,suggesting that 3D environments such as VGs require different *** that expert and non-expert users in geographic data share similar preferences for the most and least preferred visualization methods.

关键词： virtual globes spatial data quality uncertainty quality recommender system five-star 3D objects

Sisterhood at the Nexus of Love and Revolution： Coming-of-Age Narratives on Both Sides of the Cold War

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2012年第1期6卷 56-77页

作者： krista Van Fleit Hang The Department of Languages Literatures and Cultures University of South Carolina Columbia SC 29208 USA

This article examines the similarities between Song of Youth and The Best of Everything, coming-of-age novels published in China and the United States in 1958. The author finds that comparable narrative structures reveal parallels in two societies that are often viewed in stark contrast. In both novels, a feminist ideal of sisterhood is woven into the coming-of age stories of young women moving into society, and in each novel, the social background of the times determines the degree to which mainstream values are conducive to imagining a public sphere that is welcoming to women.

关键词： revolution feminism popular fiction American literature Chineseliterature Yang Mo Rona Jaffe coming-of-age novel

DNA recovery and analysis from skeletal material in modern forensic contexts

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Forensic Sciences Research 2019年第1期4卷 51-59页

作者： krista E.Latham Jessica J.Miller Biology Department Human Identification CenterUniversity of IndianapolisIndianapolisINUSA

The generation of a DNA profile from skeletal remains is an important part of the identifica-tion process in both mass disaster and unidentified person cases. Since bones and teeth are often the only biological materials remaining after exposure to environmental conditions, intense heat, certain traumatic events and in cases where a significant amount of time has passed since the death of the individual, the ability to purify large quantities of informative DNA from these hard tissues would be beneficial. Since sampling the hard tissues for gen-etic analysis is a destructive process, it is important to understand those environmental and intrinsic factors that contribute to DNA preservation. This will serve as a brief introduction to these topics, since skeletal sampling strategies and molecular taphonomy have been dis-cussed in depth elsewhere. Additionally advances in skeletal DNA extraction and analysis will be discussed. Currently there is great variation in the DNA isolation methods used by laboratories to purify DNA from the hard tissues;however, a standardized set of short tan-dem repeat (STR) loci is analyzed by many US laboratories to allow for comparisons across samples and jurisdictions. Recent advances have allowed for the generation of DNA profiles from smaller quantities of template DNA and have expanded the number of loci analyzed for greater discriminatory power and predictions regarding the geographic ancestry and phenotype of the individual. Finally, utilizing databases and expanding the number of com-parison samples will be discussed in light of their role in the identification process.

关键词： Forensic sciences forensic anthropology forensic genetics individual identification molecular taphonomy skeletal DNA Extraction DNA profiles DNA databases

Cancer cachexia,mechanism and treatment

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World Journal of Gastrointestinal Oncology 2015年第4期7卷 17-29页

作者： Tomoyoshi Aoyagi krista P Terracina Ali Raza Hisahiro Matsubara Kazuaki Takabe Division of Surgical Oncology Department of SurgeryVirginia Commonwealth University School of Medicine and the Massey Cancer Center Department of Frontier Surgery Graduate School of Medicine Chiba University

It is estimated that half of all patients with cancer eventually develop a syndrome of cachexia, with anorexia and a progressive loss of adipose tissue and skeletal muscle mass. Cancer cachexia is characterized by systemic inflammation, negative protein and energy balance, and an involuntary loss of lean body mass. It is an insidious syndrome that not only has a dramatic impact on patient quality of life, but also is associated with poor responsesto chemotherapy and decreased survival. Cachexia is still largely an underestimated and untreated condition, despite the fact that multiple mechanisms are reported to be involved in its development, with a number of cytokines postulated to play a role in the etiology of the persistent catabolic state. Existing therapies for cachexia, including orexigenic appetite stimulants, focus on palliation of symptoms and reduction of the distress of patients and families rather than prolongation of life. Recent therapies for the cachectic syndrome involve a multidisciplinary approach. Combination therapy with diet modification and/or exercise has been added to novel pharmaceutical agents, such as Megestrol acetate, medroxyprogesterone, ghrelin, omega-3-fatty acid among others. These agents are reported to have improved survival rates as well as quality of life. In this review, we will discuss the emerging understanding of the mechanisms of cancer cachexia, the current treatment options including multidisciplinary combination therapies, as well an update on new and ongoing clinical trials.

关键词： Physical exercise Pharmacological treatment Cancer cachexia

Development of a field enhanced photocatalytic device for biocide of coliform bacteria

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Journal of Environmental Sciences 2016年第6期28卷 38-44页

作者： Jeff M.Huber krista L.Carlson Otakuye Conroy-Ben Mano Misra Swomitra K.Mohanty Departments of Civil Engineering University of Utah Departments of Metallurgical Engineering University of Utah Departments of Chemical Engineering University of Utah

A field enhanced flow reactor using bias assisted photocatalysis was developed for bacterial disinfection in lab-synthesized and natural waters. The reactor provided complete inactivation of contaminated waters with flow rates of 50 mL/min. The device consisted of titanium dioxide nanotube arrays, with an externally applied bias of up to 6 V. Light intensity, applied voltage, background electrolytes and bacteria concentration were all found to impact the device performance. Complete inactivation of Escherichia coli W3110（- 8 × 10^3CFU/mL） occurred in 15 sec in the reactor irradiated at 25 mW/cm^2 with an applied voltage of 4 V in a 100 ppm NaCl solution. Real world testing was conducted using source water from Emigration Creek in Salt Lake City, Utah. Disinfection of natural creek water proved more challenging, providing complete bacterial inactivation after 25 sec at 6 V. A reduction in bactericidal efficacy was attributed to the presence of inorganic and organic species, as well as the increase in robustness of natural bacteria.

关键词： Titanium dioxide Nanotubes Immobilized Photocatalysis Escherichia coli Inactivation

Nano-formulations for transdermal drug delivery:A review

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Chinese Chemical Letters 2018年第12期29卷 1713-1724页

作者： Xingli Zhou Ying Hao Liping Yuan Sushmita Pradhan krista Shrestha Ojaswi Pradhan Hongjie Liu Wei Li Department of Dermatovenereology State Key Laboratory of BiotherapyWest China HospitalSichuan University

Transdermal drug delivery refers to a means of delivering drugs through the surface of the skin for local or systemic treatment. The drug functions after absorption through the skin into the systemic circulation via capillary action at a certain rate. Use of traditional physical and chemical enhancers to improve the transdermal permeation rate by increasing drug solubility, diffusion coefficient, and reservoir effect is not feasible owing to the toxic side effects of the overuse of chemical penetration enhancers. Nanoformulations generally vary in size and range from 10 nm to 100 nm. The smaller particle size leads to increased drug permeability, stability, retention, and targeting, making nano-formulations suitable for transdermal drug delivery. The different applications of nano-formulations(vesicles or nanoparticles and nanoemulsions) have been widely studied. Here, the classification, characteristics, transdermal mechanism, and application of the most popular nano-formulations in transdermal drug delivery system are reviewed.

关键词： Nano-formulation Transdermal drug delivery system Classification Mechanism Application