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Restoration of dysregulated CC chemokine signaling for monocyte/macrophage chemotaxis in head and neck squamous cell carcinoma patients by neem leaf glycoprotein maximizes tumor cell cytotoxicity

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Cellular & Molecular Immunology 2010年第5期7卷 396-408页

作者： krishnendu chakraborty Anamika Bose Tathagata chakraborty Koustav Sarkar Shyamal Goswami Smarajit Pal Rathindranath Baral Department of Immunoregulation and Immunodiagnostics Chittaranjan National Cancer InstituteKolkataIndia Unit of Clinical Biochemistry Chittaranjan National Cancer InstituteKolkataIndia

Previous studies have shown that the CC chemokine receptor CCR5 is downregulated on monocyte/macrophage(MO/Mw)surfaces in head and neck squamous cell carcinoma(HNSCC)patients(stage IIIB).Ligands(RANTES,MIP-1a and MIP-1b)of this chemokine receptor were also secreted in lesser quantity from MO/Mw of HNSCC patients in comparison with healthy *** an aim to restore this dysregulated receptor–ligand signaling,we have used neem leaf glycoprotein(NLGP),a novel immunomodulator reported from our *** upregulated CCR5 expression,as evidenced from studies on MO/Mw of peripheral blood from HNSCC patients as well as healthy *** of RANTES,MIP-1a and MIP-1b was also upregulated following NLGP treatment of these cells in ***,NLGP has little effect on the expression of CCR5 and the ligand RANTES in oral cancer *** restored CCR5 receptor–ligand signaling seen in MO/Mw was reflected in improved CCR5-dependent,p38 mitogen-activated protein kinase(MAPK)-mediated migration of MO/Mw after NLGP treatment to a standard *** also induces better antigen presentation and simultaneous costimulation to effector T cells by MO/Mw by upregulating human leucocyte antigen(HLA)-ABC,CD80 and *** addition,NLGP-treated MO/Mw-primed T cells can effectively lyse tumor cells in *** effects of NLGP on monocyte migration and T cell-mediated oral tumor cell killing were further demonstrated in transwell assays with or without CCR5 *** results suggest a new approach in cancer immunotherapy by modulating dysregulated CCR5 signals from MO/Mw.

关键词： CCR5 chemokine head and neck squamous cell carcinoma monocytes neem leaf glycoprotein

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Role of Partial Thoracoplasty in Lung Lesions —A Single Institute Experience

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World Journal of Cardiovascular Surgery 2019年第11期9卷 155-162页

作者： Binay Krishna Sarkar krishnendu chakraborty Pares Bandyopadhayay Department of Cardiovascular & Thoracic surgery Nil Ratan Sircar Medical College & Hospital Kolkata West Bengal India

Thoracoplasty has been a useful procedure to control and cure recalcitrant lung lesions often as a last measure to treat pulmonary infections like post-?tubercular chronic empyema with fibrocavitary lesions and residual pleural space infections after pulmonary resections. Long-standing empyemas with persistent discharge on drainage often respond poorly after decortication and?debridement alone due to non-expanding underlying lung tissue due to fibrotic changes. These cases often develop recurrent empyemas with sepsis with high morbidity and mortality. Similarly chronic space-occupying lung lesions with adjacent pulmonary damage and fibrosis leave a considerable residual space after surgery of these lesions and these persistent residual space leads to pleural space infections and empyema. In the presence of a large apical abscess and destruction of the apical pulmonary tissue forming a potential space confined by the bony thoracic cage and limited inferiorly by the rigid lining of the abscess, the cure and management of the chronic empyema especially the post-tubercular ones are particularly difficult. We address these cases in our series by performing partial thoracoplasty tailored to the site of the lesions in addition to other procedures. Partial thoracoplasty was found beneficial for selective cases of chronic empyema, obliteration of residual cavity after resectional surgery and management of the apical abscess.

关键词： Partial Thoracoplasty Chronic Empyema Residual Pleural Space Infection Apical Lung Abscess

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A Rare Case of Aortico-Right Ventricular Tunnel Along with Ventricular Septal Defect Presented as Ruptured Sinus of Valsalva in an Adult Female

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World Journal of Cardiovascular Surgery 2013年第3期3卷 119-121页

作者： Binay Krishna Sarkar krishnendu chakraborty Dilip Saha Paresh Banerjee Department of Cardiovascular & Thoracic Surgery Nil Ratan Sircar Medical College & Hospital Kolkata India

Background: Aortico-right ventricular tunnel is an extremely rare congenital defect rarely described in an infant. This diagnosis is likely to be missed due to its rare entity and similar clinical presentations with other aortico-right ventricular communications like ruptured sinus of valsalva. Methods: We report a case of previously undiagnosed aortico-right ventricular tunnel along with a perimembraneous ventricular septal defect in an 18-year-old female. She had history of exertional dyspnoea, palpitation, history of recurrent lower respiratory tract infection. She was diagnosed as a case of ruptured sinus of valsalva (RSOV) elsewhere. She had “to and fro” murmur, features of congestive cardiac failure. Her echo diagnosis was RSOV. On surgical exploration, after opening the aorta, we found a tunnel like opening in the aorta leading to the roof of RV cavity in between right and non coronary sinuses at the commissural level. Cusps were splayed wide part. Ventricular septal defect was conspicuous from right atrial approach. Post operative CT angio was done. Results: Venricular septal defect was closed from the right atrial approach and aortico-right ventricular tunnel was repaired through aortic and right venricular approach. Postoperative CT angio also confirmed the location and closure of the defects. Postoperative recovery was uneventful. Conclusions: Aortico-right ventricular tunnel in an adult female has not been reported in the literature previously. This rare entity should be considered in the differential diagnosis of a critically ill patient with a “to and fro” murmur, and signs of right heart failure.

关键词： Aortico-RV Tunnel Ventricular Septal Defect

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Molecular mechanism of nanomaterials induced liver injury:A review

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World Journal of Hepatology 2024年第4期16卷 566-600页

作者： Sanjib Kumar Das Koushik Sen Biswatosh Ghosh Nabanita Ghosh krishnendu Sinha Parames C Sil Department of Zoology Jhargram Raj CollegeJhargram 721507India Department of Zoology Bidhannagar CollegeKolkata 700064India Department of Zoology Maulana Azad CollegeKolkata 700013India Department of Molecular Medicine Bose InstituteCalcutta 700054India

The unique physicochemical properties inherent to nanoscale materials have unveiled numerous potential applications,spanning beyond the pharmaceutical and medical sectors into various consumer industries like food and ***,humans encounter nanomaterials through diverse exposure routes,giving rise to potential health *** among these materials are silica and specific metallic nanoparticles,extensively utilized in consumer products,which have garnered substantial attention due to their propensity to accumulate and induce adverse effects in the *** review paper aims to provide an exhaustive examination of the molecular mechanisms underpinning nanomaterial-induced hepatotoxicity,drawing insights from both in vitro and in vivo ***,the most frequently observed manifestations of toxicity following the exposure of cells or animal models to various nanomaterials involve the initiation of oxidative stress and ***,we delve into the existing in vitro models employed for evaluating the hepatotoxic effects of nanomaterials,emphasizing the persistent endeavors to advance and bolster the reliability of these models for nanotoxicology research.

关键词： Nanoparticles Hepatotoxicity Oxidative stress Inflammation Autophagy

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Heat transfer in boundary layer stagnation-point flow towards a shrinking sheet with non-uniform heat flux

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Chinese Physics B 2013年第7期22卷 328-333页

作者： krishnendu Bhattacharyya Department of Mathematics The University of Burdwan

In this paper, the effect of non-uniform heat flux on heat transfer in boundary layer stagnation-point flow over a shrinking sheet is studied. The variable boundary heat fluxes are considered of two types： direct power-law variation with the distance along the sheet and inverse power-law variation with the distance. The governing partial differential equations （PDEs） are transformed into non linear self-similar ordinary differential equations （ODEs） by similarity transformations, and then those are solved using very efficient shooting method. The direct variation and inverse variation of heat flux along the sheet have completely different effects on the temperature distribution. Moreover, the heat transfer characteristics in the presence of non-uniform heat flux for several values of physical parameters are also found to be interesting.

关键词： non-uniform heat flux heat transfer stagnation-point flow shrinking sheet

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Dual Solutions in Unsteady Stagnation-Point Flow over a Shrinking Sheet

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Chinese Physics Letters 2011年第8期28卷 165-168页

作者： krishnendu Bhattacharyya Department of Mathematics The University of BurdwanBurdwan-713104West BengalIndia

An analysis is made to study the dual nature of solution of unsteady stagnation-point flow due to a shrinking *** similarity transformations,the governing boundary layer equations are transformed into the self-similar nonlinear ordinary differential *** transformed equations are solved numerically using a very efficient shooting *** study reveals the conditions of existence,uniqueness and non-existence of unsteady similarity *** dual solutions for velocity distribution exist for certain values of velocity ratio parameter(c/a),and the increment in the unsteadiness parameter A increases the range of c/a where solution ***,with increasing A,the skin friction coefficient increases for the first solution and decreases for the second.

关键词： solution method unsteady

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Boundary Layer Flow and Heat Transfer over an Exponentially Shrinking Sheet

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Chinese Physics Letters 2011年第7期28卷 198-201页

作者： krishnendu Bhattacharyya Department of Mathematics the University of BurdwanBurdwan-713104West BengalIndia

An analysis is made to study boundary layer flow and heat transfer over an exponentially shrinking *** similarity transformations in exponential form,the governing boundary layer equations are transformed into self-similar nonlinear ordinary differential equations,which are then solved numerically using a very efficient shooting *** analysis reveals the conditions for the existence of steady boundary layer flow due to exponential shrinking of the sheet and it is found that when the mass suction parameter exceeds a certain critical value,steady flow is *** dual solutions for velocity and temperature distributions are *** increasing values of the mass suction parameter,the skin friction coefficient increases for the first solution and decreases for the second solution.

关键词： solution method exponential

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Heat transfer for boundary layers with cross flow

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Chinese Physics B 2014年第2期23卷 327-332页

作者： krishnendu Bhattacharyya Ioan Pop Department of Mathematics The University of Burdwan Faculty of Mathematics Babes-Bolyai University

An analysis is presented to study the dual nature of solutions for the forced convective boundary layer flow and heat transfer in a cross flow with viscous dissipation terms in the energy equation. The governing equations are transformed into a set of three self-similar ordinary differential equations by similarity transformations. These equations are solved numerically using the very efficient shooting method. This study reveals that the dual solutions of the transformed similarity equations for velocity and temperature distributions exist for certain values of the moving parameter, Prandtl number, and Eckert numbers. The reverse heat flux is observed for larger Eckert numbers; that is, heat absorption at the wall occurs.

关键词： heat transfer boundary layer cross flow viscous dissipation dual solutions

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Analytic solution for magnetohydrodynamic boundary layer flow of Casson fluid over a stretching/shrinking sheet with wall mass transfer

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Chinese Physics B 2013年第2期22卷 314-319页

作者： krishnendu Bhattacharyya Tasawar Hayat Ahmed Alsaedi Department of Mathematics The University of BurdwanBurdwan-713104West BengalIndia Department of Mathematics Quaid-I-Azam University 45320Islamabad 44000Pakistan Department of Mathematics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia

In this analysis,the magnetohydrodynamic boundary layer flow of Casson fluid over a permeable stretching/shrinking sheet in the presence of wall mass transfer is *** similarity transformations,the governing equations are converted to an ordinary differential equation and then solved *** introduction of a magnetic field changes the behavior of the entire flow dynamics in the shrinking sheet case and also has a major impact in the stretching sheet *** similarity solution is always unique in the stretching case,and in the shrinking case the solution shows dual nature for certain values of the *** stronger magnetic field,the similarity solution for the shrinking sheet case becomes unique.

关键词： magnetohydrodynamic boundary layer Casson fluid stretching/shrinking sheet wall mass transfer analytic solution

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Unsteady boundary layer flow and heat transfer over an exponentially shrinking sheet with suction in a copper-water nanofluid

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Journal of Central South University 2015年第12期22卷 4856-4863页

作者： Aurang Zaib krishnendu Bhattacharyya Sharidan Shafie Department of Mathematical Sciences Federal Urdu University of ArtsScience & Technology Department of Mathematics The University of Burdwan Department of Mathematical Sciences Faculty of ScienceUniversiti Teknologi Malaysia

An analysis of unsteady boundary layer flow and heat transfer over an exponentially shrinking porous sheet filled with a copper-water nanofluid is *** is treated as a base *** the investigation,non-uniform mass suction through the porous sheet is *** Keller-box method the transformed equations are solved *** results of skin friction coefficient,the local Nusselt number as well as the velocity and temperature profiles are presented for different flow *** results showed that the dual non-similar solutions exist only when certain amount of mass suction is applied through the porous sheet for various unsteady parameters and nanoparticle volume *** ranges of suction where dual non-similar solution exists,become larger when values of unsteady parameter as well as nanoparticle volume fraction ***,due to unsteadiness of flow dynamics and the presence of nanoparticles in flow field,the requirement of mass suction for existence of solution of boundary layer flow past an exponentially shrinking sheet is ***,the velocity boundary layer thickness decreases and thermal boundary layer thickness increases with increasing of nanoparticle volume fraction in both non-similar ***,for stronger mass suction,the velocity boundary layer thickness becomes thinner for the first solution and the effect is opposite in the case of second *** temperature inside the boundary layer increases with nanoparticle volume fraction and decreases with mass ***,for the unsteadiness and for the presence of nanoparticles,the flow separation is delayed to some extent.

关键词： unsteady boundary layer heat transfer nanofluid exponentially shrinking sheet dual non-similar solutions

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