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Anti-chikungunya activity of luteolin and apigenin rich fraction from Cynodon dactylon

Asian Pacific Journal of Tropical Medicine 2015年第5期8卷 352-358页

作者： krishnan saravana murali Srinivasan Sivasubramanian Savariar Vincent Shanmugaraj Bala Murugan Bupesh Giridaran Sundaram Dinesh Palani Gunasekaran Kaveri Krishnasamy Ramalingam Sathishkumar Plant Genetic Engineering Lab Department of Biotechnology.Bharathiar University Department of Virology King Institute of Preventive Medicine and Research Centre for Environmental Research and Development and Loyola Institute of Frontier Energy Loyola College Vellore Institute of Technology Plant Genetic Engineering Lab Department of BiotechnologyBharathiar University

Objective:To obtain Iuteolin and apigenin rich fraction from the ethanolic extract of Cynodon dactylon(L.)(***) Pers and evaluate the fraction's cytotoxicity and anti-Chikungunya potential using Vero ***:The ethanolic extract of *** was subjected to silica gel column chromatography to obtain anti-chikungunya virus(CHIKV) *** phase-HPLC and GC-MS studies were carried out to identily the major phytochemicals in the fraction using phylochemical *** and the potential of the fraction against CHIKV were evaluated in vitro using Vero *** in viral replication was assessed by reverse transcriptase-polymerase chain reaction(RT-PCR) after treating the viral infected Vero cells with the ***:Reverse Phase-HPLC and GC-MS studies confirmed the presence of flavonoids,luteolin and apigenin as major phytochemicals in the anti-CHIKV ethanolic fraction of ***- The fraction was found to exhibit potent viral inhibitory activity(about 98%) at the concentration of 50 μg/mL as observed by reduction in cytopathic effect,and the cytotoxic concentration of the fraction was found to be 250 μg/***-PCR analyses indicated that the reduction in viral mRNA synthesis in fraction treated infected cells was much higher than the viral infected control ***:Luteolin and apigenin rich ethanolic fraction from *** can be utilized as a potential therapeutic agent against CHIKV infection as the fraction does not show cytotoxicity while inhibiting the virus.

关键词： Antiviral activity Chikungunya virus Cynodon dactylon Flavonoids Luteolin Apigenin

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STUDIES ON MOLECULAR WEIGHT DISTRIBUTION OF CARBON FIBER POLYMER PRECURSORS SYNTHESIZED USING MIXED SOLVENTS

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Chinese Journal of Polymer Science 2012年第5期30卷 664-673页

作者： G.Santhana krishnan A.Burkanudeen N.murali Hemant Phadnis Materials Science Division CSIRNational Aerospace LaboratoriesBangalore-560017India Post Graduate and Research Department of Chemistry Jamal Mohammed CollegeBharathidasan UniversityTiruchirappalliIndia Malvern Application Laboratory Naimex HouseBangalore-560045India

The molecular weight distributions were estimated for carbon fiber polymer precursors such as poly（acrylonitrile-co-itaconic acid） synthesized by semi batch solution polymerization in mixed solvents media with the azonitrile compounds as initiator under the different ratios of solvent and non solvent from 0.75 to 2.5 in weight. The copolymer was characterized by using Fourier transform infrared spectroscopy （FTIR） and nuclear magnetic resonance （1H-NMR） analyses. The molecular weight distributions were evaluated by Mv/Mn ratios estimated from viscosity and osmotic measurements, and Mw/Mn estimated from size exclusion chromatography. The molecular weight distributions of these polymers as determined from M, JMn and Mw/Mn are 2.9 to 3,2 and 2.0 to 2.5 respectively. The molecular distributions were close to a narrow distribution of 2.0 when the solvent/non-solvent ratio was varied between 1.4 and 2.0. Intrinsic viscosity [η] as a function of molecular weight of poly（acrylonitrile-co-itaconic acid） was evaluated by means of low angle laser light scattering with size exclusion chromatography （SEC-LALLS） and viscometry with SEC （SEC-VISCO）. The relationship between [η] and Mw for poly（acrylonitrile-co-itaconic acid） in DMF at 50℃ was [q] = 1.1×10-5 Mw0.79, where [η] is obtained in dL/g.

关键词： Molecular weight distribution Size exclusion chromatography Osmometry Viscometry Polyacrylonitrilecopolyrner.

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Effect of angiotensin converting enzyme gene I/D polymorphism in South Indian children with nephrotic syndrome

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The Journal of Biomedical Research 2019年第3期33卷 201-207页

作者： Aravind Selvin Kumar Ramanathan Balakrishnan Karuppiah murali Vijayan Kamaraj Raju Dhivakar Mani Rathika Chinniah Manikandan Thirunavukkarasu Padma Malini Ravi Jeyaram Illiayaraja krishnan Prabha Senguttuvan Department of Pediatric Nephrology Institute of Child Health and Hospital for Children Department of Medical Genetics The Tamil Nadu Dr.M.G.R.Medical University Department of Immunology School of Biological SciencesMadurai Kamaraj University Department of Biotechnology and Genetic Engineering Bharathidasan University Department of Clinical Research Narayana Health City Department of Pediatric Nephrology Dr.Mehta’s Children’s Hospital

Nephrotic syndrome is one of the most common childhood kidney diseases. It is mostly found in the age group of 2 to 8 years. Around 10%-15% of nephrotic syndrome cases are non-responders of steroid treatment(SRNS).Angiotensin converting enzyme(ACE)(I/D) gene association studies are important for detecting kidney disease and herein we assessed the association of ACE(I/D) polymorphism with nephrotic syndrome in South Indian children. We recruited 260 nephrotic syndrome(162 boys and 98 girls) and 218(140 boys and 78 girls) control subjects. ACE I/D polymorphism was analyzed by PCR using genotype allele specific primers. In ACE(I/D), we did not find significant association for the ungrouped data of nephrotic syndrome children and the control subjects. Kidney biopsies were done in 86 nephrotic syndrome cases(minimal change disease, n = 51;focal segmental glomerulosclerosis, n = 27;diffuse mesangial proliferation, n = 8). We segregated them into the minimal change disease/focal segmental glomerulosclerosis groups and observed that the ACE’D’ allele was identified with borderline significance in cases of focal segmental glomerulosclerosis and the ’Ⅰ’ allele was assessed as having very weak association in cases of minimal change disease. ’Ⅱ’ genotype was weakly associated with minimal change disease. Gender specific analysis revealed weak association of’ID’ genotype with female nephrotic syndrome in females. Dominant expression of DD genotype was observed in males with nephrotic syndrome. Our finding indicated that ACE(I/D) has moderate association with focal segmental glomerulosclerosis. However, due to the limited number of biopsy proven focal segmental glomerulosclerosis subjects enrolled, further studies are required to confirm these results.

关键词： angiotensin converting enzyme focal segmental glomerulosclerosis minimal change disease nephrotic syndrome

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炼油厂的未来是无线炼油企业通过应用无线技术实现经济而高效的运营

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流程工业 2014年第8期 42-43,47页

作者： murali krishnan T. 艾默生过程管理亚太区

无线技术在炼油行业已经得到越来越广泛的接受和应用，无论是炼油厂的新建还是改造项目。无线可以对过去人工检测的设备进行实时测量、实时分析、实时报警和故障发生前的定期通知，从而减少非计划怠工和停车的发生几率。

关键词：无线技术炼油厂炼油企业应用运营经济炼油行业改造项目

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Parallelization of H.264 Encoder Using FPGA Based Symmetric Multi-Core Processors

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通讯和计算机（中英文版） 2011年第6期8卷 476-482页

作者： murali krishnan Elumalai Gangadharan Esakki Nirmal Kumar Dept. of Electronics and Instr Engg. Anand Institute of Higher Technology Chennai-103 India Dept. of Electronics and Comm Engg. Anand Institute of Higher Technology Chennai-103 India Dept. of Electronics and Comm Engg. Anna University Chennai-25 India

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