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Colonic adenocarcinoma,mucosa associated lymphoid tissue lymphoma and tuberculosis in a segment of colon:A case report

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World Journal of Gastrointestinal Oncology 2014年第9期6卷 377-380页

作者： Ambedkar Raj Kulandai Velu Banushree C Srinivasamurthy krishnan nagarajan Ilavarasi Sinduja Department of Pathology Sri Manakula Vinayagar Medical College Department of Radiology Sri ManakulaVinayagar Medical College

Synchronous occurrence of adenocarcinoma and mucosa associated lymphoid tissue(MALT) lymphoma of colon is rare,and its presence with coexisting tuberculosis is still *** our knowledge,this may be the first case *** the present report,we describe a 43-year-old female who presented with a history of abdominal pain,fever,loss of weight and loss of *** showed a large ulceroproliferative mass arising from the caecum,biopsy of which showed it to be adenocarcinoma of the colon.A right hemicolectomy was performed and microscopic study of the colon revealed tuberculosis and synchronous adenocarcinoma with *** of sixteen lymph nodes showed tuberculosis and three of sixteenpericoloniclymphnodes showed metastatic *** further confirmed the tumour to be adenocarcinoma with MALT *** would like to highlight the diagnostic challenges arising from the multi-faceted presentations of these three conditions.

关键词： Adenocarcinoma Mucosa associated lymphoid tissue lymphoma Tuberculosis

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Simultaneous pharmacokinetic assessment of cefadroxil and clavulanic acid in human plasma by LC-MS and its application to bioequivalence studies

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Journal of Pharmaceutical Analysis 2013年第4期3卷 285-291页

作者： Janaki Sankarachari krishnan nagarajan Chandran Sathish Vimal Renjith George Anil Dubala Department of Pharmaceutical Analysis J.S.S. College of Pharmacy

A simple, rapid and selective liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry （LC-APCI-MS） assay method has been developed and fully validated for the simultaneous quantification of cefadroxil （CF） and clavulanic acid （CA） in human plasma. Analytes and internal standard （IS） were extracted from human plasma by solid- phase extraction （SPE） technique using Sam prep （3 mL, 100 mg） extraction cartridge. The extracted samples were chromatographed on a reverse phase Cls column using a mixture of methanol： acetonitrile： 2 mM ammonium acetate （pH 3.5）（25：25：50, v/v/v） as the mobile phase at a flow rate of 0.8 mL/min. Quantification of the analytes and IS were carried out using single quadrupole LC-APCI-MS through selected-ion monitoring （SIM） at m/z 362 and m/z 198, for CF and CA, respectively. Method validation was performed as per the FDA guidelines and the results met the acceptance criteria. Plasma concentration of CF and CA followed by the oral administration of CF/CA （500/125 mg） pill to healthy male volunteers （n= 12） was measured. Area under plasma concentration-time curve from 0 to 12 h （AUC0-12 h） and 0 h extrapolated to infinity （AUC0-∞） were calculated. The ratio of AUC0-12 h/AUC0-∞ was found to be 〉 85% for all the subjects, as recommended by the FDA guidelines.

关键词： Cefadroxil Clavulanic acid LC-MS A_PCI Pharmacokinetics Bioequivalence

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Isolation of Microcrystalline Cellulose from Wood and Fabrication of Polylactic Acid(PLA)Based Green Biocomposites

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Journal of Renewable Materials 2024年第8期12卷 1455-1474页

作者： Selwin Maria Sekar Rajini nagarajan Ponsuriyaprakash Selvakumar Ismail Sikiru Oluwarotimi Kumar krishnan Faruq Mohammad Mohammed Rafi Shaik Nadir Ayrilmis Department of Mechanical Engineering Kalasalingam Academy of Research and EducationKrishnankoil626126India Department of Mechanical Engineering SSM Institute of Engineering and TechnologyDindigul624002India Department of Engineering Centre for Engineering ResearchSchool of PhysicsEngineering and Computer ScienceUniversity of HertfordshireHatfieldAL109ABUK INTI International University Persiaran Perdana BBNNilai71800Malaysia Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 2455Riyadh11451Kingdom of Saudi Arabia Department of Wood Mechanics and Technology Faculty of ForestryIstanbul University–CerrahpasaBahcekoySariyerIstanbul34473Turkey

An innovative microcrystalline cellulose(MCC)natural fibre powder-reinforced PLA biocomposite was investigated using the hand lay-up *** polymer matrix composite(PMC)samples were prepared by varying the weight percentages(wt.%)of both PLA matrix and MCC reinforcement:pure PLA/100:0,90:10,80:20,70:30,60:40 and 50:50 wt.%,*** the results obtained,MCC powder,with its impressive aspect ratio,proved to be an ideal reinforcement for the PLA,exhibiting exceptional mechanical *** was evident that the 80:20 wt.%biocomposite sample exhibited the maximum improvement in the tensile,flexural,notched impact,compressive strength and hardness by 28.85%,20.00%,91.66%,21.53%and 35.82%,respectively compared to the pure PLA ***,during the thermogravimetric analysis(TGA),the same 80:20 wt.%biocomposite sample showed a minimum weight loss of 20%at 400℃,among *** morphological study using Field Emission Scanning Electron Microscopy(FE-SEM)revealed that the uniform distribution of cellulose reinforcement in the PLA matrix actively improved the mechanical properties of the biocomposites,especially the optimal 80:20 wt.%***,it was evident that the optimal PLA/cellulose biocomposite sample could be a suitable and alternative sustainable,environmentally friendly and biodegradable material for semi/structural applications,replacing synthetic and traditional components.

关键词： Polylactic acid micro crystalline cellulose biocomposite characterizations FESEM environmental pollution

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家蚕末龄幼虫、蛹和成虫期载脂蛋白组成的变化(英文)

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昆虫学报 2017年第3期60卷 247-253页

作者： Thangaraj PRATHEEP Neelamegam RAMESHKUMAR nagarajan KAYALVIZHI Thangaiyan SUGANYA Sivashanmugam KARTHIKEYAN Muthukalingan krishnan Department of Environmental Biotechnology Bharathidasan University Tiruehirappalli-620024 India Department of Zoology Periyar University Salem-636011 India School of Bio Sciences & Technology VIT University Vellore-632014 India

【目的】载脂蛋白是一种重要的血淋巴脂蛋白,它将90%的脂类输送到内部器官。本研究旨在调查家蚕Bombyx mori各个发育期血淋巴载脂蛋白组成变化。【方法】采用溴化钾密度梯度超离心、肝素钠沉淀(heparin sodium precipitation)和连接蒸... 详细信息

【目的】载脂蛋白是一种重要的血淋巴脂蛋白,它将90%的脂类输送到内部器官。本研究旨在调查家蚕Bombyx mori各个发育期血淋巴载脂蛋白组成变化。【方法】采用溴化钾密度梯度超离心、肝素钠沉淀(heparin sodium precipitation)和连接蒸发光散射检测器的高效液相色谱(high performance liquid chromatography coupled with evaporative light scattering detector,HPLC-ELSD)等方法,检测了家蚕各个发育期血淋巴脂蛋白组成变化。【结果】从5龄幼虫到成虫的转变过程中,从幼虫期和吐丝期家蚕中分离的载脂蛋白密度分别为1.130和1.139 g/mL,但蛹期载脂蛋白密度降低(为1.083 g/mL)。应用肝素钠沉淀法对载脂蛋白组成的分析表明,家蚕吐丝期载脂蛋白主要是高密度载脂蛋白(9.8μg/μL);从吐丝期开始,低密度载脂蛋白含量增加,并在蛹期持续存在(4.2μg/μL)。在所有发育期,载脂蛋白Ⅲ含量低,在2日龄蛹中含量最高(4.0μg/μL)。另外,从吐丝期至成虫期,总脂浓度逐渐增加,从1.4μg/μL增加至3.8μg/μL。通过HPLC-ELSD对中性脂组成的分析表明,在所有发育期只含有微量的单酰甘油(<0.04μg/μL),在5龄幼虫中期至蛹期末观察到二酰甘油(0.11~0.61μg/μL),在蛹期发现三酰甘油(0.18~1.02μg/μL)。【结论】总体结果说明,在幼虫期和吐丝期,高密度载脂蛋白主要运输二酰甘油;化蛹后,高密度载脂蛋白更多地与三酰甘油有关,而与二酰甘油相关性小,并与载脂蛋白Ⅲ形成低密度载脂蛋白有关。这些结果提示载脂蛋白的转变是一个精确的时间控制过程。

关键词：家蚕载脂蛋白高密度载脂蛋白低密度载脂蛋白脂类

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A simple and cost-effective protocol for extraction of genomic DNA from ethanol preserved black flies(Simuliidae:Diptera)

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Journal of Coastal Life Medicine 2016年第9期4卷 721-725页

作者： Neelamegam Rameshkumar Sankarappan Anbalagan nagarajan Kayalvizhi Rasiravuthanahalli Kaveriyappan Govindarajan Vimalanathan Arun Prasanna Muthukalingan krishnan Department of Environmental Biotechnology Bharathidasan UniversityTiruchirappalli 620024Tamil NaduIndia Department of Zoology Sethupathy Government Arts CollegeRamanathapuram 623502Tamil NaduIndia Department of Zoology Periyar UniversitySalem 636001Tamil NaduIndia

Objective:To investigate the efficacy of extraction methodology for the proposed DNA from the ethanol preserved black flies(Simuliidae:Diptera).Methods:This study addressed a simple and effective protocol for extraction of DNA from black flies stored in the *** sizes of larval and adult black flies ranged from 1.5 to 2.5 mm and 3 to 7 mm,*** demonstrate the efficacy of the proposed methodology,the DNA was extracted from the ethanol preserved sample of black flies using the commercial *** extracted DNA was further validated in the PCR amplification using internal transcribed spacer-1 rDNA and cytochrome oxidase subunit II rDNA target ***:Interestingly,a minor modification in the proposed methodology yielded a good DNA concentration in comparison with the commercial *** extracted DNA sample using the proposed methodology was successfully validated in the PCR amplification using internal transcribed spacer-1 rDNA and cytochrome oxidase subunit II rDNA ***:The proposed DNA extraction procedure yielded good concentration of DNA from the ethanol preserved black *** added advantage is that the procedure is suitable for a range of insect species preserved in the ethanol obtained from the various field conditions.

关键词： Black flies Ethanol preservation DNA extraction PCR Amplification

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