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New Stability Indicating Method for Quantification of Impurities in Amlodipine and Benazepril Capsules by Validated HPLC

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American Journal of Analytical Chemistry 2013年第12期4卷 715-724页

作者： Rama Joga Venkata Eranki Gopichand Inti Venkatasubramanian jayaraman Raghuram Pannala Sudhakar Rao Vidiyala Jadi Sree Ramulu Department of Chemistry Sri Krishnadevaraya University Anantapur India Quality & Analytical Development Department InvaGen Pharmaceuticals Inc. Hauppauge USA Quality & Analytical Development Department InvaGen Pharmaceuticals Inc. Hauppauge USA Department of Chemistry Sri Krishnadevaraya University Anantapur India Quality Assurance Department ScieGen Pharmaceuticals Inc. Hauppauge USA

A stability indicating LC method was developed for the simultaneous determination of Amlodipine and Benazepril capsules in pharmaceutical dosage form. Efficient chromatographic separation was achieved on Symmetry C18 stationary phase with simple combination of amobile phase containing 750 mL of DI Water, 250 mL of Acetonitrile and 2 mL of Octylamine into suitable container with adjusted pH to 2.50 ± 0.05 with the aid of Ortho phosphoric acid delivered in an isocratic mode and quantification was carried out using UV detection at 240 nm at a flow rate of 1.0 mL·min-1 with an injection volume of 20 μl and ambient column temperature. This method is capable to detect both the drug components of Amlodipine and Benazepril in presence of their degradation products (Amlodipine Imp-A and Benazepril Impurity-C) with a detection level of 0.05%. Amlodipine/Benazepril in their combination drug product were exposed to thermal, photolytic, hydrolytic and oxidative stress conditions, and the samples were analysed. Peak homogeneity data of Amlodipine and Benazeprilis were obtained using PDA detector, in the stressed sample chromatograms, demonstrating the specificity. The method shows excellent linearity over a range of 0.05%-2.0% for Amlodipine, Amlodipine Impurity-A and 0.05%-5.0% for Benazepril and Benazepril Impurity-C. The correlation coefficient for Amlodipine and Benazepril is 1. The relative standard deviation was always less than 2%. The proposed method was found to be suitable and accurate for quantitative determination and the stability study of Amlodipine and Benazepril in pharmaceutical preparations. The developed HPLC method was validated with respect to linearity & range, accuracy, precision and robustness.

关键词： Column Liquid Chromatography Method Validation Stability Indicating Study Amlodipine and Benazepril

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克洛生(CLOSTATTM)能否替代抗生素生长促进剂？--一份来自商业农场的试验报告

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饲料工业 2013年第11期34卷 53-55页

作者： Sathishkumar J Manivannan K jayaraman K Rajalekshmi M 李正(译) 黄广明(校) 建明工业(印度)有限公司建明工业(珠海)有限公司

通过大规模的肉鸡试验证实添加克洛生的效果要优于添加亚甲基双水杨酸杆菌肽(BMD)的效果,BMD是一种抗生素生长促进剂。选取20个农场的120 948羽肉鸡进行试验,其中A组包括10个农场的49 308羽肉鸡,添加200 g/t的克洛生11粉剂,B组包括其他1... 详细信息

通过大规模的肉鸡试验证实添加克洛生的效果要优于添加亚甲基双水杨酸杆菌肽(BMD)的效果,BMD是一种抗生素生长促进剂。选取20个农场的120 948羽肉鸡进行试验,其中A组包括10个农场的49 308羽肉鸡,添加200 g/t的克洛生11粉剂,B组包括其他10个农场的71 640羽肉鸡,添加500 g/t的BMD。结果表明,与B组相比,克洛生能显著改善饲料转化率及校正饲料转化率(P<0.05),两个参数分别改善了6个百分点和11个百分点。同时,克洛生还能使欧洲效率因子(EEF)提高34个百分点。添加克洛生还能显著降低每羽肉鸡的生产成本、用药费及饲料费用,显著增加日增重(P<0.05)。从整体效果看,克洛生能使肉鸡日增重提高9.29%,每千克活鸡能得到2.09卢比的收益。

关键词：克洛生抗生素生长促进剂亚甲基双水杨酸杆菌肽坏死性肠炎

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A Multiplex Autoantibody Panel for Early Detection of Autoimmune Disease Activity

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Open Journal of Rheumatology and Autoimmune Diseases 2018年第2期8卷 43-52页

作者： Yuanyuan Yang Karthik Krishna Vinodh Ranganathan Vasanth jayaraman Tianhao Wang Kang Bei Hari Krishnamurthy John J. Rajasekaran Vibrant America LLC San Carlos CA USA

Background: Detection of autoantibodies has played a consolidate role in diagnosis of systemic autoimmune disorders. A cascade autoantibody testing is usually performed by employing antinuclear antibodies (ANA) test as a first screening test and the other tests as second level determinations. Here, we present that supplementing extractable nuclear antigens (ENA) tests to the ANA test may capture more autoimmunity and provide critical medical information at an early stage. In this study, we?evaluated the clinical significance of a multiplex ANA + ENA panel. Methods: A cohort of 110 subjects, identified as ANA negative but ENA positive, were followed up for two years. The detection of their ANA and anti-ENA autoantibodies was assessed with a multiplex ANA + ENA panel at Vibrant America Clinical Laboratory. Results: During two years of multi-visit follow-up, 23 out of 110 subjects (20.9%) were found to become ANA positive within an average of 385 (±144) days. Histone (50/110, 45.5%) and Chromatin (25/110, 22.7%) antibodies were the most frequently found antibodies at their first visits. The subjects who were positive for RNP (5/8, 62.5%) and SSA (Ro) (10/22, 45.5%) have the highest ratio of conversion to positive ANA. No significant correlation was observed between the conversion frequency and the number of anti-ENA antibodies being carried. Conclusion: This study, which followed up on the subjects who had disparate ANA and ENA test results, showed that anti-ENA antibodies may exist years earlier than ANA. Combining ENA tests with ANA screening may reduce false negatives and improve sensitivity.

关键词： Autoantibody ANA ENA Autoimmunity Connective Tissue Disorder

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Calcineurin Inhibitor Use and Myoclonus Association. Is There a Clinical Implication?

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Open Journal of Anesthesiology 2021年第4期11卷 85-98页

作者： Ricardo E. Verdiner Ruben Casado Arroyo Mohammad Rauf Chaudhry Narjeet Khurmi Karl Poterack Andy Gorlin Arun jayaraman Gustavo Rodriguez Department of Anesthesiology Mayo Clinic Arizona Phoenix USA Department of Medicine Universite Libre de Bruxelles Brussels Belgium Department of Neurology Texas Tech University Lubbock USA Department of Neurology Texas Tech University Health Science Center of El Paso Lubbock USA

Background: Calcineurin Inhibitors (CNIs) play a pivotal role in anti rejection therapy for transplant patients. Neurotoxicity is a known side effect that usually manifests as encephalopathy but myoclonus has also been described. Perioperative myoclonus as a manifestation of neurotoxicity, has not been well studied. Methods: We retrospectively reviewed data from 842,762 patients from the Nationwide Inpatient Sample (NIS) database from January 2011 to December 2014. Of those records we compared 56,423 patients requiring CNIs and undergoing Heart Transplant (HT) with 786,339 patients undergoing Coronary Artery Bypass Graft (CABG) surgery as controls. The objective was to study the rates of myoclonus in patients undergoing cardiac surgery, especially those requiring CNIs, and study the outcome of those patients with myoclonus. The NIS database from January 2011 to December 2014 was the source for the analysis. Patients with underlying epilepsy or hypo-ischemic encephalopathy based on ICD-9-CM codes were excluded from the study. Results: A total of 147 patients (0.26%) were found to have myoclonus in the HT group versus 338 patients (0.04%) in the CABG group, p Conclusion: In this study we have compared the rate of myoclonus found in HT patients versus CABG patients. We have identified calcineurin inhibitors as potentially contributing to myoclonus due to its neurotoxic effects. The st

关键词： Calcineurin Inhibitors Myoclonus Neurotoxicity Perioperative Mortality Renal Failure Tacrolimus Mycophenolate Endothelial Health Blood Brain Barrier

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个人计算机上用的专家系统:TK!Solver法

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微电子学与计算机 1988年第4期 42-47页

作者： Milos Konopasek and Sundaresan jayaraman 莫梧生

人工智能和微型计算机技术领城的进展已达到在便宜的个人计算机中较易地实现人工智能的某些概念.在问题求解和决策过程中,使个人计算机成为更富智能的一种专家系统软件包的实例就是TKlSolver(工具包!求解器).除了因其本身的质量而成为... 详细信息

人工智能和微型计算机技术领城的进展已达到在便宜的个人计算机中较易地实现人工智能的某些概念.在问题求解和决策过程中,使个人计算机成为更富智能的一种专家系统软件包的实例就是TKlSolver(工具包!求解器).除了因其本身的质量而成为一个专家系统外,TK!Solver还可被非计算机专业以及非人工智能专业的人员用来作为籍各专业中以数量表示的知识库来研制个人化专家系统的框架.

关键词： TK!Solver 变量表专家知识库专家系统人工智能规则表领域个人计算机 PC机

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连续式热处理炉的节能

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工业炉 1984年第2期 59-63页

作者： V·jayaraman 黄志宏

引言任何火焰炉的效率在很大程度上取决于它的工作温度。因为燃烧产物(烟气)在离开炉子时的温度相当于炉内工作温度,甚至稍高于炉内温度。图1表示不同温度的烟气所带走的热量。由图可见,烟气在260℃时所带走的热量要占总输入热量的20％,... 详细信息

引言任何火焰炉的效率在很大程度上取决于它的工作温度。因为燃烧产物(烟气)在离开炉子时的温度相当于炉内工作温度,甚至稍高于炉内温度。图1表示不同温度的烟气所带走的热量。由图可见,烟气在260℃时所带走的热量要占总输入热量的20％,到1371℃时,则升到72％。

关键词：热处理炉工业炉窑料盘输送带式炉保护气氛热耗

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Human Reproductive Health in Relation to Thyroid Alterations

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Health 2019年第8期11卷 1095-1133页

作者： Thushani Siriwardhane Karthik Krishna Qi Song Vinodh Ranganathan Vasanth jayaraman Tianhao Wang Kang Bei John J. Rajasekaran Hari Krishnamurthy Vibrant America LLC San Carlos CA USA Vibrant Sciences LLC San Carlos CA USA

Background: Thyroid alterations have adverse effects on other health systems in the body, and reproductive system is one of the most affected organs. Here, we perform a comprehensive analysis on the effects of different thyroid abnormalities on sexual and reproductive-related hormones in both men and women in different age groups. Method: A comprehensive analysis was performed on 15,043 subjects within the reproductive age (15 - 49 years). They were tested for thyroid markers (TSH, FT4, anti-TPO, anti-Tg) and 13 reproductive hormones in Vibrant America Clinical Laboratory between March 2016 to July 2018. The alterations of each reproductive hormone in hypothyroidism, hyperthyroidism, anti-TPO+ anti-Tg+ groups were evaluated. Results: A total of 10,626 women was tested. Women with hypothyroidism had elevated cortisol and low SHBG and DHEA-S. Women with hyperthyroidism showed elevated total testosterone and SHBG. Women seropositive for anti-TPO had elevated total testosterone and low cortisol. Women seropositive for anti-Tg had low parathyroid hormones. Similarly, a total of 4417 men was tested. Men with hypothyroidism had low IGF-I. Similarly, men with hyperthyroidism had low DHEA-S, but elevated estradiol, FSH, LH and prolactin. Men seropositive for anti-TPO had elevated SHBG and low progesterone. Men seropositive for anti-Tg had elevated progesterone. The reproductive and related hormone levels of age group 36 - 49 showed the most variations. Conclusion: Our results clearly show that individuals with different thyroid alterations have different effects on reproductive health, especially in the age group 36 - 49. Hence, routine testing and follow-up checkups on reproductive system would be beneficial for individuals in the age group 36 - 49 with thyroid disorders.

关键词： Reproductive Hormones Hypothyroidism Hyperthyroidism Thyroid Disease Thyroid Autoantibodies

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Synchronous colorectal liver metastases: a national survey of surgeon opinions on simultaneous resection and multidisciplinary cooperation

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Hepatobiliary Surgery and Nutrition 2018年第4期7卷 242-250页

作者： Carrie Howard Thomas W.Clements Janet P.Edwards Anthony R.MacLean W.Donald Buie Elijah Dixon Sean C.Grondin Anthony Gomes Michael McColl Sean P.Cleary Shiva jayaraman Renelle Daigle Chad G.Ball Department of Surgery University of CalgaryCalgaryAlbertaCanada Department of Surgery Lethbridge Regional HospitalLethbridgeABCanada Departments of Surgery University of TorontoTorontoONCanada

Background: The management of patients with synchronous colorectal liver metastases (sCRLM) has evolved significantly (improved chemotherapy, hepatic surgery advancements, colonic stenting, consultation synergies). We sought to better understand surgeon viewpoints on optimal referral patterns and the delivery of simultaneous resections. Methods: A 40 question on-line survey was offered to members of the Canadian surgical community. Statistical analysis was descriptive. Results: A total of 52 surgeons responded. Most colorectal surgeons (CRS) had access to and a good working relationship with regional hepatobiliary (HPB) surgeons (86%) and medical oncologists (100%). The majority (92%) believed there was a role for simultaneous resection of sCRLM, with 69% having first hand experience. Many CRS (62%) discussed all cases of known hepatic metastases with HPB prior to any resection. When a lesion was asymptomatic/minimally symptomatic, most CRS (92%) discussed them with medical oncology/HPB prior to resection (8%). Bilobar metastases (58%), patient comorbidities (35%), portal lymphadenopathy (35%), and patient age (15%) restricted CRS from obtaining HPB consultations. Many CRS (46%) did not believe that resecting hepatic metastases prior to the primary lesion might be beneficial. Most CRS (60%) reported they could not accurately predict hepatic resectability, with only 27%familiarity with evidence-based guidelines. Despite working in smaller hospitals with less access to HPB and less experience with simultaneous resections, non-CR general surgeons more commonly supported a 'liver-first' approach. Conclusions: There was general agreement between CRS and general surgeons on numerous topics, but additional education is required with regard to HPB surgical capabilities and to provide truly individualized patient-centered care.

关键词： Colorectal cancer liver metastases surgery

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