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Proton pump inhibitors and all-cause mortality risk among cancer patients

World Journal of Clinical Oncology 2025年第1期16卷 34-42页

作者： Arunkumar krishnan Carolin Victoria Schneider Declan Walsh Department of Supportive Oncology Atrium Health Levine CancerCharlotteNC 28204United States Department of Medicine Section of Hematology and OncologyWake Forest University School of MedicineWinston-SalemNC 27101United States Department of Medicine Ⅲ GastroenterologyMetabolic Diseasesand Intensive CareUniversity Hospital RWTH AachenAachen 52074Germany

BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related *** evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater *** To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize *** This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare *** study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer *** prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)*** primary outcome was all-cause *** patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding *** Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these *** a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individual

关键词： All-cause mortality Cancer Histamine-2 receptor antagonists Mortality Malignancy Proton pump inhibitors Carcinoma Outcome

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A multi-agent deep reinforcement learning approach for solving the multi-depot vehicle routing problem

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Journal of Management Analytics 2023年第3期10卷 493-515页

作者： Ali Arishi krishna.krishnan Department of Industrial Engineering King Khalid UniversityAbhaSaudi Arabia Department of Industrial Systemsand Manufacturing EngineeringWichita State UniversityWichitaKSUSA

The multi-depot vehicle routing problem(MDVRP)is one of the most essential and useful variants of the traditional vehicle routing problem(VRP)in supply chain management(SCM)and logistics *** supply chains(SC)choose the joint distribution of multiple depots to cut transportation costs and delivery ***,the ability to deliver quality and fast solutions for MDVRP remains a challenging *** optimization approaches in operation research(OR)may not be practical to solve MDVRP in *** the latest developments in artificial intelligence(AI),it becomes feasible to apply deep reinforcement learning(DRL)for solving combinatorial routing *** paper proposes a new multi-agent deep reinforcement learning(MADRL)model to solve *** experiments are conducted to evaluate the performance of the proposed *** show that the developed MADRL model can rapidly capture relative information embedded in graphs and effectively produce quality solutions in real-time.

关键词： artificial intelligence supply chain management combinatorial optimization multi-depot vehicle routing problem multi-agent deep reinforcement learning

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A two-stage metaheuristic algorithm for the dynamic vehicle routing problem in Industry 4.0 approach

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Journal of Management Analytics 2021年第1期8卷 69-83页

作者： Maryam Abdirad krishna.krishnan Deepak Gupta Department of Industrial Systemsand Manufacturing EngineeringWichita State UniversityWichitaKSUSA

Industry 4.0 is a concept that assists companies in developing a modern supply chain(MSC)system when they are faced with a dynamic *** Industry 4.0 focuses on mobility and real-time integration,it is a good framework for a dynamic vehicle routing problem(DVRP).This research works on *** aim of this research is to minimize transportation cost without exceeding the capacity constraint of each vehicle while serving customer demands from a common ***,new orders arrive at a specific time into the system while the vehicles are executing the delivery of existing *** paper presents a two-stage hybrid algorithm for solving the *** the first stage,construction algorithms are applied to develop the initial *** the second stage,improvement algorithms are *** results were designed for different sizes of *** results show the effectiveness of the proposed algorithm.

关键词： dynamic vehicle routing problem Industry 4.0 two-stage algorithm heuristic algorithms

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Three-stage algorithms for the large-scale dynamic vehicle routing problem with industry 4.0 approach

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Journal of Management Analytics 2022年第3期9卷 313-329页

作者： Maryam Abdirad krishna.krishnan Deepak Gupta Department of Industrial Systemsand Manufacturing EngineeringWichita State UniversityWichitaKS 67260USA

Companies are eager to have a smart supply chain especially when they have adynamic system. Industry 4.0 is a concept which concentrates on mobility andreal-time integration. Thus, it can be considered as a necessary component thathas to be implemented for a dynamic vehicle routing problem. The aim of thisresearch is to solve large-scale DVRP (LSDVRP) in which the delivery vehiclesmust serve customer demands from a common depot to minimize transit costswhile not exceeding the capacity constraint of each vehicle. In LSDVRP, it isdifficult to get an exact solution and the computational time complexity growsexponentially. To find near-optimal answers for this problem, a hierarchicalapproach consisting of three stages: “clustering, route-construction, routeimprovement”is proposed. The major contribution of this paper is dealing withLSDVRP to propose the three-stage algorithm with better results. The resultsconfirmed that the proposed methodology is applicable.

关键词： dynamic vehicle routing problem clustered vehicle routing problem three-stage algorithm industry 4.0

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Comparative efficacy of hyperbaric bupivacaine vs hyperbaric ropivacaine in spinal anesthesia for cesarean section:A metaanalysis

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World Journal of Methodology 2025年第2期15卷 154-165页

作者： Rishi Anand Deb Sanjay Nag Roushan Patel Prashant Sharma Vamsi krishna Uppalapati Umesh Kumar Singh Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JhārkhandIndia

BACKGROUND Intrathecal bupivacaine is the traditional anesthetic drug used in spinal anesthesia for caesarean sections(CSs),but ropivacaine has emerged as a potential *** meta-analysis compares the efficacy and safety of intrathecal hyper-baric bupivacaine vs hyperbaric ropivacaine for cesarean *** To systematically evaluate and compare the efficacy and safety of intrathecal hyperbaric bupivacaine and hyperbaric ropivacaine for spinal anesthesia in *** A thorough search of electronic databases was carried out to find pertinent randomized controlled trials(RCTs)comparing intrathecal hyperbaric ropi-vacaine and hyperbaric bupivacaine during ***,Cochrane database,Google Scholar,and Scopus were searched,and papers from January 2000 to January 2024 were deemed eligible and filtered using predetermined inclusion and exclusion *** were assessed for methodological quality,and data were extracted for time to adequate anesthesia(sensory and motor blockade),duration of sensory and motor block,hemodynamic changes and side effect *** standardized mean difference with 95%CI was used for continuous *** variables were assessed using the Mantel-Haenszel test and the random effect model to compute the odds *** Total 8 RCTs were selected from a pool of 119 search results for *** meta-analysis evaluated pooled effect sizes and assessed heterogeneity among the *** primary objective was to compare key outcomes to identify any significant variances in efficacy and safety profiles between two local *** analysis revealed that the difference in the onset of sensory blockade between the two local anesthetics was statistically insignificant(P=0.1586).However,the onset of motor blockade appeared to be faster with bupivacaine(P=0.03589).Additionally,the regression of sensory and motor blockade occurred earlier in the ropivacaine ***,the duration of the first analgesic

关键词： Ropivacaine Bupivacaine Anesthesia Spinal Cesarean section Meta-analysis

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Survival strategies for family-run homestays: analyzing user reviews through text mining

Data Science and Management

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Data Science and Management 2024年第3期7卷 228-237页

作者： Jay krishnan Biplab Bhattacharjee Maheshwar Pratap Janardan krishna Yadav Moinak Maiti Amrita School of Business Amrita Vishwa VidyapeethamCoimbatore641112India Jindal Global Business School O.P.Jindal Global UniversitySonipat131001India Department of Finance School of Economics and FinanceUniversity of the WitwatersrandJohannesburg2050South Africa

Online booking of homestays through e-travel portals is based on the virtual brand and perception,which are largely affected by user-generated electronic word-of-mouth(eWOM).With the objective of mining actionable insights from eWOM,this study conducted opinion mining for homestays located in four thematic areas of ***,various techniques have been deployed,such as sentiment and emotional analyses,topic modeling,and clustering *** themes revealed from topic modeling were breakfast,facilities provided,ambience,bathroom,cleanliness,hospitality exhibited,and satisfaction with the host.A lasso logistic regression-based predictive binary text classification model(with 97.6%accuracy)for homestay recommendations was *** findings and predictive model have implications for managers and homestay owners in devising appropriate marketing strategies and improving their overall guest experience.

关键词： Text miningTourismHomestaysTopic modelingPredictive modeling

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Relevance of epidemiology data in trauma management

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World Journal of Clinical Cases 2025年第9期13卷 65-67页

作者： krishna Kumar Govindarajan Department of Pediatric Surgery Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry 605006India

Trauma is a major cause of morbidity and mortality across the globe accounting for significant health *** of trauma care revolves round prevention,planning and execution of safety *** of the actual data regarding the type of trauma,affected age group,timings of trauma occurrence,involved part of the body constitute the initial steps in the building of the composite overview of the epidemiology of *** succession,would be the measures directed towards avoidance of trauma and capacity building of trauma center.

关键词： Trauma Epidemiology Injury Prevention Triage Registry Artificial Intelligence

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Streptomyces ghanaensis VITHM1 mediated green synthesis of silver nanoparticles： Mechanism and biological applications

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Frontiers of Chemical Science and Engineering 2016年第4期10卷 542-551页

作者： Mani Abirami krishnan Kannabiran Biomolecules and Genetic Division School of Biosciences and Technology VIT University Tamil Nadu 623014 India

We present the microbial green synthesis of silver nanoparticles （hiPs） by Streptomyces ghanaensis VITHM1 strain （MTCC No. 12465）. The secondary metabolites in the cell free supernatant of this bacterium when incubated with 1 mmol/L AgNO3, mediated the biological synthesis of AgNPs. The synthesized AgNPs were characterized by UV-visible spectrum, X-ray diffrac- tion （XRD）, atomic force microscope, scanning electron microscopy equipped with energy dispersive spectroscopy, transmission electron microscopy, FT-IR spectroscopy, dynamic light scattering and zeta potential. They were highly stable and, spherical in shape with the average size of 30-50 nm. The secondary metabolites involved in the formation of AgNPs were identified gas chromatographymass spectrography. The 3D structure of the unit cell of the synthesized AgNPs was determined using XRD data base. The synthesized AgNPs exhibited significant antibacterial activity against tested bacterial pathogens, and did not show haemolysis on human red blood cells. This green synthesis could provide a new platform to explore and use AgNPs as antibacterial therapeutic agents.

关键词： Streptomyces ghanaensis VITHM1 nanopar-ticles 3D structure antibacterial activity

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Radiation-absorption,chemical reaction,Hall and ion slip impacts on magnetohydrodynamic free convective flow over semi-infinite moving absorbent surface

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Chinese Journal of Chemical Engineering 2021年第6期34卷 40-52页

作者： M.Veera krishna Department of Mathematics Rayalaseema UniversityKurnoolAndhra Pradesh 518007India

The investigation of radiation-absorption,chemical reaction,Hall and ion-slip impacts on unsteady MHD free convective laminar flow of an incompressible viscous,electrically conducting and heat generation/absorbing fluid enclosed with a semi-infinite porous plate within a rotating frame has been *** plate is assumed to be moving with a constant velocity in the direction of fluid movement.A uniform transverse magnetic field is applied at right angles to the porous surface,which is absorbing the fluid with a suction velocity changing with *** non-dimensional governing equations for present investigation are solved analytically making use of two term harmonic and non-harmonic *** graphical results of velocity,temperature and concentration distributions on the analytical solutions are displayed and discussed with reference to pertinent *** is found that the velocity profiles decreased with an increasing in Hartmann number,rotation parameter,the Schmidt number,heat source parameter,while it increased due to an increase in permeability parameter,radiation-absorption parameter,Hall and ion slip ***,the temperature profile is an increasing function of radiation-absorption parameter,whereas an increase in chemical reaction parameter,the Schmidt number Sc or frequency of oscillations decrease the temperature profile on ***,it is found that the concentration profile is decreased with an escalating in the Schmidt number or the chemical reaction parameter.

关键词： Chemical reaction Free convection Heat source Heat transfer Mass diffusion Radiation absorption

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Contrast Enhancement Based Image Detection Using Edge Preserved Key Pixel Point Filtering

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Computer Systems Science & Engineering 2022年第8期42卷 423-438页

作者： Balakrishnan Natarajan Pushpalatha krishnan Department of Master of Computer Applications Sona College of TechnologySalem–636005India Department of Computer Applications SRM Institute of Science and TechnologyRamapuramChennai600089India

In existing methods for segmented images,either edge point extraction or preservation of edges,compromising contrast images is so sensitive to *** Degeneration Threshold Image Detection(DTID)framework has been proposed to improve the contrast of edge filtered ***,DTID uses a Rapid Bilateral Filtering process for filtering edges of contrast *** filter decomposes input images into base layers in the DTID *** minimal filtering time,Rapid Bilateral Filtering handles high dynamic contrast images for smoothening edge *** the DTID framework,Rapid Bilateral Filtering with Shift-Invariant Base Pass Domain Filter is insensitive to *** Shift-Invariant Filtering estimates value across edges for removing outliers(i.e.,noise preserving base layers of the contrast image).The intensity values are calculated in the base layer of the contrast image for accurately detecting nearby spatial locations using Shift-Invariant base Pass Domain Filter(SIDF).At last,Affine Planar Transformation is applied to detect edge filtered contrast images in the DTID framework for attaining a high quality of the *** normalizes the translation and rotation of *** this,Degeneration Threshold Image Detection maximizes average contrast enhancement quality and performs an experimental evaluation of factors such as detection accuracy,rate,and filtering time on contrast *** analysis shows that the DTID framework reduces the filtering time taken on contrast images by 54%and improves average contrast enhancement quality by 27%compared to GUMA,HMRF,SWT,and *** provides better performance on the enhancement of average contrast enhancement quality by 28%,detection accuracy rate by 26%,and reduction in filtering time taken on contrast images by 30%compared to state-of-art methods.

关键词： Rapid bilateral filtering edge preserved filtering affine planar transformation key pixel point localization shift-invariant base pass domain filter

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