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Systematic review and meta-analysis on the prophylactic role of non-steroidal anti-inflammatory drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis

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World Journal of Gastrointestinal Endoscopy 2015年第19期7卷 1341-1349页

作者： Muhammad S Sajid Amir H khawaja Mazin Sayegh krishna k singh Zinu Philipose Department of General Endoscopic and Laparoscopic Colorectal Surgery Western Sussex Hospitals NHS Foundation Trust Worthing Hospital Worthing Department of General Upper Gastrointestinal and Hepato-pancreatico-biliary Surgery Western Sussex Hospitals NHS Foundation Trust Worthing Hospital Worthing Department of Gastroenterology and Hepatology Western Sussex Hospitals NHS Foundation Trust Worthing Hospital Worthing

AIM: To critically appraise the published randomized, controlled trials on the prophylactic effectiveness of the non-steroidal anti-inflammatory drugs(NSAIDs), in reducing the risk of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis. METHODS: A systematic literature search(MEDLINE, Embase and the Cochrane Library, from inception of the databases until May 2015) was conducted to identify randomized, clinical trials investigating the role of NSAIDs in reducing the risk of post-ERCP pancreatitis. Random effects model of the meta-analysis was carried out, and results were presented as odds ratios(OR) with corresponding 95%***: Thirteen randomized controlled trials on 3378 patients were included in the final meta-analysis. There were 1718 patients in the NSAIDs group and 1660 patients in non-NSAIDs group undergoing ERCP. The use of NSAIDs(through rectal route or intramuscular route) was associated with the reduced risk of post-ERCP pancreatitis [OR, 0.52(0.38-0.72), P = 0.0001]. The use of pre-procedure NSAIDs was effective in reducing approximately 48% incidence of post-ERCP pancreatitis, number needed to treat were 16 with absolute risk reduction of 0.05. But the risk of post-ERCP pancreattis was reduced by 55% if NSAIDs were administered after procedure. Similarly, diclofenac was more effective(55%) prophylactic agent compared to indomethacin(41%).CONCLUSION: NSAIDs seem to have clinically proven advantage of reducing the risk of post-ERCP pancreatitis.

关键词： Non-steroidal drugs Pancreatitis Diclofenac Indomethacin Endoscopic retrograde cholangiopancreatography

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Comparative efficacy of hyperbaric bupivacaine vs hyperbaric ropivacaine in spinal anesthesia for cesarean section:A metaanalysis

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World Journal of Methodology 2025年第2期15卷 154-165页

作者： Rishi Anand Deb Sanjay Nag Roushan Patel Prashant Sharma Vamsi krishna Uppalapati Umesh kumar singh Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JhārkhandIndia

BACkGROUND Intrathecal bupivacaine is the traditional anesthetic drug used in spinal anesthesia for caesarean sections(CSs),but ropivacaine has emerged as a potential *** meta-analysis compares the efficacy and safety of intrathecal hyper-baric bupivacaine vs hyperbaric ropivacaine for cesarean *** To systematically evaluate and compare the efficacy and safety of intrathecal hyperbaric bupivacaine and hyperbaric ropivacaine for spinal anesthesia in *** A thorough search of electronic databases was carried out to find pertinent randomized controlled trials(RCTs)comparing intrathecal hyperbaric ropi-vacaine and hyperbaric bupivacaine during ***,Cochrane database,Google Scholar,and Scopus were searched,and papers from January 2000 to January 2024 were deemed eligible and filtered using predetermined inclusion and exclusion *** were assessed for methodological quality,and data were extracted for time to adequate anesthesia(sensory and motor blockade),duration of sensory and motor block,hemodynamic changes and side effect *** standardized mean difference with 95%CI was used for continuous *** variables were assessed using the Mantel-Haenszel test and the random effect model to compute the odds *** Total 8 RCTs were selected from a pool of 119 search results for *** meta-analysis evaluated pooled effect sizes and assessed heterogeneity among the *** primary objective was to compare key outcomes to identify any significant variances in efficacy and safety profiles between two local *** analysis revealed that the difference in the onset of sensory blockade between the two local anesthetics was statistically insignificant(P=0.1586).However,the onset of motor blockade appeared to be faster with bupivacaine(P=0.03589).Additionally,the regression of sensory and motor blockade occurred earlier in the ropivacaine ***,the duration of the first analgesic

关键词： Ropivacaine Bupivacaine Anesthesia Spinal Cesarean section Meta-analysis

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Diagnosis of COVID-19 from Chest X-Ray Images Using Wavelets-Based Depthwise Convolution Network

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Big Data Mining and Analytics 2021年第2期4卷 84-93页

作者： krishna kant singh Akansha singh Department of ECE KIET Group of InstitutionsDelhi-NCRGhaziabad 201206India Department of CSE ASETAmity University Uttar PradeshNoida 201310India

Coronavirus disease 2019 also known as COVID-19 has become a pandemic. The disease is caused by a beta coronavirus called Severe Acute Respiratory Syndrome Coronavirus 2(SARS-Co V-2). The severity of the disease can be understood by the massive number of deaths and affected patients globally. If the diagnosis is fast-paced, the disease can be controlled in a better manner. Laboratory tests are available for diagnosis, but they are bounded by available testing kits and time. The use of radiological examinations that comprise Computed Tomography(CT) can be used for the diagnosis of the disease. Specifically, chest X-Ray images can be analysed to identify the presence of COVID-19 in a patient. In this paper, an automated method for the diagnosis of COVID-19 from the chest X-Ray images is proposed. The method presents an improved depthwise convolution neural network for analysing the chest X-Ray images. Wavelet decomposition is applied to integrate multiresolution analysis in the network. The frequency sub-bands obtained from the input images are fed in the network for identifying the *** network is designed to predict the class of the input image as normal, viral pneumonia, and COVID-19. The predicted output from the model is combined with Grad-CAM visualization for diagnosis. A comparative study with the existing methods is also performed. The metrics like accuracy, sensitivity, and F1-measure are calculated for performance evaluation. The performance of the proposed method is better than the existing methodologies and thus can be used for the effective diagnosis of the disease.

关键词： coronavirus COVID-19 deep learning convolution neural network X-Ray images

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Constructing a biofunctionalized 3D-printed gelatin/sodium alginate/chitosan tri-polymer complex scaffold with improvised biological andmechanical properties for bone-tissue engineering

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Bio-Design and Manufacturing 2024年第1期7卷 57-73页

作者： Amit kumar singh krishna Pramanik Amit Biswas Centre of Excellence in Tissue Engineering Department of Biotechnology and Medical EngineeringNational Institute of TechnologyRourkela 769008India

Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering *** present study deals with further improvement in the tensile strength and biological properties of this type of scaffold to make it a potential template for bone-tissue *** experimented with adding 0%–15%(volume fraction)gelatin(GE),a protein-based biopolymer known to promote cell adhesion,proliferation,and *** resulting tri-polymer complex was used as bioink to fabricate SA/CH/GEmatrices by three-dimensional(3D)*** studies using scanning electron microscopy revealed the microfibrous porous architecture of all the structures,which had a pore size range of 383–419μm.X-ray diffraction and Fourier-transform infrared spectroscopy analyses revealed the amorphous nature of the scaffold and the strong electrostatic interactions among the functional groups of the polymers,thereby forming polyelectrolyte complexes which were found to improve mechanical properties and structural *** scaffolds exhibited a desirable degradation rate,controlled swelling,and hydrophilic characteristics which are favorable for bone-tissue *** tensile strength improved from(386±15)to(693±15)kPa due to the increased stiffness of SA/CH scaffolds upon addition of *** enhanced protein adsorption and in vitro bioactivity(forming an apatite layer)confirmed the ability of the SA/CH/GE scaffold to offer higher cellular adhesion and a bone-like environment to cells during the process of tissue *** vitro biological evaluation including the MTT assay,confocal microscopy analysis,and alizarin red S assay showed a significant increase in cell attachment,cell viability,and cell proliferation,which further improved biomineralization over the scaffold *** addition,SA/CH containing 15%gelatin designated as SA/CH/GE15 showed superior performance to the other fabricated 3D structures,demonstrating its pote

关键词： Scaffold Biomaterial Sodium alginate Chitosan Gelatin 3D printing Tissue engineering

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A Fifth Order Alternative Mapped WENO Scheme for Nonlinear Hyperbolic Conservation Laws

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Advances in Applied Mathematics and Mechanics 2022年第1期14卷 275-298页

作者： Uttam singh Rajput krishna Mohan singh Department of Mechanical and Industrial Engineering Indian Institute of Technology RoorkeeRoorkee 247667India

In this work,we have developed a fifth-order alternative mapped weighted essentially nonoscillatory(AWENO-M)finite volume scheme using non-linear weights of mapped WENO reconstruction scheme of Henrick et al.(***.,207(2005),pp.542-567)for solving hyperbolic conservation *** reconstruction of numerical flux is done using primitive variables instead of conservative *** present scheme results in less spurious oscillations near discontinuities and shows higher-order accuracy at critical points compared to the alternative WENO scheme(AWENO)based on traditional non-linear weights of Jiang and Shu(***.,228(1996),pp.202-228).The third-order Runge-kutta method has been used for solution advancement in *** Harten-Lax-van Leer-Contact(HLLC)shock-capturing method is used to provide necessary upwinding into the *** performance of the present scheme is evaluated in terms of accuracy,computational cost,and resolution of discontinuities by using various one and two-dimensional test cases.

关键词： High resolution scheme unsteady non-linear weights numerical fluxes alternative WENO scheme hyperbolic equations

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A new four-dimensional chaotic system with first Lyapunov exponent of about 22,hyperbolic curve and circular paraboloid types of equilibria and its switching synchronization by an adaptive global integral sliding mode control

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Chinese Physics B 2018年第4期27卷 214-227页

作者： Jay Prakash singh Binoy krishna Roy Zhouchao Wei Department of Electrical Engineering National Institute of Technology Silchar Silchar 788010 India School of Mathematics and Physics China University of Geosciences Wuhan 430074 China

This paper presents a new four-dimensional（4 D） autonomous chaotic system which has first Lyapunov exponent of about 22 and is comparatively larger than many existing three-dimensional（3 D） and 4 D chaotic *** proposed system exhibits hyperbolic curve and circular paraboloid types of *** system has all zero eigenvalues for a particular case of an equilibrium *** system has various dynamical behaviors like hyperchaotic,chaotic,periodic,and *** system also exhibits coexistence of *** behavior of the new system is validated using circuit *** an interesting switching synchronization phenomenon is proposed for the new chaotic *** adaptive global integral sliding mode control is designed for the switching synchronization of the proposed *** the switching synchronization,the synchronization is shown for the switching chaotic,stable,periodic,and hybrid synchronization *** of the controller designed in the paper is compared with an existing controller.

关键词： new hyperchaotic system maximum chaos an infinite number of equilibria hidden attractors switching synchronization global sliding mode control

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Geochemical Modelling of Fluoride Concentration in Hard Rock Terrain of Madhya Pradesh, India

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Acta Geologica Sinica(English Edition) 2013年第5期87卷 1421-1433页

作者： Jay krishna THAkUR Prafull singh Sudhir kumar singh Bijendra BHAGHEL Thakur International & Investment (P) Ltd. Amity Institute of Geo-Informatics and Remote Sensing (AIGIRS) Amity University k.Banerjee Centre of Atmospheric and Ocean Studies IIDS University of Allahabad Department of Earth Sciences Barkatullah University

The aim of the present study is to locate and decipher the groundwater quality, types, and hydrogeochemicai reactions, which are responsible for elevated concentration of fluoride in the Chhindwara district in Madhya Pradesh, India. Groundwater samples, quality data and other ancillary information were collected for 26 villages in the Chhindwara District, M.P. India during May 2006. The saturation index was computed for the selected samples in the region, which suggest that generally most of the minerals are saturated with respect to water. The concentration of fluoride in the region varies from 0.6 to 4.74 rag/l, which is much higher as per the national and international water quality standards. The study also reveals that the fluoride bearing rock formations are the main source of the higher concentration of fluoride in groundwater along with the conjuncture of land use change. Moreover, the area is a hard rock terrain and consists of fractured granites and amygdaloidal and highly jointed compact basalt acting as good aquifer, which is probably enriching the high content of fluoride in groundwater. High concentration of fluoride is found in deeper level of groundwater and it is possible due to rock-water interaction, which requires further detailed investigation. The highly alkaline conditions indicate fluorite dissolution, which works as a major process for higher concentration of fluoride in the study area. The results of this study will ultimately help in the identification of risk areas and taking measures to mitigate negative impacts related to fluoride pollution and toxicity.

关键词： Fluoride rock-water interaction saturation index Madhya Pradesh India

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Electrospun CNT embedded ZnO nanofiber based biosensor for electrochemical detection of Atrazine: a step closure to single molecule detection

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Microsystems & Nanoengineering 2020年第1期6卷 1353-1362页

作者： Patta Supraja Vikrant singh Siva Rama krishna Vanjari Shiv Govind singh Department of Electrical Engineering Indian Institute of TechnologyHyderabadTelangana 502285India School of Medicine University of California DavisDavisCaliforniaUSA

In this study we have reported the design and development of a facile,sensitive,selective,and label-free electrochemical sensing platform for the detection of atrazine based on MWCNT-embedded ZnO *** nanofibers were characterized using scanning electron microscope(SEM),transmission electron microscope(TEM),X-ray diffraction(XRD),X-ray photoelectron spectroscope(XPS),UV-Visible spectroscope(UV-VIS),and Fourier-transform infrared spectroscope(FTIR).Electrochemical properties of MWCNT-ZnO nanofiber-modified electrodes were assessed using electrochemical impedance spectroscopy(EIS)and cyclic voltammetry(CV).Binding event of atrazine to anti-atrazine antibody,which immobilized on nanofiber-modified electrode via EDC and NHS chemistry,was transduced with *** to high conductivity,surface area,and low bandgap of MWCNT-ZnO nanofibers,we have achieved the sensitivity and limit of detection(LoD)of sensor as 21.61(kΩμg^(−1) mL^(−1))cm^(−2) and 5.368zM for a wide detection range of 10 zM–1µ*** proposed immunosensing platform has good stability,selectivity,repeatability,and reproducibility,and are less prone to interference.

关键词： fiber fibers closure

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Perspectives and challenges of tropical medicinal herbs and modern drug discovery in the current scenario

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Asian Pacific Journal of Tropical Medicine 2019年第1期12卷 1-7页

作者： Rajesh kumar kesharwani krishna Misra Dev Bukhsh singh Department of Advanced Science & Technology NIET Nims University Rajasthan Department of Applied Science Indian Institute of Information Technology Allahabad Department of Biotechnology Institute of Biosciences and Biotechnology Chhatrapati Shahu Ji Maharaj University

Tropical diseases such as malaria, tuberculosis, trypanosomiasis, and leishmaniasis, account for a large number of deaths annually. Herbs are an excellent source of tropical medicines. Many advancements and discoveries have taken place in the field of drug discovery but still, a major population of tropical diseases relies on herbal traditional medicine. There are some challenges related to policy implementation, efficacy, resistance and toxicity of tropical medicines. There are many tropical diseases such as such as schistosomiasis, leishmaniasis, African sleeping sickness, filariasis and chagas disease which are neglected because very few pharmaceutical companies have shown their interest in developing therapeutics against these diseases of poor people. There are many benefits associated with herbal medicine such as the cost of production, patient tolerance, large scale availability, efficacy, safety, potency, recyclability, and environment friendly. A large number of natural extracts such as curcumin, artemisinin, morphine, reserpine, and hypericin, are in use for treatment of different tropical diseases for a long time. The current review is to discuss the overview of tropical medicinal herbs, its scope and limitations in the modern drug discovery process.

关键词： Herbs Natural sources Lead compounds Drug discovery Computational approaches

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Controversies in the management of acute pancreatitis:An update

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World Journal of Clinical Cases 2023年第12期11卷 2582-2603页

作者： Manish Manrai Saurabh Dawra Anupam k singh Daya krishna Jha Rakesh kochhar Department of Internal Medicine Armed Forces Medical CollegePune 411040India Department of Medicine and Gastroenterology Command HospitalPune 411040India Department of Gastroenterology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Gastroenterology Army Hospital(Research and Referral)New Delhi 11010India

This review summarized the current controversies in the management of acute pancreatitis(AP).The controversies in management range from issues involving fluid resuscitation,nutrition,the role of antibiotics and antifungals,which analgesic to use,role of anticoagulation and intervention for complications in *** interventions vary from percutaneous drainage,endoscopy or *** research and emerging data are helping to formulate better *** available evidence favors crystalloids,although the choice and type of fluid resuscitation is an area of dynamic *** nutrition aspect does not have controversy as of now as early enteral feeding is preferred most often than *** empirical use of antibiotics and antifungals are gray zones,and more data is needed for conclusive *** choice of analgesic is being studied,and the recommendations are still *** position of using anticoagulation is still awaiting *** role of intervention is well established,although the modality is constantly changing and favoring endoscopy or percutaneous drainage rather than *** is evident that more multicenter randomized controlled trials are required for establishing the standard of care in these crucial management issues of AP to improve the morbidity and mortality worldwide.

关键词： Acute pancreatitis Fluid resuscitation Antibiotics Analgesia Anti coagulation Intervention

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