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Ionic liquid mediated morphologically improved lanthanum oxide nanoparticles by Andrographis paniculata leaves extract and its biomedical applications

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Journal of Rare Earths 2020年第3期38卷 281-291页

作者： Muthulakshmi Veerasingam Balaji Murugesan Sundrarajan mahalingam Advanced Green Chemistry Lab Department of Industrial ChemistrySchool of Chemical SciencesAlagappa UniversityKaraikudi03Tamil NaduIndia

Greener synthesis of ionic liquid(IL) assisted lanthanum oxide(La2O3) nanoparticles(NPs) was followed using Andrographis paniculata leaves extract by hydrothermal method at low temperature,The IL assisted La2O3(La2O3-IL) NPs were characterized by various properties such as structural,spectral,optical,morphological,and biological *** X-ray diffraction studies confirm that La2O3-IL NPs crystallize in the form of body-centered cubic structure and average crystalline size is shown-43 *** and Laser Raman spectroscopy confirm the La-O,O-H and various functional *** La-O stretching vibration band attributes at 639 *** optical property of La2O3-IL NPs was characterized by UV-Vis and photo luminesce nce *** sharp and intense absorbance peak observed in the UV region at 288 nm can be *** the PL spectrum,we observe two different emission bands like blue and green *** morphological and particle size determination were investigated by SEM with EDX spectra and TEM *** agglomerated particles of hexagonal,spherical,and parallelogram shape are observed in the TEM *** chemical elements,binding energies as well as La metal states on the surface of these synthesized NPs were determined using ***2O3 NPs for good biological activities regarding antibacterial and anti-inflammatory potentials could be utilized in different biological applications to the food and biomedical ***2O3-IL has a high percentage of inhibitions than La2O3 and standard diclofenac.

关键词： La2O3 nanoparticles Ionic liquid X-ray diffraction X-ray photoelectron spectroscopy Antibacterial Anti-inflammatory

Enhancing the biological hydrogen production in a novel way of using co-substrates

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Waste Disposal and Sustainable Energy 2023年第4期5卷 511-524页

作者： Chelladurai Mumtha Jesuraj Kabiriyel Pambayan Ulagan mahalingam Department of Biology The Gandhigram Rural Institute-(Deemed to be University)GandhigramDindigulTamil Nadu624302India Nanostructure Lab Department of PhysicsThe Gandhigram Rural Institute-(Deemed to be University)GandhigramDindigulTamil Nadu624302India

Microbial electrolysis cell(MEC)is a potential technology to meet the increasing interest in finding new sources of energy that will not harm the *** is an alternative energy conversion technology for the production of *** is possible to produce hydrogen by fermenting biogenous wastes with hydrogen-producing *** study investigated the biohydrogen production from co-substrates using electrogenic bacteria such as Escherichia coli,Salmonella bongori,and Shewanella oneidensis in pure culture and as a co-culture,which has the potential to be used as co-substrate in ***,150 mL working-volume reactors were constructed for batch biohydrogen *** hydrogen production rate(HPR)from the co-substrate was maximum at a ratio of 75:25 g/L with a co-culture of 2.35 mL/(L h).Fabricated a single-chamber membrane-free microelectrolysis cell to evaluate the power density,current density,voltage,HPR,chemical oxygen demand(COD)removal efficiency and Columbic *** electron microscope(SEM)imaging confirmed the binding of electrogenic bacteria to anode and *** efficiency of electrical conductivity of MEC was analyzed by three different electrodes,namely,nickel,copper and *** HPR was high using nickel when compared to the other two *** HPR of a single chamber using a nickel electrode was 2.8 HPR ml/L H_(2) d^(−1) and provided a power density of 17.7 mW/m^(2) at pH *** study suggests that the nickel cathode in a single chamber could be a promising sustainable source for stable power generation.

关键词： Microelectrolysis Biohydrogen Nickel Aluminum Copper Graphite

Intra-population genetic variance for grain iron and zinc contents and agronomic traits in pearl millet

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The Crop Journal 2016年第1期4卷 48-54页

作者： mahalingam Govindaraj Kedar N.Rai Ponnusamy Shanmugasundaram International Crops Research Institute for the Semi-arid Tropics (ICRISAT) Centre for Plant Breeding and Genetics Tamil Nadu Agricultural University

Crop biofortification is a sustainable approach for fighting micronutrient malnutrition in the world. The estimation of variance components in genetically broad-based populations provides information about their genetic architecture, allowing the design of an appropriate biofortification breeding method for cross-pollinated crops such as pearl millet. The objective of this study was to estimate intra-population genetic variance using self(S1) and half-sib(HS) progenies in two populations, AIMP92901 and ICMR312. Field trials were evaluated in two contrasting seasons(2009 rainy and 2010 summer; otherwise called environments) in Alfisols at ICRISAT, Patancheru. Analyses of variance showed highly significant variation for S1 s and HS progenies, reflecting high within-population genetic variation for both micronutrients and other key traits. However, the HS showed narrow ranges and lower genetic variances than the S1 for all of the traits. The micronutrients were highly positively correlated in S1(r = 0.77 to 0.86; P < 0.01) and HS(r = 0.74 to 0.77; P < 0.01)progenies of both populations, implying concurrent genetic improvement for both micronutrients. The genetic variance component was different among populations for Fe and Zn contents across environments, with AIMP92901 showing a greater proportion of dominance and ICMR312 greater additive variance for these micronutrients. The estimates of variance(additive and dominance) were specific for each population, given their dependence on the additive and dominance effects of the segregating loci, which also differ among populations. The possible causes for such differences were discussed. The results showed that the expression of these micronutrients in pearl millet shows largely additive variance, so that breeding high-iron hybrids will require incorporation of these micronutrient traits into both parental lines.

关键词： Genetic variance Iron Micronutrient malnutrition Pearl millet Zinc

Nanocrystal-semiconductor interface： Atomic-resolution cross-sectional transmission electron microscope study of lead sulfide nanocrystal quantum dots on crystalline silicon

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Nano Research 2014年第2期7卷 219-227页

作者： Zachary Lingley kris.namu.thy mahalingam Siyuan Lus Gail J. Brown Anupam Madhukar Mork Family Department of Chemical Engineering and Materials Science University of Southern California Los Angeles California 90089 USA Air Force Research Laboratory Materials and Manufacturing Directorate Wright-Patterson Air Force Base Ohio 45433-7707 USA Department of Physics and Astronomy University of Southern California Los Angeles California 90089 USA

We report on a cross-sectional high resolution transmission electron microscope study of lead sulfide nanocrystal quantum dots （NCQDs） dispersed on electron-transparent silicon nanopillars that enables nearly atomically-resolved simultaneous imaging of the entire composite： the quantum dot, the interfacial region, and the silicon substrate. Considerable richness in the nanocrystal shape and orientation with respect to the substrate lattice is observed. The average NCQD-substrate separation is found to be significantly smaller than the length of the ligands on the NCQDs. Complementary photoluminescence measurements show that light emission from PbS NCQDs on silicon is effectively quenched which we attribute to intrinsic mechanisms of energy and charge transfer from PbS NCQDs to Si.

关键词： nanocrystal quantum dots semiconductor substrate interface atomic structure high resolutiontransmission electronmicroscopy energy and charge transfer solar cells

Differential mRNA Translation in Medicago truncatula Accessions with Contrasting Responses to Ozone-Induced Oxidative Stress

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Molecular Plant 2012年第1期5卷 187-204页

作者： Michael Puckett Niranjani J. lyer YuhongTang Xin-Bin Dai Patrick Zhao Ramamurthy mahalingam 246 Noble Research Center Department of Biochemistry and Molecular Biology Oklahoma State University Stillwater OK 74078 USA Samuel Roberts Noble Foundation 2510 Sam Noble Parkway Ardmore OK 73401 USA

Acute ozone is a model abiotic elicitor of oxidative stress and a useful tool for understanding biochemical and molecular events during oxidative signaling. Two Medicago truncatula accessions with contrasting responses to ozone were used to examine translational regulation during ozone stress. In ozone-resistant JE154, significant reduction in ri- bosome loading was observed within one hour of ozone treatment, suggesting energy homeostasis as a vital factor for oxidative stress management. Polysomal RNA-based expression profiling with Affymetrix arrays revealed extensive changes in the translatomes of both accessions. Messenger RNAs with low GC content in their 5＇ and 3＇-UTRs were pref- erentially associated with polysomes during oxidative stress. Genebins analysis revealed extensive changes in various gene ontologies in both accessions. Extensive changes in nicotinate and nicotinamide metabolism genes were corrobo- rated with increased levels of NAD＋ and NADH in JE154. The significantly lower NAD＋：NADH redox status in JE154, in conjunction with higher ATP amounts, provided a cellular milieu conducive for overcoming oxidative stress. Low levels of ATP, NADH, and suppression of antioxidant defense responses, abet build-up of ozone-derived ROS and ultimately lead to oxidative cell death in Jemalong.

关键词： Abiotic/environmental stress oxidative and photo-oxidative stress gene expression Medicago truncatula.

Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2885-2900页

作者： Porkizhi Arjunan Durga Kathirvelu Gokulnath mahalingam Ashish Kumar Goel Uday George Zacharaiah Alok Srivastava Srujan Marepally Center for Stem Cell Research(A Unit of inStem Bengaluru)Christian Medical College CampusBagayamVellore 632002Tamil NaduIndia Manipal academy for higher education Mangalore 576104KarnatakaIndia Department of Hematology Christian Medical College&HospitalVellore 632004Tamil NaduIndia Department of Hepatology Christian Medical College&HospitalVellore 632004Tamil NaduIndia

Inherited genetic disorders of the liver pose a significant public health *** transplantation is often limited by the availability of donor livers and the exorbitant costs of immunosuppressive *** overcome these limitations,nucleic acid therapy provides a hopeful alternative that enables gene repair,gene supplementation,and gene silencing with suitable *** viral vectors are the most efficient and preferred for gene therapy,pre-existing immunity debilitating immune responses limit their *** a potential alternative,lipid nanoparticle-mediated vectors are being explored to deliver multiple nucleic acid forms,including pDNA,mRNA,siRNA,and ***,we discuss the broader applications of lipid nanoparticles,from protein replacement therapy to restoring the disease mechanism through nucleic acid delivery and gene editing,as well as multiple preclinical and clinical studies as a potential alternative to liver transplantation.

关键词： Lipid nanoparticle Liver disorders Gene therapy Gene editing Nucleic acid delivery pDNA mRNA siRNA ASO Clinical trials

Vaccine development for leptospirosis:A systematic review

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Asian Pacific Journal of Tropical Medicine 2023年第12期16卷 533-545页

作者： Yocyny Surendran mahalingam Nandikha Syafinaz Amin-Nordin Sandeep Kumar Dhanda Mohamad Ridhuan Mohd Ali Narcisse MS Joseph Department of Medical Microbiology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400Malaysia Department of Biomedical Science Faculty of MedicineQuest International University30250Malaysia Department of Oncology St Jude Children’s Research Hospital Memphis38105USA Institute for Medical Research Ministry of HealthMalaysia

Objective:To assess the efficacy of various types of vaccines developed for ***:A comprehensive search was conducted in three databases:PubMed,Scopus,and Cochrane *** authors(YS and MN)selected the articles based on manual *** study eligibility criteria are all Leptospira species regardless of any cluster(pathogenic,intermediate and non-pathogenic).This study recorded articles with positive and negative results and showed a comparison among various membrane proteins as vaccine *** studies on the effectiveness of outer membrane protein as vaccine candidates were also *** articles obtained in the databases were imported into the WPS spreadsheet,and duplicate documents were removed ***:A total of 24 studies were included in the review,which evaluated various types of leptospirosis *** vaccines were developed and tested;however,the heterogeneity of Leptospira species pose a *** an effective approach,an epitope based vaccine shows quite a promising ***,sufficient validation,testing and clinical trials are ***:Developing an effective vaccine for leptospirosis remains a global health *** significant progress has been made in recent years,there is a need for further research to optimize vaccine development and to ensure that vaccines are accessible and effective for high-risk populations.

关键词： Leptospira Vaccine candidate Outer membrane protein

Blockchain Based Redistricting with Public Participation

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Journal of Information Security 2022年第3期13卷 140-164页

作者： mahalingam Ramkumar Naresh Adhikari Mississippi State University Starkville MS USA Slippery Rock University Slippery Rock PA USA

Redistricting is the process of grouping all census blocks within a region to form larger subdivisions, or districts. The process is typically subject to some hard rules and some (soft) preferences to improve fairness of the solution. Achieving public consensus on the fairness of proposed redistricting plans is highly desirable. Unfortunately, fair redistricting is an NP hard optimization problem. The complexity of the process makes it even more challenging to convince the public of the fairness of the proposed solution. This paper proposes a completely transparent blockchain based strategy to promote public participation in the redistricting process, to increase public confidence in the outcome of the process. The proposed approach is based on the fact that one does not have to worry about how the NP hard problem was solved, as long as it is possible for anyone to compute a “goodness” metric for the proposed plan. In the proposed approach, anyone can submit a plan along with the expected metric. Only the plan with the best claimed metric needs to be evaluated in a blockchain network.

关键词： Redistricting Authenticated Data Structures Blockchain Ledger

Authoritative and Unbiased Responses to Geographic Queries

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Journal of Information Security 2022年第3期13卷 101-126页

作者： mahalingam Ramkumar Naresh Adhikari Mississippi State University Starkville MS USA Slippery Rock University Slippery Rock PA USA

A protocol for processing geographic data is proposed to guarantee authoritative and unbiased responses to geographic queries, without the need to rely on trusted third parties. The integrity of the proposed authoritative and unbiased geographic services (AUGS) protocol is guaranteed by employing novel hash tree based authenticated data structures (ADS) in conjunction with a blockchain ledger. Hash tree based ADSes are used to incrementally compute a succinct dynamic commitments to AUGS data. A blockchain ledger is used to record 1) transactions that trigger updates to AUGS data, and 2) the updated cryptographic commitments to AUGS data. Untrusted service providers are required to provide verification objects (VOs) as proof-of-correctness of their responses to AUGS queries. Anyone with access to commitments in ledger entries can verify the proof.

关键词： Authenticated Data Structures Blockchain Ledger Geographic Information Systems