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ImprovingMultiple Sclerosis Disease Prediction Using Hybrid Deep Learning Model

Computers, Materials and Continua 2024年第1期81卷 643-661页

作者： Ojo, Stephen krichen, moez Alamro, Meznah A. Mihoub, Alaeddine Sampedro, Gabriel Avelino Kniezova, Jaroslava Department of Electrical and Computer Engineering College of Engineering Anderson University Anderson SC 29621 United States Faculty of Computing and Information Al-Baha University Al-Baha 65528 Saudi Arabia ReDCAD Laboratory University of Sfax Sfax 3038 Tunisia Department of Information Technology College of Computer & Information Science Princess Nourah Bint Abdul Rahman University Riyadh 11564 Saudi Arabia Department of Management Information Systems College of Business and Economics Qassim University P.O. Box 6640 Buraidah 51452 Saudi Arabia School of Management and Information Technology De La Salle-College of Saint Benilde Manila 1004 Philippines Department of Information Management and Business Systems Faculty of Management Comenius University Bratislava Bratislava 2582005 Slovakia

Myelin damage and a wide range of symptoms are caused by the immune system targeting the central nervous system in Multiple Sclerosis (MS), a chronic autoimmune neurological condition. It disrupts signals between the brain and body, causing symptoms including tiredness, muscle weakness, and difficulty with memory and balance. Traditional methods for detecting MS are less precise and time-consuming, which is a major gap in addressing this problem. This gap has motivated the investigation of new methods to improve MS detection consistency and accuracy. This paper proposed a novel approach named FAD consisting of Deep Neural Network (DNN) fused with an Artificial Neural Network (ANN) to detect MS with more efficiency and accuracy, utilizing regularization and combat over-fitting. We use gene expression data for MS research in the GEO GSE17048 dataset. The dataset is preprocessed by performing encoding, standardization using min-max-scaler, and feature selection using Recursive Feature Elimination with Cross-Validation (RFECV) to optimize and refine the dataset. Meanwhile, for experimenting with the dataset, another deep-learning hybridmodel is integratedwith differentML models, including Random Forest (RF), Gradient Boosting (GB), XGBoost (XGB), K-Nearest Neighbors (KNN) and Decision Tree (DT). Results reveal that FAD performed exceptionally well on the dataset, which was evident with an accuracy of 96.55% and an F1-score of 96.71%. The use of the proposed FAD approach helps in achieving remarkable results with better accuracy than previous studies. © 2024 The Authors.

关键词： Feature Selection

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Analytical Comparison of Resource Search Algorithms in Non-DHT Mobile Peer-to-Peer Networks

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Computers, Materials & Continua 2021年第7期68卷 983-1001页

作者： Ajay Arunachalam Vinayakumar Ravi moez krichen Roobaea Alroobaea Jehad Saad Alqurni Centre for Applied Autonomous Sensor Systems(AASS) Örebro UniversityÖrebroSweden Center for Articial Intelligence Prince Mohammad Bin Fahd UniversityKhobarSaudi Arabia Faculty of CSIT Al-Baha UniversitySaudi Arabia ReDCAD LaboratoryUniversity of SfaxTunisia Department of Computer Science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Education Technologies College of EducationImam Abdulrahman Bin Faisal UniversitySaudi Arabia

One of the key challenges in ad-hoc networks is the resource discovery *** efciently&quickly the queried resource/object can be resolved in such a highly dynamic self-evolving network is the underlying question?Broadcasting is a basic technique in the Mobile Ad-hoc Networks(MANETs),and it refers to sending a packet from one node to every other node within the transmission *** is a type of broadcast where the received packet is retransmitted once by every *** naive ooding technique oods the network with query messages,while the random walk scheme operates by contacting subsets of each node’s neighbors at every step,thereby restricting the search *** earlier works have mainly focused on the simulation-based analysis of ooding technique,and its variants,in a wired network ***,there have been some empirical studies in peer-to-peer(P2P)networks,the analytical results are still lacking,especially in the context of mobile P2P *** this article,we mathematically model different widely used existing search techniques,and compare with the proposed improved random walk method,a simple lightweight approach suitable for the non-DHT *** provide analytical expressions to measure the performance of the different ooding-based search techniques,and our proposed *** analytically derive 3 relevant key performance measures,i.e.,the *** of steps needed to nd a resource,the probability of locating a resource,and the *** of messages generated during the entire search process.

关键词： Mathematical model MANET P2P networks P2P MANET unstructured search algorithms Peer-to-Peer ad-hoc ooding random walk resource discovery content discovery mobile peer-to-peer broadcast peer

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Mathematical Model Validation of Search Protocols in MP2P Networks

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Computers, Materials & Continua 2021年第8期68卷 1807-1829页

作者： Ajay Arunachalam Vinayakumar Ravi moez krichen Roobaea Alroobaea Saeed Rubaiee Centre for Applied Autonomous Sensor Systems(AASS) Örebro UniversityÖrebroSweden Center for Artificial Intelligence Prince Mohammad Bin Fahd UniversityKhobarSaudi Arabia Faculty of CSIT Al-Baha UniversitySaudi Arabia ReDCAD LaboratoryUniversity of SfaxTunisia Department of Computer Science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Industrial and Systems Engineering College of EngineeringUniversity of JeddahJeddahSaudi Arabia

Broadcasting is a basic technique in Mobile ad-hoc network(MANET),and it refers to sending a packet from one node to every other node within the transmission *** is a type of broadcast where the received packet is retransmitted once by every *** naive flooding technique,floods the network with query messages,while the random walk technique operates by contacting the subsets of every node’s neighbors at each step,thereby restricting the search *** of the key challenges in an ad-hoc network is the resource or content discovery problem which is about locating the queried *** earlier works have mainly focused on the simulation-based analysis of flooding,and its variants under a wired ***,there have been some empirical studies in peer-to-peer(P2P)networks,the analytical results are still lacking,especially in the context of P2P systems running over *** this paper,we describe how P2P resource discovery protocols perform badly over *** address the limitations,we propose a new protocol named ABRW(Address Broadcast Random Walk),which is a lightweight search approach,designed considering the underlay topology aimed to better suit the unstructured *** provide the mathematical model,measuring the performance of our proposed search scheme with different widely popular benchmarked search ***,we also derive three relevant search performance metrics,i.e.,mean *** steps needed to find a resource,the probability of finding a resource,and the mean *** message *** validated the analytical expressions through *** simulation results closely matched with our analyticalmodel,justifying our *** proposed search algorithm under such highly dynamic self-evolving networks performed better,as it reduced the search latency,decreased the overall message overhead,and still equally had a good success rate.

关键词： Search protocols random walk MANET P2P networks P2P MANET mathematical model peer-to-peer wireless ad hoc network flooding mobile P2P unstructured P2P NS-2 network simulator

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A Formal Testing Model for Operating Room Control System Using Internet of Things

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Computers, Materials & Continua 2021年第3期66卷 2997-3011页

作者： moez krichen Seifeddine Mechti Roobaea Alroobaea Elyes Said Parminder Singh Osamah Ibrahim Khalaf Mehedi Masud Faculty of CSIT AlBaha UniversityAlBahaSaudi Arabia&ReDCAD LaboratorySfax UniversitySfaxTunisia MIRACL Laboratory Sfax UniversitySfaxTunisia Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia International Institute of Technology of Sfax SfaxTunisia School of Computer Science and Engineering Lovely Professional UniversityPhagwara CityIndia Al-Nahrain Nanorenewable Energy Research Center Al-Nahrain UniversityBaghdadIraq

Technological advances in recent years have significantly changed the way an operating room *** work aims to create a platformto solve the problems of operating room occupancy and prepare the rooms with an environment that is favorable for all *** this system,a doctor can control all operation rooms,especially before an operation,and monitor their temperature and humidity to prepare for the ***,in the event of a problem,an alert is sent to the nurse responsible for the room and medical stuff so that the problem can be *** platformis tested using a Raspberry PI card and *** sensors are connected to a cloud layer that collects and analyzes the temperature and humidity values obtained from the environment during an *** result of experimentations is visualized through a web application and an Android *** platform also considers the security aspects such as authorization to access application functionalities for the Web and the mobile *** can also test and evaluate the system’s existing problems and vulnerabilities using the IEEE and owasp IoT ***,the proposed framework is extended with a model based testing technique that may be adopted for validating the security aspects.

关键词： Communication Internet of Things control rooms sensors cloud robot

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Multi-Criteria Fuzzy-Based Decision Making Algorithm to Optimize the VHO Performance in Hetnets

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Computers, Materials & Continua 2022年第1期70卷 323-341页

作者： A.Prithiviraj A.Maheswari D.Balamurugan Vinayakumar Ravi moez krichen Roobaea Alroobaea Saeed Rubaiee Sankar Sennan Department of CSE Sona College of TechnologySalem636005India Department of CSE Dr.M.G.R.Educational and Research InstituteChennai600095India Center for Artificial Intelligence PrinceMohammad Bin Fahd UniversityKhobarSaudi Arabia Faculty of CSIT Al-Baha UniversitySaudi Arabia ReDCAD laboratory University of SfaxTunisia Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Industrial and Systems Engineering College of EngineeringUniversity of JeddahJaddahSaudi Arabia

Despite the seemingly exponential growth of mobile and wireless communication,this same technology aims to offer uninterrupted access to different wireless systems like Radio Communication,Bluetooth,and Wi-Fi to achieve better network connection which in turn gives the best quality of service(QoS).Many analysts have established many handover decision systems(HDS)to enable assured continuous mobility between various radio access *** is one of themost significant problems considered in wireless communication *** application needs a distinct QoS,so the network choice may shift *** achieve this objective and to choose the finest networks,it is important to select a best decision making algorithm that chooses the most effective network for every application that the user requires,dependent on QoS ***,the main goal of the proposed system is to provide an enhanced vertical handover(VHO)decision making programby using aMulti-CriteriaFuzzy-Based algorithm to choose the best *** Multi-Criteria algorithms and a Fuzzy-Based algorithm is implemented successfully for optimal network selection and also to minimize the probability of false ***,a double packet buffer is utilized to decrease the packet loss by 1.5%and to reduce the number of handovers up to 50%compared to the existing *** addition,the network setup has an optimized mobilitymanagement system to supervise the movement of the mobile nodes.

关键词： Vertical handover mobility management handover decision systems multi-criteria fuzzy logic QoS false handover

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Genetic investigation of the ubiquitin-protein ligase E3A gene as putative target in Angelman syndrome

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World Journal of Clinical Cases 2024年第3期12卷 503-516页

作者： Wiem Manoubi Marwa Mahdouani Dorra Hmida Ameni Kdissa Aida Rouissi Ilhem Turki Neji Gueddiche Najla Soyah Ali Saad Christian Bouwkamp Ype Elgersma Soumaya Mougou-Zerelli moez Gribaa Laboratory of Human Cytogenetics Molecular Genetics and Reproductive BiologyFarhat Hached University HospitalSousse 4000Tunisia Higher Institute of Biotechnology of Monastir University of MonastirMonastir 3000Tunisia Department of Neuropediatry La Rabta HospitalTunis 2000Tunisia Department of Pediatric Farhat Hached University HospitalSousse 4000Tunisia Department of Neuroscience Erasmus MCthe NetherlandsRotterdam 3112 tdNetherlands

BACKGROUND Angelman syndrome(AS)is caused by maternal chromosomal deletions,imprinting defects,paternal uniparental disomy involving chromosome 15 and the ubiquitin-protein ligase UBE3A gene *** the genetic basis remains unclear for several *** To investigate the involvement of UBE3A gene in AS and identifying new potential genes using exome *** We established a cohort study in 50 patients referred to Farhat Hached University Hospital between 2006 and 2021,with a strong suspicion of AS and absence of chromosomal *** UBE3A gene was screened for mutation *** unrelated patients issued from consanguineous families were subjected to exome *** We describe seven UBE3A variants among them 3 none previously described including intronic variants c.2220+14T>C(intron14),c.2507+43T>A(Exon15)and insertion in Exon7:c.30-47_*** exome sequencing revealed 22 potential genes that could be involved in AS-like syndromes that should be investigated *** Screening for UBE3A mutations in AS patients has been proven to be useful to confirm the *** exome findings could rise to new potential alternative target genes for genetic counseling.

关键词： Angelman syndrome Ubiquitin-protein ligase E3A Exome Consanguinity Polymorphism

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RELATIVE ESSENTIAL SPECTRA INVOLVING RELATIVE DEMICOMPACT UNBOUNDED LINEAR OPERATORS

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Acta Mathematica Scientia 2014年第2期34卷 546-556页

作者： Bilel krichen Department of Mathematics Preparatory Engineering Institute

In this article, we introduce the concept of demicompactness with respect to a closed densely defined linear operator, as a generalization of the class of demicompact operator introduced by Petryshyn in [24] and we establish some new results in Fredholm theory. Moreover, we apply the obtained results to discuss the incidence of some perturbation results on the behavior of relative essential spectra of unbounded linear operators acting on Banach spaces. We conclude by characterizations of the relative Schechter＇s and approximate essential spectrum.

关键词： Demicompact linear operator relative essential spectrum Fredholm and semi-Fredholm operators measure of noncompactness.

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Existence and exponential stability of weighted pseudo-almost periodic solutions for genetic regulatory networks with time-varying delays

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International Journal of Biomathematics 2021年第2期14卷 119-138页

作者： moez Ayachi University of Gabes Faculty of Sciences of GabesLR17ES11 Mathematics and Applications6072GabesTunisia

The importance of prediction for genetic regulatory network(GRNs)makes mathematical modeling a prominent *** this paper,we consider weighted pseudo-almost periodic solutions for a class of GRNs with time-varying *** establish the existence,uniqueness,and global exponential stability by employing the theory of dichotomy,the fixed point theorem,and differential inequality.A numerical example along with a graphical illustration are presented to support our main *** results extend existing GRNs models using almost periodic functions to support a wider range of regulatory processes.

关键词： Weighted pseudo-almost periodic solutions genetic regulatory networks time-varying delays global exponential stability

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Morphological and physiological responses to drought stress of carob trees in Mediterranean ecosystems

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Journal of Arid Land 2023年第5期15卷 562-577页

作者： Khouloud ZAGOUB Khouloud krichen Mohamed CHAIEB Lobna F MNIF Laboratory of Ecosystems and Biodiversity in Arid Land of Tunisia Faculty of SciencesUniversity of SfaxSfax 3000Tunisia

The greatest failure rate of reforestation programs is basically related to water deficit,especially at the seedling ***,the main objective of this work is to investigate the responses of three accessions of carob trees(Ceratonia siliqua L.)with 2-year-old from different climate regions to drought generated by four water treatments:Tc(250 mm),T1(180 mm),T2(100 mm),and T3(50 mm).The first accession(A1)comes from the protected national park of Ichkeul in northern *** zone belongs to the bioclimatic sub-humid *** second accession(A2)comes from Melloulech,located in the center-east of Tunisia,belonging to the bioclimatic semi-arid *** third accession(A3)comes from the mountain of Matmata,located in the south of Tunisia,belonging to the bioclimatic hyper-arid *** experiment was undertaken in a *** exchange indices(net photosynthesis(A),stomatal conductance(gs),transpiration rate(E),and internal CO_(2) concentration(Ci))were ***(Ψpd)and midday(Ψmd)leaf water potentials,relative soil water content(SWC),and morphological parameters(plant height(H),number of leaves(NL),number of leaflets(Nl),and number of branches(NB))were *** results showed that significant differences(P<0.001)were found between physiological and morphological parameters of each *** highest growth potential was recorded for Tc treatment in both accessions A1 and *** decreases in gs,E,Ci,and SWC were recorded with the increases in water stress applied from treatment T1 to *** and significant correlations were found between SWC andΨpd for all studied accessions.Ψpd andΨmd decreased as water stress increased,ranging from–0.96 to–1.50 MPa at sunrise and from–1.94 to–2.83 MPa at midday,respectively,under control and T3 *** accessions responded to drought through exhibiting significant changes in their physiological and morphological *** accessions A1 and A2 showed greater drought tol

关键词： Ceratonia siliqua L. water stress soil moisture stomatal conductance predawn leaf water potential minimum water potential

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Fixed Point Theorems for(p, q)-Quasi-Contraction Mappings in Cone Metric Spaces

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Chinese Annals of Mathematics,Series B 2016年第2期37卷 211-220页

作者： Wajdi CHAKER Abdelaziz GHRIBI Aref JERIBI Bilel krichen Higher Institute of Applied Biology Medenine El Jorf Road Km 22MedenineTunisia Higher Institute of Business Administration of Sfax Airport Road Km 4 B.P.N1013 3018 B.P.1013SfaxTunisia Department of Mathematics Faculty of Science of SfaxSoukra Road Km 3.5B.P.11713000SfaxTunisia Department of Mathematics Preparatory Engineering InstituteMenzel Chaker Road Km 0.5B.P.1172-3018SfaxTunisia

In this work, the authors introduce the concept of(p, q)-quasi-contraction mapping in a cone metric space. We prove the existence and uniqueness of a fixed point for a(p, q)-quasi-contraction mapping in a complete cone metric space. The results of this paper generalize and unify further fixed point theorems for quasi-contraction, convex contraction mappings and two-sided convex contraction of order 2.

关键词： Fixed points (p q)-Quasi-contractions Cone metric space

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