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Computer Administering of the Psychological Investigations: Set-Relational Representation

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Open Journal of Applied Sciences 2012年第2期2卷 110-114页

作者： krasimir yordzhev Ivelina Peneva Department of Psychology Faculty of Philosophy South-West University Blagoevgrad Bulgaria Faculty of Mathematics and Natural Sciences South-West University Blagoevgrad Bulgaria

Computer administering of a psychological investigation is the computer representation of the entire procedure of psychological assessments—test construction, test implementation, results evaluation, storage and maintenance of the developed database, its statistical processing, analysis and interpretation. A mathematical description of psychological assessment with the aid of personality tests is discussed in this article. The set theory and the relational algebra are used in this description. A relational model of data, needed to design a computer system for automation of certain psychological assessments is given. Some finite sets and relation on them, which are necessary for creating a personality psychological test, are described. The described model could be used to develop real software for computer administering of any psychological test and there is full automation of the whole process: test construction, test implementation, result evaluation, storage of the developed database, statistical implementation, analysis and interpretation. A software project for computer administering personality psychological tests is suggested.

关键词： Computer Administering Computer Testing Computer Psycho Diagnostic Mathematical Modeling Set Theory Relational Algebra Databases

Mass effect,aneurysms and flow diverters:Is the pipeline embolization device the Lone Virtuoso?Commentary on‘Pipeline embolization device for intracranial aneurysms presenting with mass effect:a large Chinese cohort’by Zhao et al

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Stroke & Vascular Neurology 2024年第4期9卷 457-458页

作者： Alexander Sirakov Georgi Vladev Kristina Sirakova Kristian Ninov krasimir Minkin Vasil Karakostov Stanimir Sirakov Interventional Radiology University Hospital St Ivan RilskiSofiaBulgaria Medical University of Sofia SofiaBulgaria

In the treatment of symptomatic intracranial aneurysms,the study by Zhao et al stands as a notable addition to the growing body of literature.^(1) Their investigation regarding the Pipeline Embolisation Device’s(PED,Covi-dien/Medtronic,Irvine,California,USA)effi-cacy in alleviating mass effect offers valuable insights that further contribute to the evolving landscape of neurointerventional *** applaud the authors for their dedicated efforts in tackling an essential facet of aneu-rysm *** with studies involving extensive cohorts is always enlight-ening,as they ignite discussions and open avenues for fresh research opportunities.

关键词： aneurysm Irvine intracranial

International scientific communications in the field of colorectal tumour markers

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World Journal of Gastrointestinal Surgery 2017年第5期9卷 127-138页

作者： krasimir Ivanov Ivan Donev Department of General and Operative Surgery Professor Paraskev Stoyanov Medical University of Varna Clinic of Medical Oncology St. Marina University Hospital of Varna

AIM To analyze scientometrically the dynamic science internationalization on colorectal tumour markers as reflected in five information portals and to outline the significant journals, scientists and *** A retrospective problem-oriented search was performed in Web of Science Core Collection(Wo S), MEDLINE, BIOSIS Citation Index(BIOSIS) and Scopus for 1986-2015 as well as in Dervent Innovations Index(Derwent) for 1995-2015. Several specific scientometric parameters of the publication output and citation activity were comparatively analyzed. The following scientometric parameters were analyzed:(1) annual dynamics of publications;(2) scientific institutions;(3) journals;(4) authors;(5) scientific forums;(6) patents-number of patents, names and countries of inventors, and(7) citations(number of citations to publications by single authors received in WoS, BIOSIS Citation Index and Scopus).RESULTS There is a trend towards increasing publication output on colorectal tumour markers worldwide along with high citation rates. Authors from 70 countries have published their research results in journals and conference proceedings in 21 languages. There is considerable country stratification similar to that in most systematic investigations. The information provided to end users and scientometricians varies between these data-bases in terms of most parameters due to different journal coverage, indexing systems and editorial policy. The lists of the so-called "core" journals and most productive authors in Wo S, BIOSIS, MEDLINE and Scopus along with the list of the most productive authors-inventors in Derwent present a particular interest to the beginners in the field, the institutional and national science managers and the journal editorial board members. The role of the purposeful assessment of scientific forums and patents is emphasized. CONCLUSION Our results along with this problem-oriented collection containing the researchers' names, addresses and publication

关键词： Colorectal tumour markers Scientometrics International scientific communications Web of Science MEDLINE BIOSIS Scopus Derwent

Renal cell carcinoma presented with a rare case of icteric Stauffer syndrome:A case report

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World Journal of Clinical Cases 2022年第25期10卷 9087-9095页

作者： Dimitar R Popov krasimir A Antonov Evelina G Atanasova Christo P Pentchev Lyuben M Milatchkov Maria D Petkova krasimir G Neykov Rosen K Nikolov Medical University of Sofia Sofia 1431Bulgaria Clinic of Gastroenterology University Hospital’St.Ivan Rilski’Sofia 1431Bulgaria Clinic of Urology National Oncology HospitalSofia 1756Bulgaria

BACKGROUND Paraneoplastic syndromes remain poorly understood and manifest as multifaceted clinical symptoms,making their diagnosis *** can be observed in various *** rare cases,it can be a paraneoplastic manifestation,most often associated with renal cell carcinoma and other urogenital tumors,as well as with bronchial *** classical form of Stauffer syndrome presents with a reversible anicteric increase of cholestatic liver function tests,thrombocytosis,coagulation impairment,and hepatosplenomegaly,without any proven hepatobiliary obstruction or *** SUMMARY We report a patient who presented with elevated liver enzymes,cholestatic jaundice,weight loss and pruritus,in whom renal cell carcinoma was incidentally found during ***,laboratory,and imaging tests excluded primary hepatic cause or metastatic *** and laboratory abnormalities reversed completely a few months after *** case is an example of the many sides of renal cell carcinoma,and it focuses the clinicians’attention on the differential diagnosis of cholestasis,including Stauffer syndrome and its ***,the correct diagnosis can be straightforward and the associated malignancy can be treated *** cases should be followed up with a multidisciplinary ***(IL)-6 is proposed to contribute to the pathophysiology of the *** probable mechanism is proinflammatory activity by the IL-6 cytokine,causing elevation of C-reactive protein and haptoglobin and inhibition of hepatobiliary transporter gene expression,impairing biliary *** Despite being rare,Stauffer syndrome is a potentially reversible paraneoplastic condition,when the primary cause is *** syndrome should be considered by clinicians because of the remediable liver disturbance,after successful treatment of the underlying malignancy.

关键词： Jaundice Cholestasis Renal cell carcinoma Stauffer syndrome Case report

Delivery of coenzyme Q10 loaded micelle targets mitochondrial ROS and enhances efficiency of mesenchymal stem cell therapy in intervertebral disc degeneration

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Bioactive Materials 2023年第5期23卷 247-260页

作者： Junyuan Sun Fei Yang Lianlei Wang Haichao Yu Zhijie Yang Jingjing Wei krasimir Vasilev Xuesong Zhang Xinyu Liu Yunpeng Zhao Department of Orthopaedics Qilu HospitalCheeloo College of MedicineShandong UniversityJinanShandong250012PR China School of Pharmaceutical Sciences Shandong UniversityJinanShandong250012PR China School of Medicine Nankai UniversityTianjin300071PR China Department of Orthopaedics The Fourth Medical CentreChinese People’s Liberation Army General HospitalBeijing100048PR China Key Laboratory of Colloid and Interface Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShandong UniversityJinanShandong250100PR China Academic Unit of STEM University of South AustraliaMawson LakesAdelaide5095South AustraliaAustralia College of Medicine and Public Health Flinders UniversityBedford Park5042South AustraliaAustralia

Stem cell transplantation has been proved a promising therapeutic instrument in intervertebral disc degeneration(IVDD).However,the elevation of oxidative stress in the degenerated region impairs the efficiency of mesenchymal stem cells(BMSCs)transplantation treatment via exaggeration of mitochondrial ROS and promotion of BMSCs ***,we applied an emulsion-confined assembly method to encapsulate Coenzyme Q10(Co-Q10),a promising hydrophobic antioxidant which targets mitochondria ROS,into the lecithin micelles,which renders the insoluble Co-Q10 dispersible in water as stable *** micelles are injectable,which displayed efficient ability to facilitate Co-Q10 to get into BMSCs in vitro,and exhibited prolonged release of Co-Q10 in intervertebral disc tissue of animal *** to mere use of Co-Q10,the Co-Q10 loaded micelle possessed better bioactivities,which elevated the viability,restored mitochondrial structure as well as function,and enhanced production of ECM components in rat ***,it is demonstrated that the injection of this micelle with BMSCs retained disc height and alleviated IVDD in a rat needle puncture ***,these Co-Q10 loaded micelles play a protective role in cell survival and differentiation through antagonizing mitochondrial ROS,and might be a potential therapeutic agent for IVDD.

关键词： Intervertebral disc degeneration Coenzyme Q10 Mesenchymal stem cell Reactive oxygen species Micelle

Ombitasvir, paritaprevir, ritonavir, dasabuvir and ribavirin in cirrhosis after complete destruction of hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第8期22卷 2630-2635页

作者： Zahariy Krastev Deian Jelev krasimir Antonov Tanya Petkova Evelina Atanasova Nadezhda Zheleva Bojidar Tomov Yana Boyanova Lyudmila Mateva Clinic of Gastroenterology University Hospital "St. Ivan Rilski"

We observed a sustained viral response(SVR) of ombitasvir/paritaprevir/ritonavir, dasabuvir and ribavirin therapy, for 12 wk, in two cases with compensated liver cirrhosis and fully destroyed early hepatocellular carcinoma(HCC). Patients were infected with hepatitis C virus(HCV) genotype 1b and were previous null responders/relapsers to interferon-alpha/ribavirin(IFN/RBV). There was a rapid suppression of HCV RNA to undetectable levels within the first two treatment weeks. SVR was achieved even after marked reduction of the RBV dose. The treatment was well tolerated. Both subjects experienced worsening of liver disease during therapy, in different patterns: severe, transient, predominantly direct hyperbilirubinemia without cytolysis(case 1) or progressive increase of aminotransferases(grade 4) without severe hyperbilirubinemia(case 2).Adverse events spontaneously resolved. The patients remained in a good clinical condition without hepatic decompensation. There was no re-occurrence of HCC. This is the first report for treatment of HCV cirrhosis after complete HCC destruction.

关键词： Ombitasvir Paritaprevir Ritonavir Dasabuvir Ribavirin Hepatitis C virus cirrhosis Hepatocellular carcinoma

CeO_2修饰介孔TiO_2和ZrO_2负载金催化剂催化废气中CO和挥发性有机化合物降解(英文)

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催化学报 2015年第4期36卷 579-587页

作者： Vasko Idakiev Dimitar Dimitrov Tatyana Tabakova krasimir Ivanov Zhong-Yong Yuan Bao-Lian Su Institute of Catalysis Bulgarian Academy of Sciences 1113 Sofia Bulgaria Department of Chemistry Agricultural University 4000 Plovdiv Bulgaria Institute of New Catalytic Materials Science College of Chemistry Nankai University Tianjin 300071 China Laboratory of Inorganic Materials Chemistry University ofNamur (FUNDP) 61 rue de Bruxelles B5000 Namur Belgium

Mesoporous 氧化物 TiO 2 和 ZrO 2, 经由中立 C 13(EO)6–Zr(OC3 H 7)4 集会小径，和 deposition–precipitation (DP ) 准备的修改 ceria 的 TiO 2 和 ZrO 2, 方法，展示高表面区域和一致毛孔尺寸分布被用作对金催化剂的支持。支持的... 详细信息

Mesoporous 氧化物 TiO 2 和 ZrO 2, 经由中立 C 13(EO)6–Zr(OC3 H 7)4 集会小径，和 deposition–precipitation (DP ) 准备的修改 ceria 的 TiO 2 和 ZrO 2, 方法，展示高表面区域和一致毛孔尺寸分布被用作对金催化剂的支持。支持的金催化剂为空气污染物质的催化消退被估计，即，公司， CH 3 哦，并且(CH 3)2 O。金牌被一个 DP 方法在 mesoporous 氧化物上支持。支持和催化剂被粉末 X 光检查衍射，高分辨率的传播电子显微镜学， N 2 adsorption–desorption 分析，和规划温度的减小技术描绘。在象由 ceria 的结构、催化的性质的积极修正一样的 ceria 和 mesoporous ZrO 2 和 TiO 2 之间的 synergistic 相互作用的高度被观察。ceria 添加剂与 mesoporous 氧化物交往并且在支持的 reducibility 上导致强壮的效果。催化剂的催化行为被讨论决定修改在金 nanoparticles 和 ceria-mesoporous 氧化物支持之间的添加剂和可能的相互作用的 ceria 的角色。在修改 ceria 的 mesoporous ZrO 2 上支持的金催化剂显示了优异催化活动(在 10 °C 和 CH 3 在 60 °C 的 OH ) 。高催化的活动能被归因于支持的能力帮助氧空缺形成。研究显示修改 ceria 的 mesoporous 氧化物支持作为对基于黄金的催化剂的支持有潜力。

关键词：介孔二氧化钛改性添加剂二氧化铈金催化剂挥发性有机化合物氧化锆 CO 支撑

Improvement of Plant Growing Techniques in Drying up and Water Scarcity Conditions

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Journal of Environmental Science and Engineering(A) 2013年第10期2卷 593-605页

作者： Georgi Mitev krasimir Bratoev Jivko Demirev Department of Agricultural Engineering University of Ruse Ruse 7017 Bulgaria

Due to its specificity, seasonality and location of large areas, the crops are exposed to the greatest degree of risks posed by climate change. To maintain stability and increase yields, it is imperative to implement an innovative approach by which to optimize certain processes such as tillage, sowing and irrigation. The main tasks of innovative solutions are proposed to increase the soil water holding capacities in the root layer over a prolonged period of time, and improve the accuracy of the drilling process for row crops and vegetables by using biodegradable materials, and on this basis to optimize the irrigation by use of specialized software products to determine irrigation scheduling and irrigation requirements.

关键词： Plant climate change innovative technologies soil water holding properties accurate drilling with biodegradable materials watering schedules and rates.

Corrigendum to“Delivery of coenzyme Q10 loaded micelle targets mitochondrial ROS and enhances efficiency of mesenchymal stem cell therapy in intervertebral disc degeneration”[***.23(2023)247-260]

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Bioactive Materials 2023年第6期24卷 171-173页

This corrects the article“Delivery of coenzyme Q10 loaded micelle targets mitochondrial ROS and enhances efficiency of mesenchymal stem cell therapy in intervertebral disc degeneration”in volume 23 on page *** authors regret that the printed version of the above article contains some errors which are not identified during the proofing stage.

关键词： loaded micelle coenzyme