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世界核心医学期刊文摘（心脏病学分册） 2005年第7期1卷 24-25页

作者： kragelund c. Grφnning B. Kφber L. 赵和平 Dr. Dept. of c.rdiol. and Endoc.inology Frederiksberg Hospital University of Copenhagen Nordre Fasanvej 57 DK-2000 Frederiksberg Denmark

BAc.GROUND: The level of the inac.ive N-terminal fragment of pro-brain(B-type) natriuretic.peptide(BNP)-is a strong predic.or of mortality among patients with ac.te c.ronary syndromes and may be a strong prognostic.marker in patients with c.ronic.c.ronary heart disease as well. We assessed the relationship between N-terminal pro-BNP(NT-pro-BNP) levels and long-term mortality from all c.uses in a large c.hort of patients with stable c.ronary heart disease. METHODS: NT-pro-BNP was measured in baseline serum samples from 1034 patients referred for angiography bec.use of symptoms or signs of c.ronary heart disease. The rate of death from all c.uses was determined after a median follow-up of nine years. RESULTS: At follow-up, 288 patients had died. The median NT-pro-BNP level was signific.ntly lower among patients who survived than among those who died(120 pg per milliliter[interquartile range, 50 to 318] vs. 386 pg per milliliter[interquartile range, 146 to 897], Pc.lar ejec.ion frac.ion(LVEF) and a lower c.eatinine c.earanc. rate, and were more likely to have a history of myoc.rdial infarc.ion, c.inic.lly signific.nt c.ronary artery disease, and diabetes than patients with NT-pro-BNP levels in the lowest quartile. In a multivariable c.x regression model, the hazard ratio for death from any c.use for the patients with NT-pro-BNP levels in the fourth quartile as c.mpared with those in the first quartile was 2.4(95 perc.nt c.nfidenc. interval, 1.5 to 4.0; Pc.information beyond that provided by c.nventional risk fac.ors, inc.uding the patients age; sex; family history with respec. to isc.emic.heart disease; the presenc. or absenc. of a history of myoc.rdial infarc.ion, angina, hypertension, diabetes, or c.ronic.heart failure; c.eatinine c.earanc. rate; body-mass index; smoking status; plasma lipid levels; LVEF; and the presenc.

关键词：稳定型冠心病 N-末端心肌梗死史预后信息慢性心衰预后指标射血分数左室收缩功能缺血性心脏病血管造影术

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