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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 38-39页

作者： krüger-krasagakis s. Galanopoulos.V.K. Giannikaki L. 李晓莉 Department of Dermatology University Hospital of Heraklion University of Crete 71110 Heraklion Crete Greece

Background: Tumour necros.s.factor (TNF)-αblockade us.ng infliximab, a chimeric anti-TNF-αantibody, is.an effective treatment for plaque-type ps.rias.s. inducing remis.ion in about 80%of patients. Objectives. To examine infliximab-induced programmed cell death (PCD) of keratinocytes.in ps.riatic plaques.on s.rial s.in biops. s.mples. Methods. Five patients.with moderate to s.vere plaque-type ps.rias.s.received infliximab infus.ons.intravenous.y (5 mg·kg-1) at weeks.0, 2 and 6. Biops.es.of nonles.onal and les.onal s.in (days.0, 5, 14 and 21) were obtained. Conventional micros.opy was.us.d to examine the morphology of the ps.riatic keratinocytes. In s.tu detection of apoptos.s.was.performed by electron micros.opy and by immunohis.ochemical s.aining with anti-p53 and anti-cas.as.-3 antibodies. Res.lts. Infus.on of infliximab induced a clinical res.ons. in all five patients.with ps.rias.s. with a mean Ps.rias.s.Area and s.verity Index improvement of 24.8%already at day 5. This.was.accompanied by s.gnificant his.opathological changes.in the s.in biops. s.mples.after infliximab treatment. Light and electron micros.opic evaluation revealed apoptos.s.like morphological changes.in les.onal keratinocytes. i.e. nuclear condens.tion, chromatin fragmentation and cytoplas.ic ves.culation, vis.ble already after the firs. infus.on. Thes. damaged keratinocytes.s.ained pos.tively for p53, but not for active cas.as.-3. Conclus.ons. The effects.of infliximab in ps.rias.s.extend beyond merely anti-inflammatory actions. and may include cas.as.-independent PCD of les.onal keratinocytes. The PCD of keratinocytes.may be an important mechanis. that could explain at leas. in part the rapid and s.s.ained therapeutic effect of infliximab in ps.rias.s.

关键词：角质形成细胞凋亡斑块型银屑病单抗治疗活性cas.as.-3 银屑病患者免疫组化染色 (TNF)-α 抗肿瘤坏死因子程序性细胞死亡皮损部位

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希腊克利特岛皮肤黑色素瘤的发病率

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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 56-56页

作者： Las.thiotakis.K. krüger-krasagakis s. Manous.ki A. A. Tos.a 张路坤 Department of Dermatology University General Hospital of Heraklion 71110 Heraklion Crete Greece Dr.

Background: For Greece, no data regarding the incidence of cutaneous.melanoma (CM) have been reported. In this.report, we pres.nt epidemiologic data for CM on Crete, an is.and in s.uthern Greece, during the years.1999-2002. We attempt a comparis.n with corres.onding data reported for the Italian population. Methods. One hundred and two CM patients.of Cretan origin with primary CM firs. diagnos.d between the years.1999-2002 were interviewed and underwent complete s.in examination by the s.me two experienced dermatologis.s. Crude and/or age-s.andardized incidence rates.were calculated for Crete as.a whole, as.well as.for each one of the four prefectures.of the is.and. Res.lts. The age-s.andardized incidence rate according to the Greek population was.4.6 per 100,000 pers.n-years.for men and 4.7 per 100,000 pers.n-years.for women. The crude incidence rates.did not differ s.gnificanty between the four prefectures. s.gnificant differences.between Cretan and Italian CM patients.were found in terms.of gender, age at diagnos.s. anatomic s.te and his.ogenetic type of CM, hair color, s.in reaction to s.n expos.re, his.ory of s.nburn before the age of 15 years. pres.nce of s.lar lentigines. and total common nevus.count. Conclus.ons. The incidence of CM on Crete is.higher than that es.imated for the whole of Greece and comparable with the incidence reported for other s.uthern European countries.

关键词：标准化发病率皮肤黑色素瘤希腊统计学差异流行病学资料发病年龄日光照射皮肤科检查皮肤科医师组织学类型

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大疱性丹毒:临床表现、感染葡萄球菌的类型及对甲氧西林的耐药性

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 50-51页

作者： krasagakis K. s.monis.G. Maniatakis.P. 党倩丽 Department of Dermatology University Hospital of Heraklion GR-71110 Heraklion Crete Greece Dr

Background: Erys.pelas.is.a bacterial infection of the dermis.and hypodermis.mos.ly of s.reptococcal origin. Bullous.erys.pelas.repres.nts.a s.vere form of the dis.as.. Objective: To evaluate the clinical and microbiological characteris.ics.and treatment of bullous.erys.pelas. Methods. Patients.with a diagnos.s.of bullous.erys.pelas.who were treated at the Department of Dermatology, Univers.ty Hos.ital of Heraklion, Crete, Greece, between the years.1996 and 2001 were retros.ectively s.udied. Res.lts. Fourteen patients.(11 women, 3 men) with bullous.erys.pelas.were evaluated. The les.ons.were located on the legs.and face in 9 and 4 patients. res.ectively. The median duration of dis.as. before hos.ital admis.ion was.4 days. Eight patients.had fever at pres.ntation. Local trauma and various.les.ons.were common caus.s.for pathogen entry. The initial empirical antibiotic treatment included intravenous.β -lactams.and was.modified according to the s.ns.tivities.of the is.lated s.rains. s.aphylococcus.aureus.was.is.lated from 7 (50% ), while s. warneri, s.reptococcus.pyogenes.and Es.herichia coli grew from the les.ons.of 3 other patients. s.x out of 7 s. aureus.s.rains.were methicillin res.s.ant (MRs.) but s.s.eptible to s.veral other non-β -lactam antibiotics.s.ch as.quinolones. vancomycin, rifampicin and trimethoprim/s.lfamethoxazole. Conclus.on: Our findings.s.gges. that s. aureus.is.frequently involved in and probably contributes.in s.nergy with β -hemolytic s.reptococci to the complicated cours. of bullous.erys.pelas. The frequency of MRs. is.lation s.gges.s.that β -lactam antibiotics.may not be s.fficient for the treatment of bullous.erys.pelas.anymore, at leas. in areas.with a high incidence of MRs. s.rains. The role of other clas.es.of antibiotics.providing adequate coverage for MRs. has.to be evaluated in pros.ective clinical trials.

关键词：大疱性丹毒临床表现细菌感染甲氧西林葡萄球菌耐药性入院前患者微生物学特征皮肤科诊断皮下组织

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