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The role of antioxidants and pro-oxidants in colon cancer

World Journal of Gastrointestinal Oncology 2014年第3期6卷 55-66页

作者： William L Stone koyamangalath krishnan Sharon E Campbell Victoria E Palau Department of Pediatrics James H Quillen College of MedicineEast Tennessee State UniversityJohnson CityTN 37614United States Department of Internal Medicine James H Quillen College of MedicineEast Tennessee State UniversityJohnson CityTN 37614United States Department of Biochemistry James H Quillen College of MedicineEast Tennessee State UniversityJohnson CityTN 37614United States Department of Pharmaceutical Sciences Gatton College of PharmacyEast Tennessee State UniversityJohnson CityTN 37614United States

This review focuses on the roles antioxidants and prooxidants in colorectal cancer(CRC).Considerable evidence suggests that environmental factors play key roles in the incidence of sporadic *** pro-oxidant factors play an etiological role in CRC it is reasonable to expect causal interconnections between the wellcharacterized risk factors for CRC,oxidative stress and *** smoking,a high dietary consumption of n-6 polyunsaturated fatty acids and alcohol intake are all associated with increased CRC *** risk factors are all pro-oxidant stressors and their connections to oxidative stress,the intestinal microbiome,intestinal microfold cells,cyclooxygenase-2 and CRCare detailed in this *** a strong case can be made for pro-oxidant stressors in causing CRC,the role of food antioxidants in preventing CRC is less *** is clear that not every micronutrient with antioxidant activity can prevent *** is plausible,however,that the optimal food antioxidants for preventing CRC have not yet been critically *** evidence suggests that RRR-gamma-tocopherol(the primary dietary form of vitamin E)or other"non-alpha-tocopherol"forms of vitamin E(e.g.,tocotrienols)might be *** is an antioxidant and its consumption is linked to a decreased risk of CRC.

关键词： Colorectal cancer Vitamin E Tocopherols Tocotrienols Oxidative stress Microbiome Intestinal Cyclooxygenase-2 Intestinal microfold cells Alcohol Cigarette smoke Antioxidants Genotoxicity

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