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中华高血压杂志 2021年第11期29卷 1155-1155页

作者： Furuhashi m Sakai A Tanaka m Higashiura Y mori K koyama m Ohnishi H Saitoh S Shimamoto K 赵狄(摘译) 郑武洪(审校) 不详

血管紧张素转换酶2(angiotensin-converting enzyme 2,ACE2)是新型冠状病毒棘突蛋白的受体。ACE2将血管紧张素Ⅱ转换为血管紧张素(1-7)。裂解的ACE2可以在血浆和尿液中测定到,但血浆与尿中ACE2的调节情况目前还不清楚。研究人员评估了20... 详细信息

血管紧张素转换酶2(angiotensin-converting enzyme 2,ACE2)是新型冠状病毒棘突蛋白的受体。ACE2将血管紧张素Ⅱ转换为血管紧张素(1-7)。裂解的ACE2可以在血浆和尿液中测定到,但血浆与尿中ACE2的调节情况目前还不清楚。研究人员评估了2017 Tanno-Sobetsu队列研究中的日本参与者605例[男/女:280/325,年龄(65±15)岁]的血浆与尿中ACE2水平。结果显示,与女性比较,男性尿ACE2显著降低,但血浆ACE2显著升高。

关键词： ACE2 血管紧张素转换酶2 队列研究新型冠状病毒血管紧张素Ⅱ 棘突蛋白 angiotensin 血浆

10年研究期间脂肪肝指数升高与男性和女性新发高血压独立相关

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中华高血压杂志(中英文) 2021年第10期 1027-1027页

作者： Higashiura Y Furuhashi m Tanaka m Takahashi S mori K miyamori D koyama m Ohnishi H moniwa N Numata K Hisasue T Hanawa N miura T 袁源郑武洪

J Am Heart Assoc,2021,10(14):e021430.脂肪肝指数(fatty liver index,FLI)是非酒精性脂肪肝的预测因子,已有报道显示FLI与几种代谢紊乱相关。考虑到FLI水平存在性别差异,本研究假设男性或女性中FLI在很大程度上与高血压发病相关。方...

J Am Heart Assoc,2021,10(14):e021430.脂肪肝指数(fatty liver index,FLI)是非酒精性脂肪肝的预测因子,已有报道显示FLI与几种代谢紊乱相关。考虑到FLI水平存在性别差异,本研究假设男性或女性中FLI在很大程度上与高血压发病相关。方法与结果:本研究在接受每年健康体检的普通人群(n=28 990)中探索10年期间FLI与高血压发病的相关性。排除缺失数据和基线时患有高血压的人群后,

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An Experimental Study of Carbon Dioxide Condensation in mini Channels

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Journal of Thermal Science 2004年第4期13卷 358-365页

作者： Shigeru koyama Institute of Advanced material Study Kyushu University Kasuga-koen 6-1 Kasuga-shi Fukuoka 816-8580Japan

In this study, the local characteristics of pressure drop and heat transfer were investigated experimentally for carbon dioxide condensation in a multi-port extruded aluminum test section, which had 10 circular channels each with 1.31 mm inner diameter. The CO2 was cooled with cooling water flow inside the copper blocks that were attached at both sides of the test section. The temperatures at the outer surface of the test section were measured with 24 K-type thermocouples embedded in the upper and lower surfaces along the length. Local heat fluxes were measured with 12 heat flux sensors to estimate the local enthalpies, temperatures and heat transfer coefficients. Bulk mean temperatures of CO2 at the inlet and outlet of the test section were measured with 2 K-type thermocouples. The measurements were performed for the pressure ranged from 6.48 to 7.3 mPa, inlet temperature of CO2 from 21.63 to 31.33℃, heat flux from 1.10 to 8.12 kW/m2, mass velocity from 123.2 to 315.2 kg/m2s, and vapor quality from 0 to 1. The results indicate that pressure drop is very small along the test section, heat transfer coefficient in the two-phase region is higher than that in the single-phase, and mass velocity has important effect on condensation heat transfer characteristics. In addition, experimental data were compared with previous correlations and large discrepancies were observed.

关键词： carbon dioxide condensation heat transfer pressure drop mini channels.

Study on adsorption behavior of cesium using ammonium tungstophosphate(AWP)-calcium alginate microcapsules

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Science China Chemistry 2012年第9期55卷 1719-1725页

作者： WU Yan mImURA Hitoshi NIIBORI Yuichi OHNISHI Takashi koyama Shinichi WEI YueZhou School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Graduate School of Engineering Tohoku University Aramaki-Aza-Aoba 6-6-01-2Sendai980-8579Japan Japan Atomic Energy Agency 4002 NaritaO-arai-machiIbaraki311-1393Japan

A functional microcapsule was prepared by encapsulating the fine crystalline ammonium tungstophosphate(AWP) in calcium alginate polymer(CaALG).The characterization of AWP-CaALG microcapsule was examined by SEm and *** adsorption behavior of Cs(I),Rb(I),Sr(II),Pd(II),Ru(III),Rh(III),La(III),Ce(III),Dy(III) and Zr(IV) was investigated by the batch *** batch experiments were carried out by varying the shaking times,HNO 3 concentration,and initial concentration of metal *** large K d values above 10 5 cm 3 /g for Cs(I) were obtained in the range of 0.1-5 m HNO 3,resulting in a separation factor of Cs/Rb exceeding 10 *** contrast,the K d values of Sr(II),Pd(II),Ru(III),La(III),Dy(III),Ce(III) and Zr(IV) were considerably lower than 50 cm 3 /*** K d value of Cs(I) decreased in the order of the coexisting ions,H + > Na + >> NH 4 +,and a linear relationship with a slop of about 1 was obtained between log K d and log [NH 4 + ]([NH 4 + ] > 0.01 m).The adsorption of Cs(I) was found to be controlled by chemisorption mechanism,and followed a Langmuir-type adsorption equation.A high uptake percentage of 99.4% for Cs(I) was obtained by using the dissolved solutions of spent fuel from FBR-JOYO(JAEA).

关键词：吸附行为海藻酸钙微胶囊行为研究铯钨铵钯(Ⅱ)

Fabrication and Characterization of Novel 3-D Hollow Waveguide for Widely Tunable Devices

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光学学报 2003年第S1期23卷 255-256页

作者： Toru miura Fumio koyama Akihiro matsutani microsystem Research Center Tokyo Institute of Technology 4259 Nagatsuta Midori-ku Yokohama 226-8503 JapanMicrosystem Research Center Tokyo Institute of Technology 4259 Nagatsuta Midori-ku Yokohama 226-8503 JapanMicrosystem Research Center Tokyo Institute of Technology 4259 Nagatsuta Midori-ku Yokohama 226-8503 Japan

We propose a novel 3-dimensional hollow waveguide with a variable air core for widely tunable *** observed a wavelength shift of 1.8 nm in a hollow waveguide resonator with a displacement of 6μm in an air core.

关键词： for on with as mode Fabrication and Characterization of Novel 3-D Hollow Waveguide for Widely Tunable Devices of in

VISUALIZATION OF DYNAmIC ORGANIZATION OF CYTOSKELETON GELS IN LIVING CELLS BY HYBRID-SPm

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Chinese Journal of Polymer Science 2003年第2期21卷 169-174页

作者： K.Kawabata Y.Sado m.Nagayama T.Nitta K.Nemoto Y.koyama H.Haga Divisions of Biological Sciences Graduate School of Science Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDepartment of Biochemistry Hokkaido University Graduate School of Medicine Sapporo 060-8638 JapanDivisions of Physics Graduate School of Science Hokkaido University 060-0810 Sapporo

We succeeded in performing of hybrid Scanning Probe microscopy (hybrid-SPm) in which mechanical-SPm andfluorescence microscopy are combined. This technique is able to measure simultaneously mechanical properties anddistribution of cytoskeletons of living cells by using green fluorescent protein. We measured evolution of both local elasticityand distributions of actin stress fibers in an identical fibroblast living in physiological conditions. The SPm experimentsrevealed that stiffer lines develop in living cells, which correspond to actin stress fibers. The elasticity of the actin stressfibers is as high as 100 kPa. We discuss mechanical effects on the development of actin filament networks.

关键词： Scanning probe microscopy Green fluorescent protein Fibroblast Cell migration, Cytoskeleton Elasticity

Numerical modeling for the coupled thermo-mechanical processes and spalling phenomena in sp Pillar Stability Experiment (APSE)

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Journal of Rock mechanics and Geotechnical Engineering 2013年第1期5卷 58-72页

作者： T.koyama m.Chijimatsu H.Shimizu S.Nakama T.Fujita A.Kobayashi Y.Ohnishi Department of Urban management Kyoto University Hazama Corporation Institute of Fluid Science Tohoku University Japan Atomic Energy Agency (JAEA) Faculty of Environmental and Urban Engineering Kansai University Kyoto University

In this paper, the coupled thermo-mechanical （Tm） processes in the AEspoe Pillar Stability Experiment （APSE） carried out by the Swedish Nuclear Fuel and Waste management Company （SKB） were simulated using both continuum and discontinuum based numerical methods. Two-dimensional （2D） and three- dimensional （3D） finite element method （FEm） and 2D distinct element method （DEm） with particles were used. The main objective for the large scale in situ experiment is to investigate the yielding strength of crystalline rock and the formation of the excavation disturbed/damaged zone （EDZ） during excavation of two boreholes, pressurizing of one of the boreholes and heating. For the DEm simulations, the heat flow algorithm was newly introduced into the original code. The calculated stress, displacement and temperature distributions were compared with the ones obtained from in situ measurements and FEm simulations. A parametric study for initial microcracks was also performed to reproduce the spalling phenomena observed in the APSE.

关键词： Coupled thermo-mechanical (Tm)processesAspoe Pillar Stability Experiment (APSE)Excavation disturbed/damaged zone (EDZ)Finite element method (FEm)Distinct element method (DEm)

InAsSb thick epilayers applied to long wavelength photoconductors

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International Journal of minerals,metallurgy and materials 2013年第4期20卷 393-396页

作者： Yu-zhu Gao Xiu-ying Gong Guang-hui Wu Yan-bin Feng Takamitsu makino Hirofumi Kan Tadanobu koyama Yasuhiro Hayakawa School of Electronics and Information Engineering Tongji University Huaxing Infrared Device Co. Hamamatsu Photonics K.K. Research Institute of Electronics Shizuoka University

InAs0.052Sb0.948 epilayers with cutoff wavelengths longer than 8 μm were successfully grown on InAs substrates using melt epitaxy （mE）. Scanning electron microscopy observations show that the interface between the epilayers and substrates is flat, indicating the good quality of the epilayers, and the thickness of the epilayers is 40 μm. Photoconductors were fabricated using InAs0.052Sb0.948 thick epilayers grown by mE. Ge optical lenses were set on the photoconductors. At room temperature, the photoresponse wavelength range was 2-10μm. The peak detectivity Dλp reached 5.4 × 10^9 cm-Hz^1/2.W^-1 for the immersed detectors. The detectivity D^＊ was 9.3 × 10^8 and 1.3 × 10^8 ***^1/2.W^-1 at the wavelength of 8 and 9 μm, respectively. The good performance of the uncooled InAsSb detectors was experimentally validated.

关键词： semiconducting indium compounds thick epilayers long wavelength photoconductors detectivity

Endoscopic diagnosis of Barrett's esophagus

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World Journal of Gastroenterology 2012年第26期18卷 3477-3478页

作者： Tomoyuki Akiyama Yusuke Sekino Hiroshi Iida Shigeru koyama Eiji Gotoh Shin maeda Atsushi Nakajima masahiko Inamori Department of Gastroenterology Tokyo Metropolitan Hiroo HospitalTokyo 150-0013Japan Gastroenterology Division Yokohama City University HospitalYokohama 2360004Japan Department of medical Education Yokohama City University School of MedicineYokohama 2360004Japan Office of Postgraduate medical Education Yokohama City University HospitalYokohama 2360004Japan

The Prague C and m Criteria have been developed for the objective endoscopic diagnosis of Barrett's esophagus(BE).BE arises between the squamocolumnar junction and the gastroesophageal junction at the proximal margin of the gastric *** this study,we reported that 43.0% of the subjects examined were diagnosed with BE based on the Prague C and m *** criticism by John Dent proposed that our data should be considered invalid because the prevalence of BE reported in our study was extraordinarily high and discordant with previous *** predicted that the position of the gastroesophageal junction in our study was judged to be lower than the actual position due to the effacement of the proximal ends of the gastric folds because of the routine use of a high degree of air distension during typical Japanese endoscopic *** endoscopic evaluation of the superior gastric folds is certainly influenced by the degree of air distension of the ***,in our study,the proximal limit of the gastric mucosal folds was prospectively imaged while the oesophagus was minimally ***,under a high level of air distension,the distal ends of the palisade-shaped longitudinal vessels were imaged because they are more easily observed when *** the majority of patients,the distal ends of the palisade-shaped longitudinal vessels correspond to the proximal limit of the gastric mucosal *** endoscopic evaluation was appropriately performed according to the Prague C and m *** suspect that the high prevalence of BE in our study may be due to the inclusion of ultrashort-segment BE,which defines BE with an affected mucosal length under 5 mm,in our positive results.

关键词：内镜食管诊断胃粘膜布拉格交界处患病率标准