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Open Journal of Pediatrics 2023年第5期13卷 719-726页

作者： Bangoura Kaba Diallo Fatoumata Binta Kolié Ouo-Ouo Camara Salematou Hassimiou Diallo Mohamed Lamine Diop Mamadou moustapha Camara Emmanuel kouyate moustapha Department of Pediatrics Donka CHU Conakry Guinea Department of Pediatrics Gamal Abdel Nasser Conakry University Conakry Guinea

Renal damage is one of the most frequent and serious manifestations of systemic lupus erythematosus (SLE). Even if this disease is the prerogative of female adults, it can affect children especially during the peri-pubertal period. The aim of this work is to highlight the clinical-biological and progressive characteristics of lupus nephropathy in children.

关键词： Nephropathy Lupus Child

Evaluation of Glomerular Filtration Rate and Urinary Abnormalities in Children with Cancer before Chemotherapy

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Open Journal of Pediatrics 2023年第4期13卷 594-603页

作者： Mamadou moustapha Diop Aissata Barry Ouo Ouo Kolié Emanuel Camara Mohamed Lamine Diallo Kaba Bangoura Mamadou Aliou Doukouré Pé Neabel Beimy Dienab Diallo moustapha kouyate Mohamed Lamine Kaba Department of Pediatrics Faculty of Health Sciences and Technologies Gamal Abdel Nasser University Conakry Republic of Guinea Pediatric Emergency CHU Donka Ministry of Higher Education Scientific Research and Innovation Conakry Republic of Guinea Hemodialysis Department CHU Donka Ministry of Higher Education Scientific Research and Innovation Conakry Republic of Guinea

Introduction: Glomerular filtration is an important elimination pathway for many types of chemotherapy. Accurate estimation of glomerular filtration is essential in the management of children with cancer. Methodology: This was a prospective cross-sectional study of the descriptive type extending over a period of 6 months from July 01 to December 31, 2021 on all children with cancer followed in the pediatric hemato-oncology unit of the HND with a renal, blood and urinary assessment associated with the GFR calculated by the SCHWARTZ formula during the study period. Results: During the study period, we registered 41 new cases of cancer in the pediatric oncology unit. The age group of 0 - 5 years was the most represented, i.e. 65.85% and the average age was 5.6 ± 4 years. The most cited clinical signs were fever ie 56.10% followed by abdominal pain 34.15% and anemia 26.83%. The most represented diagnosis was Burkitt’s Lymphoma, i.e. 26.83% followed by Retinoblastoma 24.39%. Mean serum creatinine was 70.65 ± 68.93 μmol/L. In our series, patients whose normal glomerular filtration rate were more represented, i.e. 70.73% and 29.27% had an abnormal GFR with an average of 87.28 ± 70 mL/min/1.73m2. Proteinuria and leukocyturia were observed in 31.71% and 19.51% respectively. Glycosuria and hematuria with common frequencies of 2.44% of patients. Conclusion: The prevention of renal toxicity of anticancer drugs always involves the precise evaluation of renal function using the Schwartz formula in children. .

关键词： GFR Child Cancer Chemotherapy

Posterior Urethral Valves without Reflux Associated with Bilateral Renal Cortical Atrophy: Diagnosis and Management

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Open Journal of Pediatrics 2023年第6期13卷 791-797页

作者： Bangoura Kaba Kolie Ouo-Ouo Camara Salematou Hassimiou Bangoura M’mah Aminata Camara Emmanuel Diallo Mohamed Lamine Diallo Fatoumata Binta Diop Mamadou moustapha kouyate moustapha Beimy Pé Pediatrics Department CHU Donka Conakry Guinea Gamal Abdel Nasser University of Conakry Conakry Guinea Institute of Nutrition Conakry Guinea

The objective of this case report was to highlight the characteristics of posterior urethral valves observed in a 3-year-old patient and to describe their management. The case of a 4-year-old patient treated for a posterior urethral valve with bilateral renal cortical atrophy was reviewed. The diagnosis was confirmed by abdominal ultrasound, cystography and abdominal CT. He was referred to Martinique (a tertiary health establishment) for effective support. From the acute situation to the fortuitous discovery, its understanding must be deepened because of the potential immediate symptomatic impact in the form of renal colic which can be associated with sepsis, as well as in the long term on renal function. This observation is intended to help the attending physician to initiate his diagnosis and treatment.

关键词： Valves Urethra Posterior

Transient Diabetes Induced by L-Asparaginase

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Open Journal of Pediatrics 2023年第6期13卷 862-865页

作者： Mamadou moustapha Diop M’mah Aminata Bangoura Aissata Barry Emmanuel Camara Kolié Ouo Ouo Pé Neabei Beimy Mohamed Lamine Diallo Kaba Bangoura moustapha kouyate Mohamed Lamine Kaba Aka Nbga Department of Paediatrics Faculty of Health Sciences and Techniques Gamal Abdel Nasser University Conakry Republic of Guinea Urgence Pédiatrique CHU Donka Ministère de l’enseignement de la recherche scientifique et de l’innovation Conakry Republic of Guinea Haemodialysis Department CHU Donka Ministry of Education Scientific Research and Innovation Conakry Republic of Guinea

Background: Although hyperglycaemia is one of the known side effects of L-asparaginase, its contribution to the development of diabetic ketoacidosis (DKA) is less well known in the literature. Asparaginase is an essential component of treatment protocols for acute lymphoblastic leukaemia (ALL) in combination with other chemotherapeutic drugs. On further evaluation, she was found to have high anion gap metabolic acidosis, hyperglycaemia and ketonuria. In recent decades, the use of these chemotherapeutic agents has led to a decrease in mortality and disease-free survival in ALL. L-asparaginase is one of the chemotherapy protocols used in the treatment of acute lymphoblastic leukaemia (ALL) and can induce hyperglycaemia which is aggravated by the concomitant use of corticosteroids. We report the observation of a 14-year-old girl treated with chemotherapy (GFA LAL protocol) who developed transient diabetes following the use of L-asparaginase. She was treated at the Donka paediatric haemato-oncology unit by a multidisciplinary team including a paediatric oncologist, a psychologist and a diabetologist. The aim of this study was to highlight blood glucose monitoring before and after the use of asparaginase in acute lymphoblastic leukaemia. Conclusion: We conclude that the occurrence of ketoacidosis following the use of asparaginase is a rare event. We recommend close monitoring of blood glucose levels for hyperglycaemia in patients with ALL receiving L-asparaginase.

关键词： Asparaginase Diabetes ALL Donka

Lupus Nephropathy: Observation of a Case: Clinical Aspect, Evolution and Management at the West Guyana General Pediatric Service

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Open Journal of Pediatrics（儿科学期刊） 2023年第5期

作者： Bangoura Kaba Diallo Fatoumata Binta Kolié Ouo-Ouo Camara Salematou Hassimiou Diallo Mohamed Lamine Diop Mamadou moustapha Camara Emmanuel kouyate moustapha

Evaluation of Glomerular Filtration Rate and Urinary Abnormalities in Children with Cancer before Chemotherapy

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Open Journal of Pediatrics（儿科学期刊） 2023年第4期

Posterior Urethral Valves without Reflux Associated with Bilateral Renal Cortical Atrophy: Diagnosis and Management

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Open Journal of Pediatrics（儿科学期刊） 2023年第6期

Transient Diabetes Induced by L-Asparaginase

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Open Journal of Pediatrics（儿科学期刊） 2023年第6期