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Increased plasma galectin-1 correlates with advanced glycation end products and interleukin-1β in patients with proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 692-694页

作者： Keitaro Hase Atsuhiro Kanda kousuke noda Susumu Ishida Laboratory of Ocular Cell Biology and Visual Science Department of Ophthalmology Faculty of Medicine and Graduate School of Medicine Hokkaido University

Dear Editor,Galectin-1, one of galactoside-binding lectin family proteins, has been shown to regulate cell growth, migration, and proliferation, where it binds many receptors depending on their glycosylation profile, ... 详细信息

关键词： Increased plasma galectin-1 correlates with advanced glycation end products and interleukin-1β in patients with proliferative diabetic retinopathy diabetic retinopathy

Anterior proliferative vitreoretinopathy in a patient with Coats disease

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 343-345页

作者： Satoru Kase Shohei Mori kousuke noda Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of Medicine Hokkaido University

Dear Editor,I am Satoru Kase,from the Department of Ophthalmology,Faculty of Medicine and Graduate School of Medicine,Hokkaido University,Sapporo,Japan.I write to present a case of Coats disease showing anterior proli... 详细信息

关键词： PVR NVG Anterior proliferative vitreoretinopathy in a patient with Coats disease

Laser speckle flowgraphy findings in a patient with radiation retinopathy

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 172-174页

作者： Satoru Kase Ayaka Hasegawa Kiriko Hirooka Hiroaki Endo kousuke noda Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan Department of Ophthalmology Teine Keijinkai HospitalSapporo 006-0811Japan

Dear Editor,I am Satoru Kase, from Hokkaido University Hospital, Japan. Choroidal melanoma is a serious intraocular tumor, which threatens patients’ vision and life. Treatments for choroidal melanoma consist of surge... 详细信息

关键词： melanoma surgery intraocular

Phosphorylation of alphaB-crystallin in epiretinal membrane of human proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1100-1105页

作者： Yoko Dong Zhenyu Dong Satoru Kase Ryo Ando Junichi Fukuhara Satoshi Kinoshita Saori Inafuku Yoshiaki Tagawa Erdal Tan Ishizuka Wataru Saito Miyuki Murata Atsuhiro Kanda kousuke noda Susumu Ishida Laboratory of Ocular Cell Biology and Visual Science Department of Ophthalmology Hokkaido University Graduate School of Medicine

AIMTo examine phosphorylation of alphaB-crystallin (p-αBC), a vascular endothelial growth factor (VEGF) chaperone, and immunohistochemically investigate relationship between p-αBC, VEGF and phosphorylated p38-mitogen-activated protein kinase (p-p38 MAPK) in the epiretinal membrane of human proliferative diabetic retinopathy (PDR).METHODSEleven epiretinal membranes of PDR surgically excised were included in this study. Two normal retinas were also collected from enucleation tissues due to choroidal melanoma. Paraformaldehyde-fixed, paraffin-embedded tissue sections were processed for immunohistochemistry with anti-p-αBC, VEGF, CD31, and p-p38 MAPK *** for p-αBC was observed in all of the epiretinal membranes examined, where phosphorylation on serine (Ser) 59 showed strongest immunoreactivity in over 70% of the membranes. The immunolocalization of p-αBC was detected in the CD31-positive endothelial cells, and co-localized with VEGF and p-p38 MAPK in PDR membranes. Immunoreactivity for p-αBC, however, was undetectable in endothelial cells of the normal retinas, where p-p38 MAPK immunoreactivity was less marked than PDR *** of αBC, in particular, phosphorylation on Ser59 by p-p38 MAPK may play a potential role as a molecular chaperon for VEGF in the pathogenesis of epiretinal membranes in PDR.

关键词： phosphorylated alphaB-crystallin vascular endothelial growth factor neovascularization proliferative diabetic retinopathy

Recent developments in two-dimensional (2D) correlation spectroscopy

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Chinese Chemical Letters 2015年第2期26卷 167-172页

作者： Isao noda Department of Materials Science & Engineering University of Delaware

Recent noteworthy developments in the field of two-dimensional（2D） correlation spectroscopy are reviewed.2D correlation spectroscopy has become a very popular tool due to its versatility and relative ease of *** technique utilizes a spectroscopic or other analytical probe from a number of selections for a broad range of sample systems by employing different types of external perturbations to induce systematic variations in intensities of *** spectral intensity variations are then converted into2 D spectra by a form of correlation analysis for subsequent *** different types of 2D correlation approaches have been *** particular,2D hetero-correlation and multiple perturbation correlation analyses,including orthogonal sample design scheme,are discussed in this *** references to other important developments in the field of 2D correlation spectroscopy,such as projection correlation and codistribution analysis,were also provided.

关键词： Two-dimensional correlation spectroscopy Hetero-correlation Multiple perturbation correlation Orthogonal sample design

Electron transfer governed by light-matter interaction at metal-semiconductor interface

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npj Computational Materials 2020年第1期6卷 1628-1635页

作者： Kenji Iida Masashi noda Department of Theoretical and Computational Molecular Science Institute for Molecular ScienceMyodaijiOkazaki 444-8585Japan Center for Computational Sciences University of Tsukuba1-1-1 TennodaiTsukuba 305-8577Japan

The photoexcitation of heterostructures consisting of metallic nanoclusters and a semiconductor has been extensively investigated in relation to interests in photocatalysis and optical *** optoelectronic functions of the heterostructures originate from localized surface plasmon resonance,which can induce electron and resonance energy *** it is well known that photoinduced electronic interaction between a metallic nanocluster and a semiconductor is responsible for the resonance energy transfer,the electron transfer associated with the photoinduced electronic interaction has not been *** this paper,we elucidate the photoexcitation dynamics of a silver nanocluster/TiO_(2) heterostructure using an original first-principles computational approach that explicitly deals with light–matter *** is shown that the photoinduced silver–TiO_(2) electronic interaction causes excited electrons to be directly transferred from the silver nanocluster to the TiO2 layer without passing through the conduction band of the silver nanocluster.

关键词： silver interaction transfer

Effects of wing deformation on aerodynamic performance of a revolving insect wing

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Acta Mechanica Sinica 2014年第6期30卷 819-827页

作者： Ryusuke noda Toshiyuki Nakata Hao Liu Graduate School of Engineering Chiba University 1-33 Yayoi-cho Inage-ku Chiba Japan Shanghai Jiao Tong University and Chiba University International Cooperative Research Center (SJTU-CUICRC) Structure and Motion Laboratory The Royal Veterinary CollegeUniversity of London Hawkshead LaneNorth Mymms Hatfield AL9 7TA United Kingdom

Flexible wings of insects and bio-inspired micro air vehicles generally deform remarkably during flapping flight owing to aerodynamic and inertial forces,which is of highly nonlinear fluid-structure interaction（FSI）*** elucidate the novel mechanisms associated with flexible wing aerodynamics in the low Reynolds number regime,we have built up a FSI model of a hawkmoth wing undergoing revolving and made an investigation on the effects of flexible wing deformation on aerodynamic performance of the revolving wing *** take into account the characteristics of flapping wing kinematics we designed a kinematic model for the revolving wing in two-fold：acceleration and steady rotation,which are based on hovering wing kinematics of hawkmoth,Manduca *** results show that both aerodynamic and inertial forces demonstrate a pronounced increase during acceleration phase,which results in a significant wing *** the aerodynamic force turns to reduce after the wing acceleration terminates due to the burst and detachment of leading-edge vortices（LEVs）,the dynamic wing deformation seem to delay the burst of LEVs and hence to augment the aerodynamic force during and even after the *** the phase of steady rotation,the flexible wing model generates more ver-tical force at higher angles of attack（40°–60°）but less horizontal force than those of a rigid wing *** is because the wing twist in spanwise owing to aerodynamic forces results in a reduction in the effective angle of attack at wing tip,which leads to enhancing the aerodynamics performance by increasing the vertical force while reducing the horizontal ***,our results point out the importance of the fluid-structure interaction in evaluating flexible wing aerodynamics：the wing deformation does play a significant role in enhancing the aerodynamic performances but works differently during acceleration and steady rotation,which is mainly induced by inertial force in accelerati

关键词： Insect flight Flexible wing Revolving wing Fluid-structure interaction

Gravitational effects on global hemodynamics in different postures:A closed-loop multiscale mathematical analysis

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Acta Mechanica Sinica 2017年第3期33卷 595-618页

作者： Xiancheng Zhang Shigeho noda Ryutaro Himeno Hao Liu Graduate School of Engineering Chiba University Computational Science Research Program RIKEN Shanghai Jiao Tong University and Chiba University International Cooperative Research Center (SJTU-CU ICRC)

We present a novel methodology and strategy to predict pressures and flow rates in the global cardiovascular network in different postures varying from supine to upright. A closed-loop, multiscale mathematical model of the entire cardiovascular system (CVS) is developed through an integration of one-dimensional (1D) modeling of the large systemic arteries and veins, and zero-dimensional (0D) lumped-parameter modeling of the heart, the cardiac-pulmonary circulation, the cardiac and venous valves, as well as the microcirculation. A versatile junction model is proposed and incorporated into the 1D model to cope with splitting and/or merging flows across a multibranched junction, which is validated to be capable of estimating both subcritical and supercritical flows while ensuring the mass conservation and total pressure continuity. To model gravitational effects on global hemodynamics during postural change, a robust venous valve model is further established for the 1D venous flows and distributed throughout the entire venous network with consideration of its anatomically realistic numbers and locations. The present integrated model is proven to enable reasonable prediction of pressure and flow rate waveforms associated with cardiopulmonary circulation, systemic circulation in arteries and veins, as well as microcirculation within normal physiological ranges, particularly in mean venous pressures, which well match the in vivo measurements. Applications of the cardiovascular model at different postures demonstrate that gravity exerts remarkable influence on arterial and venous pressures, venous returns and cardiac outputs whereas venous pressures below the heart level show a specific correlation between central venous and hydrostatic pressures in right atrium and veins.

关键词： Gravitational effects Cardiovascular system (CVS) Postural change Multiscale cardiovascular model Multibranched junction model Venous valve

A simulation-based study on longitudinal gust response of flexible flapping wings

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Acta Mechanica Sinica 2018年第6期34卷 1048-1060页

作者： Toshiyuki Nakata Ryusuke noda Shinobu Kumagai Hao Liu Graduate School of Engineering Chiba UniversityChiba 263-8522Japan Department of Mechanical Engineering Kanto Gakuin UniversityKanagawa 263-8501Japan

Winged animals such as insects are capable of flying and surviving in an unsteady and unpredictable aerial *** generate and control aerodynamic forces by flapping their flexible *** the dynamic shape changes of their flapping wings are known to enhance the efficiency of their flight,they can also affect the stability of a flapping wing flyer under unpredictable disturbances by responding to the sudden changes of aerodynamic forces on the *** order to test the hypothesis,the gust response of flexible flapping wings is investigated numerically with a specific focus on the passive maintenance of aerodynamic forces by the wing *** computational model is based on a dynamic flight simulator that can incorporate the realistic morphology,the kinematics,the structural dynamics,the aerodynamics and the fluid-structure interactions of a hovering *** longitudinal gusts are imposed against the tethered model of a hovering hawkmoth with flexible flapping *** is found that the aerodynamic forces on the flapping wings are affected by the gust,because of the increase or decrease in relative wingtip velocity or kinematic angle of *** passive shape change of flexible wings can,however,reduce the changes in the magnitude and direction of aerodynamic forces by the gusts from various directions,except for the downward *** adaptive response of the flexible structure to stabilise the attitude can be classified into the mechanical feedback,which works passively with minimal delay,and is of great importance to the design of bio-inspired flapping wings for micro-air vehicles.

关键词： Insect flight Flapping wing Flexible wing Gust response Fluid-structure interaction Mechanical feedback