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International Journal of Ophthalmology(English edition) 2021年第5期14卷 777-779页

作者： Satoru Kase kousuke Noda Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan

Dear Editor,I am *** Kase,from the Department of Ophthalmology,Faculty of Medicine and Graduate School of Medicine,Hokkaido University.I write to present a case of choroidal melanoma arising from a thickened ***"pachychoroid"has recently been proposed as an entity comprising an increase in the choroidal thickness and dilatation of large choroidal vessels(so-called pachyvessels)[1].

关键词： choroidal melanoma Medicine

Increased plasma galectin-1 correlates with advanced glycation end products and interleukin-1β in patients with proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 692-694页

作者： Keitaro Hase Atsuhiro Kanda kousuke Noda Susumu Ishida Laboratory of Ocular Cell Biology and Visual Science Department of Ophthalmology Faculty of Medicine and Graduate School of Medicine Hokkaido University

Dear Editor,Galectin-1, one of galactoside-binding lectin family proteins, has been shown to regulate cell growth, migration, and proliferation, where it binds many receptors depending on their glycosylation profile, ... 详细信息

关键词： Increased plasma galectin-1 correlates with advanced glycation end products and interleukin-1β in patients with proliferative diabetic retinopathy diabetic retinopathy

Anterior proliferative vitreoretinopathy in a patient with Coats disease

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 343-345页

作者： Satoru Kase Shohei Mori kousuke Noda Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of Medicine Hokkaido University

Dear Editor,I am Satoru Kase,from the Department of Ophthalmology,Faculty of Medicine and Graduate School of Medicine,Hokkaido University,Sapporo,Japan.I write to present a case of Coats disease showing anterior proli... 详细信息

关键词： PVR NVG Anterior proliferative vitreoretinopathy in a patient with Coats disease

Molecular targeting to treat gastric cancer

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World Journal of Gastroenterology 2014年第38期20卷 13741-13755页

作者： Keishiro Aoyagi Kikuo Kouhuji Junya Kizaki Taro Isobe kousuke Hashimoto Kazuo Shirouzu Department of Surgery Kurume University School of Medicine

Trastuzumab that targets human epidermal growth factor receptor 2 (HER2) protein is the only approved molecular targeting agent for treating gastric cancer in Japan and the outcomes have been favorable. However, trastuzumab is effective for only 10% to 20% of the population with gastric cancer that expresses HER2 protein. Molecular targeting therapy with bevacizumab against vascular endothelial growth factors (VEGF) and with cetuximab and panitumumab against the epidermal growth factors pathway that have been approved for treating colorectal cancer are not considered effective for treating gastric cancer according to several clinical trials. However, ramucirumab that targets VEGF receptor-2 prolonged overall survival in a large phase III clinical trial and it might be an effective molecular targeting therapy for gastric cancer. The significance of molecular targeting therapy for gastric cancer remains controversial. A large-scale randomized clinical trial of novel molecular targeting agents with which to treat gastric cancer is needed.

关键词： Gastric cancer Molecular targeting therapy Human epidermal growth factor receptor 2 protein Vascular endothelial growth factors/Vascular endothelial growth factor receptor pathway Epidermal growth factors pathway

Ultra-Short Pulse Tracking by Using Wavelength Dispersion for a Short-Time Optical Buffer

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光学学报 2003年第S1期23卷 601-602页

作者： Tsuyoshi Konishi Hideaki Furukawa kousuke Asano Kazuyoshi Itoh Graduate School of Engineering Department of Material and Life Science Osaka University JAPANGraduate School of Engineering Department of Material and Life Science Osaka University JAPANGraduate School of Engineering Department of Material and Life Science Osaka University JAPANGraduate School of Engineering Department of Material and Life Science Osaka University JAPAN

To synchronize a control signal with a packet signal in response to changing timing jitter, we investigate ultra-short pulse tracking by using wavelength dispersion for a short-time optical buffer in an optical router.

关键词： for on in by Ultra-Short Pulse Tracking by Using Wavelength Dispersion for a Short-Time Optical Buffer

A CIN-like TCP transcription factor(LsTCP4)having retrotransposon insertion associates with a shift from Salinas type to Empire type in crisphead lettuce(Lactuca sativa L.)

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Horticulture Research 2020年第1期7卷 2597-2610页

作者： kousuke Seki Kenji Komatsu Keisuke Tanaka Masahiro Hiraga Hiromi Kajiya-Kanegae Hideo Matsumura Yuichi Uno Nagano Vegetable and Ornamental Crops Experiment Station Tokoo 1066-1SougaShiojiriNagano 399-6461Japan Department of Bioresource Development Tokyo University of AgricultureFunako1737AtsugiKanagawa 243-0034Japan NODAI Genome Research Center Tokyo University of AgricultureSakuragaoka 1-1-1SetagayaTokyo 156-8502Japan Nagano Fruit Tree Experiment Station Ogawara 492SuzakaNagano 382-0072Japan Research Center for Agricultural Information Technology NAROKannondai 3-1-1TsukubaIbaraki 305-8517Japan Gene Research Center Shinshu Seki et al.Horticulture Research(2020)7:15 Page 13 of 14 UniversityTsuneta 3-15-1UedaNagano 386-8567Japan Plant Science Division Department of Bioresource ScienceGraduate School of Agricultural ScienceKobe UniversityRokkodai 1-1NadaKobeHyogo 657-8501Japan

To improve several agronomic traits in crisphead lettuce(Lactuca sativa L.)under high-temperature growth conditions,we investigated the correlation among those traits in multiple cultivars and performed genetic mapping of their causal *** a field cultivation test of Empire type(serrated leaf)and Salinas type(wavy leaf)cultivars,Empire type cultivars showed increased tipburn susceptibility and late bolting compared with Salinas type *** attempted genetic mapping of leaf shape and bolting time by ddRAD-seq using the F2 population derived from a cross between‘VI185’(Empire type)and‘ShinanoGreen’(Salinas type).These analyses suggested that both traits are controlled by a single locus in *** of 51 commercial lettuce cultivars with a tightly linked marker(LG5_v8_252.743Mbp)at this locus showed an association between its genotype and the serrated leaf *** further fine mapping and transcriptome analysis,a gene encoding putative CIN-like TCP transcription factor was determined to be a candidate gene at this locus and was designated as *** insertion of retrotransposable element was found in the allele of‘VI185’,and its transcript level in the leaves was lower than that in‘ShinanoGreen’.Because shapes of leaf epidermal cells in‘VI185’were similar to those in the TCP family mutant of Arabidopsis thaliana,the leaf shape phenotype was likely caused by reduced expression of ***,because it is known that the TCP family protein also controls flowering time via interaction with FT in ***,it was highly possible that LsTCP4 gave pleiotropic effects on both leaf shape and bolting time in lettuce.

关键词： cultivar insertion Lactuca

Laser speckle flowgraphy findings in a patient with radiation retinopathy

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 172-174页

作者： Satoru Kase Ayaka Hasegawa Kiriko Hirooka Hiroaki Endo kousuke Noda Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan Department of Ophthalmology Teine Keijinkai HospitalSapporo 006-0811Japan

Dear Editor,I am Satoru Kase, from Hokkaido University Hospital, Japan. Choroidal melanoma is a serious intraocular tumor, which threatens patients’ vision and life. Treatments for choroidal melanoma consist of surge... 详细信息

关键词： melanoma surgery intraocular

Synthesis and Characterization of Triarylamine-Based Block Copolymers by Combination of C-N Coupling and ATRP for Photorefractive Applications

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Open Journal of Organic Polymer Materials 2012年第4期2卷 53-62页

作者： Zhenbo Cao kousuke kousuke Tsuchiy Takeshi Shimomura Kenji Ogino Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology Tokyo Japan

Poly(4-butyltriarylamine)s with t-butyldimethylsilyl terminal protecting group (PBTPA-TBS) with various molecular weights were prepared by C-N coupling polymerization. The resulting precursors were postfunctionalized and subse- quently used as macroinitiators for atom transfer radial polymerization (ATRP) of n-butyl acrylate (n-BA) and ethyl acrylate (EA). Both the polymerization processes were controlled and the polymers were characterized by 1H NMR, gel permeation chromatography (GPC) and thermal properties, which confirmed the successful synthesis of all the poly-mers. The microphase separated behaviors of the poly (4-butyltriarylamine)-block-poly (butyl acrylate) (PBTPA-b-PBA) were examined by AFM in the film showing phase separation structures for all the polymers. The photorefractive property of the composite based on PBTPA-b-PBA block copolymer was evaluated by two-beam coupling experiment. A relative high gain coefficient of 42.7 cm?1 was obtained at the electric field of 31 V/?m.

关键词： C-N Coupling Atrp Triarylamine Acrylate Ester Photorefractivity

Development of a System for Location Finding of Low-Level Sound Source by Using Human Acoustic System with Stochastic Resonance

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Journal of Mechanics Engineering and Automation 2014年第5期4卷 403-411页

作者： kousuke Miyaji Katsuyoshi Tsujita Department of Biomedical Engineering Osaka Institute of Technology Osaka 535-8585 Japan Department of Robotics Faculty of Engineering Osaka Institute of Technology Osaka 535-8585 Japan

The purpose of this study is to develop a system that enables location finding of a small sound. The location finding of a small sound has some difficulties such as high computational costs or disturbances from the ambient noises and reflected waves. The proposed system is composed of a biologically-inspired system which uses a hearing mechanism based on the human ear and a mechanism for perceiving weak signals that uses stochastic resonance. The location finding mechanism in the proposed system is based on the time-lag detecting architecture. On the other hand, the stochastic resonance mechanism can pick up the small sound source in the ambient noises. Using this proposed system, we implemented the location finding of small sounds through numerical simulations and hardware experiments. Good results were obtained for the small sound source location finding.

关键词： Sound source location human acoustic system low-level sound stochastic resonance.